Aldh3a2 (aldehyde dehydrogenase 3 family, member A2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Aldh3a2 (aldehyde dehydrogenase 3 family, member A2) Rattus norvegicus
Analyze
Symbol: Aldh3a2
Name: aldehyde dehydrogenase 3 family, member A2
RGD ID: 61866
Description: Enables 3-chloroallyl aldehyde dehydrogenase activity. Involved in formaldehyde metabolic process and response to reactive oxygen species. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome. Orthologous to human ALDH3A2 (aldehyde dehydrogenase 3 family member A2); PARTICIPATES IN phytanic acid degradation pathway; Refsum disease pathway; arginine and proline metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alcohol dehydrogenase family 3 subfamily A2; alcohol dehydrogenase family 3, subfamily A2; aldehyde dehydrogenase 3A2; aldehyde dehydrogenase 4; aldehyde dehydrogenase family 3 member A2; aldehyde dehydrogenase family 3, subfamily A2; Aldh4; FALDH; fatty aldehyde dehydrogenase; microsomal aldehyde dehydrogenase; msALDH
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,427,789 - 46,448,449 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1046,407,993 - 46,448,648 (-)EnsemblGRCr8
mRatBN7.21045,928,313 - 45,949,366 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,908,524 - 45,949,281 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1050,630,818 - 50,651,382 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01050,121,209 - 50,141,773 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01045,624,781 - 45,645,345 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01047,525,486 - 47,546,535 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,525,493 - 47,546,345 (-)Ensemblrn6Rnor6.0
Rnor_5.01047,300,324 - 47,321,002 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41047,400,518 - 47,421,064 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1045,182,182 - 45,202,711 (-)NCBICelera
RGSC_v3.11047,414,148 - 47,434,687 (-)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-methylcholine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
Acetyl tributyl citrate  (ISO)
aconitine  (EXP)
acrolein  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antimonite  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chloroform  (EXP)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crotonaldehyde  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
eugenol  (EXP)
finasteride  (EXP)
folic acid  (ISO)
folpet  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
GSK-J4  (ISO)
indometacin  (EXP)
inulin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel sulfate  (ISO)
ochratoxin A  (EXP,ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
phlorizin  (ISO)
phytol  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
Yessotoxin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Fatty aldehyde dehydrogenase: potential role in oxidative stress protection and regulation of its gene expression by insulin. Demozay D, etal., J Biol Chem 2004 Feb 20;279(8):6261-70. Epub 2003 Nov 24.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Immunocytochemical and biochemical demonstration of formaldhyde dehydrogenase (class III alcohol dehydrogenase) in the nucleus. Iborra FJ, etal., J Histochem Cytochem 1992 Dec;40(12):1865-78.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Molecular cloning, sequencing, and expression of cDNA for rat liver microsomal aldehyde dehydrogenase. Miyauchi K, etal., J Biol Chem 1991 Oct 15;266(29):19536-42.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8528251   PMID:9133646   PMID:12865426   PMID:15110319   PMID:17510064   PMID:18035827   PMID:18614015   PMID:23376485   PMID:25047030   PMID:25286108  


Genomics

Comparative Map Data
Aldh3a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,427,789 - 46,448,449 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1046,407,993 - 46,448,648 (-)EnsemblGRCr8
mRatBN7.21045,928,313 - 45,949,366 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,908,524 - 45,949,281 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1050,630,818 - 50,651,382 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01050,121,209 - 50,141,773 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01045,624,781 - 45,645,345 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01047,525,486 - 47,546,535 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,525,493 - 47,546,345 (-)Ensemblrn6Rnor6.0
Rnor_5.01047,300,324 - 47,321,002 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41047,400,518 - 47,421,064 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1045,182,182 - 45,202,711 (-)NCBICelera
RGSC_v3.11047,414,148 - 47,434,687 (-)NCBI
Cytogenetic Map10q22NCBI
ALDH3A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381719,648,136 - 19,677,596 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1719,647,291 - 19,685,760 (+)Ensemblhg38GRCh38
GRCh371719,551,449 - 19,580,909 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361719,492,656 - 19,521,500 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341719,492,682 - 19,521,495NCBI
Celera1716,965,422 - 16,994,253 (+)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1718,931,182 - 18,960,005 (+)NCBIHuRef
CHM1_11719,560,917 - 19,589,757 (+)NCBICHM1_1
T2T-CHM13v2.01719,596,758 - 19,626,215 (+)NCBIT2T-CHM13v2.0
Aldh3a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,114,240 - 61,158,267 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1161,114,243 - 61,158,290 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381161,223,417 - 61,267,528 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,223,417 - 61,267,464 (-)Ensemblmm10GRCm38
MGSCv371161,058,257 - 61,080,629 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361161,060,950 - 61,083,322 (-)NCBIMGSCv36mm8
MGSCv361161,674,448 - 61,696,820 (-)NCBIMGSCv36mm8
Cytogenetic Map11B2NCBI
cM Map1137.96NCBI
Aldh3a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955467140,760 - 162,742 (-)Ensembl
ChiLan1.0NW_004955467141,592 - 162,376 (-)NCBIChiLan1.0ChiLan1.0
ALDH3A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21954,640,441 - 54,683,013 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11759,452,286 - 59,494,725 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01731,455,386 - 31,482,985 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11736,599,830 - 36,628,102 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1736,599,835 - 36,628,102 (-)EnsemblpanPan2panpan1.1
ALDH3A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1540,515,768 - 40,641,377 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl540,515,030 - 40,641,463 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha540,657,648 - 40,782,777 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0540,676,970 - 40,739,907 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0540,621,779 - 40,644,870 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl540,653,806 - 40,740,897 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1540,593,134 - 40,717,947 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0540,538,776 - 40,664,129 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0540,731,446 - 40,856,529 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aldh3a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560260,436,975 - 60,460,173 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936881127,023 - 150,292 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936881127,090 - 150,269 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH3A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1259,936,848 - 59,954,358 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11259,936,838 - 59,953,677 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21262,591,931 - 62,608,903 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH3A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11618,213,284 - 18,241,261 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1618,213,487 - 18,239,271 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660592,605,746 - 2,633,744 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh3a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248495,912,273 - 5,938,007 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248495,911,711 - 5,941,706 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Aldh3a2
90 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:636
Count of miRNA genes:289
Interacting mature miRNAs:361
Transcripts:ENSRNOT00000066109
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Rat63  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21045,939,295 - 45,939,457 (+)MAPPERmRatBN7.2
Rnor_6.01047,536,469 - 47,536,628NCBIRnor6.0
Rnor_5.01047,311,307 - 47,311,466UniSTSRnor5.0
RGSC_v3.41047,411,494 - 47,411,653UniSTSRGSC3.4
RGSC_v3.41047,411,493 - 47,411,653RGDRGSC3.4
Celera1045,193,158 - 45,193,300UniSTS
RGSC_v3.11047,425,117 - 47,425,276RGD
RH 3.4 Map10530.49UniSTS
RH 3.4 Map10530.49RGD
RH 2.0 Map10508.5RGD
SHRSP x BN Map1041.9499RGD
FHH x ACI Map1039.32RGD
Cytogenetic Map10q22UniSTS
D10Got73  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81046,438,667 - 46,438,923 (+)Marker Load Pipeline
mRatBN7.21045,939,198 - 45,939,456 (+)MAPPERmRatBN7.2
Rnor_6.01047,536,372 - 47,536,627NCBIRnor6.0
Rnor_5.01047,311,210 - 47,311,465UniSTSRnor5.0
RGSC_v3.41047,411,396 - 47,411,652RGDRGSC3.4
RGSC_v3.41047,411,397 - 47,411,652UniSTSRGSC3.4
Celera1045,193,061 - 45,193,299UniSTS
RGSC_v3.11047,425,019 - 47,425,275RGD
RH 2.0 Map10526.9RGD
Cytogenetic Map10q22UniSTS
RH129148  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21045,928,401 - 45,928,616 (+)MAPPERmRatBN7.2
Rnor_6.01047,525,575 - 47,525,789NCBIRnor6.0
Rnor_5.01047,300,413 - 47,300,627UniSTSRnor5.0
RGSC_v3.41047,400,600 - 47,400,814UniSTSRGSC3.4
Celera1045,182,264 - 45,182,478UniSTS
RH 3.4 Map10530.08UniSTS
Cytogenetic Map10q22UniSTS
RH140634  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81046,445,408 - 46,446,230 (+)Marker Load Pipeline
mRatBN7.21045,945,941 - 45,946,763 (+)MAPPERmRatBN7.2
Rnor_6.01047,543,111 - 47,543,932NCBIRnor6.0
Rnor_5.01047,317,951 - 47,318,772UniSTSRnor5.0
RGSC_v3.41047,418,138 - 47,418,959UniSTSRGSC3.4
Celera1045,199,785 - 45,200,606UniSTS
RH 3.4 Map10528.67UniSTS
Cytogenetic Map10q22UniSTS
RH140757  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21045,948,794 - 45,949,001 (+)MAPPERmRatBN7.2
Rnor_6.01047,545,964 - 47,546,170NCBIRnor6.0
Rnor_5.01047,320,804 - 47,321,010UniSTSRnor5.0
RGSC_v3.41047,420,991 - 47,421,197UniSTSRGSC3.4
Celera1045,202,638 - 45,202,844UniSTS
RH 3.4 Map10529.89UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000066109   ⟹   ENSRNOP00000061762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1046,427,789 - 46,448,648 (-)Ensembl
mRatBN7.2 Ensembl1045,928,320 - 45,949,281 (-)Ensembl
Rnor_6.0 Ensembl1047,525,493 - 47,546,037 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077461   ⟹   ENSRNOP00000070512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1046,431,369 - 46,448,398 (-)Ensembl
mRatBN7.2 Ensembl1045,931,900 - 45,948,892 (-)Ensembl
Rnor_6.0 Ensembl1047,526,531 - 47,546,345 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094032   ⟹   ENSRNOP00000091575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1046,431,207 - 46,448,398 (-)Ensembl
mRatBN7.2 Ensembl1045,931,738 - 45,948,892 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102182   ⟹   ENSRNOP00000090663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1046,407,993 - 46,448,398 (-)Ensembl
mRatBN7.2 Ensembl1045,908,524 - 45,948,892 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103164   ⟹   ENSRNOP00000091330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1046,430,645 - 46,448,648 (-)Ensembl
mRatBN7.2 Ensembl1045,928,306 - 45,949,281 (-)Ensembl
RefSeq Acc Id: NM_031731   ⟹   NP_113919
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,427,789 - 46,448,335 (-)NCBI
mRatBN7.21045,928,320 - 45,948,868 (-)NCBI
Rnor_6.01047,525,493 - 47,546,037 (-)NCBI
Rnor_5.01047,300,324 - 47,321,002 (-)NCBI
RGSC_v3.41047,400,518 - 47,421,064 (-)RGD
Celera1045,182,182 - 45,202,711 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246529   ⟹   XP_006246591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,429,086 - 46,448,449 (-)NCBI
mRatBN7.21045,928,313 - 45,949,366 (-)NCBI
Rnor_6.01047,525,486 - 47,546,535 (-)NCBI
Rnor_5.01047,300,324 - 47,321,002 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_113919 (Get FASTA)   NCBI Sequence Viewer  
  XP_006246591 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41555 (Get FASTA)   NCBI Sequence Viewer  
  EDM04679 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061762
  ENSRNOP00000091330
GenBank Protein P30839 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113919   ⟸   NM_031731
- UniProtKB: P30839 (UniProtKB/Swiss-Prot),   A6HF75 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246591   ⟸   XM_006246529
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AF13 (UniProtKB/TrEMBL),   G3V9W6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070512   ⟸   ENSRNOT00000077461
Ensembl Acc Id: ENSRNOP00000061762   ⟸   ENSRNOT00000066109
Ensembl Acc Id: ENSRNOP00000091575   ⟸   ENSRNOT00000094032
Ensembl Acc Id: ENSRNOP00000091330   ⟸   ENSRNOT00000103164
Ensembl Acc Id: ENSRNOP00000090663   ⟸   ENSRNOT00000102182
Protein Domains
Aldehyde dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30839-F1-model_v2 AlphaFold P30839 1-484 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697260
Promoter ID:EPDNEW_R7785
Type:initiation region
Name:Aldh3a2_1
Description:aldehyde dehydrogenase 3 family, member A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01047,546,059 - 47,546,119EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61866 AgrOrtholog
BioCyc Gene G2FUF-24818 BioCyc
Ensembl Genes ENSRNOG00000002342 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000066109 ENTREZGENE
  ENSRNOT00000103164 ENTREZGENE
Gene3D-CATH Aldehyde Dehydrogenase, Chain A, domain 1 UniProtKB/Swiss-Prot
  Aldehyde Dehydrogenase, Chain A, domain 2 UniProtKB/Swiss-Prot
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot
  Ald_DH_C UniProtKB/Swiss-Prot
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot
  Ald_DH_N UniProtKB/Swiss-Prot
  Aldehyde_DH_dom UniProtKB/Swiss-Prot
  Aldehyde_DH_NAD(P) UniProtKB/Swiss-Prot
KEGG Report rno:65183 UniProtKB/Swiss-Prot
NCBI Gene 65183 ENTREZGENE
PANTHER ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER A2 UniProtKB/Swiss-Prot
  PTHR43570 UniProtKB/Swiss-Prot
Pfam Aldedh UniProtKB/Swiss-Prot
PhenoGen Aldh3a2 PhenoGen
PIRSF ALDH UniProtKB/Swiss-Prot
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002342 RatGTEx
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot
TIGR TC230052
UniProt A0A0G2JY43_RAT UniProtKB/TrEMBL
  A0A8I6AE89_RAT UniProtKB/TrEMBL
  A0A8I6AF13 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GJ33_RAT UniProtKB/TrEMBL
  A6HF75 ENTREZGENE, UniProtKB/TrEMBL
  AL3A2_RAT UniProtKB/Swiss-Prot
  G3V9W6 ENTREZGENE, UniProtKB/TrEMBL
  P30839 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Aldh3a2  aldehyde dehydrogenase 3 family, member A2  Aldh3a2  aldehyde dehydrogenase family 3, subfamily A2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-05-08 Aldh3a2  Aldehyde dehydrogenase family 3, subfamily A2      Name changed to reflect Human nomenclature 62408 APPROVED
2001-05-08 Aldh3a2  Alcohol dehydrogenase family 3, subfamily A2      Name withdrawn, does not match Human nomenclature 62408 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the endoplasmic reticulum membrane 61536