Per2 (period circadian regulator 2) - Rat Genome Database

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Gene: Per2 (period circadian regulator 2) Rattus norvegicus
Analyze
Symbol: Per2
Name: period circadian regulator 2
RGD ID: 61945
Description: Predicted to enable several functions, including enzyme binding activity; transcription coactivator activity; and transcription corepressor binding activity. Involved in circadian rhythm; negative regulation of transcription by RNA polymerase II; and neural retina development. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of Cry-Per complex. Predicted to be active in cytoplasm and nucleus. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome; advanced sleep phase syndrome 1; alcohol dependence; cocaine dependence; and fetal alcohol spectrum disorder. Orthologous to human PER2 (period circadian regulator 2); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: circadian clock protein PERIOD 2; period circadian clock 2; period circadian protein homolog 2; period homolog 2; period homolog 2 (Drosophila); rPER2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,454,828 - 99,497,069 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl999,454,830 - 99,496,993 (-)EnsemblGRCr8
mRatBN7.2992,007,289 - 92,049,551 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl992,007,296 - 92,049,459 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9100,434,053 - 100,476,216 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,569,813 - 105,611,980 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,933,398 - 103,975,592 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,555,154 - 98,597,362 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,555,169 - 98,597,359 (-)Ensemblrn6Rnor6.0
Rnor_5.0998,231,202 - 98,273,371 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4990,645,342 - 90,687,509 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera989,548,336 - 89,590,505 (-)NCBICelera
RGSC_v3.1990,850,110 - 90,892,278 (-)NCBI
Cytogenetic Map9q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acamprosate  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
Ampullosporin  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
chloroprene  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cocaine  (ISO)
cocaine hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethyl maleate  (EXP)
dioxygen  (EXP)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
Erionite  (ISO)
ethanol  (ISO)
ferric oxide  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gallic acid  (ISO)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
glycine betaine  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
linsidomine  (ISO)
manganese(II) chloride  (EXP)
melatonin  (EXP)
menadione  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
milrinone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
plumbagin  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
quercetin  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
styrene  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
torcetrapib  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
trovafloxacin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zalcitabine  (EXP)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Cry-Per complex  (ISO)
cytoplasm  (IBA,IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
perinuclear region of cytoplasm  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Requirement of mammalian Timeless for circadian rhythmicity. Barnes JW, etal., Science 2003 Oct 17;302(5644):439-42.
2. Role of the circadian clock gene Per2 in adaptation to cold temperature. Chappuis S, etal., Mol Metab. 2013 May 10;2(3):184-93. doi: 10.1016/j.molmet.2013.05.002. eCollection 2013.
3. Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat. Chen CP, etal., J Neurochem. 2004 Mar;88(6):1547-54. doi: 10.1046/j.1471-4159.2003.02300.x.
4. Prenatal ethanol exposure alters the expression of period genes governing the circadian function of beta-endorphin neurons in the hypothalamus. Chen CP, etal., J Neurochem. 2006 May;97(4):1026-33. doi: 10.1111/j.1471-4159.2006.03839.x.
5. Per and neuropeptide expression in the rat suprachiasmatic nuclei: compartmentalization and differential cellular induction by light. Dardente H, etal., Brain Res 2002 Dec 27;958(2):261-71.
6. Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability. Forsyth CB, etal., Am J Physiol Gastrointest Liver Physiol. 2013 Jul 15;305(2):G185-95. doi: 10.1152/ajpgi.00354.2012. Epub 2013 May 9.
7. Hypermethylation of Proopiomelanocortin and Period 2 Genes in Blood Are Associated with Greater Subjective and Behavioral Motivation for Alcohol in Humans. Gangisetty O, etal., Alcohol Clin Exp Res. 2019 Feb;43(2):212-220. doi: 10.1111/acer.13932. Epub 2018 Dec 31.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system. Hamaguchi H, etal., Biochem J. 2004 Aug 15;382(Pt 1):43-50.
11. Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured Rat-1 fibroblasts. Hirota T, etal., J Biol Chem 2002 Nov 15;277(46):44244-51.
12. Dec1 and Dec2 are regulators of the mammalian molecular clock. Honma S, etal., Nature 2002 Oct 24;419(6909):841-4.
13. Reduced expression of circadian clock genes in male alcoholic patients. Huang MC, etal., Alcohol Clin Exp Res. 2010 Nov;34(11):1899-904. doi: 10.1111/j.1530-0277.2010.01278.x. Epub 2010 Aug 24.
14. A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Kawamoto T, etal., Biochem Biophys Res Commun. 2004 Jan 2;313(1):117-24.
15. Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats. Matejů K, etal., J Comp Neurol. 2010 Sep 1;518(17):3630-44. doi: 10.1002/cne.22421.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Nuclear entry mechanism of rat PER2 (rPER2): role of rPER2 in nuclear localization of CRY protein. Miyazaki K, etal., Mol Cell Biol 2001 Oct;21(19):6651-9.
18. Indication of circadian oscillations in the rat pancreas. Muhlbauer E, etal., FEBS Lett. 2004 Apr 23;564(1-2):91-6.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2. Ohsaki K, etal., J Biochem. 2008 Nov;144(5):609-18. doi: 10.1093/jb/mvn112. Epub 2008 Sep 8.
21. Antiphase circadian expression between BMAL1 and period homologue mRNA in the suprachiasmatic nucleus and peripheral tissues of rats. Oishi K, etal., Biochem Biophys Res Commun. 1998 Dec 18;253(2):199-203.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. Development of morphine-induced tolerance and withdrawal: involvement of the clock gene mPer2. Perreau-Lenz S, etal., Eur Neuropsychopharmacol. 2010 Jul;20(7):509-17. doi: 10.1016/j.euroneuro.2010.03.006.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Multitissue circadian expression of rat period homolog (rPer2) mRNA is governed by the mammalian circadian clock, the suprachiasmatic nucleus in the brain. Sakamoto K, etal., J Biol Chem 1998 Oct 16;273(42):27039-42.
28. Molecular characterization and nuclear localization of rat timeless-like gene product. Sakamoto S, etal., Biochem Biophys Res Commun. 2000 Dec 9;279(1):131-8.
29. Serotonin inhibits glutamate- but not PACAP-induced per gene expression in the rat suprachiasmatic nucleus at night. Sanggaard KM, etal., Eur J Neurosci 2003 Mar;17(6):1245-52.
30. Persistent Changes in Stress-Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol. Sarkar DK, etal., Alcohol Clin Exp Res. 2019 Sep;43(9):1887-1897. doi: 10.1111/acer.14148. Epub 2019 Aug 6.
31. Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability. Shumay E, etal., Transl Psychiatry. 2012 Mar 6;2(3):e86. doi: 10.1038/tp.2012.11.
32. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
33. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Toh KL, etal., Science. 2001 Feb 9;291(5506):1040-3.
34. Effect of fluoxetine and cocaine on the expression of clock genes in the mouse hippocampus and striatum. Uz T, etal., Neuroscience. 2005;134(4):1309-16. doi: 10.1016/j.neuroscience.2005.05.003.
35. Differential gene expression in the rat caudate putamen after "binge" cocaine administration: advantage of triplicate microarray analysis. Yuferov V, etal., Synapse 2003 Jun 15;48(4):157-69.
Additional References at PubMed
PMID:9989497   PMID:11395012   PMID:11889036   PMID:12710990   PMID:12738229   PMID:12843397   PMID:14593213   PMID:14645221   PMID:14701732   PMID:15193530   PMID:15689618   PMID:15792371  
PMID:15860628   PMID:15864751   PMID:16580135   PMID:16595674   PMID:16675517   PMID:16678973   PMID:16923124   PMID:17310242   PMID:17404161   PMID:17544223   PMID:17915197   PMID:17986006  
PMID:18208549   PMID:18511208   PMID:18810660   PMID:18817849   PMID:19036829   PMID:19103603   PMID:19122877   PMID:19217292   PMID:19222559   PMID:19402751   PMID:19559014   PMID:19605937  
PMID:19740747   PMID:19887760   PMID:19917250   PMID:20096750   PMID:20159955   PMID:20205554   PMID:20424134   PMID:20738730   PMID:20962226   PMID:21035761   PMID:21063915   PMID:21076970  
PMID:21182399   PMID:21363938   PMID:21484443   PMID:21547532   PMID:21613214   PMID:21621196   PMID:21680841   PMID:21767615   PMID:21768648   PMID:21775066   PMID:21952132   PMID:22170608  
PMID:22208286   PMID:22274616   PMID:22381761   PMID:22504074   PMID:22767893   PMID:23106436   PMID:23167790   PMID:23418588   PMID:23738784   PMID:23785138   PMID:23850797   PMID:23850969  
PMID:23864491   PMID:23977055   PMID:24124556   PMID:24133102   PMID:24268780   PMID:24413057   PMID:24549704   PMID:24619734   PMID:24737000   PMID:25068868   PMID:25669688   PMID:25760074  
PMID:26213916   PMID:26271538   PMID:26656624   PMID:26892296   PMID:26901093   PMID:27362940   PMID:27365111   PMID:27999821   PMID:28423013   PMID:29165002   PMID:29894471   PMID:30627637  
PMID:31822134   PMID:32777474   PMID:32964673   PMID:37338051  


Genomics

Comparative Map Data
Per2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,454,828 - 99,497,069 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl999,454,830 - 99,496,993 (-)EnsemblGRCr8
mRatBN7.2992,007,289 - 92,049,551 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl992,007,296 - 92,049,459 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9100,434,053 - 100,476,216 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,569,813 - 105,611,980 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,933,398 - 103,975,592 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,555,154 - 98,597,362 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,555,169 - 98,597,359 (-)Ensemblrn6Rnor6.0
Rnor_5.0998,231,202 - 98,273,371 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4990,645,342 - 90,687,509 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera989,548,336 - 89,590,505 (-)NCBICelera
RGSC_v3.1990,850,110 - 90,892,278 (-)NCBI
Cytogenetic Map9q36NCBI
PER2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382238,244,044 - 238,300,065 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2238,244,044 - 238,290,102 (-)Ensemblhg38GRCh38
GRCh372239,152,685 - 239,197,251 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,817,418 - 238,861,946 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342238,934,685 - 238,979,092NCBI
Celera2232,865,233 - 232,909,762 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2230,943,837 - 230,988,232 (-)NCBIHuRef
CHM1_12239,158,528 - 239,203,056 (-)NCBICHM1_1
T2T-CHM13v2.02238,733,782 - 238,779,869 (-)NCBIT2T-CHM13v2.0
Per2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39191,343,699 - 91,387,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl191,343,704 - 91,387,046 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38191,415,977 - 91,459,351 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl191,415,982 - 91,459,324 (-)Ensemblmm10GRCm38
MGSCv37193,312,559 - 93,355,905 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36193,246,388 - 93,289,702 (-)NCBIMGSCv36mm8
Celera194,353,350 - 94,396,834 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.13NCBI
Per2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555422,338,099 - 2,371,274 (+)Ensembl
ChiLan1.0NW_0049555422,331,547 - 2,369,011 (+)NCBIChiLan1.0ChiLan1.0
PER2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213140,876,886 - 140,921,469 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B140,891,847 - 140,936,401 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B125,477,021 - 125,521,577 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B244,328,122 - 244,371,040 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B244,328,122 - 244,371,040 (-)EnsemblpanPan2panpan1.1
PER2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12548,716,499 - 48,761,617 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2548,717,173 - 48,758,755 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2549,211,912 - 49,257,033 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02549,102,140 - 49,147,315 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2549,102,151 - 49,143,375 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12548,977,242 - 49,022,398 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02548,765,877 - 48,806,293 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02548,998,242 - 49,043,270 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Per2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303190,676,406 - 190,718,243 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936525221,510 - 263,295 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936525221,601 - 263,284 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PER2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15137,793,422 - 137,837,070 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115137,793,419 - 137,837,854 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215152,264,819 - 152,284,153 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PER2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110124,270,917 - 124,316,031 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10124,269,543 - 124,315,904 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604075,104,175 - 75,149,164 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Per2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248473,361,170 - 3,390,405 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248473,359,174 - 3,399,584 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Per2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14163,414,226 - 163,446,131 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Per2
364 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:281
Count of miRNA genes:174
Interacting mature miRNAs:220
Transcripts:ENSRNOT00000027506
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat

Markers in Region
AW524487  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2992,035,203 - 92,035,384 (+)MAPPERmRatBN7.2
Rnor_6.0998,583,068 - 98,583,248NCBIRnor6.0
Rnor_5.0998,259,116 - 98,259,296UniSTSRnor5.0
RGSC_v3.4990,673,254 - 90,673,434UniSTSRGSC3.4
Celera989,576,250 - 89,576,430UniSTS
Cytogenetic Map9q36UniSTS
BI276674  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2992,034,821 - 92,034,960 (+)MAPPERmRatBN7.2
Rnor_6.0998,582,686 - 98,582,824NCBIRnor6.0
Rnor_5.0998,258,734 - 98,258,872UniSTSRnor5.0
RGSC_v3.4990,672,872 - 90,673,010UniSTSRGSC3.4
Celera989,575,868 - 89,576,006UniSTS
RH 3.4 Map9785.49UniSTS
Cytogenetic Map9q36UniSTS
PMC124275P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2992,008,649 - 92,009,153 (+)MAPPERmRatBN7.2
Rnor_6.0998,556,510 - 98,557,013NCBIRnor6.0
Rnor_5.0998,232,558 - 98,233,061UniSTSRnor5.0
RGSC_v3.4990,646,696 - 90,647,199UniSTSRGSC3.4
Celera989,549,690 - 89,550,193UniSTS
Cytogenetic Map9q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027506   ⟹   ENSRNOP00000027507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl999,454,830 - 99,496,993 (-)Ensembl
mRatBN7.2 Ensembl992,007,296 - 92,049,459 (-)Ensembl
Rnor_6.0 Ensembl998,555,169 - 98,597,359 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109112   ⟹   ENSRNOP00000077245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl999,454,830 - 99,496,993 (-)Ensembl
mRatBN7.2 Ensembl992,007,296 - 92,049,459 (-)Ensembl
RefSeq Acc Id: NM_031678   ⟹   NP_113866
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,454,830 - 99,496,993 (-)NCBI
mRatBN7.2992,007,296 - 92,049,459 (-)NCBI
Rnor_6.0998,555,156 - 98,597,323 (-)NCBI
Rnor_5.0998,231,202 - 98,273,371 (-)NCBI
RGSC_v3.4990,645,342 - 90,687,509 (-)RGD
Celera989,548,336 - 89,590,505 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245476   ⟹   XP_006245538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,454,828 - 99,496,878 (-)NCBI
mRatBN7.2992,007,289 - 92,049,353 (-)NCBI
Rnor_6.0998,555,154 - 98,597,225 (-)NCBI
Rnor_5.0998,231,202 - 98,273,371 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596618   ⟹   XP_017452107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,454,828 - 99,497,069 (-)NCBI
mRatBN7.2992,007,289 - 92,049,551 (-)NCBI
Rnor_6.0998,555,154 - 98,597,362 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039084160   ⟹   XP_038940088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,454,828 - 99,476,594 (-)NCBI
mRatBN7.2992,007,289 - 92,029,049 (-)NCBI
RefSeq Acc Id: XM_063267668   ⟹   XP_063123738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,454,828 - 99,496,878 (-)NCBI
RefSeq Acc Id: NP_113866   ⟸   NM_031678
- UniProtKB: Q9Z301 (UniProtKB/Swiss-Prot),   A6JQS5 (UniProtKB/TrEMBL),   A0A8I5Y7B9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245538   ⟸   XM_006245476
- Peptide Label: isoform X1
- UniProtKB: Q9Z301 (UniProtKB/Swiss-Prot),   A6JQS5 (UniProtKB/TrEMBL),   A0A8I5Y7B9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452107   ⟸   XM_017596618
- Peptide Label: isoform X1
- UniProtKB: Q9Z301 (UniProtKB/Swiss-Prot),   A6JQS5 (UniProtKB/TrEMBL),   A0A8I5Y7B9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027507   ⟸   ENSRNOT00000027506
RefSeq Acc Id: XP_038940088   ⟸   XM_039084160
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000077245   ⟸   ENSRNOT00000109112
RefSeq Acc Id: XP_063123738   ⟸   XM_063267668
- Peptide Label: isoform X1
- UniProtKB: Q9Z301 (UniProtKB/Swiss-Prot),   A0A8I5Y7B9 (UniProtKB/TrEMBL),   A6JQS5 (UniProtKB/TrEMBL)
Protein Domains
PAC   PAS   PAS fold-3   Period circadian protein homolog 1-3 PAS-A   Period circadian protein homolog PER 1-3 bHLH-like   Period circadian-like C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z301-F1-model_v2 AlphaFold Q9Z301 1-1257 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696861
Promoter ID:EPDNEW_R7386
Type:initiation region
Name:Per2_1
Description:period circadian regulator 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0998,597,372 - 98,597,432EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61945 AgrOrtholog
BioCyc Gene G2FUF-26713 BioCyc
Ensembl Genes ENSRNOG00000020254 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027506 ENTREZGENE
  ENSRNOT00000027506.6 UniProtKB/Swiss-Prot
Gene3D-CATH PAS domain UniProtKB/Swiss-Prot
InterPro PAS UniProtKB/Swiss-Prot
  PAS-like_dom_sf UniProtKB/Swiss-Prot
  PAS_fold_3 UniProtKB/Swiss-Prot
  Per1-3_PAS-A UniProtKB/Swiss-Prot
  Period_circadian-like_C UniProtKB/Swiss-Prot
  Period_circadian_regulator UniProtKB/Swiss-Prot
KEGG Report rno:63840 UniProtKB/Swiss-Prot
NCBI Gene 63840 ENTREZGENE
PANTHER PERIOD CIRCADIAN PROTEIN UniProtKB/Swiss-Prot
  PERIOD CIRCADIAN PROTEIN HOMOLOG 2 UniProtKB/Swiss-Prot
Pfam bHLH_PER UniProtKB/Swiss-Prot
  PAS_3 UniProtKB/Swiss-Prot
  Per3-like_PAS-A UniProtKB/Swiss-Prot
  Period_C UniProtKB/Swiss-Prot
PhenoGen Per2 PhenoGen
PROSITE PAS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020254 RatGTEx
SMART PAS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55785 UniProtKB/Swiss-Prot
TIGR TC231261
UniProt A0A8I5Y7B9 ENTREZGENE, UniProtKB/TrEMBL
  A6JQS5 ENTREZGENE, UniProtKB/TrEMBL
  PER2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-09 Per2  period circadian regulator 2  Per2  period circadian clock 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-02 Per2  period circadian clock 2  Per2  period homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Per2  period homolog 2 (Drosophila)    period homolog 2   Name updated 1299863 APPROVED
2002-06-10 Per2  period homolog 2       Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a nucleus localization signal in the central domain; has PAS domians near the N-terminal which can interact with and regulate the activity of PAS domain transcriptional factors, such as CLOCK and BMAL 61691
gene_domains contains a nucleus localization signal in the central domain; has PAS domians near the N-terminal which can interact with and regulate the activity of PAS domain transcriptional factors, such as CLOCK and BMAL 69505
gene_domains contains PAS (PER-ARNT-SIM) domains near the N-terminus which regulate PAS domain transcriptional factors 631232
gene_process controls circadian rhythms 61691
gene_process controls circadian rhythms 631232