Psma6 (proteasome 20S subunit alpha 6)

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Gene: Psma6 (proteasome 20S subunit alpha 6) Rattus norvegicus

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Symbol:

Psma6

Name:

proteasome 20S subunit alpha 6

RGD ID:

61849

Description:

Predicted to enable NF-kappaB binding activity and RNA binding activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in sarcomere. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PSMA6 (proteasome 20S subunit alpha 6); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

alpha-1; macropain iota chain; MGC72876; multicatalytic endopeptidase complex iota chain; proteasome (prosome, macropain) subunit, alpha type 6; proteasome alpha 6 subunit; proteasome iota chain; proteasome subunit alpha 6; proteasome subunit alpha type-6; proteasome subunit alpha-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PSMA6 (proteasome 20S subunit alpha 6)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Psma6 (proteasome subunit alpha 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Psma6 (proteasome 20S subunit alpha 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PSMA6 (proteasome 20S subunit alpha 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PSMA6 (proteasome 20S subunit alpha 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Psma6 (proteasome 20S subunit alpha 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PSMA6 (proteasome 20S subunit alpha 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PSMA6 (proteasome 20S subunit alpha 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Psma6 (proteasome 20S subunit alpha 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Psma6 (proteasome subunit alpha 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Homo sapiens (human):	PSMA6 (proteasome 20S subunit alpha 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	psma6b (proteasome subunit alpha 6b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	psma6a (proteasome subunit alpha 6a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG30382	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SCL1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pas-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Prosalpha1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	psma6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Related Pseudogenes:

Psma6-ps1 Psma6-ps5

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	78,500,676 - 78,531,693 (+)	NCBI		GRCr8
mRatBN7.2	6	72,765,534 - 72,796,554 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	72,765,473 - 72,796,554 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	73,199,417 - 73,216,739 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	73,505,773 - 73,523,097 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	72,934,448 - 72,951,769 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	76,174,460 - 76,205,429 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	76,174,452 - 76,205,426 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	85,711,990 - 85,742,474 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	75,649,844 - 75,667,404 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	75,652,972 - 75,670,527 (+)	NCBI
Celera	6	71,619,646 - 71,637,029 (+)	NCBI		Celera
Cytogenetic Map	6	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brain-Lung-Thyroid Syndrome (ISO)

ectodermal dysplasia and immunodeficiency 2 (ISO)

human immunodeficiency virus infectious disease (ISO)

myocardial infarction (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,3,7,8-tetrabromodibenzodioxine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (EXP)

3H-1,2-dithiole-3-thione (ISO)

4,4'-sulfonyldiphenol (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

amiodarone (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzbromarone (EXP)

benzo[a]pyrene (EXP,ISO)

bis(2-chloroethyl) sulfide (EXP)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloropicrin (ISO)

clobetasol (ISO)

clofibrate (EXP)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

ivermectin (ISO)

L-ethionine (EXP)

lovastatin (ISO)

menadione (ISO)

methidathion (ISO)

methimazole (EXP)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

nefazodone (EXP)

nimesulide (EXP)

nitrofen (EXP)

omeprazole (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (EXP)

PhIP (EXP)

pirinixic acid (EXP,ISO)

pregnenolone 16alpha-carbonitrile (EXP)

propiconazole (ISO)

Propiverine (EXP)

quercitrin (ISO)

resveratrol (ISO)

sulfadimethoxine (EXP)

T-2 toxin (EXP)

tamoxifen (ISO)

tanespimycin (ISO)

tert-butyl hydroperoxide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tungsten (ISO)

valdecoxib (EXP)

valproic acid (EXP)

warfarin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of NF-kappaB transcription factor activity (ISO,ISS)

proteasome-mediated ubiquitin-dependent protein catabolic process (IBA)

proteolysis involved in protein catabolic process (IEA,ISO,ISS)

Cellular Component

cytoplasm (IEA,ISO)

myofibril (IDA)

nuclear matrix (ISO,ISS)

nucleoplasm (ISO)

nucleus (IBA,IEA,ISO,ISS)

P-body (ISO,ISS)

proteasome complex (ISO)

proteasome core complex (ISO,ISS)

proteasome core complex, alpha-subunit complex (IBA,IEA,ISO,ISS)

ribosome (ISO,ISS)

sarcomere (IDA)

Molecular Function

NF-kappaB binding (ISO)

protein binding (ISO)

RNA binding (ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

ubiquitin/proteasome degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Proteasomes are tightly associated to myofibrils in mature skeletal muscle.	Bassaglia Y, etal., Exp Cell Res. 2005 Jan 15;302(2):221-32.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Molecular cloning of cDNAs for rat proteasomes: deduced primary structures of four other subunits.	Tamura T, etal., J Biochem (Tokyo) 1992 Oct;112(4):530-4.

Additional References at PubMed

PMID:7681138	PMID:9096325	PMID:9688553	PMID:10852819	PMID:12477932	PMID:14743216	PMID:15489334	PMID:16845397	PMID:16857966	PMID:17323924	PMID:20458337	PMID:20498273
PMID:21630459	PMID:22078707	PMID:22793692	PMID:22871113	PMID:23376485	PMID:29867124	PMID:30133132	PMID:30287505	PMID:30361391

Genomics

Comparative Map Data

Psma6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	78,500,676 - 78,531,693 (+)	NCBI		GRCr8
mRatBN7.2	6	72,765,534 - 72,796,554 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	72,765,473 - 72,796,554 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	73,199,417 - 73,216,739 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	73,505,773 - 73,523,097 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	72,934,448 - 72,951,769 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	76,174,460 - 76,205,429 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	76,174,452 - 76,205,426 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	85,711,990 - 85,742,474 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	75,649,844 - 75,667,404 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	75,652,972 - 75,670,527 (+)	NCBI
Celera	6	71,619,646 - 71,637,029 (+)	NCBI		Celera
Cytogenetic Map	6	q23	NCBI

PSMA6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	35,278,558 - 35,317,493 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	35,278,633 - 35,317,493 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	35,747,764 - 35,786,699 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	34,831,325 - 34,856,431 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	34,831,324 - 34,856,429	NCBI
Celera	14	15,625,404 - 15,650,528 (+)	NCBI		Celera
Cytogenetic Map	14	q13.2	NCBI
HuRef	14	15,875,787 - 15,900,913 (+)	NCBI		HuRef
CHM1_1	14	35,761,317 - 35,786,430 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	29,466,162 - 29,505,113 (+)	NCBI		T2T-CHM13v2.0

Psma6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	55,431,007 - 55,465,244 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	55,431,007 - 55,465,239 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	55,384,222 - 55,418,459 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	55,384,222 - 55,418,454 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	56,499,812 - 56,519,446 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	56,317,027 - 56,336,581 (+)	NCBI		MGSCv36	mm8
Celera	12	56,548,065 - 56,567,699 (+)	NCBI		Celera
Cytogenetic Map	12	C1	NCBI
cM Map	12	23.94	NCBI

Psma6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	25,750,270 - 25,787,533 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	25,751,578 - 25,787,533 (-)	NCBI	ChiLan1.0	ChiLan1.0

PSMA6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	36,604,909 - 36,630,164 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	35,821,412 - 35,846,667 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	16,044,300 - 16,069,521 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	34,227,495 - 34,252,354 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	34,214,271 - 34,252,347 (+)	Ensembl	panpan1.1		panPan2

PSMA6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	14,010,899 - 14,038,141 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	14,010,939 - 14,038,134 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	13,807,535 - 13,834,775 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	14,116,970 - 14,144,066 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	14,117,011 - 14,144,063 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	13,818,618 - 13,845,898 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	13,883,420 - 13,910,936 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	14,173,313 - 14,200,558 (+)	NCBI		UU_Cfam_GSD_1.0

Psma6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	45,937,259 - 45,961,803 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936494	9,443,176 - 9,467,697 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PSMA6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	64,578,243 - 64,616,491 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	64,578,247 - 64,603,351 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	69,487,814 - 69,525,983 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PSMA6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	12,099,804 - 12,127,477 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	12,099,937 - 12,127,309 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	1,062,970 - 1,090,568 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Psma6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624838	1,449,266 - 1,486,382 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624838	1,449,362 - 1,474,597 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Psma6
133 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	111
Count of miRNA genes:	91
Interacting mature miRNAs:	99
Transcripts:	ENSRNOT00000009666
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9590290	Uminl2	Urine mineral level QTL 2	3.96	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	6	38783989	83783989	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	72202632	130919985	Rat
634307	Bp141	Blood pressure QTL 141	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	35230417	80230417	Rat
634330	Pia16	Pristane induced arthritis QTL 16	3.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	6	45790088	104200226	Rat
1331789	Rf37	Renal function QTL 37	3.224		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	72202632	115200186	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
70176	Mcsm1	Mammary carcinoma susceptibility modifier QTL 1			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	58632962	103632962	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	72227641	130729205	Rat
1558641	Cm47	Cardiac mass QTL 47	2.9	0.001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	6	57730540	104085867	Rat
1641904	Alcrsp4	Alcohol response QTL 4			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	6	67262953	112262953	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
9590140	Scort4	Serum corticosterone level QTL 4	14.49	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	38783989	83783989	Rat
731173	Uae22	Urinary albumin excretion QTL 22	10.1		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	72227641	81132889	Rat
9590306	Scort18	Serum corticosterone level QTL 18	2.88	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	38783989	83783989	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
4889848	Pur25	Proteinuria QTL 25	14	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	56728562	90198260	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	72202632	130729475	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	33309549	81132889	Rat
70196	BpQTLcluster7	Blood pressure QTL cluster 7	6.82		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	72202632	117202632	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	72227641	130729205	Rat
1300075	Glom7	Glomerulus QTL 7	5.6	0.0000002	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	6	71201409	116201409	Rat
2290393	Uae37	Urinary albumin excretion QTL 37		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
1300143	Rf14	Renal function QTL 14	2.92		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	34434137	77102317	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	61747639	106747639	Rat
6893332	Cm74	Cardiac mass QTL 74	0.4	0.64	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	57730540	104085867	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006240098	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC115158	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC062232	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D10755	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212808	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217234	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220193	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB870593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC928002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009666 ⟹ ENSRNOP00000009666

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	72,779,123 - 72,796,553 (+)	Ensembl
Rnor_6.0 Ensembl	6	76,188,083 - 76,205,426 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000084062 ⟹ ENSRNOP00000071403

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	72,765,473 - 72,796,554 (+)	Ensembl
Rnor_6.0 Ensembl	6	76,174,452 - 76,205,426 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096468 ⟹ ENSRNOP00000085716

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	72,786,733 - 72,796,554 (+)	Ensembl

RefSeq Acc Id:

NM_017283 ⟹ NP_058979

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	78,514,347 - 78,531,693 (+)	NCBI
mRatBN7.2	6	72,779,206 - 72,796,554 (+)	NCBI
Rnor_6.0	6	76,188,083 - 76,205,429 (+)	NCBI
Rnor_5.0	6	85,711,990 - 85,742,474 (+)	NCBI
RGSC_v3.4	6	75,649,844 - 75,667,404 (+)	RGD
Celera	6	71,619,646 - 71,637,029 (+)	RGD

Sequence:

show sequence

GGGGTGTGTGTGTGTGTGTGCGCTACGGGGTGTAGACTGTGTCTGAAATAGCGGGAACGCCATG
TCCCGTGGTTCCAGCGCCGGTTTTGACCGGCACATTACTATTTTCTCTCCCGAGGGCCGACTCT
ACCAAGTAGAATATGCTTTTAAGGCTATTAACCAGGGTGGACTTACATCTGTAGCTGTCAGAGG
AAAGGACTGCGCAGTTATTGTCACACAGAAGAAAGTACCTGACAAACTACTGGATTCCAGCACC
GTGACTCACTTATTCAAGATAACGGAAAACATTGGCTGTGTGATGACAGGAATGACAGCTGACA
GCAGATCCCAGGTACAGAGGGCACGCTATGAAGCAGCTAACTGGAAATACAAATATGGCTATGA
GATTCCTGTGGACATGCTGTGTAAAAGAATTGCTGATATTTCTCAAGTCTACACACAGAATGCT
GAAATGAGGCCACTTGGTTGTTGTATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAAG
TGTACAAGTGTGATCCTGCAGGCTACTACTGTGGCTTTAAAGCCACCGCAGCAGGAGTGAAGCA
GACAGAGTCAACCAGCTTCCTCGAAAAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAG
ACAGTGGAAACTGCAATCACATGCCTGTCTACTGTTCTGTCGATTGATTTCAAACCTTCAGAAA
TCGAAGTTGGAGTAGTTACAGTTGAAAATCCTAAATTCAGGATTCTTACAGAAGCAGAGATTGA
CGCTCACCTTGTGGCTCTAGCAGAGAGAGACTGAACACTCTTATCAGCTTACCAGATCCATGAT
GCCATGTGCCTATGTGTTTAGTAACAACAAACCGACATCTTAGAGGCCCTGGATTGAAGATGGA
AACTCTCCCACTCCTCCTGCCACTGACTGGTTAGGACTCTGTATAAATAAAACAGTGCTTTTGG
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006240098 ⟹ XP_006240160

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	78,500,676 - 78,531,693 (+)	NCBI
mRatBN7.2	6	72,765,534 - 72,796,554 (+)	NCBI
Rnor_6.0	6	76,174,460 - 76,205,429 (+)	NCBI
Rnor_5.0	6	85,711,990 - 85,742,474 (+)	NCBI

Sequence:

show sequence

TGGGGCAGGGTTGAGTCCTAGGCTGAGGGGTTGGGACAAAGCATCCACCTCCACGGAACAGCTA
CTTTTAGGTGGATAATGGCCAATCTCCGAAAAAAATATGCTTTTAAGGCTATTAACCAGGGTGG
ACTTACATCTGTAGCTGTCAGAGGAAAGGACTGCGCAGTTATTGTCACACAGAAGAAAGTACCT
GACAAACTACTGGATTCCAGCACCGTGACTCACTTATTCAAGATAACGGAAAACATTGGCTGTG
TGATGACAGGAATGACAGCTGACAGCAGATCCCAGGTACAGAGGGCACGCTATGAAGCAGCTAA
CTGGAAATACAAATATGGCTATGAGATTCCTGTGGACATGCTGTGTAAAAGAATTGCTGATATT
TCTCAAGTCTACACACAGAATGCTGAAATGAGGCCACTTGGTTGTTGTATGATTTTAATTGGTA
TAGATGAAGAGCAAGGCCCTCAAGTGTACAAGTGTGATCCTGCAGGCTACTACTGTGGCTTTAA
AGCCACCGCAGCAGGAGTGAAGCAGACAGAGTCAACCAGCTTCCTCGAAAAAAAAGTGAAGAAG
AAATTTGATTGGACATTTGAACAGACAGTGGAAACTGCAATCACATGCCTGTCTACTGTTCTGT
CGATTGATTTCAAACCTTCAGAAATCGAAGTTGGAGTAGTTACAGTTGAAAATCCTAAATTCAG
GATTCTTACAGAAGCAGAGATTGACGCTCACCTTGTGGCTCTAGCAGAGAGAGACTGAACACTC
TTATCAGCTTACCAGATCCATGATGCCATGTGCCTATGTGTTTAGTAACAACAAACCGACATCT
TAGAGGCCCTGGATTGAAGATGGAAACTCTCCCACTCCTCCTGCCACTGACTGGTTAGGACTCT
GTATAAATAAAACAGTGCTTTTGGAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_058979	(Get FASTA)	NCBI Sequence Viewer
	XP_006240160	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH62232	(Get FASTA)	NCBI Sequence Viewer
	BAA01587	(Get FASTA)	NCBI Sequence Viewer
	CBF59415	(Get FASTA)	NCBI Sequence Viewer
	CBU84659	(Get FASTA)	NCBI Sequence Viewer
	EDM03426	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009666.3
	ENSRNOP00000071403.1
	ENSRNOP00000085716.1
	ENSRNOP00055018686
	ENSRNOP00060028969
	ENSRNOP00065005177
GenBank Protein	P60901	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_058979 ⟸ NM_017283

- UniProtKB:

P60901 (UniProtKB/Swiss-Prot), A6HBM1 (UniProtKB/TrEMBL), A0A8I6GE69 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSS
TVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQN
AEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFE
QTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD

hide sequence

RefSeq Acc Id:	XP_006240160 ⟸ XM_006240098
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K0D7 (UniProtKB/TrEMBL), A0A8I6GE69 (UniProtKB/TrEMBL)
- Sequence:	show sequence MANLRKKYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGM TADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQ GPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFK PSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD hide sequence

Ensembl Acc Id:

ENSRNOP00000009666 ⟸ ENSRNOT00000009666

Ensembl Acc Id:

ENSRNOP00000071403 ⟸ ENSRNOT00000084062

Ensembl Acc Id:

ENSRNOP00000085716 ⟸ ENSRNOT00000096468

Protein Domains

Proteasome alpha-type subunits

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P60901-F1-model_v2	AlphaFold	P60901	1-246	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694608

Promoter ID:

EPDNEW_R5129

Type:

initiation region

Name:

Psma6_2

Description:

proteasome subunit alpha 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R5130

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	76,174,472 - 76,174,532	EPDNEW

RGD ID:

13694605

Promoter ID:

EPDNEW_R5130

Type:

initiation region

Name:

Psma6_1

Description:

proteasome subunit alpha 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R5129

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	76,188,071 - 76,188,131	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61849	AgrOrtholog
BioCyc Gene	G2FUF-37488	BioCyc
Ensembl Genes	ENSRNOG00000007114	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055013444	UniProtKB/Swiss-Prot
	ENSRNOG00060020304	UniProtKB/Swiss-Prot
	ENSRNOG00065005071	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000009666.7	UniProtKB/Swiss-Prot
	ENSRNOT00000084062.2	UniProtKB/TrEMBL
	ENSRNOT00000096468.1	UniProtKB/TrEMBL
	ENSRNOT00055023043	UniProtKB/Swiss-Prot
	ENSRNOT00060035234	UniProtKB/Swiss-Prot
	ENSRNOT00065007447	UniProtKB/Swiss-Prot
Gene3D-CATH	3.60.20.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:6888689	IMAGE-MGC_LOAD
InterPro	Ntn_hydrolases_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Proteasome_alpha	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Proteasome_alpha-type	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Proteasome_asu_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Proteasome_sua/b	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Proteasome_subunit_alpha6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29673	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:72876	IMAGE-MGC_LOAD
NCBI Gene	29673	ENTREZGENE
PANTHER	PROTEASOME SUBUNIT ALPHA TYPE-6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEASOME SUBUNIT ALPHA/BETA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Proteasome	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Proteasome_A_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Psma6	PhenoGen
PROSITE	PROTEASOME_ALPHA_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEASOME_ALPHA_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000007114	RatGTEx
	ENSRNOG00055013444	RatGTEx
	ENSRNOG00060020304	RatGTEx
	ENSRNOG00065005071	RatGTEx
SMART	Proteasome_A_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56235	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K0D7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GE69	ENTREZGENE, UniProtKB/TrEMBL
	A6HBM1	ENTREZGENE, UniProtKB/TrEMBL
	P60901	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	P34062	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-09-13	Psma6	proteasome 20S subunit alpha 6	Psma6	proteasome subunit alpha 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-08-19	Psma6	proteasome subunit alpha 6	Psma6	proteasome (prosome, macropain) subunit, alpha type 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Psma6	proteasome (prosome, macropain) subunit, alpha type 6			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)