Ptprn2 (protein tyrosine phosphatase, receptor type N2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Ptprn2 (protein tyrosine phosphatase, receptor type N2) Rattus norvegicus
Analyze
Symbol: Ptprn2
Name: protein tyrosine phosphatase, receptor type N2
RGD ID: 61904
Description: Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in insulin secretion involved in cellular response to glucose stimulus; neurotransmitter secretion; and regulation of secretion. Located in endoplasmic reticulum lumen; secretory granule; and terminal bouton. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Orthologous to human PTPRN2 (protein tyrosine phosphatase receptor type N2); PARTICIPATES IN type 1 diabetes mellitus pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: phogrin; protein tyrosine phosphatase receptor-type N polypeptide 2; protein tyrosine phosphatase, receptor type, N polypeptide 2; protein tyrosine phosphatase, receptor-type, N polypeptide 2; PTP NE-6; PTPNE6; R-PTP-N2; receptor-type tyrosine-protein phosphatase N2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86143,582,568 - 144,334,573 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6143,582,547 - 144,336,744 (+)EnsemblGRCr8
mRatBN7.26137,439,572 - 138,191,575 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6137,439,540 - 138,191,575 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6140,874,866 - 141,626,022 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06137,499,335 - 138,243,617 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06138,047,241 - 138,799,129 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06144,384,773 - 145,133,042 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6144,384,773 - 145,133,042 (+)Ensemblrn6Rnor6.0
Rnor_5.06153,312,968 - 154,056,676 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46143,787,884 - 144,549,042 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6135,102,182 - 135,845,915 (+)NCBICelera
RGSC_v3.16143,794,070 - 144,555,221 (+)NCBI
Cytogenetic Map6q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cefaloridine  (EXP)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
dorsomorphin  (ISO)
ellagic acid  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylparaben  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
gentamycin  (EXP)
GSK-J4  (ISO)
iron dichloride  (ISO)
lead(0)  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Autoantibodies to IA-2beta improve diabetes risk assessment in high-risk relatives. Achenbach P, etal., Diabetologia. 2008 Mar;51(3):488-92. Epub 2008 Jan 9.
2. Spontaneous peripheral T-cell responses to the IA-2beta (phogrin) autoantigen in young nonobese diabetic mice. Achenbach P, etal., J Autoimmun. 2002 Nov;19(3):111-6.
3. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027.
4. PTP NE-6: a brain-enriched receptor-type protein tyrosine phosphatase with a divergent catalytic domain. Fitzgerald LR, etal., J Neurochem 1997 May;68(5):1820-9.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Receptor-type PTP-NP inhibition of Dynamin-1 GTPase activity is associated with neuronal depolarization. Jiang S, etal., Cell Signal. 2006 Sep;18(9):1439-46. Epub 2006 Jan 18.
7. Characterization and chromosomal localization of PTP-NP-2, a new isoform of protein tyrosine phosphatase-like receptor, expressed on synaptic boutons. Jiang S, etal., Gene. 1998 Jul 30;215(2):345-59.
8. HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes. Kelemen K, etal., J Immunol. 2004 Mar 15;172(6):3955-62.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Excitatory and Inhibitory Neurons in the Hippocampus Exhibit Molecularly Distinct Large Dense Core Vesicles. Ramírez-Franco JJ, etal., Front Cell Neurosci. 2016 Aug 31;10:202. doi: 10.3389/fncel.2016.00202. eCollection 2016.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Molecular cloning of phogrin, a protein-tyrosine phosphatase homologue localized to insulin secretory granule membranes. Wasmeier C and Hutton JC, J Biol Chem 1996 Jul 26;271(30):18161-70.
Additional References at PubMed
PMID:15788565   PMID:19361477   PMID:20097759   PMID:21732083   PMID:23382219   PMID:34607132  


Genomics

Comparative Map Data
Ptprn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86143,582,568 - 144,334,573 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6143,582,547 - 144,336,744 (+)EnsemblGRCr8
mRatBN7.26137,439,572 - 138,191,575 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6137,439,540 - 138,191,575 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6140,874,866 - 141,626,022 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06137,499,335 - 138,243,617 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06138,047,241 - 138,799,129 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06144,384,773 - 145,133,042 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6144,384,773 - 145,133,042 (+)Ensemblrn6Rnor6.0
Rnor_5.06153,312,968 - 154,056,676 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46143,787,884 - 144,549,042 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6135,102,182 - 135,845,915 (+)NCBICelera
RGSC_v3.16143,794,070 - 144,555,221 (+)NCBI
Cytogenetic Map6q33NCBI
PTPRN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387157,539,056 - 158,587,823 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7157,539,056 - 158,587,823 (-)Ensemblhg38GRCh38
GRCh377157,331,750 - 158,380,515 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367157,024,516 - 158,073,179 (-)NCBIBuild 36Build 36hg18NCBI36
Build 347156,831,230 - 157,879,894NCBI
Celera7151,758,421 - 152,708,128 (-)NCBICelera
Cytogenetic Map7q36.3NCBI
HuRef7151,062,797 - 152,022,430 (-)NCBIHuRef
CHM1_17157,340,603 - 158,388,873 (-)NCBICHM1_1
T2T-CHM13v2.07158,727,687 - 159,797,184 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27156,563,177 - 157,584,848 (-)NCBI
Ptprn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912116,449,316 - 117,241,787 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12116,449,340 - 117,240,469 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812116,485,695 - 117,278,167 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12116,485,720 - 117,276,849 (+)Ensemblmm10GRCm38
MGSCv3712117,724,193 - 118,516,640 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612110,685,719 - 111,477,358 (+)NCBIMGSCv36mm8
MGSCv3612116,927,842 - 117,718,802 (+)NCBIMGSCv36mm8
Cytogenetic Map12F2NCBI
cM Map1262.65NCBI
Ptprn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955579364,748 - 833,729 (-)Ensembl
ChiLan1.0NW_004955579366,441 - 862,837 (-)NCBIChiLan1.0ChiLan1.0
PTPRN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26193,988,298 - 195,067,961 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1745,998,563 - 47,078,226 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07149,158,513 - 150,390,077 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17160,850,042 - 161,756,328 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7160,851,703 - 161,756,325 (-)EnsemblpanPan2panpan1.1
PTPRN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11619,904,468 - 20,562,585 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1619,905,473 - 20,602,680 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1620,472,150 - 21,134,670 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01621,636,514 - 22,361,137 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11620,003,354 - 20,728,392 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01620,586,565 - 21,312,677 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01620,639,115 - 21,366,802 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptprn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118752,917 - 1,422,817 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493679755,217 - 151,201 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl18721,131 - 1,389,607 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.118721,125 - 1,389,609 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2181,081,388 - 1,085,384 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121125,655,787 - 126,622,503 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607221,894,122 - 23,016,772 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptprn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624800648,264 - 1,117,312 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624800501,884 - 1,116,795 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ptprn2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17118,845,382 - 119,570,869 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:544
Count of miRNA genes:254
Interacting mature miRNAs:321
Transcripts:ENSRNOT00000006942
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
D6Rat4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26137,848,730 - 137,848,904 (+)MAPPERmRatBN7.2
Rnor_6.06144,792,505 - 144,792,678NCBIRnor6.0
Rnor_5.06153,718,972 - 153,719,145UniSTSRnor5.0
RGSC_v3.46144,200,728 - 144,200,901UniSTSRGSC3.4
RGSC_v3.46144,200,727 - 144,200,901RGDRGSC3.4
Celera6135,504,276 - 135,504,449UniSTS
RGSC_v3.16144,206,914 - 144,207,088RGD
RH 3.4 Map6923.9RGD
RH 3.4 Map6923.9UniSTS
RH 2.0 Map61203.5RGD
SHRSP x BN Map683.9998RGD
FHH x ACI Map699.32RGD
Cytogenetic Map6q33UniSTS
D6Rat1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86143,944,560 - 143,944,780 (+)Marker Load Pipeline
mRatBN7.26137,801,573 - 137,801,795 (+)MAPPERmRatBN7.2
Rnor_6.06144,745,354 - 144,745,573NCBIRnor6.0
Rnor_5.06153,671,821 - 153,672,040UniSTSRnor5.0
RGSC_v3.46144,152,352 - 144,152,572RGDRGSC3.4
RGSC_v3.46144,152,353 - 144,152,572UniSTSRGSC3.4
Celera6135,457,174 - 135,457,393UniSTS
RGSC_v3.16144,158,540 - 144,158,759RGD
RH 3.4 Map6924.0RGD
RH 3.4 Map6924.0UniSTS
RH 2.0 Map61203.5RGD
SHRSP x BN Map682.8898RGD
FHH x ACI Map695.64RGD
Cytogenetic Map6q33UniSTS
D6Rat215  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86143,654,749 - 143,654,961 (+)Marker Load Pipeline
mRatBN7.26137,511,759 - 137,511,971 (+)MAPPERmRatBN7.2
Rnor_6.06144,456,707 - 144,456,918NCBIRnor6.0
Rnor_5.06153,384,902 - 153,385,113UniSTSRnor5.0
RGSC_v3.46143,860,093 - 143,860,305RGDRGSC3.4
RGSC_v3.46143,860,094 - 143,860,305UniSTSRGSC3.4
Celera6135,173,984 - 135,174,195UniSTS
RGSC_v3.16143,866,280 - 143,866,492RGD
FHH x ACI Map6101.32UniSTS
FHH x ACI Map6101.32RGD
Cytogenetic Map6q33UniSTS
D6Got203  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26138,166,889 - 138,167,082 (+)MAPPERmRatBN7.2
Rnor_6.06145,108,357 - 145,108,549NCBIRnor6.0
Rnor_5.06154,032,025 - 154,032,217UniSTSRnor5.0
RGSC_v3.46144,524,330 - 144,524,522RGDRGSC3.4
RGSC_v3.46144,524,330 - 144,524,522UniSTSRGSC3.4
Celera6135,821,151 - 135,821,341UniSTS
RGSC_v3.16144,530,517 - 144,530,709RGD
RH 3.4 Map6929.0RGD
RH 3.4 Map6929.0UniSTS
RH 2.0 Map61207.9RGD
Cytogenetic Map6q33UniSTS
RH133268  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26138,056,604 - 138,057,914 (+)MAPPERmRatBN7.2
Rnor_6.06144,997,198 - 144,998,545NCBIRnor6.0
Rnor_5.06153,922,415 - 153,923,762UniSTSRnor5.0
RGSC_v3.46144,413,491 - 144,414,838UniSTSRGSC3.4
Celera6135,711,347 - 135,712,690UniSTS
RH 3.4 Map6936.0UniSTS
Cytogenetic Map6q33UniSTS
RH140469  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26138,063,571 - 138,063,671 (+)MAPPERmRatBN7.2
Rnor_6.06145,004,202 - 145,004,301NCBIRnor6.0
Rnor_5.06153,929,419 - 153,929,518UniSTSRnor5.0
RGSC_v3.46144,420,495 - 144,420,594UniSTSRGSC3.4
Celera6135,718,232 - 135,718,331UniSTS
RH 3.4 Map6922.1UniSTS
Cytogenetic Map6q33UniSTS
RH131937  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26137,885,505 - 137,885,703 (+)MAPPERmRatBN7.2
Rnor_6.06144,825,959 - 144,826,156NCBIRnor6.0
Rnor_5.06153,753,404 - 153,753,601UniSTSRnor5.0
RGSC_v3.46144,239,975 - 144,240,172UniSTSRGSC3.4
Celera6135,541,086 - 135,541,283UniSTS
RH 3.4 Map6923.9UniSTS
Cytogenetic Map6q33UniSTS
RH131993  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26138,190,802 - 138,190,988 (+)MAPPERmRatBN7.2
Rnor_6.06145,132,270 - 145,132,455NCBIRnor6.0
Rnor_5.06154,055,904 - 154,056,089UniSTSRnor5.0
RGSC_v3.46144,548,270 - 144,548,455UniSTSRGSC3.4
Celera6135,845,143 - 135,845,328UniSTS
RH 3.4 Map6921.6UniSTS
Cytogenetic Map6q33UniSTS
RH142979  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26138,164,840 - 138,165,127 (+)MAPPERmRatBN7.2
Rnor_6.06145,106,309 - 145,106,595NCBIRnor6.0
Rnor_5.06154,029,977 - 154,030,263UniSTSRnor5.0
RGSC_v3.46144,522,282 - 144,522,568UniSTSRGSC3.4
Celera6135,819,103 - 135,819,389UniSTS
RH 3.4 Map6928.8UniSTS
Cytogenetic Map6q33UniSTS
BF396367  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26138,084,234 - 138,084,396 (+)MAPPERmRatBN7.2
Rnor_6.06145,025,076 - 145,025,237NCBIRnor6.0
Rnor_5.06153,950,186 - 153,950,347UniSTSRnor5.0
RGSC_v3.46144,441,423 - 144,441,584UniSTSRGSC3.4
Celera6135,738,821 - 135,738,982UniSTS
RH 3.4 Map6929.2UniSTS
Cytogenetic Map6q33UniSTS
BE120609  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26138,186,246 - 138,186,414 (+)MAPPERmRatBN7.2
Rnor_6.06145,127,714 - 145,127,881NCBIRnor6.0
Rnor_5.06154,051,348 - 154,051,515UniSTSRnor5.0
RGSC_v3.46144,543,714 - 144,543,881UniSTSRGSC3.4
Celera6135,840,587 - 135,840,754UniSTS
RH 3.4 Map6929.0UniSTS
Cytogenetic Map6q33UniSTS
BF405459  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26138,096,514 - 138,096,652 (+)MAPPERmRatBN7.2
Rnor_6.06145,037,355 - 145,037,492NCBIRnor6.0
Rnor_5.06153,962,465 - 153,962,602UniSTSRnor5.0
RGSC_v3.46144,453,703 - 144,453,840UniSTSRGSC3.4
Celera6135,751,101 - 135,751,238UniSTS
RH 3.4 Map6919.1UniSTS
Cytogenetic Map6q33UniSTS
AU047288  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86143,901,296 - 143,901,471 (+)Marker Load Pipeline
mRatBN7.26137,758,301 - 137,758,476 (+)MAPPERmRatBN7.2
Rnor_6.06144,702,088 - 144,702,264NCBIRnor6.0
Rnor_5.06153,628,555 - 153,628,731UniSTSRnor5.0
RGSC_v3.46144,109,087 - 144,109,263UniSTSRGSC3.4
Celera6135,414,668 - 135,414,822UniSTS
Cytogenetic Map6q33UniSTS
AU048803  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26138,033,163 - 138,033,292 (+)MAPPERmRatBN7.2
Rnor_6.06144,973,761 - 144,973,889NCBIRnor6.0
Rnor_5.06153,898,978 - 153,899,106UniSTSRnor5.0
RGSC_v3.46144,390,054 - 144,390,182UniSTSRGSC3.4
Celera6135,687,998 - 135,688,126UniSTS
Cytogenetic Map6q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 9 60 151 90 89 58 50 58 6 296 139 10 125 75 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000006942   ⟹   ENSRNOP00000006942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6143,582,547 - 144,334,022 (+)Ensembl
mRatBN7.2 Ensembl6137,439,572 - 138,191,575 (+)Ensembl
Rnor_6.0 Ensembl6144,384,773 - 145,133,042 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116222   ⟹   ENSRNOP00000093030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6143,582,575 - 144,334,022 (+)Ensembl
mRatBN7.2 Ensembl6137,439,540 - 138,191,575 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134948   ⟹   ENSRNOP00000103482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6143,582,550 - 144,336,744 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000160214   ⟹   ENSRNOP00000110350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6143,582,550 - 144,336,744 (+)Ensembl
RefSeq Acc Id: NM_031600   ⟹   NP_113788
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86143,582,568 - 144,334,573 (+)NCBI
mRatBN7.26137,439,572 - 138,191,575 (+)NCBI
Rnor_6.06144,384,773 - 145,133,042 (+)NCBI
Rnor_5.06153,312,968 - 154,056,676 (+)NCBI
RGSC_v3.46143,787,884 - 144,549,042 (+)RGD
Celera6135,102,182 - 135,845,915 (+)RGD
Sequence:
RefSeq Acc Id: XM_039111861   ⟹   XP_038967789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86143,582,655 - 144,334,023 (+)NCBI
mRatBN7.26137,439,658 - 138,191,027 (+)NCBI
RefSeq Acc Id: XM_039111862   ⟹   XP_038967790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86143,582,656 - 144,334,023 (+)NCBI
mRatBN7.26137,439,658 - 138,189,570 (+)NCBI
RefSeq Acc Id: XM_039111863   ⟹   XP_038967791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86143,582,655 - 144,334,023 (+)NCBI
mRatBN7.26137,439,658 - 138,189,570 (+)NCBI
RefSeq Acc Id: NP_113788   ⟸   NM_031600
- Peptide Label: precursor
- UniProtKB: Q63475 (UniProtKB/Swiss-Prot),   A6KDL9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006942   ⟸   ENSRNOT00000006942
RefSeq Acc Id: XP_038967789   ⟸   XM_039111861
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AHT8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967791   ⟸   XM_039111863
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038967790   ⟸   XM_039111862
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000093030   ⟸   ENSRNOT00000116222
Ensembl Acc Id: ENSRNOP00000103482   ⟸   ENSRNOT00000134948
Ensembl Acc Id: ENSRNOP00000110350   ⟸   ENSRNOT00000160214
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63475-F1-model_v2 AlphaFold Q63475 1-1004 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694910
Promoter ID:EPDNEW_R5434
Type:initiation region
Name:Ptprn2_1
Description:protein tyrosine phosphatase, receptor type N2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06144,384,730 - 144,384,790EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61904 AgrOrtholog
BioCyc Gene G2FUF-35508 BioCyc
Ensembl Genes ENSRNOG00000005003 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006942 ENTREZGENE
  ENSRNOT00000006942.5 UniProtKB/Swiss-Prot
  ENSRNOT00000116222 ENTREZGENE
  ENSRNOT00000160214 ENTREZGENE
Gene3D-CATH 3.30.70.2470 UniProtKB/Swiss-Prot
  3.90.190.10 UniProtKB/Swiss-Prot
InterPro IA-2/IA-2_beta UniProtKB/Swiss-Prot
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot
  PTPase_domain UniProtKB/Swiss-Prot
  Receptor_IA-2_dom UniProtKB/Swiss-Prot
  Receptor_IA-2_ectodomain_sf UniProtKB/Swiss-Prot
  Tyr_Pase_AS UniProtKB/Swiss-Prot
  Tyr_Pase_cat UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
KEGG Report rno:29714 UniProtKB/Swiss-Prot
NCBI Gene 29714 ENTREZGENE
PANTHER PTHR46106 UniProtKB/Swiss-Prot
  RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2 UniProtKB/Swiss-Prot
Pfam Receptor_IA-2 UniProtKB/Swiss-Prot
  Y_phosphatase UniProtKB/Swiss-Prot
PhenoGen Ptprn2 PhenoGen
PRINTS PRTYPHPHTASE UniProtKB/Swiss-Prot
PROSITE TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005003 RatGTEx
SMART PTPc UniProtKB/Swiss-Prot
  PTPc_motif UniProtKB/Swiss-Prot
  RESP18 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot
TIGR TC218024
UniProt A0A8I6AHT8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LNE6_RAT UniProtKB/TrEMBL
  A6KDL9 ENTREZGENE, UniProtKB/TrEMBL
  A6KDM1_RAT UniProtKB/TrEMBL
  PTPR2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Ptprn2  protein tyrosine phosphatase, receptor type N2  Ptprn2  protein tyrosine phosphatase, receptor type, N polypeptide 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ptprn2  protein tyrosine phosphatase, receptor type, N polypeptide 2    protein tyrosine phosphatase, receptor-type, N polypeptide 2  Name updated 1299863 APPROVED
2002-06-10 Ptprn2  protein tyrosine phosphatase, receptor-type, N polypeptide 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to insulin secretory granule membranes 61724