Nr4a3 (nuclear receptor subfamily 4, group A, member 3) - Rat Genome Database

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Gene: Nr4a3 (nuclear receptor subfamily 4, group A, member 3) Rattus norvegicus
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Symbol: Nr4a3
Name: nuclear receptor subfamily 4, group A, member 3
RGD ID: 61882
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; nuclear glucocorticoid receptor binding activity; and protein homodimerization activity. Involved in several processes, including animal organ regeneration; positive regulation of cardiac muscle hypertrophy; and regulation of type B pancreatic cell proliferation. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in extraskeletal myxoid chondrosarcoma. Orthologous to human NR4A3 (nuclear receptor subfamily 4 group A member 3); INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neuron-derived orphan receptor; neuron-derived orphan receptor 1; neuron-derived orphan receptor 1/2; NOR-2; nuclear hormone receptor NOR-1/NOR-2; nuclear receptor subfamily 4 group A member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8567,157,141 - 67,198,287 (+)NCBIGRCr8
mRatBN7.2562,361,588 - 62,401,489 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl562,361,822 - 62,402,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx564,336,680 - 64,376,440 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0566,155,972 - 66,195,731 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0566,125,439 - 66,165,198 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0563,781,801 - 63,822,890 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl563,781,801 - 63,821,637 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0568,298,772 - 68,339,861 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4564,713,468 - 64,753,311 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1564,718,506 - 64,758,343 (+)NCBI
Celera565,193,786 - 65,233,628 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
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Original Reference(s)
Nr4a3Ratcongenital disorder of glycosylation Ii  ISONR4A3 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital disorder of glycosylation type 1IClinVarPMID:20813212 and PMID:28492532
Nr4a3Ratcongenital disorder of glycosylation type II  ISONR4A3 (Homo sapiens)8554872ClinVar Annotator: match by term: CDG IiClinVarPMID:20813212 and PMID:28492532
Nr4a3Ratcongenital myasthenic syndrome 14  ISONR4A3 (Homo sapiens)8554872ClinVar Annotator: match by term: Myasthenic syndrome more ...ClinVarPMID:20813212 and PMID:28492532
Nr4a3Ratintellectual disability  ISONR4A3 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Nr4a3Ratnephronophthisis  ISONR4A3 (Homo sapiens)8554872ClinVar Annotator: match by term: NephronophthisisClinVarPMID:12872123 and PMID:28492532
Nr4a3Ratthoracic aortic aneurysm  ISONR4A3 (Homo sapiens)8554872ClinVar Annotator: match by term: Thoracic aortic aneurysms and dissectionsClinVarPMID:20813212 and PMID:28492532
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Original Reference(s)
Nr4a3Ratextraskeletal myxoid chondrosarcoma  ISONR4A3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Nr4a3RatHypercholesterolemia  ISONR4A3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16005304
Nr4a3RatInsulin Resistance  ISONR4A3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17785466
Nr4a3Ratjuvenile rheumatoid arthritis  ISONR4A3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19565504
Nr4a3Ratrheumatoid arthritis  ISONR4A3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19192274
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Original Reference(s)
Nr4a3Ratextraskeletal myxoid chondrosarcoma  ISONR4A3 (Homo sapiens)7240710 OMIM 

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Nr4a3Rat(-)-epigallocatechin 3-gallate multiple interactionsISONR4A3 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of NR4A3 mRNACTDPMID:22079256
Nr4a3Rat1,2,4-trimethylbenzene increases expressionEXP 6480464pseudocumene results in increased expression of NR4A3 proteinCTDPMID:17337753
Nr4a3Rat1,8-cineole decreases expressionISONR4A3 (Homo sapiens)6480464Eucalyptol results in decreased expression of NR4A3 mRNACTDPMID:36331666
Nr4a3Rat15-acetyldeoxynivalenol increases expressionISONR4A3 (Homo sapiens)648046415-acetyldeoxynivalenol results in increased expression of NR4A3 mRNACTDPMID:23792671
Nr4a3Rat17beta-estradiol increases expressionISONR4A3 (Homo sapiens)6480464Estradiol results in increased expression of NR4A3 mRNACTDPMID:31614463
Nr4a3Rat2,2',5,5'-tetrachlorobiphenyl decreases expressionISONR4A3 (Homo sapiens)64804642 more ...CTDPMID:36804509
Nr4a3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISONr4a3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of NR4A3 mRNACTDPMID:19933214 and PMID:24058054
Nr4a3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of NR4A3 mRNACTDPMID:33387578
Nr4a3Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISONr4a3 (Mus musculus)64804642 more ...CTDPMID:38648751
Nr4a3Rat2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactionsISONR4A3 (Homo sapiens)6480464geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of NR4A3 mRNA]CTDPMID:16005304
Nr4a3Rat3,3',4,4',5-pentachlorobiphenyl increases expressionISONr4a3 (Mus musculus)64804643 more ...CTDPMID:30312631
Nr4a3Rat3,3',4,4',5-pentachlorobiphenyl multiple interactionsISONr4a3 (Mus musculus)64804643 more ...CTDPMID:30312631
Nr4a3Rat4,4'-diaminodiphenylmethane decreases expressionISONr4a3 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in decreased expression of NR4A3 mRNACTDPMID:18648102
Nr4a3Rat4,4'-sulfonyldiphenol increases expressionEXP 6480464bisphenol S results in increased expression of NR4A3 mRNACTDPMID:26186136
Nr4a3Rat4-hydroxyphenyl retinamide increases expressionISONr4a3 (Mus musculus)6480464Fenretinide results in increased expression of NR4A3 mRNACTDPMID:28973697
Nr4a3Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of NR4A3 mRNACTDPMID:24780913
Nr4a3Rat6-propyl-2-thiouracil multiple interactionsISONr4a3 (Mus musculus)6480464[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of NR4A3 mRNACTDPMID:36706583
Nr4a3Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of NR4A3 mRNACTDPMID:25825206 and PMID:30047161
Nr4a3Rat6alpha-methylprednisolone decreases expressionISONR4A3 (Homo sapiens)6480464Methylprednisolone results in decreased expression of NR4A3 mRNACTDPMID:19192274
Nr4a3Rat8-Br-cAMP increases expressionISONR4A3 (Homo sapiens)64804648-Bromo Cyclic Adenosine Monophosphate results in increased expression of NR4A3 mRNACTDPMID:22079614

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Biological Process
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Nr4a3Ratadult behavior acts_upstream_of_or_withinISONr4a3 (Mus musculus)1624291MGI:3037444 PMID:11784868RGDPMID:11784868
Nr4a3Ratanimal organ regeneration  IEP 1566537 RGD 
Nr4a3Rataxon guidance acts_upstream_of_or_withinISONr4a3 (Mus musculus)1624291MGI:3037444 PMID:15456880RGDPMID:15456880
Nr4a3Ratcellular respiration involved_inISSUniProtKB:Q9QZB61600115GO_REF:0000024UniProtGO_REF:0000024
Nr4a3Ratcellular respiration involved_inISONr4a3 (Mus musculus)1624291 PMID:18325999RGDPMID:18325999
Nr4a3Ratcellular response to catecholamine stimulus involved_inISSUniProtKB:Q9QZB61600115GO_REF:0000024UniProtGO_REF:0000024
Nr4a3Ratcellular response to catecholamine stimulus involved_inISONr4a3 (Mus musculus)1624291 PMID:18325999RGDPMID:18325999
Nr4a3Ratcellular response to corticotropin-releasing hormone stimulus involved_inISSUniProtKB:Q9QZB61600115GO_REF:0000024UniProtGO_REF:0000024
Nr4a3Ratcellular response to corticotropin-releasing hormone stimulus involved_inISONr4a3 (Mus musculus)1624291 PMID:10523643RGDPMID:10523643
Nr4a3Ratcellular response to corticotropin-releasing hormone stimulus involved_inIBAMGI:1352454 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nr4a3Ratcellular response to leptin stimulus involved_inISSUniProtKB:Q9QZB61600115GO_REF:0000024UniProtGO_REF:0000024
Nr4a3Ratcellular response to leptin stimulus involved_inISONr4a3 (Mus musculus)1624291 PMID:19523439RGDPMID:19523439
Nr4a3Ratcommon myeloid progenitor cell proliferation involved_inISSUniProtKB:Q9QZB61600115GO_REF:0000024UniProtGO_REF:0000024
Nr4a3Ratcommon myeloid progenitor cell proliferation involved_inISONr4a3 (Mus musculus)1624291 PMID:24806827RGDPMID:24806827
Nr4a3Ratdendritic cell apoptotic process acts_upstream_ofISONr4a3 (Mus musculus)1624291 PMID:19164597RGDPMID:19164597
Nr4a3Ratenergy homeostasis involved_inISSUniProtKB:Q9QZB61600115GO_REF:0000024UniProtGO_REF:0000024
Nr4a3Ratenergy homeostasis involved_inISONr4a3 (Mus musculus)1624291 PMID:19523439 and PMID:23897430RGDPMID:19523439 and PMID:23897430
Nr4a3Ratfat cell differentiation involved_inISSUniProtKB:Q9QZB61600115GO_REF:0000024UniProtGO_REF:0000024
Nr4a3Ratfat cell differentiation involved_inISONr4a3 (Mus musculus)1624291 PMID:18945812RGDPMID:18945812
Nr4a3Ratgastrulation involved_inISONr4a3 (Mus musculus)1624291 PMID:13129926RGDPMID:13129926
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Cellular Component

  
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Original Reference(s)
Nr4a3Ratnucleus is_active_inIBAFB:FBgn0014859 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nr4a3Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Nr4a3Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Nr4a3Ratnucleus located_inIEAInterPro:IPR003070 and InterPro:IPR0030721600115GO_REF:0000002InterProGO_REF:0000002
Nr4a3Rattranscription regulator complex part_ofIBAMGI:1352454 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nr4a3Rattranscription regulator complex part_ofISONr4a3 (Mus musculus)1624291 PMID:9155013RGDPMID:9155013

Molecular Function
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Nr4a3RatcAMP response element binding enablesISSUniProtKB:Q9QZB61600115GO_REF:0000024UniProtGO_REF:0000024
Nr4a3RatcAMP response element binding enablesISONr4a3 (Mus musculus)1624291 PMID:23897430RGDPMID:23897430
Nr4a3RatDNA binding  IDA 1566537 RGD 
Nr4a3RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Nr4a3RatDNA binding enablesIEAInterPro:IPR003070 and InterPro:IPR0030721600115GO_REF:0000002InterProGO_REF:0000002
Nr4a3RatDNA-binding transcription activator activity enablesISONr4a3 (Mus musculus)1624291 PMID:18325999RGDPMID:18325999
Nr4a3RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISONR4A3 (Homo sapiens)1624291 PMID:20558821RGDPMID:20558821
Nr4a3RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAARBA:ARBA000277591600115GO_REF:0000117UniProtGO_REF:0000117
Nr4a3RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISONr4a3 (Mus musculus)1624291 PMID:19153266 more ...RGDPMID:19153266 more ...
Nr4a3RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIDA 10054079PMID:10523643UniProt 
Nr4a3RatDNA-binding transcription factor activity enablesIEAInterPro:IPR0016281600115GO_REF:0000002InterProGO_REF:0000002
Nr4a3RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAMGI:1352454 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nr4a3Rathistone acetyltransferase binding enablesISONr4a3 (Mus musculus)1624291UniProtKB:B2RWS6 more ...RGDPMID:12709428
Nr4a3Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Nr4a3Ratnuclear glucocorticoid receptor binding enablesIPIUniProtKB:P0415010047331PMID:15591535UniProt 
Nr4a3Ratnuclear glucocorticoid receptor binding enablesIBAMGI:1352456 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nr4a3Ratnuclear receptor activity enablesIEAInterPro:IPR003070 and InterPro:IPR0030721600115GO_REF:0000002InterProGO_REF:0000002
Nr4a3Ratprotein binding enablesIPIUniProtKB:P2700810054073PMID:25625556UniProt 
Nr4a3Ratprotein binding enablesISONR4A3 (Homo sapiens)1624291UniProtKB:A8MQ03 more ...RGDPMID:12543801 and PMID:32296183
Nr4a3Ratprotein binding enablesIPIUniProtKB:Q6231810047236PMID:19321449UniProt 
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Reference Title
Reference Citation
1. The orphan receptor NOR1 participates in isoprenaline-induced cardiac hypertrophy by regulating PARP-1. Feng XJ, etal., Br J Pharmacol. 2015 Jun;172(11):2852-63. doi: 10.1111/bph.13091. Epub 2015 Mar 26.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation. Maira M, etal., Mol Cell Biol. 1999 Nov;19(11):7549-57.
4. Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor. Martens C, etal., Mol Endocrinol. 2005 Apr;19(4):885-97. Epub 2004 Dec 9.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells. Ohkura N, etal., Biochem Biophys Res Commun 1994 Dec 30;205(3):1959-65.
8. NOR-2 (neuron-derived orphan receptor), a brain zinc finger protein, is highly induced during liver regeneration. Petropoulos I, etal., FEBS Lett. 1995 Sep 25;372(2-3):273-8.
9. TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77. Rambaud J, etal., J Biol Chem. 2009 May 22;284(21):14147-56. doi: 10.1074/jbc.M809023200. Epub 2009 Mar 25.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. Nkx6.1 regulates islet beta-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. Tessem JS, etal., Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5242-7. doi: 10.1073/pnas.1320953111. Epub 2014 Mar 24.
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PMID:7914660   PMID:8961274   PMID:9155013   PMID:11784868   PMID:12709428   PMID:13129926   PMID:15155786   PMID:15456880   PMID:16945922   PMID:18325999   PMID:18945812   PMID:19103603  
PMID:19150624   PMID:19153266   PMID:19164597   PMID:19270309   PMID:19359610   PMID:19523439   PMID:20558821   PMID:20566846   PMID:20851110   PMID:21868379   PMID:22936731   PMID:23390133  
PMID:23554459   PMID:23897430   PMID:24022864   PMID:24584059   PMID:24586680   PMID:24806827   PMID:25451221   PMID:25852083   PMID:27221116   PMID:33840679   PMID:38943627  



Nr4a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8567,157,141 - 67,198,287 (+)NCBIGRCr8
mRatBN7.2562,361,588 - 62,401,489 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl562,361,822 - 62,402,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx564,336,680 - 64,376,440 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0566,155,972 - 66,195,731 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0566,125,439 - 66,165,198 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0563,781,801 - 63,822,890 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl563,781,801 - 63,821,637 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0568,298,772 - 68,339,861 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4564,713,468 - 64,753,311 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1564,718,506 - 64,758,343 (+)NCBI
Celera565,193,786 - 65,233,628 (-)NCBICelera
Cytogenetic Map5q22NCBI
NR4A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38999,821,885 - 99,866,891 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl999,821,855 - 99,866,891 (+)EnsemblGRCh38hg38GRCh38
GRCh379102,584,167 - 102,629,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369101,623,958 - 101,668,994 (+)NCBINCBI36Build 36hg18NCBI36
Build 34999,668,563 - 99,708,728NCBI
Celera973,097,532 - 73,142,572 (+)NCBICelera
Cytogenetic Map9q31.1NCBI
HuRef972,183,339 - 72,228,487 (+)NCBIHuRef
CHM1_19102,730,616 - 102,775,645 (+)NCBICHM1_1
T2T-CHM13v2.09111,993,520 - 112,038,527 (+)NCBIT2T-CHM13v2.0
Nr4a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39448,045,098 - 48,086,446 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl448,045,153 - 48,086,447 (+)EnsemblGRCm39 Ensembl
GRCm38448,045,078 - 48,086,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl448,045,153 - 48,086,447 (+)EnsemblGRCm38mm10GRCm38
MGSCv37448,064,120 - 48,096,224 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36448,072,348 - 48,104,452 (+)NCBIMGSCv36mm8
Celera448,073,263 - 48,105,416 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.07NCBI
Nr4a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541925,779,178 - 25,818,706 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541925,779,368 - 25,817,445 (-)NCBIChiLan1.0ChiLan1.0
NR4A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21139,597,195 - 39,640,348 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1939,599,566 - 39,642,716 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0970,907,056 - 70,950,221 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1999,028,151 - 99,049,949 (+)NCBIpanpan1.1PanPan1.1panPan2
NR4A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11156,806,506 - 56,846,997 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1156,812,804 - 56,847,689 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1155,238,295 - 55,278,535 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01157,915,798 - 57,956,020 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1157,915,647 - 57,955,434 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11156,420,068 - 56,460,272 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01156,444,924 - 56,485,181 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01157,144,349 - 57,184,553 (+)NCBIUU_Cfam_GSD_1.0
Nr4a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947171,704,489 - 171,743,204 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365248,252,381 - 8,289,157 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365248,252,321 - 8,290,747 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR4A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1241,570,010 - 241,611,727 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11241,569,867 - 241,611,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21269,813,286 - 269,852,707 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NR4A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11239,568,085 - 39,611,704 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1239,567,852 - 39,606,837 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660352,937,605 - 2,981,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr4a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248251,097,432 - 1,141,446 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248251,098,915 - 1,141,373 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Nr4a3
213 total Variants

Predicted Target Of
Summary Value
Count of predictions:438
Count of miRNA genes:234
Interacting mature miRNAs:323
Transcripts:ENSRNOT00000008302
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 40 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat

1 to 10 of 40 rows
D5Wox30  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8567,196,634 - 67,196,783 (+)Marker Load Pipeline
mRatBN7.2562,401,082 - 62,401,231 (+)MAPPERmRatBN7.2
Rnor_6.0563,821,238 - 63,821,386NCBIRnor6.0
Rnor_5.0568,338,209 - 68,338,357UniSTSRnor5.0
RGSC_v3.4564,752,905 - 64,753,053UniSTSRGSC3.4
Celera565,194,044 - 65,194,192UniSTS
Cytogenetic Map5q22UniSTS
PMC133552P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2562,368,056 - 62,368,486 (+)MAPPERmRatBN7.2
Rnor_6.0563,788,213 - 63,788,642NCBIRnor6.0
Rnor_5.0568,305,184 - 68,305,613UniSTSRnor5.0
RGSC_v3.4564,719,880 - 64,720,309UniSTSRGSC3.4
Celera565,226,787 - 65,227,216UniSTS
Cytogenetic Map5q22UniSTS
RH141611  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2562,400,896 - 62,401,113 (+)MAPPERmRatBN7.2
Rnor_6.0563,821,052 - 63,821,268NCBIRnor6.0
Rnor_5.0568,338,023 - 68,338,239UniSTSRnor5.0
RGSC_v3.4564,752,719 - 64,752,935UniSTSRGSC3.4
Celera565,194,162 - 65,194,378UniSTS
RH 3.4 Map5413.0UniSTS
Cytogenetic Map5q22UniSTS
BF390776  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2562,402,511 - 62,402,678 (+)MAPPERmRatBN7.2
Rnor_6.0563,822,667 - 63,822,833NCBIRnor6.0
Rnor_5.0568,339,638 - 68,339,804UniSTSRnor5.0
RGSC_v3.4564,754,334 - 64,754,500UniSTSRGSC3.4
Celera565,192,598 - 65,192,764UniSTS
RH 3.4 Map5416.7UniSTS
Cytogenetic Map5q22UniSTS
PMC133552P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8567,164,788 - 67,165,141 (+)Marker Load Pipeline
mRatBN7.2562,369,234 - 62,369,588 (+)MAPPERmRatBN7.2
Rnor_6.0563,789,391 - 63,789,744NCBIRnor6.0
Rnor_5.0568,306,362 - 68,306,715UniSTSRnor5.0
RGSC_v3.4564,721,058 - 64,721,411UniSTSRGSC3.4
Celera565,225,685 - 65,226,038UniSTS
Cytogenetic Map5q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 67 66 35 25 35 6 194 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000008302   ⟹   ENSRNOP00000008302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl562,361,822 - 62,402,733 (+)Ensembl
Rnor_6.0 Ensembl563,781,801 - 63,821,637 (+)Ensembl
RefSeq Acc Id: NM_031628   ⟹   NP_113816
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8567,157,198 - 67,197,041 (+)NCBI
mRatBN7.2562,361,645 - 62,401,489 (+)NCBI
Rnor_6.0563,781,801 - 63,821,644 (+)NCBI
Rnor_5.0568,298,772 - 68,339,861 (+)NCBI
RGSC_v3.4564,713,468 - 64,753,311 (+)RGD
Celera565,193,786 - 65,233,628 (-)RGD
Sequence:
RefSeq Acc Id: XM_039110691   ⟹   XP_038966619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8567,157,141 - 67,198,287 (+)NCBI
mRatBN7.2562,361,588 - 62,399,680 (+)NCBI
RefSeq Acc Id: XM_039110692   ⟹   XP_038966620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8567,158,042 - 67,198,287 (+)NCBI
mRatBN7.2562,362,196 - 62,399,680 (+)NCBI
RefSeq Acc Id: XM_063288331   ⟹   XP_063144401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8567,161,973 - 67,198,287 (+)NCBI
RefSeq Acc Id: NP_113816   ⟸   NM_031628
- UniProtKB: Q63516 (UniProtKB/Swiss-Prot),   Q2XPY2 (UniProtKB/Swiss-Prot),   Q9QWQ3 (UniProtKB/Swiss-Prot),   P51179 (UniProtKB/Swiss-Prot),   A6KJG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008302   ⟸   ENSRNOT00000008302
RefSeq Acc Id: XP_038966619   ⟸   XM_039110691
- Peptide Label: isoform X1
- UniProtKB: Q63516 (UniProtKB/Swiss-Prot),   Q2XPY2 (UniProtKB/Swiss-Prot),   P51179 (UniProtKB/Swiss-Prot),   Q9QWQ3 (UniProtKB/Swiss-Prot),   A6KJG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966620   ⟸   XM_039110692
- Peptide Label: isoform X1
- UniProtKB: Q63516 (UniProtKB/Swiss-Prot),   Q2XPY2 (UniProtKB/Swiss-Prot),   P51179 (UniProtKB/Swiss-Prot),   Q9QWQ3 (UniProtKB/Swiss-Prot),   A6KJG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144401   ⟸   XM_063288331
- Peptide Label: isoform X1
- UniProtKB: Q9QWQ3 (UniProtKB/Swiss-Prot),   Q63516 (UniProtKB/Swiss-Prot),   Q2XPY2 (UniProtKB/Swiss-Prot),   P51179 (UniProtKB/Swiss-Prot),   A6KJG2 (UniProtKB/TrEMBL)
NR LBD   Nuclear receptor

Name Modeler Protein Id AA Range Protein Structure
AF-P51179-F1-model_v2 AlphaFold P51179 1-628 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693723
Promoter ID:EPDNEW_R4247
Type:single initiation site
Name:Nr4a3_1
Description:nuclear receptor subfamily 4, group A, member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0563,781,889 - 63,781,949EPDNEW


1 to 40 of 44 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-41362 BioCyc
Ensembl Genes ENSRNOG00000005964 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008302 ENTREZGENE
  ENSRNOT00000008302.5 UniProtKB/Swiss-Prot
  ENSRNOT00000142521 ENTREZGENE
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot
  NOR1_rcpt UniProtKB/Swiss-Prot
  Nuc_orph_rcpt UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:58853 UniProtKB/Swiss-Prot
NCBI Gene 58853 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot
  NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 3 UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PhenoGen Nr4a3 PhenoGen
PRINTS NORNUCRECPTR UniProtKB/Swiss-Prot
  NUCLEARECPTR UniProtKB/Swiss-Prot
  STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005964 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
TIGR TC207340
UniProt A6KJG2 ENTREZGENE, UniProtKB/TrEMBL
  A6KJG4_RAT UniProtKB/TrEMBL
  A6KJG5_RAT UniProtKB/TrEMBL
  NR4A3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q2XPY2 ENTREZGENE
  Q63516 ENTREZGENE
1 to 40 of 44 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nr4a3  nuclear receptor subfamily 4, group A, member 3      Name updated 70584 APPROVED

Note Type Note Reference
gene_function binds to the B1a response-element 61676