Pak2 Rat Gene (p21 protein (Cdc42/Rac)-activated kinase 2)

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Keyword

Gene:
Pak2 ( Rattus norvegicus )
p21 protein (Cdc42/Rac)-activated kinase 2
Description: mitogen activated protein kinase that mediates bFGF-induced neurite outgrowth via activation by ERK kinase
Synonyms: gamma-PAK; p21 (CDKN1A)-activated kinase 2;
ArrayIDs: 6582932; 1369650_at; 5650773; U35345_s_at; GE21929; 6533449; A_42_P689755; 5905931; 6690227; 1396267_at; 6709070; 6134648; 6169729; 6541730; 1388345_at; 5765470; 6298325; rc_AI230632_at; 6059216; 6258781; 6502106; 6212741; 5802168; 6199650;  (details...)
Gene Type: protein-coding

Additional Data

Homologs
Homo sapiens: PAK2     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Pak2     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Pak2 genome assembly 3.1 11 70587549 - 70646100
Rat Celera Assembly 11 68130464 - 68189148
RGSC genome assembly v3.4 11 70529961 - 70588515
Cytogenetic 11 q22
Mus musculus Pak2 Mouse genome assembly build 36.1 16 32017949 - 32079359
Cytogenetic 16 16 B2
Homo sapiens PAK2 human genome assembly 3 197955224 - 198047662
Human genome assembly build 36.2 3 197951312 - 198043756
Cytogenetic 3 q29

View comparative maps:      NCBI MapViewer

Genome
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Annotation
Molecular Function

Note Reference

phosphorylates protein serine/threonine residues 61685, 70317

Gene Ontology

nucleotide binding,  identical protein binding,  ATP binding ... (details...)
Biological Process

Gene Ontology

protein amino acid autophosphorylation (details...)
Cellular Component

Gene Ontology

perinuclear region of cytoplasm,  nucleus,  cytoplasm ... (details...)
Expression

Note Reference

expressed in many tissues 61685, 70317

External Links
Databases
DATABASE ID SOURCE
SMART: S_TKc IPI
SMART: PBD IPI
PROSITE: PROTEIN_KINASE_ST IPI
PROSITE: PROTEIN_KINASE_DOM IPI
PROSITE: CRIB IPI
PROSITE: PROTEIN_KINASE_ATP IPI
UNIPARC: UPI0000131222 IPI
KEGG Report: rno:29432 ENTREZGENE
HomoloGene Group ID: 99711 ENTREZGENE
Germonline: 61953
Pfam: Pkinase IPI
Pfam: PBD IPI
KEGG Pathway: 04360 ENTREZGENE
KEGG Pathway: 05211 ENTREZGENE
KEGG Pathway: 04012 ENTREZGENE
KEGG Pathway: 04510 ENTREZGENE
KEGG Pathway: 04010 ENTREZGENE
KEGG Pathway: 04660 ENTREZGENE
KEGG Pathway: 04810 ENTREZGENE
InterPro: Prot_kinase_cat_dom. IPI
InterPro: Kinase-like_dom. IPI
InterPro: PAK_box_Rho_bd. IPI
InterPro: Protein_kinase_ATP_BS. IPI
InterPro: Se/Thr_prot_kinase-like_dom. IPI
InterPro: Ser/Thr_kinase_Pak-rel. IPI
InterPro: Ser/Thr_prot_kinase_AS. IPI
InterPro: Ser/Thr_prot_kinase_dom. IPI
IPI: IPI00211615 IPI
Ensembl Protein: ENSRNOP00000040162 IPI
Entrez Gene: Pak2 ENTREZGENE
UniProt: PAK2_RAT IPI
Ensembl Genes: ENSRNOG00000001747 IPI
Superfamily-SCOP: Kinase_like IPI
PANTHER: Pak_like IPI
Sequences
Nucleotide: U19967 Get FASTA Search GEO Profiles
Nucleotide: CH473967 Get FASTA Search GEO Profiles
Nucleotide: U35345 Get FASTA Search GEO Profiles
Nucleotide: NM_053306 Get FASTA Search GEO Profiles
Nucleotide: S80221 Get FASTA Search GEO Profiles
(View all 5 Nucleotide Accessions)
Protein: NP_445758 Get FASTA
Protein: EDM11448 Get FASTA
Protein: AAB35608 Get FASTA
Protein: AAF06695 Get FASTA
Protein: AAA79064 Get FASTA
Protein: Q64303 Get FASTA
(View all 6 Protein Accessions)
Clusters
UniGene: 3840

References
Curated References
7 references in RGD related to Pak2

Other References
9 other references at PubMed related to Pak2

Database Information
RGD ID 61953
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

27-MAY-09: Pak2 p21 protein (Cdc42/Rac)-activated kinase 2 Pak2 p21 (CDKN1A)-activated kinase 2 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863

10-JUN-02: Pak2 p21 (CDKN1A)-activated kinase 2 APPROVED Symbol and Name status set to approved 70586