Slc29a1 (solute carrier family 29 member 1) - Rat Genome Database

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Gene: Slc29a1 (solute carrier family 29 member 1) Rattus norvegicus
Analyze
Symbol: Slc29a1
Name: solute carrier family 29 member 1
RGD ID: 61899
Description: Enables uridine transmembrane transporter activity. Involved in several processes, including excitatory postsynaptic potential; lactation; and uridine transmembrane transport. Located in basolateral plasma membrane. Is active in postsynapse and presynapse. Used to study brain ischemia. Orthologous to human SLC29A1 (solute carrier family 29 member 1 (Augustine blood group)); PARTICIPATES IN azathioprine pharmacodynamics pathway; gemcitabine pharmacodynamics pathway; gemcitabine pharmacokinetics pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ENT1; equilibrative NBMPR-sensitive nucleoside transporter; equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; equilibrative nucleoside transporter 1; NBMPR-sensitive equilibrative nucleoside transporter; nucleoside transporter, es-type; rENT1; solute carrier family 29 (equilibrative nucleoside transporter), member 1; solute carrier family 29 (nucleoside transporters) member 1; solute carrier family 29 (nucleoside transporters), member 1; solute carrier family 29, member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8922,897,099 - 22,911,640 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl922,902,471 - 22,914,620 (+)EnsemblGRCr8
mRatBN7.2915,399,661 - 15,414,203 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl915,399,612 - 15,414,203 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx923,986,255 - 24,000,708 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0929,048,932 - 29,063,385 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0927,349,692 - 27,364,145 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0917,784,468 - 17,799,008 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,784,468 - 17,799,005 (+)Ensemblrn6Rnor6.0
Rnor_5.0916,673,067 - 16,687,772 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4911,000,054 - 11,014,914 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera913,143,672 - 13,158,179 (+)NCBICelera
RGSC_v3.1910,997,375 - 11,012,235 (+)NCBI
Cytogenetic Map9q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloroethane  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2'-deoxyadenosine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2-[4-[4,4-bis(4-fluorophenyl)butyl]-1-piperazinyl]-N-(2,6-dimethylphenyl)acetamide  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-methylthioinosine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
adenosine  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cilostazol  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
cytidine  (EXP,ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
Diisodecyl phthalate  (ISO)
dilazep  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
guanosine  (EXP,ISO)
heptachlor  (EXP)
hydrogen cyanide  (ISO)
inosine  (EXP,ISO)
manganese(II) chloride  (EXP)
mercury dichloride  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylephrine  (EXP)
pirinixic acid  (EXP,ISO)
potassium cyanide  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
ribavirin  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymidine  (EXP,ISO)
ticagrelor  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
uridine  (EXP,ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vinorelbine  (ISO)
vitamin E  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IEA,ISO,ISS)
basolateral plasma membrane  (IDA,IEA,ISO,ISS)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)
postsynapse  (IDA)
presynapse  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Control of glutamatergic neurotransmission in the rat spinal dorsal horn by the nucleoside transporter ENT1. Ackley MA, etal., J Physiol 2003 Apr 15;548(Pt 2):507-17. Epub 2003 Feb 28.
2. Nitrobenzylthioinosine (NBMPR) binding and nucleoside transporter ENT1 mRNA expression after prolonged wakefulness and recovery sleep in the cortex and basal forebrain of rat. Alanko L, etal., J Sleep Res. 2003 Dec;12(4):299-304.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Lactation stage-dependent expression of transporters in rat whole mammary gland and primary mammary epithelial organoids. Gilchrist SE and Alcorn J, Fundam Clin Pharmacol. 2009 Aug 21.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Localization of the NBMPR-sensitive equilibrative nucleoside transporter, ENT1, in the rat dorsal root ganglion and lumbar spinal cord. Governo RJ, etal., Brain Res. 2005 Oct 19;1059(2):129-38. doi: 10.1016/j.brainres.2005.08.017. Epub 2005 Oct 14.
7. High glucose suppresses expression of equilibrative nucleoside transporter 1 (ENT1) in rat cardiac fibroblasts through a mechanism dependent on PKC-zeta and MAP kinases. Grden M, etal., J Cell Physiol. 2008 Apr;215(1):151-60.
8. Basolateral uptake of nucleosides by Sertoli cells is mediated primarily by equilibrative nucleoside transporter 1. Klein DM, etal., J Pharmacol Exp Ther. 2013 Jul;346(1):121-9. doi: 10.1124/jpet.113.203265. Epub 2013 May 2.
9. Chronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transport. Kobayashi S, etal., J Neurochem. 2000 Feb;74(2):621-32.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Immunocytochemical demonstration of the equilibrative nucleoside transporter rENT1 in rat sinoatrial node. Musa H, etal., J Histochem Cytochem. 2002 Mar;50(3):305-9.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Astrocytes and neurons: different roles in regulating adenosine levels. Parkinson FE, etal., Neurol Res. 2005 Mar;27(2):153-60.
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. Reduced ability to release adenosine by diabetic rat cardiac fibroblasts due to altered expression of nucleoside transporters. Podgorska M, etal., J Physiol. 2006 Oct 1;576(Pt 1):179-89. Epub 2006 Jul 27.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Ceftriaxone treatment affects the levels of GLT1 and ENT1 as well as ethanol intake in alcohol-preferring rats. Sari Y, etal., J Mol Neurosci. 2013 Nov;51(3):779-87. doi: 10.1007/s12031-013-0064-y. Epub 2013 Jul 27.
20. Influx mechanism of 2',3'-dideoxyinosine and uridine at the blood-placenta barrier. Sato K, etal., Placenta. 2009 Mar;30(3):263-9. Epub 2009 Jan 8.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Molecular cloning and functional characterization of nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENT1 and rENT2) from rat tissues. Yao SY, etal., J Biol Chem 1997 Nov 7;272(45):28423-30.
Additional References at PubMed
PMID:8986748   PMID:9396714   PMID:11085929   PMID:11179696   PMID:12527552   PMID:15489334   PMID:19801629   PMID:19946888   PMID:23147119   PMID:25490964   PMID:27567601   PMID:28322028  
PMID:31346513   PMID:31520644   PMID:32445645   PMID:33174009  


Genomics

Comparative Map Data
Slc29a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8922,897,099 - 22,911,640 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl922,902,471 - 22,914,620 (+)EnsemblGRCr8
mRatBN7.2915,399,661 - 15,414,203 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl915,399,612 - 15,414,203 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx923,986,255 - 24,000,708 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0929,048,932 - 29,063,385 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0927,349,692 - 27,364,145 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0917,784,468 - 17,799,008 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,784,468 - 17,799,005 (+)Ensemblrn6Rnor6.0
Rnor_5.0916,673,067 - 16,687,772 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4911,000,054 - 11,014,914 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera913,143,672 - 13,158,179 (+)NCBICelera
RGSC_v3.1910,997,375 - 11,012,235 (+)NCBI
Cytogenetic Map9q12NCBI
SLC29A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38644,219,615 - 44,234,142 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl644,219,245 - 44,236,432 (+)Ensemblhg38GRCh38
GRCh37644,187,352 - 44,201,879 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36644,295,220 - 44,309,866 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34644,295,370 - 44,309,856NCBI
Celera645,740,406 - 45,755,032 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef643,909,392 - 43,924,018 (+)NCBIHuRef
CHM1_1644,190,982 - 44,205,608 (+)NCBICHM1_1
T2T-CHM13v2.0644,053,799 - 44,068,307 (+)NCBIT2T-CHM13v2.0
Slc29a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391745,896,126 - 45,910,544 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1745,896,126 - 45,910,532 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381745,585,200 - 45,599,618 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1745,585,200 - 45,599,606 (-)Ensemblmm10GRCm38
MGSCv371745,722,171 - 45,729,342 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361745,048,803 - 45,055,974 (-)NCBIMGSCv36mm8
Celera1749,020,645 - 49,027,816 (-)NCBICelera
Cytogenetic Map17B3- CNCBI
cM Map1722.59NCBI
Slc29a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,855,434 - 9,861,929 (+)Ensembl
ChiLan1.0NW_0049554379,850,279 - 9,862,412 (+)NCBIChiLan1.0ChiLan1.0
SLC29A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2558,723,206 - 58,738,556 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1654,593,281 - 54,608,635 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0643,815,006 - 43,830,290 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1645,099,149 - 45,113,689 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl645,099,243 - 45,113,689 (+)EnsemblpanPan2panpan1.1
SLC29A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11212,632,233 - 12,644,669 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1212,634,194 - 12,644,667 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1212,663,478 - 12,670,038 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01213,113,302 - 13,127,046 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1213,113,455 - 13,127,044 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11212,646,180 - 12,652,739 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01212,733,889 - 12,740,450 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01212,827,606 - 12,834,165 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc29a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494648,097,652 - 48,111,152 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647615,846,606 - 15,862,548 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647615,849,054 - 15,862,486 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC29A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl739,218,051 - 39,234,685 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1739,217,974 - 39,234,683 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2745,087,418 - 45,104,152 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC29A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11727,934,537 - 27,949,120 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1727,931,945 - 27,949,006 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604444,272,955 - 44,287,547 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc29a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475415,624,429 - 15,632,996 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475415,623,960 - 15,636,377 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc29a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1484,294,983 - 84,303,716 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc29a1
146 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:268
Count of miRNA genes:166
Interacting mature miRNAs:193
Transcripts:ENSRNOT00000026831
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat

Markers in Region
RH137046  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2915,413,893 - 15,414,101 (+)MAPPERmRatBN7.2
Rnor_6.0917,798,699 - 17,798,906NCBIRnor6.0
Rnor_5.0916,687,463 - 16,687,670UniSTSRnor5.0
RGSC_v3.4911,014,607 - 11,014,814UniSTSRGSC3.4
Celera913,157,872 - 13,158,079UniSTS
RH 3.4 Map977.1UniSTS
Cytogenetic Map9q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 89 59 6 352 189 11 142 80 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001432780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC096454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF015304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000026831   ⟹   ENSRNOP00000026831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl922,902,471 - 22,911,637 (+)Ensembl
mRatBN7.2 Ensembl915,403,193 - 15,414,193 (+)Ensembl
Rnor_6.0 Ensembl917,784,468 - 17,799,005 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107209   ⟹   ENSRNOP00000085028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl922,903,545 - 22,911,637 (+)Ensembl
mRatBN7.2 Ensembl915,403,245 - 15,414,136 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108087   ⟹   ENSRNOP00000082743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl922,903,386 - 22,914,620 (+)Ensembl
mRatBN7.2 Ensembl915,403,217 - 15,414,203 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111451   ⟹   ENSRNOP00000092147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl922,902,471 - 22,911,120 (+)Ensembl
mRatBN7.2 Ensembl915,399,612 - 15,413,683 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000139340   ⟹   ENSRNOP00000103586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl922,905,158 - 22,914,620 (+)Ensembl
RefSeq Acc Id: NM_031684   ⟹   NP_113872
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,897,099 - 22,911,638 (+)NCBI
mRatBN7.2915,399,661 - 15,414,201 (+)NCBI
Rnor_6.0917,784,468 - 17,799,006 (+)NCBI
Rnor_5.0916,673,067 - 16,687,772 (+)NCBI
RGSC_v3.4911,000,054 - 11,014,914 (+)RGD
Celera913,143,672 - 13,158,179 (+)RGD
Sequence:
RefSeq Acc Id: XM_006244560   ⟹   XP_006244622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,900,393 - 22,911,640 (+)NCBI
mRatBN7.2915,403,112 - 15,414,203 (+)NCBI
Rnor_6.0917,787,967 - 17,799,008 (+)NCBI
Rnor_5.0916,673,067 - 16,687,772 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244561   ⟹   XP_006244623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,900,613 - 22,911,640 (+)NCBI
mRatBN7.2915,403,143 - 15,414,203 (+)NCBI
Rnor_6.0917,787,980 - 17,799,008 (+)NCBI
Rnor_5.0916,673,067 - 16,687,772 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244562   ⟹   XP_006244624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,900,648 - 22,911,640 (+)NCBI
mRatBN7.2915,403,229 - 15,414,203 (+)NCBI
Rnor_6.0917,787,987 - 17,799,008 (+)NCBI
Rnor_5.0916,673,067 - 16,687,772 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244563   ⟹   XP_006244625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,900,277 - 22,911,640 (+)NCBI
mRatBN7.2915,402,819 - 15,414,203 (+)NCBI
Rnor_6.0917,787,670 - 17,799,008 (+)NCBI
Rnor_5.0916,673,067 - 16,687,772 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039084162   ⟹   XP_038940090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,900,660 - 22,911,640 (+)NCBI
mRatBN7.2915,403,361 - 15,414,203 (+)NCBI
RefSeq Acc Id: XM_063267671   ⟹   XP_063123741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,903,092 - 22,911,640 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001419709 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419710 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419711 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419712 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419713 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419714 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419715 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419716 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419717 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419718 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419719 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419720 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419721 (Get FASTA)   NCBI Sequence Viewer  
  NP_113872 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244622 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244623 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244624 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244625 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940090 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123741 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB88049 (Get FASTA)   NCBI Sequence Viewer  
  AAH78789 (Get FASTA)   NCBI Sequence Viewer  
  EDM18743 (Get FASTA)   NCBI Sequence Viewer  
  EDM18744 (Get FASTA)   NCBI Sequence Viewer  
  EDM18745 (Get FASTA)   NCBI Sequence Viewer  
  EDM18746 (Get FASTA)   NCBI Sequence Viewer  
  EDM18747 (Get FASTA)   NCBI Sequence Viewer  
  EDM18748 (Get FASTA)   NCBI Sequence Viewer  
  EDM18749 (Get FASTA)   NCBI Sequence Viewer  
  EDM18750 (Get FASTA)   NCBI Sequence Viewer  
  EDM18751 (Get FASTA)   NCBI Sequence Viewer  
  EDM18752 (Get FASTA)   NCBI Sequence Viewer  
  EDM18753 (Get FASTA)   NCBI Sequence Viewer  
  EDM18754 (Get FASTA)   NCBI Sequence Viewer  
  EDM18755 (Get FASTA)   NCBI Sequence Viewer  
  EDM18756 (Get FASTA)   NCBI Sequence Viewer  
  EDM18757 (Get FASTA)   NCBI Sequence Viewer  
  EDM18758 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026831
  ENSRNOP00000082743.1
  ENSRNOP00000085028
GenBank Protein O54698 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113872   ⟸   NM_031684
- UniProtKB: O54698 (UniProtKB/Swiss-Prot),   A0A8L2QGW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244625   ⟸   XM_006244563
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006244622   ⟸   XM_006244560
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006244623   ⟸   XM_006244561
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006244624   ⟸   XM_006244562
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000026831   ⟸   ENSRNOT00000026831
RefSeq Acc Id: XP_038940090   ⟸   XM_039084162
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000085028   ⟸   ENSRNOT00000107209
Ensembl Acc Id: ENSRNOP00000092147   ⟸   ENSRNOT00000111451
Ensembl Acc Id: ENSRNOP00000082743   ⟸   ENSRNOT00000108087
RefSeq Acc Id: XP_063123741   ⟸   XM_063267671
- Peptide Label: isoform X1
- UniProtKB: O54698 (UniProtKB/Swiss-Prot),   A0A8L2QGW6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103586   ⟸   ENSRNOT00000139340

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54698-F1-model_v2 AlphaFold O54698 1-457 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696539
Promoter ID:EPDNEW_R7064
Type:initiation region
Name:Slc29a1_1
Description:solute carrier family 29 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0917,784,423 - 17,784,483EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61899 AgrOrtholog
BioCyc Gene G2FUF-28176 BioCyc
Ensembl Genes ENSRNOG00000019752 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026831 ENTREZGENE
  ENSRNOT00000107209 ENTREZGENE
  ENSRNOT00000108087.1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7132212 IMAGE-MGC_LOAD
InterPro ENT1/ENT2 UniProtKB/Swiss-Prot
  Eqnu_transpt UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
KEGG Report rno:63997 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93345 IMAGE-MGC_LOAD
NCBI Gene 63997 ENTREZGENE
PANTHER PTHR10332 UniProtKB/Swiss-Prot
  PTHR10332:SF9 UniProtKB/Swiss-Prot
Pfam Nucleoside_tran UniProtKB/Swiss-Prot
PharmGKB SLC29A1 RGD
PhenoGen Slc29a1 PhenoGen
PIRSF ENT UniProtKB/Swiss-Prot
PRINTS DERENTRNSPRT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019752 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
TIGR TC229706
UniProt A0A8I6A1R8_RAT UniProtKB/TrEMBL
  A0A8I6AHA8_RAT UniProtKB/TrEMBL
  A0A8L2QGW6 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LSR3_RAT UniProtKB/TrEMBL
  A6JIX4_RAT UniProtKB/TrEMBL
  A6JIY1_RAT UniProtKB/TrEMBL
  A6JIY7_RAT UniProtKB/TrEMBL
  A6JIY9_RAT UniProtKB/TrEMBL
  O54698 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc29a1  solute carrier family 29 member 1  Slc29a1  solute carrier family 29 (equilibrative nucleoside transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc29a1  solute carrier family 29 (equilibrative nucleoside transporter), member 1  Slc29a1  solute carrier family 29 (nucleoside transporters), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc29a1  solute carrier family 29 (nucleoside transporters), member 1    solute carrier family 29, member 1   Name updated 1299863 APPROVED
2002-06-10 Slc29a1  solute carrier family 29, member 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs inhibited by nitrobenzylthioinosine 61755
gene_drugs inhibited by nitrobenzylthioinosine 1299118
gene_expression expressed in dorsal horn, particularly within laminae I-III 1299118
gene_process modulates glutaminergic synaptic transmission 1299118