Gene:	Fzd1 ( Rattus norvegicus ) frizzled homolog 1 (Drosophila)
Description:	G-protein-coupled receptor; may mediate signals required for normal morphogenesis and differentiation; may play a role in bone resorption
Synonyms:	frizzled homolog 1, (Drosophila); Drosophila polarity gene (frizzled) homologue; Drosophila polarity gene homolog 1;
ArrayIDs:	6494493; A_44_P170527; GE1134565; 1370256_at; A_42_P628953; L02529_at; A_44_P366960; 6619275; 6703404; 6062324;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: FZD1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Fzd1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Fzd1 genome assembly 3.1 4 26006310 - 26010460     Rat Celera Assembly 4 24743049 - 24747198     RGSC genome assembly v3.4 4 25994423 - 25999379     Cytogenetic 4 q13 Mus musculus Fzd1 Mouse genome assembly build 36.1 5 4753839 - 4757971     Cytogenetic 5 5 A1 Homo sapiens FZD1 human genome assembly 7 90538433 - 90542783     Human genome assembly build 36.2 7 90731719 - 90736068     Cytogenetic 7 q21   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology protein binding,  non-G-protein coupled 7TM receptor activity,  G-protein coupled receptor activity (details...)
Biological Process	Gene Ontology multicellular organismal development,  G-protein coupled receptor protein signaling pathway,  cell-cell signaling ...  (details...)
Cellular Component	Gene Ontology membrane,  integral to membrane (details...)
Disease	Ontology Breast Neoplasms (details...)
Expression	Note Reference widely expressed 61590
Pathway	Ontology Wnt signaling pathway,  canonical Wnt signaling pathway (details...)
Protein	Note Reference 641 amino acids 61590
External Links
Databases	DATABASE ID SOURCE SMART: FRI IPI PROSITE: G_PROTEIN_RECEP_F2_4 IPI PROSITE: FZ IPI UNIPARC: UPI0000186036 IPI KEGG Report: rno:58868 ENTREZGENE HomoloGene Group ID: 20750 ENTREZGENE Germonline: 61916 Pfam: Fz IPI Pfam: Frizzled IPI KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 05217 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 04916 ENTREZGENE InterPro: GPCR_2-like. IPI InterPro: Frizzled_related. IPI InterPro: Frizzled. IPI InterPro: Frizzled-like_dom. IPI InterPro: Frizzled_Cys-rich. IPI InterPro: Frizzled_dom_subgr. IPI Ensembl Protein: ENSRNOP00000021979 IPI IPI: IPI00362521 IPI Gene3D-CATH: Frizzled_Cys-rich IPI Entrez Gene: Fzd1 ENTREZGENE TIGR: TC205498 UniProt: FZD1_RAT IPI Ensembl Genes: ENSRNOG00000016242 IPI Superfamily-SCOP: Frizzled_Cys-rich IPI PANTHER: Fz_related IPI PRINTS: FRIZZLED. IPI
Sequences	Nucleotide: NM_021266 Get FASTA Search GEO Profiles Nucleotide: AC111275 Get FASTA Search GEO Profiles Nucleotide: CH474013 Get FASTA Search GEO Profiles (View all 3 Nucleotide Accessions) Protein: EDL84350 Get FASTA Protein: Q08463 Get FASTA Protein: NP_067089 Get FASTA (View all 3 Protein Accessions)
Clusters	UniGene: 6575
References
Curated References	8 references in RGD related to Fzd1
Other References	3 other references at PubMed related to Fzd1
Database Information
RGD ID	61916
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-JUN-02: Fzd1 frizzled homolog 1 (Drosophila) APPROVED Name updated 70584