Psma6 (proteasome 20S subunit alpha 6) - Rat Genome Database

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Gene: Psma6 (proteasome 20S subunit alpha 6) Rattus norvegicus
Analyze
Symbol: Psma6
Name: proteasome 20S subunit alpha 6
RGD ID: 61849
Description: Predicted to enable NF-kappaB binding activity and RNA binding activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of inflammatory response. Located in sarcomere. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PSMA6 (proteasome 20S subunit alpha 6); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-1; macropain iota chain; MGC72876; multicatalytic endopeptidase complex iota chain; proteasome (prosome, macropain) subunit, alpha type 6; proteasome alpha 6 subunit; proteasome iota chain; proteasome subunit alpha 6; proteasome subunit alpha type-6; proteasome subunit alpha-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Psma6-ps1   Psma6-ps5  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,500,676 - 78,531,693 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl678,500,736 - 78,531,717 (+)EnsemblGRCr8
mRatBN7.2672,765,534 - 72,796,554 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl672,765,473 - 72,796,554 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx673,199,417 - 73,216,739 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0673,505,773 - 73,523,097 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0672,934,448 - 72,951,769 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0676,174,460 - 76,205,429 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,174,452 - 76,205,426 (+)Ensemblrn6Rnor6.0
Rnor_5.0685,711,990 - 85,742,474 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4675,649,844 - 75,667,404 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera671,619,646 - 71,637,029 (+)NCBICelera
RGSC_v3.1675,652,972 - 75,670,527 (+)NCBI
Cytogenetic Map6q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furfural  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
lovastatin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methidathion  (ISO)
methimazole  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
nobiletin  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
Propiverine  (EXP)
quercitrin  (ISO)
resveratrol  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulfadimethoxine  (EXP)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tanespimycin  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tungsten  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
ciliary tip  (ISO)
cytoplasm  (IEA,ISO)
cytosol  (IBA)
myofibril  (IDA)
nuclear matrix  (ISO,ISS)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO,ISS)
P-body  (ISO,ISS)
proteasome complex  (IEA,ISO)
proteasome core complex  (IEA,ISO,ISS)
proteasome core complex, alpha-subunit complex  (IBA,IEA,ISO,ISS)
ribosome  (ISO,ISS)
sarcomere  (IDA)
sperm end piece  (ISO)
synaptic vesicle  (NAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proteasomes are tightly associated to myofibrils in mature skeletal muscle. Bassaglia Y, etal., Exp Cell Res. 2005 Jan 15;302(2):221-32.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. An abundance of free regulatory (19S) proteasome particles regulates neuronal synapses. Sun C, etal., Science. 2023 May 26;380(6647):eadf2018. doi: 10.1126/science.adf2018. Epub 2023 May 26.
10. Molecular cloning of cDNAs for rat proteasomes: deduced primary structures of four other subunits. Tamura T, etal., J Biochem (Tokyo) 1992 Oct;112(4):530-4.
Additional References at PubMed
PMID:7681138   PMID:9096325   PMID:9688553   PMID:10852819   PMID:12477932   PMID:14743216   PMID:15489334   PMID:16845397   PMID:16857966   PMID:17323924   PMID:20458337   PMID:20498273  
PMID:21630459   PMID:22078707   PMID:22793692   PMID:22871113   PMID:23376485   PMID:29867124   PMID:30133132   PMID:30287505   PMID:30361391  


Genomics

Comparative Map Data
Psma6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,500,676 - 78,531,693 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl678,500,736 - 78,531,717 (+)EnsemblGRCr8
mRatBN7.2672,765,534 - 72,796,554 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl672,765,473 - 72,796,554 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx673,199,417 - 73,216,739 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0673,505,773 - 73,523,097 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0672,934,448 - 72,951,769 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0676,174,460 - 76,205,429 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,174,452 - 76,205,426 (+)Ensemblrn6Rnor6.0
Rnor_5.0685,711,990 - 85,742,474 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4675,649,844 - 75,667,404 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera671,619,646 - 71,637,029 (+)NCBICelera
RGSC_v3.1675,652,972 - 75,670,527 (+)NCBI
Cytogenetic Map6q23NCBI
PSMA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381435,278,558 - 35,317,493 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1435,278,633 - 35,318,734 (+)Ensemblhg38GRCh38
GRCh371435,747,764 - 35,786,699 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361434,831,325 - 34,856,431 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341434,831,324 - 34,856,429NCBI
Celera1415,625,404 - 15,650,528 (+)NCBICelera
Cytogenetic Map14q13.2NCBI
HuRef1415,875,787 - 15,900,913 (+)NCBIHuRef
CHM1_11435,761,317 - 35,786,430 (+)NCBICHM1_1
T2T-CHM13v2.01429,466,162 - 29,505,113 (+)NCBIT2T-CHM13v2.0
Psma6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391255,431,007 - 55,465,244 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1255,431,007 - 55,465,239 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381255,384,222 - 55,418,459 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1255,384,222 - 55,418,454 (+)Ensemblmm10GRCm38
MGSCv371256,499,812 - 56,519,446 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361256,317,027 - 56,336,581 (+)NCBIMGSCv36mm8
Celera1256,548,065 - 56,567,699 (+)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1223.94NCBI
Psma6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540925,750,270 - 25,787,533 (-)Ensembl
ChiLan1.0NW_00495540925,751,578 - 25,787,533 (-)NCBIChiLan1.0ChiLan1.0
PSMA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21536,604,909 - 36,630,164 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11435,821,412 - 35,846,667 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01416,044,300 - 16,069,521 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11434,227,495 - 34,252,354 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1434,214,271 - 34,252,347 (+)EnsemblpanPan2panpan1.1
PSMA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1814,010,899 - 14,038,141 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl814,010,939 - 14,038,134 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha813,807,535 - 13,834,775 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0814,116,970 - 14,144,066 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl814,117,011 - 14,144,063 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1813,818,618 - 13,845,898 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0813,883,420 - 13,910,936 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0814,173,313 - 14,200,558 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Psma6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864045,937,259 - 45,961,803 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364949,443,108 - 9,463,397 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364949,443,176 - 9,467,697 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl764,578,243 - 64,616,491 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1764,578,247 - 64,603,351 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2769,487,814 - 69,525,983 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PSMA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12412,099,804 - 12,127,477 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2412,099,937 - 12,127,309 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660531,062,970 - 1,090,568 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psma6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248381,449,266 - 1,486,382 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248381,449,362 - 1,474,597 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Psma6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1768,625,305 - 68,642,720 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Psma6
197 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:91
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000009666
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)66345744194939581Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)66345744194939581Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009666   ⟹   ENSRNOP00000009666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl678,500,736 - 78,531,717 (+)Ensembl
mRatBN7.2 Ensembl672,779,123 - 72,796,553 (+)Ensembl
Rnor_6.0 Ensembl676,188,083 - 76,205,426 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084062   ⟹   ENSRNOP00000071403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl678,500,736 - 78,531,689 (+)Ensembl
mRatBN7.2 Ensembl672,765,473 - 72,796,554 (+)Ensembl
Rnor_6.0 Ensembl676,174,452 - 76,205,426 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096468   ⟹   ENSRNOP00000085716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl678,521,873 - 78,531,690 (+)Ensembl
mRatBN7.2 Ensembl672,786,733 - 72,796,554 (+)Ensembl
RefSeq Acc Id: NM_017283   ⟹   NP_058979
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8678,514,347 - 78,531,693 (+)NCBI
mRatBN7.2672,779,206 - 72,796,554 (+)NCBI
Rnor_6.0676,188,083 - 76,205,429 (+)NCBI
Rnor_5.0685,711,990 - 85,742,474 (+)NCBI
RGSC_v3.4675,649,844 - 75,667,404 (+)RGD
Celera671,619,646 - 71,637,029 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240098   ⟹   XP_006240160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8678,500,676 - 78,531,693 (+)NCBI
mRatBN7.2672,765,534 - 72,796,554 (+)NCBI
Rnor_6.0676,174,460 - 76,205,429 (+)NCBI
Rnor_5.0685,711,990 - 85,742,474 (+)NCBI
Sequence:
RefSeq Acc Id: NP_058979   ⟸   NM_017283
- UniProtKB: P60901 (UniProtKB/Swiss-Prot),   A6HBM1 (UniProtKB/TrEMBL),   A0A8I6GE69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240160   ⟸   XM_006240098
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0D7 (UniProtKB/TrEMBL),   A0A8I6GE69 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009666   ⟸   ENSRNOT00000009666
Ensembl Acc Id: ENSRNOP00000071403   ⟸   ENSRNOT00000084062
Ensembl Acc Id: ENSRNOP00000085716   ⟸   ENSRNOT00000096468
Protein Domains
Proteasome alpha-type subunits

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P60901-F1-model_v2 AlphaFold P60901 1-246 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694608
Promoter ID:EPDNEW_R5129
Type:initiation region
Name:Psma6_2
Description:proteasome subunit alpha 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5130  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0676,174,472 - 76,174,532EPDNEW
RGD ID:13694605
Promoter ID:EPDNEW_R5130
Type:initiation region
Name:Psma6_1
Description:proteasome subunit alpha 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5129  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0676,188,071 - 76,188,131EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61849 AgrOrtholog
BioCyc Gene G2FUF-37488 BioCyc
Ensembl Genes ENSRNOG00000007114 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009666 ENTREZGENE
  ENSRNOT00000009666.7 UniProtKB/Swiss-Prot
  ENSRNOT00000084062 ENTREZGENE
Gene3D-CATH 3.60.20.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6888689 IMAGE-MGC_LOAD
InterPro Ntn_hydrolases_N UniProtKB/Swiss-Prot
  Proteasome_alpha UniProtKB/Swiss-Prot
  Proteasome_alpha-type UniProtKB/Swiss-Prot
  Proteasome_asu_N UniProtKB/Swiss-Prot
  Proteasome_sua/b UniProtKB/Swiss-Prot
  Proteasome_subunit_alpha6 UniProtKB/Swiss-Prot
KEGG Report rno:29673 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72876 IMAGE-MGC_LOAD
NCBI Gene 29673 ENTREZGENE
PANTHER PROTEASOME SUBUNIT ALPHA/BETA UniProtKB/Swiss-Prot
Pfam Proteasome UniProtKB/Swiss-Prot
  Proteasome_A_N UniProtKB/Swiss-Prot
PhenoGen Psma6 PhenoGen
PROSITE PROTEASOME_ALPHA_1 UniProtKB/Swiss-Prot
  PROTEASOME_ALPHA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007114 RatGTEx
SMART Proteasome_A_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56235 UniProtKB/Swiss-Prot
UniProt A0A0G2K0D7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GE69 ENTREZGENE, UniProtKB/TrEMBL
  A6HBM1 ENTREZGENE, UniProtKB/TrEMBL
  P60901 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P34062 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-13 Psma6  proteasome 20S subunit alpha 6  Psma6  proteasome subunit alpha 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-08-19 Psma6  proteasome subunit alpha 6  Psma6  proteasome (prosome, macropain) subunit, alpha type 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Psma6  proteasome (prosome, macropain) subunit, alpha type 6      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference