Stx6 (syntaxin 6) - Rat Genome Database

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Gene: Stx6 (syntaxin 6) Rattus norvegicus
Analyze
Symbol: Stx6
Name: syntaxin 6
RGD ID: 61915
Description: Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in endocytic recycling; retrograde transport, endosome to Golgi; and synaptic vesicle to endosome fusion. Located in recycling endosome and trans-Golgi network membrane. Is active in synaptic vesicle membrane. Orthologous to human STX6 (syntaxin 6); INTERACTS WITH 2-methoxyethanol; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93348; Syn6; syntaxin-6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81369,882,647 - 69,928,895 (+)NCBIGRCr8
mRatBN7.21367,332,329 - 67,378,580 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1367,332,314 - 67,378,576 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1369,917,560 - 69,963,589 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01371,231,256 - 71,277,146 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01368,491,771 - 68,538,463 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01372,804,218 - 72,850,757 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1372,804,218 - 72,852,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01377,739,763 - 77,785,254 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41370,121,864 - 70,169,379 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11370,135,943 - 70,183,455 (+)NCBI
Celera1367,207,720 - 67,253,510 (+)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Stx6Rat1q24 Deletion Syndrome  ISOSTX6 (Homo sapiens)8554872ClinVar Annotator: match by term: 1q24q25 microdeletion syndromeClinVarPMID:21548129 more ...
Stx6Ratautosomal recessive chronic granulomatous disease 2  ISOSTX6 (Homo sapiens)8554872ClinVar Annotator: match by term: Granulomatous disease more ...ClinVarPMID:28492532
Stx6Ratgastrointestinal stromal tumor  ISOSTX6 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Stx6Ratparathyroid carcinoma  ISOSTX6 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Original Reference(s)
Stx6Ratneuronal ceroid lipofuscinosis 6A  ISOSTX6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23516525
Stx6Ratprogressive supranuclear palsy  ISOSTX6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21685912

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Original Reference(s)
Stx6Rat(-)-demecolcine increases expressionISOSTX6 (Homo sapiens)6480464Demecolcine results in increased expression of STX6 mRNACTDPMID:23649840
Stx6Rat1,2-dimethylhydrazine multiple interactionsISOStx6 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of STX6 mRNACTDPMID:22206623
Stx6Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOStx6 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of STX6 mRNACTDPMID:21570461
Stx6Rat2-methoxyethanol increases expressionEXP 6480464methyl cellosolve results in increased expression of STX6 mRNACTDPMID:19643169
Stx6Rat3,4-methylenedioxymethamphetamine increases expressionISOStx6 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of STX6 mRNACTDPMID:20188158
Stx6Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOSTX6 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STX6 mRNACTDPMID:28628672
Stx6Rat4,4'-sulfonyldiphenol increases expressionISOStx6 (Mus musculus)6480464bisphenol S results in increased expression of STX6 mRNACTDPMID:39298647
Stx6Rataflatoxin B1 affects expressionISOSTX6 (Homo sapiens)6480464Aflatoxin B1 affects the expression of STX6 proteinCTDPMID:20106945
Stx6Rataflatoxin B1 increases methylationISOSTX6 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of STX6 intronCTDPMID:30157460
Stx6Rataflatoxin B1 increases expressionISOSTX6 (Homo sapiens)6480464Aflatoxin B1 results in increased expression of STX6 mRNACTDPMID:22100608
Stx6Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of STX6 mRNACTDPMID:16483693
Stx6Ratbenzo[a]pyrene increases expressionISOStx6 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of STX6 mRNACTDPMID:22228805
Stx6Ratbenzo[a]pyrene increases expressionISOSTX6 (Homo sapiens)6480464Benzo(a)pyrene results in increased expression of STX6 mRNACTDPMID:32234424
Stx6Ratbenzo[a]pyrene increases methylationISOStx6 (Mus musculus)6480464Benzo(a)pyrene results in increased methylation of STX6 exon and Benzo(a)pyrene results in increased methylation of STX6 intronCTDPMID:27901495
Stx6Ratbenzo[a]pyrene affects methylationISOSTX6 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of STX6 promoterCTDPMID:27901495
Stx6Ratbenzo[a]pyrene diol epoxide I increases expressionISOSTX6 (Homo sapiens)64804647 more ...CTDPMID:26238291
Stx6Ratbeta-lapachone increases expressionISOSTX6 (Homo sapiens)6480464beta-lapachone results in increased expression of STX6 mRNACTDPMID:38218311
Stx6Ratbisphenol A affects expressionEXP 6480464bisphenol A affects the expression of STX6 mRNACTDPMID:25181051
Stx6Ratbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of STX6 mRNACTDPMID:30816183 and PMID:34947998
Stx6Ratbisphenol A multiple interactionsISOSTX6 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STX6 mRNACTDPMID:28628672

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Biological Process
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Original Reference(s)
Stx6Ratendocytic recycling acts_upstream_of_or_withinISOSTX6 (Homo sapiens)1624291 PMID:25799061RGDPMID:25799061
Stx6Ratendocytic recycling acts_upstream_of_or_withinIEAUniProtKB:O43752 and ensembl:ENSP000002583011600115GO_REF:0000107EnsemblGO_REF:0000107
Stx6Ratendocytic recycling involved_inIDA 152995575PMID:30962439UniProt 
Stx6Ratendocytic recycling involved_inISOSTX6 (Homo sapiens)1624291 PMID:23677696RGDPMID:23677696
Stx6Ratendosome organization acts_upstream_of_or_withinISOStx6 (Mus musculus)1624291 PMID:14668490RGDPMID:14668490
Stx6RatGolgi vesicle transport involved_inIEAInterPro:IPR0152601600115GO_REF:0000002InterProGO_REF:0000002
Stx6Ratintracellular protein transport involved_inIBAPANTHER:PTN000461349 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Stx6Ratintracellular protein transport involved_inIEAInterPro:IPR0060121600115GO_REF:0000002InterProGO_REF:0000002
Stx6Ratmembrane fusion involved_inIEAGO:00054841600115GO_REF:0000108GOCGO_REF:0000108
Stx6Ratprotein transport involved_inIEAUniProtKB-KW:KW-06531600115GO_REF:0000043UniProtGO_REF:0000043
Stx6Ratregulation of protein localization involved_inISOSTX6 (Homo sapiens)1624291 PMID:16154903RGDPMID:16154903
Stx6Ratregulation of protein localization involved_inISOStx6 (Mus musculus)1624291 PMID:22190682RGDPMID:22190682
Stx6Ratregulation of protein localization involved_inIEAUniProtKB:O43752 and ensembl:ENSP000002583011600115GO_REF:0000107EnsemblGO_REF:0000107
Stx6Ratretrograde transport, endosome to Golgi involved_inIDA 152995575PMID:30962439UniProt 
Stx6Ratretrograde transport, endosome to Golgi involved_inIEAUniProtKB:O43752 and ensembl:ENSP000002583011600115GO_REF:0000107EnsemblGO_REF:0000107
Stx6Ratretrograde transport, endosome to Golgi involved_inIBAPANTHER:PTN008572346 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Stx6Ratretrograde transport, endosome to Golgi involved_inISOSTX6 (Homo sapiens)1624291 PMID:19224922RGDPMID:19224922
Stx6Ratsynaptic vesicle to endosome fusion involved_inIDA 12050136PMID:17004320SynGO 
Stx6Ratsynaptic vesicle to endosome fusion involved_inIMP 12050136PMID:17004320SynGO 
Stx6Ratvesicle docking involved_inIBAMGI:109355 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component
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Original Reference(s)
Stx6Ratcytosol located_inISOSTX6 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Stx6Ratcytosol located_inIEAUniProtKB:O43752 and ensembl:ENSP000002583011600115GO_REF:0000107EnsemblGO_REF:0000107
Stx6Ratearly endosome located_inISOSTX6 (Homo sapiens)1624291 PMID:10506127RGDPMID:10506127
Stx6Ratearly endosome located_inIEAUniProtKB:O43752 and ensembl:ENSP000002583011600115GO_REF:0000107EnsemblGO_REF:0000107
Stx6Ratendomembrane system is_active_inIBAFB:FBgn0011708 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Stx6Ratendosome located_inIEAUniProtKB-KW:KW-09671600115GO_REF:0000043UniProtGO_REF:0000043
Stx6RatGolgi apparatus located_inISOSTX6 (Homo sapiens)1624291 PMID:19224922 and PMID:23818989RGDPMID:19224922 and PMID:23818989
Stx6RatGolgi apparatus located_inIEAUniProtKB-SubCell:SL-01321600115GO_REF:0000044UniProtGO_REF:0000044
Stx6RatGolgi apparatus located_inIEAUniProtKB:O43752 and ensembl:ENSP000002583011600115GO_REF:0000107EnsemblGO_REF:0000107
Stx6RatGolgi apparatus located_inIEAUniProtKB-KW:KW-03331600115GO_REF:0000043UniProtGO_REF:0000043
Stx6RatGolgi apparatus located_inISOStx6 (Mus musculus)1624291 PMID:14622145 more ...RGDPMID:14622145 more ...
Stx6RatGolgi apparatus located_inISOSTX6 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Stx6RatGolgi membrane located_inIEAUniProtKB-SubCell:SL-01341600115GO_REF:0000044UniProtGO_REF:0000044
Stx6Ratmembrane located_inIEAInterPro:IPR006012 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Stx6Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Stx6Ratmembrane located_inISOStx6 (Mus musculus)1624291 PMID:15886206RGDPMID:15886206
Stx6Ratnucleoplasm located_inIEAUniProtKB:O43752 and ensembl:ENSP000002583011600115GO_REF:0000107EnsemblGO_REF:0000107
Stx6Ratnucleoplasm located_inISOSTX6 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Stx6Ratorganelle membrane located_inIEAARBA:ARBA000276241600115GO_REF:0000117UniProtGO_REF:0000117
Stx6Ratperinuclear region of cytoplasm located_inISOSTX6 (Homo sapiens)1624291 PMID:10506127 and PMID:16154903RGDPMID:10506127 and PMID:16154903
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Molecular Function
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Reference Title
Reference Citation
1. Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells. Ahras M, etal., J Cell Biol. 2006 Apr 24;173(2):241-51. Epub 2006 Apr 17.
2. A new syntaxin family member implicated in targeting of intracellular transport vesicles. Bock JB, etal., J Biol Chem 1996 Jul 26;271(30):17961-5.
3. Syntaxin 6 functions in trans-Golgi network vesicle trafficking. Bock JB, etal., Mol Biol Cell. 1997 Jul;8(7):1261-71.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors. Koike S and Jahn R, Nat Commun. 2019 Apr 8;10(1):1608. doi: 10.1038/s41467-019-09617-9.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. A novel syntaxin 6-interacting protein, SHIP164, regulates syntaxin 6-dependent sorting from early endosomes. Otto GP, etal., Traffic. 2010 May;11(5):688-705. doi: 10.1111/j.1600-0854.2010.01049.x.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton. Richardson SC, etal., Mol Biol Cell 2004 Mar;15(3):1197-210. Epub 2003 Dec 10.
13. Evidence for early endosome-like fusion of recently endocytosed synaptic vesicles. Rizzoli SO, etal., Traffic. 2006 Sep;7(9):1163-76.
14. The Rab5 effector EEA1 interacts directly with syntaxin-6. Simonsen A, etal., J Biol Chem. 1999 Oct 8;274(41):28857-60.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Molecular anatomy of a trafficking organelle. Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
17. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
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PMID:11384996   PMID:12082176   PMID:12857877   PMID:14622145   PMID:14742717   PMID:15489334   PMID:15689499   PMID:15800058   PMID:15886206   PMID:16154903   PMID:16428329   PMID:17003038  
PMID:17003121   PMID:18406529   PMID:19224922   PMID:19338761   PMID:19620288   PMID:22190682   PMID:22783020   PMID:22871113   PMID:23485813   PMID:23677696   PMID:25799061  



Stx6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81369,882,647 - 69,928,895 (+)NCBIGRCr8
mRatBN7.21367,332,329 - 67,378,580 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1367,332,314 - 67,378,576 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1369,917,560 - 69,963,589 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01371,231,256 - 71,277,146 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01368,491,771 - 68,538,463 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01372,804,218 - 72,850,757 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1372,804,218 - 72,852,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01377,739,763 - 77,785,254 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41370,121,864 - 70,169,379 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11370,135,943 - 70,183,455 (+)NCBI
Celera1367,207,720 - 67,253,510 (+)NCBICelera
Cytogenetic Map13q21NCBI
STX6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381180,972,725 - 181,022,870 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1180,972,712 - 181,023,121 (-)EnsemblGRCh38hg38GRCh38
GRCh371180,941,861 - 180,992,006 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361179,208,798 - 179,258,669 (-)NCBINCBI36Build 36hg18NCBI36
Build 341177,673,835 - 177,723,703NCBI
Celera1154,049,189 - 154,099,059 (-)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1152,173,031 - 152,222,901 (-)NCBIHuRef
CHM1_11182,364,849 - 182,414,723 (-)NCBICHM1_1
T2T-CHM13v2.01180,327,972 - 180,378,137 (-)NCBIT2T-CHM13v2.0
Stx6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391155,034,374 - 155,083,405 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1155,034,461 - 155,084,002 (+)EnsemblGRCm39 Ensembl
GRCm381155,158,628 - 155,207,567 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1155,158,715 - 155,208,256 (+)EnsemblGRCm38mm10GRCm38
MGSCv371157,005,833 - 157,050,647 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361156,920,960 - 156,965,735 (+)NCBIMGSCv36mm8
Celera1157,590,422 - 157,635,333 (+)NCBICelera
Cytogenetic Map1G3NCBI
cM Map166.46NCBI
Stx6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540620,048,155 - 20,089,906 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540620,042,552 - 20,089,853 (-)NCBIChiLan1.0ChiLan1.0
STX6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2168,748,337 - 68,798,313 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1168,406,649 - 68,456,600 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01156,450,202 - 156,500,143 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11160,117,825 - 160,167,314 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1160,117,825 - 160,167,314 (-)Ensemblpanpan1.1panPan2
STX6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1714,452,663 - 14,506,120 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl714,458,404 - 14,556,917 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha714,030,381 - 14,083,562 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0714,179,873 - 14,232,084 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl714,184,065 - 14,232,056 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1714,089,893 - 14,143,515 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0714,196,719 - 14,249,919 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0714,320,679 - 14,373,902 (-)NCBIUU_Cfam_GSD_1.0
Stx6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934490,515,308 - 90,558,479 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364818,362,050 - 8,399,737 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364818,362,059 - 8,405,228 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STX6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9122,529,727 - 122,580,608 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19122,533,737 - 122,580,631 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29134,569,941 - 134,616,721 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STX6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12548,380,359 - 48,427,279 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2548,397,712 - 48,426,676 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605549,763,242 - 49,813,281 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stx6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247711,227,052 - 1,265,158 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247711,222,809 - 1,264,662 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Stx6
175 total Variants

Predicted Target Of
Summary Value
Count of predictions:200
Count of miRNA genes:134
Interacting mature miRNAs:163
Transcripts:ENSRNOT00000035145
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 32 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303028Bp329Blood pressure QTL 329arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135849787273485113Rat

1 to 10 of 32 rows
RH128466  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21367,378,267 - 67,378,483 (+)MAPPERmRatBN7.2
Rnor_6.01372,850,445 - 72,850,660NCBIRnor6.0
Rnor_5.01377,784,942 - 77,785,157UniSTSRnor5.0
RGSC_v3.41370,169,067 - 70,169,282UniSTSRGSC3.4
Celera1367,253,198 - 67,253,413UniSTS
RH 3.4 Map13359.3UniSTS
Cytogenetic Map13q21UniSTS
RH138891  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21367,340,810 - 67,341,016 (+)MAPPERmRatBN7.2
Rnor_6.01372,812,688 - 72,812,893NCBIRnor6.0
Rnor_5.01377,748,233 - 77,748,438UniSTSRnor5.0
RGSC_v3.41370,130,344 - 70,130,549UniSTSRGSC3.4
Celera1367,216,183 - 67,216,388UniSTS
RH 3.4 Map13353.9UniSTS
Cytogenetic Map13q21UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000035145   ⟹   ENSRNOP00000037536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1367,332,314 - 67,368,957 (+)Ensembl
Rnor_6.0 Ensembl1372,804,218 - 72,852,967 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099649   ⟹   ENSRNOP00000080858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1367,332,329 - 67,378,576 (+)Ensembl
RefSeq Acc Id: NM_031665   ⟹   NP_113853
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81369,882,647 - 69,928,895 (+)NCBI
mRatBN7.21367,332,329 - 67,378,580 (+)NCBI
Rnor_6.01372,804,218 - 72,850,757 (+)NCBI
Rnor_5.01377,739,763 - 77,785,254 (+)NCBI
RGSC_v3.41370,121,864 - 70,169,379 (+)RGD
Celera1367,207,720 - 67,253,510 (+)RGD
Sequence:
Protein RefSeqs NP_113853 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52709 (Get FASTA)   NCBI Sequence Viewer  
  AAH81769 (Get FASTA)   NCBI Sequence Viewer  
  EDM09512 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080858.1
  ENSRNOP00000103517
GenBank Protein Q63635 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113853   ⟸   NM_031665
- UniProtKB: Q63635 (UniProtKB/Swiss-Prot),   A6ICY5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000037536   ⟸   ENSRNOT00000035145
Ensembl Acc Id: ENSRNOP00000080858   ⟸   ENSRNOT00000099649
t-SNARE coiled-coil homology

Name Modeler Protein Id AA Range Protein Structure
AF-Q63635-F1-model_v2 AlphaFold Q63635 1-255 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698905
Promoter ID:EPDNEW_R9430
Type:initiation region
Name:Stx6_1
Description:syntaxin 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01372,804,245 - 72,804,305EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-17848 BioCyc
Ensembl Genes ENSRNOG00000003402 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000099649.1 UniProtKB/Swiss-Prot
  ENSRNOT00000128442 ENTREZGENE
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot
  1.20.58.90 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7134641 IMAGE-MGC_LOAD
InterPro SNARE UniProtKB/Swiss-Prot
  Syntaxin-6_N UniProtKB/Swiss-Prot
  Syntaxin/epimorphin_CS UniProtKB/Swiss-Prot
  T_SNARE_dom UniProtKB/Swiss-Prot
KEGG Report rno:60562 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93348 IMAGE-MGC_LOAD
NCBI Gene 60562 ENTREZGENE
PANTHER GOLGI SNARE BET1-RELATED UniProtKB/Swiss-Prot
Pfam SNARE UniProtKB/Swiss-Prot
  Syntaxin-6_N UniProtKB/Swiss-Prot
PhenoGen Stx6 PhenoGen
PROSITE SYNTAXIN UniProtKB/Swiss-Prot
  T_SNARE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003402 RatGTEx
SMART t_SNARE UniProtKB/Swiss-Prot
Superfamily-SCOP SNARE fusion complex UniProtKB/Swiss-Prot
  SSF47661 UniProtKB/Swiss-Prot
UniProt A0A8L2QLH0_RAT UniProtKB/TrEMBL
  A6ICY5 ENTREZGENE, UniProtKB/TrEMBL
  Q63635 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Stx6  syntaxin 6       Name updated 70584 APPROVED

Note Type Note Reference
gene_cellular_localization localized to the Golgi apparatus 61759
gene_function vesicular transport receptor 61759
gene_protein 255 amino acids 61759