Lgals7 (galectin 7) - Rat Genome Database

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Gene: Lgals7 (galectin 7) Rattus norvegicus
Analyze
Symbol: Lgals7
Name: galectin 7
RGD ID: 61951
Description: Predicted to enable carbohydrate binding activity. Predicted to be involved in apoptotic process. Predicted to be located in cytoplasm; extracellular region; and nucleus. Predicted to be active in cornified envelope. Orthologous to several human genes including LGALS7 (galectin 7); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: gal-7; Galectin-7; lectin, galactose binding, soluble 7; lectin, galactoside-binding, soluble, 7
RGD Orthologs
Human
Mouse
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,275,092 - 93,279,529 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl193,273,836 - 93,279,528 (+)EnsemblGRCr8
mRatBN7.2184,148,612 - 84,152,016 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,150,252 - 84,152,015 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx189,560,269 - 89,562,025 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0198,019,035 - 98,020,821 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,316,129 - 91,317,885 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0187,044,823 - 87,047,223 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,045,335 - 87,047,223 (+)Ensemblrn6Rnor6.0
Rnor_5.0188,224,505 - 88,227,841 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,968,263 - 83,970,018 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera178,540,566 - 78,542,321 (+)NCBICelera
RGSC_v3.1184,046,373 - 84,048,126 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Changes in galectin-7 and cytokeratin-19 expression during the progression of malignancy in thyroid tumors: diagnostic and biological implications. Rorive S, etal., Mod Pathol 2002 Dec;15(12):1294-301.
7. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8889548   PMID:9697310   PMID:19199708   PMID:21677144   PMID:23376485   PMID:33416139  


Genomics

Comparative Map Data
Lgals7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,275,092 - 93,279,529 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl193,273,836 - 93,279,528 (+)EnsemblGRCr8
mRatBN7.2184,148,612 - 84,152,016 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,150,252 - 84,152,015 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx189,560,269 - 89,562,025 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0198,019,035 - 98,020,821 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,316,129 - 91,317,885 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0187,044,823 - 87,047,223 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,045,335 - 87,047,223 (+)Ensemblrn6Rnor6.0
Rnor_5.0188,224,505 - 88,227,841 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,968,263 - 83,970,018 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera178,540,566 - 78,542,321 (+)NCBICelera
RGSC_v3.1184,046,373 - 84,048,126 (+)NCBI
Cytogenetic Map1q21NCBI
LGALS7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,770,968 - 38,773,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,770,968 - 38,773,517 (-)Ensemblhg38GRCh38
GRCh38.p14 Ensembl1938,789,200 - 38,791,754 (+)Ensemblhg38GRCh38
GRCh371939,261,608 - 39,264,157 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361943,953,445 - 43,955,983 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341943,971,693 - 43,974,232NCBI
Celera1936,063,616 - 36,066,165 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,727,171 - 35,729,720 (+)NCBIHuRef
CHM1_11939,262,048 - 39,264,610 (-)NCBICHM1_1
T2T-CHM13v2.01941,575,026 - 41,577,575 (-)NCBIT2T-CHM13v2.0
Lgals7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,563,258 - 28,565,711 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,563,278 - 28,565,709 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38728,863,796 - 28,866,285 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,863,853 - 28,866,284 (+)Ensemblmm10GRCm38
MGSCv37729,649,405 - 29,651,303 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36728,573,146 - 28,575,044 (+)NCBIMGSCv36mm8
Celera723,425,320 - 23,427,218 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.94NCBI
Lgals7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,261,564 - 13,263,639 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368011,426,987 - 1,428,935 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049368011,426,920 - 1,428,976 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGALS7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1647,588,983 - 47,604,520 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,151,691 - 43,230,013 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Lgals7
45 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:118
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000027620
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat

Markers in Region
RH137014  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8193,278,950 - 93,279,488 (+)Marker Load Pipeline
mRatBN7.2184,151,437 - 84,151,975 (+)MAPPERmRatBN7.2
Rnor_6.0187,046,644 - 87,047,181NCBIRnor6.0
Rnor_5.0188,227,262 - 88,227,799UniSTSRnor5.0
RGSC_v3.4183,969,440 - 83,969,977UniSTSRGSC3.4
Celera178,541,743 - 78,542,280UniSTS
RH 3.4 Map1829.8UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 9 47 89 44 50 19 73 19 6 229 138 2 75 51 90 31 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000027620   ⟹   ENSRNOP00000027620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl193,276,437 - 93,279,528 (+)Ensembl
mRatBN7.2 Ensembl184,150,252 - 84,152,013 (+)Ensembl
Rnor_6.0 Ensembl187,045,796 - 87,047,221 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084393   ⟹   ENSRNOP00000068607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl193,273,836 - 93,279,528 (+)Ensembl
mRatBN7.2 Ensembl184,150,312 - 84,152,015 (+)Ensembl
Rnor_6.0 Ensembl187,045,335 - 87,047,223 (+)Ensembl
RefSeq Acc Id: NM_022582   ⟹   NP_072104
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,277,774 - 93,279,529 (+)NCBI
mRatBN7.2184,150,261 - 84,152,016 (+)NCBI
Rnor_6.0187,045,467 - 87,047,222 (+)NCBI
Rnor_5.0188,224,505 - 88,227,841 (+)NCBI
RGSC_v3.4183,968,263 - 83,970,018 (+)RGD
Celera178,540,566 - 78,542,321 (+)RGD
Sequence:
RefSeq Acc Id: XM_039109505   ⟹   XP_038965433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,275,092 - 93,279,526 (+)NCBI
mRatBN7.2184,148,612 - 84,152,016 (+)NCBI
RefSeq Acc Id: XM_039109509   ⟹   XP_038965437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,275,092 - 93,279,526 (+)NCBI
mRatBN7.2184,148,612 - 84,152,016 (+)NCBI
RefSeq Acc Id: NP_072104   ⟸   NM_022582
- UniProtKB: O54958 (UniProtKB/Swiss-Prot),   P97590 (UniProtKB/Swiss-Prot),   A6J9L7 (UniProtKB/TrEMBL),   F8WG95 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068607   ⟸   ENSRNOT00000084393
Ensembl Acc Id: ENSRNOP00000027620   ⟸   ENSRNOT00000027620
RefSeq Acc Id: XP_038965433   ⟸   XM_039109505
- Peptide Label: isoform X1
- UniProtKB: P97590 (UniProtKB/Swiss-Prot),   O54958 (UniProtKB/Swiss-Prot),   A6J9L7 (UniProtKB/TrEMBL),   F8WG95 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965437   ⟸   XM_039109509
- Peptide Label: isoform X1
- UniProtKB: P97590 (UniProtKB/Swiss-Prot),   O54958 (UniProtKB/Swiss-Prot),   A6J9L7 (UniProtKB/TrEMBL),   F8WG95 (UniProtKB/TrEMBL)
Protein Domains
Galectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97590-F1-model_v2 AlphaFold P97590 1-136 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689890
Promoter ID:EPDNEW_R413
Type:single initiation site
Name:Lgals7_1
Description:galectin 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0187,045,444 - 87,045,504EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61951 AgrOrtholog
BioCyc Gene G2FUF-60211 BioCyc
Ensembl Genes ENSRNOG00000020380 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027620 ENTREZGENE
  ENSRNOT00000027620.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot
  Galectin-like UniProtKB/Swiss-Prot
  Galectin_CRD UniProtKB/Swiss-Prot
KEGG Report rno:29518 UniProtKB/Swiss-Prot
NCBI Gene 29518 ENTREZGENE
PANTHER PTHR11346 UniProtKB/Swiss-Prot
  PTHR11346:SF107 UniProtKB/Swiss-Prot
Pfam Gal-bind_lectin UniProtKB/Swiss-Prot
PhenoGen Lgals7 PhenoGen
PROSITE GALECTIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020380 RatGTEx
SMART Gal-bind_lectin UniProtKB/Swiss-Prot
  GLECT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot
TIGR TC218382
UniProt A0A8L2QZL5_RAT UniProtKB/TrEMBL
  A6J9L7 ENTREZGENE, UniProtKB/TrEMBL
  F8WG95 ENTREZGENE, UniProtKB/TrEMBL
  LEG7_RAT UniProtKB/Swiss-Prot
  O54958 ENTREZGENE
  P97590 ENTREZGENE
UniProt Secondary O54958 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-18 Lgals7  galectin 7  Lgals7  lectin, galactoside-binding, soluble, 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-30 Lgals7  lectin, galactoside-binding, soluble, 7  Lgals7  lectin, galactose binding, soluble 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Lgals7  lectin, galactose binding, soluble 7      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference