Nr4a3 (nuclear receptor subfamily 4, group A, member 3) - Rat Genome Database

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Gene: Nr4a3 (nuclear receptor subfamily 4, group A, member 3) Rattus norvegicus
Analyze
Symbol: Nr4a3
Name: nuclear receptor subfamily 4, group A, member 3
RGD ID: 61882
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; nuclear glucocorticoid receptor binding activity; and protein homodimerization activity. Involved in several processes, including animal organ regeneration; positive regulation of cardiac muscle hypertrophy; and regulation of type B pancreatic cell proliferation. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in extraskeletal myxoid chondrosarcoma. Orthologous to human NR4A3 (nuclear receptor subfamily 4 group A member 3); INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neuron-derived orphan receptor; neuron-derived orphan receptor 1; neuron-derived orphan receptor 1/2; NOR-2; nuclear hormone receptor NOR-1/NOR-2; nuclear receptor subfamily 4 group A member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8567,157,141 - 67,198,287 (+)NCBIGRCr8
mRatBN7.2562,361,588 - 62,401,489 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl562,361,822 - 62,402,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx564,336,680 - 64,376,440 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0566,155,972 - 66,195,731 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0566,125,439 - 66,165,198 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0563,781,801 - 63,822,890 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl563,781,801 - 63,821,637 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0568,298,772 - 68,339,861 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4564,713,468 - 64,753,311 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1564,718,506 - 64,758,343 (+)NCBI
Celera565,193,786 - 65,233,628 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,8-cineole  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
6alpha-methylprednisolone  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
atrazine  (EXP,ISO)
azathioprine  (ISO)
bathocuproine disulfonic acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
Calcimycin  (ISO)
cannabidiol  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dieldrin  (ISO)
diiodine  (ISO)
dioxygen  (EXP)
dipentyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenoterol  (ISO)
fluoranthene  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
glyphosate  (EXP)
graphite  (EXP)
haloperidol  (EXP)
hydrogen cyanide  (ISO)
ionomycin  (ISO)
isoprenaline  (ISO)
kainic acid  (EXP)
ketamine  (EXP)
L-ascorbic acid  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
mabuterol  (ISO)
malathion  (ISO)
melphalan  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
mevalonic acid  (ISO)
milrinone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenformin  (EXP)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propan-2-ol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP)
raloxifene  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salmeterol xinafoate  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
Shikonin  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium hypochlorite  (ISO)
Soman  (EXP)
styrene  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
torcetrapib  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP)
triphenylstannane  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
Y-27632  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult behavior  (ISO)
animal organ regeneration  (IEP)
axon guidance  (ISO)
cellular respiration  (ISO,ISS)
cellular response to catecholamine stimulus  (ISO,ISS)
cellular response to corticotropin-releasing hormone stimulus  (IBA,ISO,ISS)
cellular response to leptin stimulus  (ISO,ISS)
common myeloid progenitor cell proliferation  (ISO,ISS)
dendritic cell apoptotic process  (ISO)
energy homeostasis  (ISO,ISS)
fat cell differentiation  (ISO,ISS)
gastrulation  (ISO,ISS)
hippocampus development  (ISO)
inner ear morphogenesis  (ISO)
intracellular receptor signaling pathway  (IEA)
intracellular signal transduction  (ISO,ISS)
mast cell degranulation  (ISO,ISS)
mesoderm formation  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO,ISS)
neuromuscular process controlling balance  (ISO)
neuron apoptotic process  (ISO)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive regulation of cardiac muscle hypertrophy  (IMP)
positive regulation of cell cycle  (ISO)
positive regulation of D-glucose transmembrane transport  (ISO,ISS)
positive regulation of dendritic cell apoptotic process  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (ISO,ISS)
positive regulation of feeding behavior  (ISO,ISS)
positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway  (ISO,ISS)
positive regulation of mast cell cytokine production  (ISO,ISS)
positive regulation of monocyte aggregation  (ISO,ISS)
positive regulation of smooth muscle cell proliferation  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
regulation of smooth muscle cell proliferation  (ISO,ISS)
regulation of transcription by RNA polymerase II  (IBA)
regulation of type B pancreatic cell proliferation  (IMP)
response to hydrogen peroxide  (ISO)
response to peptide hormone  (IEP)
semicircular canal morphogenesis  (ISO)
smooth muscle cell apoptotic process  (ISO)
vestibular reflex  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The orphan receptor NOR1 participates in isoprenaline-induced cardiac hypertrophy by regulating PARP-1. Feng XJ, etal., Br J Pharmacol. 2015 Jun;172(11):2852-63. doi: 10.1111/bph.13091. Epub 2015 Mar 26.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation. Maira M, etal., Mol Cell Biol. 1999 Nov;19(11):7549-57.
4. Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor. Martens C, etal., Mol Endocrinol. 2005 Apr;19(4):885-97. Epub 2004 Dec 9.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells. Ohkura N, etal., Biochem Biophys Res Commun 1994 Dec 30;205(3):1959-65.
8. NOR-2 (neuron-derived orphan receptor), a brain zinc finger protein, is highly induced during liver regeneration. Petropoulos I, etal., FEBS Lett. 1995 Sep 25;372(2-3):273-8.
9. TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77. Rambaud J, etal., J Biol Chem. 2009 May 22;284(21):14147-56. doi: 10.1074/jbc.M809023200. Epub 2009 Mar 25.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. Nkx6.1 regulates islet beta-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. Tessem JS, etal., Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5242-7. doi: 10.1073/pnas.1320953111. Epub 2014 Mar 24.
Additional References at PubMed
PMID:7914660   PMID:8961274   PMID:9155013   PMID:11784868   PMID:12709428   PMID:13129926   PMID:15155786   PMID:15456880   PMID:16945922   PMID:18325999   PMID:18945812   PMID:19103603  
PMID:19150624   PMID:19153266   PMID:19164597   PMID:19270309   PMID:19359610   PMID:19523439   PMID:20558821   PMID:20566846   PMID:20851110   PMID:21868379   PMID:22936731   PMID:23390133  
PMID:23554459   PMID:23897430   PMID:24022864   PMID:24584059   PMID:24586680   PMID:24806827   PMID:25451221   PMID:25852083   PMID:27221116   PMID:33840679   PMID:38943627  


Genomics

Comparative Map Data
Nr4a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8567,157,141 - 67,198,287 (+)NCBIGRCr8
mRatBN7.2562,361,588 - 62,401,489 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl562,361,822 - 62,402,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx564,336,680 - 64,376,440 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0566,155,972 - 66,195,731 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0566,125,439 - 66,165,198 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0563,781,801 - 63,822,890 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl563,781,801 - 63,821,637 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0568,298,772 - 68,339,861 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4564,713,468 - 64,753,311 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1564,718,506 - 64,758,343 (+)NCBI
Celera565,193,786 - 65,233,628 (-)NCBICelera
Cytogenetic Map5q22NCBI
NR4A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38999,821,885 - 99,866,891 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl999,821,855 - 99,866,891 (+)EnsemblGRCh38hg38GRCh38
GRCh379102,584,167 - 102,629,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369101,623,958 - 101,668,994 (+)NCBINCBI36Build 36hg18NCBI36
Build 34999,668,563 - 99,708,728NCBI
Celera973,097,532 - 73,142,572 (+)NCBICelera
Cytogenetic Map9q31.1NCBI
HuRef972,183,339 - 72,228,487 (+)NCBIHuRef
CHM1_19102,730,616 - 102,775,645 (+)NCBICHM1_1
T2T-CHM13v2.09111,993,520 - 112,038,527 (+)NCBIT2T-CHM13v2.0
Nr4a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39448,045,098 - 48,086,446 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl448,045,153 - 48,086,447 (+)EnsemblGRCm39 Ensembl
GRCm38448,045,078 - 48,086,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl448,045,153 - 48,086,447 (+)EnsemblGRCm38mm10GRCm38
MGSCv37448,064,120 - 48,096,224 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36448,072,348 - 48,104,452 (+)NCBIMGSCv36mm8
Celera448,073,263 - 48,105,416 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.07NCBI
Nr4a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541925,779,178 - 25,818,706 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541925,779,368 - 25,817,445 (-)NCBIChiLan1.0ChiLan1.0
NR4A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21139,597,195 - 39,640,348 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1939,599,566 - 39,642,716 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0970,907,056 - 70,950,221 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1999,028,151 - 99,049,949 (+)NCBIpanpan1.1PanPan1.1panPan2
NR4A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11156,806,506 - 56,846,997 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1156,812,804 - 56,847,689 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1155,238,295 - 55,278,535 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01157,915,798 - 57,956,020 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1157,915,647 - 57,955,434 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11156,420,068 - 56,460,272 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01156,444,924 - 56,485,181 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01157,144,349 - 57,184,553 (+)NCBIUU_Cfam_GSD_1.0
Nr4a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947171,704,489 - 171,743,204 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365248,252,381 - 8,289,157 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365248,252,321 - 8,290,747 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR4A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1241,570,010 - 241,611,727 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11241,569,867 - 241,611,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21269,813,286 - 269,852,707 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NR4A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11239,568,085 - 39,611,704 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1239,567,852 - 39,606,837 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660352,937,605 - 2,981,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr4a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248251,097,432 - 1,141,446 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248251,098,915 - 1,141,373 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nr4a3
213 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:438
Count of miRNA genes:234
Interacting mature miRNAs:323
Transcripts:ENSRNOT00000008302
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat

Markers in Region
D5Wox30  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2562,401,082 - 62,401,231 (+)MAPPERmRatBN7.2
Rnor_6.0563,821,238 - 63,821,386NCBIRnor6.0
Rnor_5.0568,338,209 - 68,338,357UniSTSRnor5.0
RGSC_v3.4564,752,905 - 64,753,053UniSTSRGSC3.4
Celera565,194,044 - 65,194,192UniSTS
Cytogenetic Map5q22UniSTS
PMC133552P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2562,368,056 - 62,368,486 (+)MAPPERmRatBN7.2
Rnor_6.0563,788,213 - 63,788,642NCBIRnor6.0
Rnor_5.0568,305,184 - 68,305,613UniSTSRnor5.0
RGSC_v3.4564,719,880 - 64,720,309UniSTSRGSC3.4
Celera565,226,787 - 65,227,216UniSTS
Cytogenetic Map5q22UniSTS
RH141611  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2562,400,896 - 62,401,113 (+)MAPPERmRatBN7.2
Rnor_6.0563,821,052 - 63,821,268NCBIRnor6.0
Rnor_5.0568,338,023 - 68,338,239UniSTSRnor5.0
RGSC_v3.4564,752,719 - 64,752,935UniSTSRGSC3.4
Celera565,194,162 - 65,194,378UniSTS
RH 3.4 Map5413.0UniSTS
Cytogenetic Map5q22UniSTS
BF390776  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2562,402,511 - 62,402,678 (+)MAPPERmRatBN7.2
Rnor_6.0563,822,667 - 63,822,833NCBIRnor6.0
Rnor_5.0568,339,638 - 68,339,804UniSTSRnor5.0
RGSC_v3.4564,754,334 - 64,754,500UniSTSRGSC3.4
Celera565,192,598 - 65,192,764UniSTS
RH 3.4 Map5416.7UniSTS
Cytogenetic Map5q22UniSTS
PMC133552P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2562,369,234 - 62,369,588 (+)MAPPERmRatBN7.2
Rnor_6.0563,789,391 - 63,789,744NCBIRnor6.0
Rnor_5.0568,306,362 - 68,306,715UniSTSRnor5.0
RGSC_v3.4564,721,058 - 64,721,411UniSTSRGSC3.4
Celera565,225,685 - 65,226,038UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 67 66 35 25 35 6 194 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000008302   ⟹   ENSRNOP00000008302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl562,361,822 - 62,402,733 (+)Ensembl
Rnor_6.0 Ensembl563,781,801 - 63,821,637 (+)Ensembl
RefSeq Acc Id: NM_031628   ⟹   NP_113816
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8567,157,198 - 67,197,041 (+)NCBI
mRatBN7.2562,361,645 - 62,401,489 (+)NCBI
Rnor_6.0563,781,801 - 63,821,644 (+)NCBI
Rnor_5.0568,298,772 - 68,339,861 (+)NCBI
RGSC_v3.4564,713,468 - 64,753,311 (+)RGD
Celera565,193,786 - 65,233,628 (-)RGD
Sequence:
RefSeq Acc Id: XM_039110691   ⟹   XP_038966619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8567,157,141 - 67,198,287 (+)NCBI
mRatBN7.2562,361,588 - 62,399,680 (+)NCBI
RefSeq Acc Id: XM_039110692   ⟹   XP_038966620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8567,158,042 - 67,198,287 (+)NCBI
mRatBN7.2562,362,196 - 62,399,680 (+)NCBI
RefSeq Acc Id: XM_063288331   ⟹   XP_063144401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8567,161,973 - 67,198,287 (+)NCBI
RefSeq Acc Id: NP_113816   ⟸   NM_031628
- UniProtKB: Q63516 (UniProtKB/Swiss-Prot),   Q2XPY2 (UniProtKB/Swiss-Prot),   Q9QWQ3 (UniProtKB/Swiss-Prot),   P51179 (UniProtKB/Swiss-Prot),   A6KJG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008302   ⟸   ENSRNOT00000008302
RefSeq Acc Id: XP_038966619   ⟸   XM_039110691
- Peptide Label: isoform X1
- UniProtKB: Q63516 (UniProtKB/Swiss-Prot),   Q2XPY2 (UniProtKB/Swiss-Prot),   P51179 (UniProtKB/Swiss-Prot),   Q9QWQ3 (UniProtKB/Swiss-Prot),   A6KJG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966620   ⟸   XM_039110692
- Peptide Label: isoform X1
- UniProtKB: Q63516 (UniProtKB/Swiss-Prot),   Q2XPY2 (UniProtKB/Swiss-Prot),   P51179 (UniProtKB/Swiss-Prot),   Q9QWQ3 (UniProtKB/Swiss-Prot),   A6KJG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144401   ⟸   XM_063288331
- Peptide Label: isoform X1
- UniProtKB: Q9QWQ3 (UniProtKB/Swiss-Prot),   Q63516 (UniProtKB/Swiss-Prot),   Q2XPY2 (UniProtKB/Swiss-Prot),   P51179 (UniProtKB/Swiss-Prot),   A6KJG2 (UniProtKB/TrEMBL)
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51179-F1-model_v2 AlphaFold P51179 1-628 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693723
Promoter ID:EPDNEW_R4247
Type:single initiation site
Name:Nr4a3_1
Description:nuclear receptor subfamily 4, group A, member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0563,781,889 - 63,781,949EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61882 AgrOrtholog
BioCyc Gene G2FUF-41362 BioCyc
Ensembl Genes ENSRNOG00000005964 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055020913 UniProtKB/Swiss-Prot
  ENSRNOG00060005198 UniProtKB/Swiss-Prot
  ENSRNOG00065010687 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008302.5 UniProtKB/Swiss-Prot
  ENSRNOT00055035695 UniProtKB/Swiss-Prot
  ENSRNOT00060008639 UniProtKB/Swiss-Prot
  ENSRNOT00065017297 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Retinoid X Receptor UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOR1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_orph_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58853 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 58853 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nr4a3 PhenoGen
PRINTS NORNUCRECPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEARECPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005964 RatGTEx
  ENSRNOG00055020913 RatGTEx
  ENSRNOG00060005198 RatGTEx
  ENSRNOG00065010687 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear receptor ligand-binding domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC207340
UniProt A6KJG2 ENTREZGENE, UniProtKB/TrEMBL
  A6KJG4_RAT UniProtKB/TrEMBL
  A6KJG5_RAT UniProtKB/TrEMBL
  NR4A3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q2XPY2 ENTREZGENE
  Q63516 ENTREZGENE
  Q9QWQ3 ENTREZGENE
UniProt Secondary Q2XPY2 UniProtKB/Swiss-Prot
  Q63516 UniProtKB/Swiss-Prot
  Q9QWQ3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nr4a3  nuclear receptor subfamily 4, group A, member 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds to the B1a response-element 61676