Nrgn (neurogranin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Nrgn (neurogranin) Rattus norvegicus
Analyze
Symbol: Nrgn
Name: neurogranin
RGD ID: 61833
Description: Enables calmodulin binding activity; phosphatidic acid binding activity; and phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in associative learning; modulation of chemical synaptic transmission; and telencephalon development. Located in several cellular components, including dendritic spine head; neuronal cell body; and trans-Golgi network transport vesicle membrane. Is active in glutamatergic synapse and postsynaptic membrane. Biomarker of hypothyroidism. Orthologous to human NRGN (neurogranin); INTERACTS WITH 1,4-dithiothreitol; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BICKS; neurogranin (protein kinase C substrate RC3); neurogranin (protein kinase C substrate, RC3); ng; protein kinase C substrate 7.5 kDa protein; RC3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8845,444,223 - 45,452,417 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl845,444,223 - 45,452,417 (-)EnsemblGRCr8
mRatBN7.2837,255,462 - 37,263,659 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl837,256,930 - 37,257,516 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx841,271,907 - 41,280,115 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0839,554,961 - 39,563,169 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0837,417,880 - 37,426,088 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0840,015,049 - 40,023,193 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl840,015,049 - 40,023,193 (-)Ensemblrn6Rnor6.0
Rnor_5.0840,015,873 - 40,024,017 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4838,790,596 - 38,799,077 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera837,191,658 - 37,199,870 (+)NCBICelera
RGSC_v3.1838,799,361 - 38,807,843 (-)NCBI
Cytogenetic Map8q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,4-dithiothreitol  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloramine T  (EXP)
chromium(6+)  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
diallyl trisulfide  (ISO)
diiodine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fisetin  (EXP)
flavonoids  (EXP)
fluoxetine  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glycidol  (EXP)
glyphosate  (EXP)
ketamine  (EXP)
L-1,4-dithiothreitol  (EXP)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methimazole  (ISO)
methylmercury chloride  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
naphthalene  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pentachlorophenol  (EXP)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phytoestrogen  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
testosterone  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Neurogranin in the development of the rat telencephalon. Alvarez-Bolado G, etal., Neuroscience. 1996 Jul;73(2):565-80.
2. Levothyroxin restores hypothyroidism-induced impairment of LTP of hippocampal CA1: electrophysiological and molecular studies. Alzoubi KH, etal., Exp Neurol. 2005 Oct;195(2):330-41.
3. Dendritic translocation of RC3/neurogranin mRNA in normal aging, Alzheimer disease and fronto-temporal dementia. Chang JW, etal., J Neuropathol Exp Neurol. 1997 Oct;56(10):1105-18.
4. Neurogranin binds to phosphatidic acid and associates to cellular membranes. Dominguez-Gonzalez I, etal., Biochem J. 2007 May 15;404(1):31-43.
5. Antibodies to postsynaptic PKC substrate neurogranin prevent long-term potentiation in hippocampal CA1 neurons. Fedorov NB, etal., Eur J Neurosci. 1995 Apr 1;7(4):819-22.
6. Activity-dependent translocation of neurogranin to neuronal nuclei. Garrido-Garcia A, etal., Biochem J. 2009 Dec 10;424(3):419-29. doi: 10.1042/BJ20091071.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Pre- and postsynaptic localization of RC3/neurogranin in the adult rat spinal cord: an immunohistochemical study. Houben MP, etal., J Neurosci Res. 2000 Mar 15;59(6):750-9.
10. Characterization of a 7.5-kDa protein kinase C substrate (RC3 protein, neurogranin) from rat brain. Huang KP, etal., Arch Biochem Biophys. 1993 Sep;305(2):570-80.
11. [Prenatal restraint stress decreases neurogranin expression in rat offspring hippocampus]. Li H, etal., Sheng Li Xue Bao. 2007 Jun 25;59(3):299-304.
12. Selective recognition of phosphatidylinositol 3,4,5-trisphosphate by a synthetic peptide. Lu PJ and Chen CS, J Biol Chem. 1997 Jan 3;272(1):466-72.
13. Differential regulation of primary protein kinase C substrate (MARCKS, MLP, GAP-43, RC3) mRNAs in the hippocampus during kainic acid-induced seizures and synaptic reorganization. McNamara RK and Lenox RH, J Neurosci Res. 2000 Nov 1;62(3):416-26.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Sleep deprivation differentially alters the mRNA and protein levels of neurogranin in rat brain. Neuner-Jehle M, etal., Brain Res. 1995 Jul 10;685(1-2):143-53.
17. Neurogranin is locally concentrated in rat cortical and hippocampal neurons. Neuner-Jehle M, etal., Brain Res. 1996 Sep 9;733(1):149-54.
18. Regulation of synaptic plasticity genes during consolidation of fear conditioning. Ressler KJ, etal., J Neurosci. 2002 Sep 15;22(18):7892-902.
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Structure and regulation of the gene encoding the neuron-specific protein kinase C substrate neurogranin (RC3 protein). Sato T, etal., J Biol Chem 1995 Apr 28;270(17):10314-22.
22. The nature of the compensatory response to low thyroid hormone in the developing brain. Sharlin DS, etal., J Neuroendocrinol. 2010 Mar;22(3):153-65. doi: 10.1111/j.1365-2826.2009.01947.x. Epub 2009 Dec 23.
23. Localization of RC3 (neurogranin) in rat brain subcellular fractions. Watson JB, etal., Brain Res Mol Brain Res. 1994 Dec;27(2):323-8.
24. Subtractive cDNA cloning of RC3, a rodent cortex-enriched mRNA encoding a novel 78 residue protein. Watson JB, etal., J Neurosci Res 1990 Aug;26(4):397-408.
25. Localization of the protein kinase C phosphorylation/calmodulin-binding substrate RC3 in dendritic spines of neostriatal neurons. Watson JB, etal., Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8581-5.
26. Neurogranin enhances synaptic strength through its interaction with calmodulin. Zhong L, etal., EMBO J. 2009 Oct 7;28(19):3027-39. doi: 10.1038/emboj.2009.236. Epub 2009 Aug 27.
Additional References at PubMed
PMID:12718558   PMID:12950461   PMID:15046861   PMID:15262982   PMID:15389613   PMID:18305102   PMID:20654708   PMID:21198977   PMID:22458599   PMID:22848456   PMID:22871113   PMID:24821301  
PMID:25547065   PMID:26084473   PMID:31020616   PMID:31691647   PMID:35678097   PMID:38376763  


Genomics

Comparative Map Data
Nrgn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8845,444,223 - 45,452,417 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl845,444,223 - 45,452,417 (-)EnsemblGRCr8
mRatBN7.2837,255,462 - 37,263,659 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl837,256,930 - 37,257,516 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx841,271,907 - 41,280,115 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0839,554,961 - 39,563,169 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0837,417,880 - 37,426,088 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0840,015,049 - 40,023,193 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl840,015,049 - 40,023,193 (-)Ensemblrn6Rnor6.0
Rnor_5.0840,015,873 - 40,024,017 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4838,790,596 - 38,799,077 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera837,191,658 - 37,199,870 (+)NCBICelera
RGSC_v3.1838,799,361 - 38,807,843 (-)NCBI
Cytogenetic Map8q22NCBI
NRGN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811124,739,942 - 124,747,210 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11124,739,939 - 124,747,210 (+)Ensemblhg38GRCh38
GRCh3711124,609,838 - 124,617,106 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611124,114,952 - 124,122,309 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411124,114,951 - 124,122,309NCBI
Celera11121,770,006 - 121,777,279 (+)NCBICelera
Cytogenetic Map11q24.2NCBI
HuRef11120,552,258 - 120,559,543 (+)NCBIHuRef
CHM1_111124,495,926 - 124,503,199 (+)NCBICHM1_1
T2T-CHM13v2.011124,768,605 - 124,775,873 (+)NCBIT2T-CHM13v2.0
Nrgn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39937,455,789 - 37,464,041 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl937,455,788 - 37,464,200 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38937,544,493 - 37,552,745 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl937,544,492 - 37,552,904 (-)Ensemblmm10GRCm38
MGSCv37937,352,078 - 37,360,330 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36937,294,164 - 37,302,480 (-)NCBIMGSCv36mm8
Celera934,761,619 - 34,769,859 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map920.78NCBI
Nrgn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541225,809,512 - 25,818,237 (+)Ensembl
ChiLan1.0NW_00495541225,809,512 - 25,818,237 (+)NCBIChiLan1.0ChiLan1.0
NRGN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29125,435,369 - 125,442,680 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111126,540,227 - 126,547,550 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011119,566,934 - 119,574,248 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111123,482,202 - 123,487,969 (+)NCBIPanPan1.1PanPan1.1panPan2
NRGN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.159,673,107 - 9,679,819 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl59,673,809 - 9,679,799 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha59,717,970 - 9,724,685 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.059,612,706 - 9,619,416 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl59,613,423 - 9,619,565 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.159,684,878 - 9,691,574 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.059,655,270 - 9,661,983 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.059,691,811 - 9,698,514 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nrgn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947106,944,036 - 106,951,546 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367431,196,433 - 1,197,610 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367431,191,716 - 1,199,108 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRGN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl951,969,823 - 51,977,228 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1951,967,313 - 51,977,197 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2957,482,955 - 57,492,694 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NRGN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11115,888,289 - 115,895,809 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1115,894,095 - 115,894,313 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604310,222,773 - 10,230,087 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nrgn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624927753,956 - 762,662 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624927753,967 - 762,663 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nrgn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1833,710,872 - 33,718,951 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nrgn
21 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:79
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000014404
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625851589833Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
70206Alc20Alcohol consumption QTL 202drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)83910625849610361Rat

Markers in Region
RH125210  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2837,255,957 - 37,256,145 (+)MAPPERmRatBN7.2
Rnor_6.0840,015,542 - 40,015,729NCBIRnor6.0
Rnor_5.0840,016,366 - 40,016,553UniSTSRnor5.0
RGSC_v3.4838,791,089 - 38,791,276UniSTSRGSC3.4
Celera837,199,190 - 37,199,377UniSTS
Cytogenetic Map8q21UniSTS
UniSTS:224475  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2837,256,061 - 37,256,163 (+)MAPPERmRatBN7.2
Rnor_6.0840,015,646 - 40,015,747NCBIRnor6.0
Rnor_5.0840,016,470 - 40,016,571UniSTSRnor5.0
RGSC_v3.4838,791,193 - 38,791,294UniSTSRGSC3.4
Celera837,199,172 - 37,199,273UniSTS
Cytogenetic Map8q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 134 81 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000014404   ⟹   ENSRNOP00000014404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl845,444,223 - 45,452,417 (-)Ensembl
mRatBN7.2 Ensembl837,256,930 - 37,257,516 (-)Ensembl
Rnor_6.0 Ensembl840,015,049 - 40,023,193 (-)Ensembl
RefSeq Acc Id: NM_024140   ⟹   NP_077054
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8845,444,223 - 45,452,417 (-)NCBI
mRatBN7.2837,255,465 - 37,263,659 (-)NCBI
Rnor_6.0840,015,049 - 40,023,193 (-)NCBI
Rnor_5.0840,015,873 - 40,024,017 (-)NCBI
RGSC_v3.4838,790,596 - 38,799,077 (-)RGD
Celera837,191,658 - 37,199,870 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_077054 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42023 (Get FASTA)   NCBI Sequence Viewer  
  AAA80223 (Get FASTA)   NCBI Sequence Viewer  
  EDL84070 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014404
GenBank Protein Q04940 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077054   ⟸   NM_024140
- UniProtKB: Q04940 (UniProtKB/Swiss-Prot),   A0A8L2UIU9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014404   ⟸   ENSRNOT00000014404
Protein Domains
Collagen-like   IQ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q04940-F1-model_v2 AlphaFold Q04940 1-78 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695862
Promoter ID:EPDNEW_R6387
Type:initiation region
Name:Nrgn_1
Description:neurogranin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0840,023,097 - 40,023,157EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61833 AgrOrtholog
BioCyc Gene G2FUF-31064 BioCyc
Ensembl Genes ENSRNOG00000010688 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000014404 ENTREZGENE
Gene3D-CATH 1.20.5.190 UniProtKB/Swiss-Prot
InterPro IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot
KEGG Report rno:64356 UniProtKB/Swiss-Prot
NCBI Gene 64356 ENTREZGENE
PANTHER NEUROMODULIN UniProtKB/Swiss-Prot
  SPERM SURFACE PROTEIN SP17 UniProtKB/Swiss-Prot
Pfam PF00612 UniProtKB/Swiss-Prot
PhenoGen Nrgn PhenoGen
PROSITE PS50096 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010688 RatGTEx
SMART SM00015 UniProtKB/Swiss-Prot
UniProt A0A8L2UIU9 ENTREZGENE, UniProtKB/TrEMBL
  A6KRK6_RAT UniProtKB/TrEMBL
  NEUG_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nrgn  neurogranin      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 78-amino acid 729177
gene_regulation gene expression stimulated by phorbol 12-myristate 13-acetate 729177