Npy4r (neuropeptide Y receptor Y4) - Rat Genome Database

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Gene: Npy4r (neuropeptide Y receptor Y4) Rattus norvegicus
Analyze
Symbol: Npy4r
Name: neuropeptide Y receptor Y4
RGD ID: 61864
Description: Enables pancreatic polypeptide receptor activity and peptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Orthologous to several human genes including NPY4R (neuropeptide Y receptor Y4); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: neuropeptide Y receptor type 4; NPY4-R; pancreatic polypeptide receptor 1; PP1; Ppyr1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,474,051 - 9,475,307 (-)NCBIGRCr8
mRatBN7.2169,467,801 - 9,469,057 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,467,801 - 9,469,057 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx169,481,156 - 9,482,412 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,625,865 - 10,627,121 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,476,211 - 9,477,467 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,489,450 - 10,490,706 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,489,450 - 10,490,706 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0168,808,683 - 8,809,939 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4169,787,170 - 9,788,426 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1169,787,167 - 9,788,424 (-)NCBI
Celera165,747,166 - 5,748,422 (+)NCBICelera
Cytogenetic Map16p15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor. Lundell I, etal., Proc Natl Acad Sci U S A 1996 May 14;93(10):5111-5.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. Yan H, etal., Proc Natl Acad Sci U S A 1996 May 14;93(10):4661-5.
Additional References at PubMed
PMID:7493937   PMID:7592911   PMID:8641440   PMID:9210181   PMID:10698177   PMID:16950545   PMID:35453028  


Genomics

Comparative Map Data
Npy4r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,474,051 - 9,475,307 (-)NCBIGRCr8
mRatBN7.2169,467,801 - 9,469,057 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,467,801 - 9,469,057 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx169,481,156 - 9,482,412 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,625,865 - 10,627,121 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,476,211 - 9,477,467 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,489,450 - 10,490,706 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,489,450 - 10,490,706 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0168,808,683 - 8,809,939 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4169,787,170 - 9,788,426 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1169,787,167 - 9,788,424 (-)NCBI
Celera165,747,166 - 5,748,422 (+)NCBICelera
Cytogenetic Map16p15NCBI
NPY4R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381046,461,099 - 46,470,668 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1046,461,099 - 46,465,958 (-)EnsemblGRCh38hg38GRCh38
GRCh371047,083,457 - 47,088,320 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361046,503,540 - 46,508,326 (+)NCBINCBI36Build 36hg18NCBI36
Build 341046,503,539 - 46,508,325NCBI
Cytogenetic Map10q11.22NCBI
CHM1_11047,901,251 - 47,906,033 (-)NCBICHM1_1
T2T-CHM13v2.01047,347,139 - 47,357,909 (-)NCBIT2T-CHM13v2.0
Npy4r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391433,867,603 - 33,874,376 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1433,865,949 - 33,874,446 (-)EnsemblGRCm39 Ensembl
GRCm381434,145,646 - 34,152,419 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1434,143,992 - 34,152,489 (-)EnsemblGRCm38mm10GRCm38
MGSCv371434,958,832 - 34,965,605 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361432,973,084 - 32,981,581 (-)NCBIMGSCv36mm8
Celera1430,407,960 - 30,414,733 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.8NCBI
Npy4r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555106,198,051 - 6,199,169 (+)NCBIChiLan1.0ChiLan1.0
LOC100985913
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2859,498,601 - 59,505,133 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11059,503,918 - 59,510,353 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01043,769,740 - 43,776,225 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11046,822,670 - 46,827,451 (+)NCBIpanpan1.1PanPan1.1panPan2
NPY4R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1434,816,566 - 34,820,774 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha434,804,534 - 34,811,739 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0435,173,909 - 35,181,111 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl435,177,642 - 35,178,769 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.0435,187,785 - 35,194,992 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0435,694,368 - 35,701,559 (+)NCBIUU_Cfam_GSD_1.0
NPY4R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11488,276,340 - 88,283,720 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21495,760,996 - 95,768,322 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Npy4r
3 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat

Markers in Region
PMC60063P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,468,017 - 9,468,749 (+)MAPPERmRatBN7.2
Rnor_6.01610,489,667 - 10,490,398NCBIRnor6.0
Rnor_5.0168,808,900 - 8,809,631UniSTSRnor5.0
RGSC_v3.4169,787,387 - 9,788,118UniSTSRGSC3.4
Celera165,747,474 - 5,748,205UniSTS
Cytogenetic Map16p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium
Low 3 6 15 8 1 8 28 11
Below cutoff 4 19 16 6 16 62 21 12

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000083105   ⟹   ENSRNOP00000069607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,467,801 - 9,469,057 (-)Ensembl
Rnor_6.0 Ensembl1610,489,450 - 10,490,706 (-)Ensembl
RefSeq Acc Id: NM_031581   ⟹   NP_113769
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,474,051 - 9,475,307 (-)NCBI
mRatBN7.2169,467,801 - 9,469,057 (-)NCBI
Rnor_6.01610,489,450 - 10,490,706 (-)NCBI
Rnor_5.0168,808,683 - 8,809,939 (-)NCBI
RGSC_v3.4169,787,170 - 9,788,426 (-)RGD
Celera165,747,166 - 5,748,422 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113769 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB07761 (Get FASTA)   NCBI Sequence Viewer  
  AAB87736 (Get FASTA)   NCBI Sequence Viewer  
  CAA92322 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069607
  ENSRNOP00000069607.1
  ENSRNOP00055014577
  ENSRNOP00060020052
  ENSRNOP00065021344
GenBank Protein Q63447 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_113769   ⟸   NM_031581
- UniProtKB: Q62892 (UniProtKB/Swiss-Prot),   Q63447 (UniProtKB/Swiss-Prot),   A6KFT0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069607   ⟸   ENSRNOT00000083105
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63447-F1-model_v2 AlphaFold Q63447 1-375 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61864 AgrOrtholog
BioCyc Gene G2FUF-12071 BioCyc
Ensembl Genes ENSRNOG00000061026 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055010727 UniProtKB/Swiss-Prot
  ENSRNOG00060014726 UniProtKB/Swiss-Prot
  ENSRNOG00065016316 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000083105 ENTREZGENE
  ENSRNOT00000083105.2 UniProtKB/Swiss-Prot
  ENSRNOT00055018135 UniProtKB/Swiss-Prot
  ENSRNOT00060025160 UniProtKB/Swiss-Prot
  ENSRNOT00065027160 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPY4_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPY_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29471 UniProtKB/Swiss-Prot
NCBI Gene 29471 ENTREZGENE
PANTHER NEUROPEPTIDE Y RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROPEPTIDE Y RECEPTOR TYPE 4-RELATED UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Npy4r PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRPEPTIDEY4R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRPEPTIDEYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061026 RatGTEx
  ENSRNOG00055010727 RatGTEx
  ENSRNOG00060014726 RatGTEx
  ENSRNOG00065016316 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KFT0 ENTREZGENE, UniProtKB/TrEMBL
  NPY4R_RAT UniProtKB/Swiss-Prot
  Q62892 ENTREZGENE
  Q63447 ENTREZGENE
UniProt Secondary Q62892 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-04 Npy4r  neuropeptide Y receptor Y4  Ppyr1  pancreatic polypeptide receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ppyr1  pancreatic polypeptide receptor 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology 75% amino acid sequence identity to human homolog 729496