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Gene: Pex2 (peroxisomal biogenesis factor 2) Rattus norvegicus

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Symbol:

Pex2

Name:

peroxisomal biogenesis factor 2

RGD ID:

61814

Description:

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including fatty acid metabolic process; negative regulation of cell population proliferation; and pexophagy. Predicted to act upstream of or within several processes, including bile acid biosynthetic process; cholesterol homeostasis; and protein import into peroxisome matrix, substrate release. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 5B and peroxisome biogenesis disorder 5A. Orthologous to human PEX2 (peroxisomal biogenesis factor 2); INTERACTS WITH (R)-noradrenaline; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

PAF-1; peroxin-2; peroxisomal membrane protein 3; peroxisomal membrane protein 3 35 kDa; peroxisomal membrane protein 3, 35 kDa; peroxisome assembly factor 1; peroxisome assembly factor-1; peroxisome biogenesis factor 2; Pxmp3

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PEX2 (peroxisomal biogenesis factor 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Mus musculus (house mouse):	Pex2 (peroxisomal biogenesis factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pex2 (peroxisomal biogenesis factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PEX2 (peroxisomal biogenesis factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PEX2 (peroxisomal biogenesis factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pex2 (peroxisomal biogenesis factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PEX2 (peroxisomal biogenesis factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PEX2 (peroxisomal biogenesis factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pex2 (peroxisomal biogenesis factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Pex2 (peroxisomal biogenesis factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Pex2 (peroxisomal biogenesis factor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PEX2 (peroxisomal biogenesis factor 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PEX2 (peroxisomal biogenesis factor 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pex2 (peroxisomal biogenesis factor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pex2 (peroxisomal biogenesis factor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PEX2	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PEX2	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Pex2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Pex2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	prx-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	prx-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pex2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pex2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	97,957,479 - 97,973,767 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	97,948,443 - 97,981,092 (+)	Ensembl				GRCr8
mRatBN7.2	2	96,050,380 - 96,072,928 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	96,045,958 - 96,073,404 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	102,587,325 - 102,603,512 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	100,708,411 - 100,724,598 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	95,763,317 - 95,779,508 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	98,251,756 - 98,269,185 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	98,252,925 - 98,269,184 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	117,990,545 - 118,007,746 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	98,361,891 - 98,378,715 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	91,566,959 - 91,583,216 (+)	NCBI		Celera
RGSC_v3.1	2	98,306,852 - 98,323,677 (+)	NCBI
Cytogenetic Map	2	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

infantile Refsum disease (ISO)

peroxisomal biogenesis disorder (ISO)

peroxisome biogenesis disorder 1A (ISO)

peroxisome biogenesis disorder 5A (ISO)

Peroxisome biogenesis disorder 5B (ISO)

retinitis pigmentosa 1 (ISO)

Zellweger Leukodystrophy (ISO)

Zellweger syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

(R)-noradrenaline (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

Butylbenzyl phthalate (EXP)

chromium(6+) (ISO)

clofibrate (ISO)

clotrimazole (EXP)

cocaine (EXP)

dibutyl phthalate (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

finasteride (EXP)

flavonoids (EXP)

flutamide (EXP)

formaldehyde (ISO)

gentamycin (EXP)

heptanal (ISO)

hexanal (ISO)

indometacin (EXP)

inulin (ISO)

isoprenaline (ISO)

lead diacetate (ISO)

lead(0) (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

mercury dibromide (ISO)

methapyrilene (EXP)

methimazole (EXP)

nefazodone (EXP)

nonanal (ISO)

octanal (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (ISO)

potassium chromate (ISO)

propanal (ISO)

quercetin (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sulindac (EXP)

thapsigargin (ISO)

thioacetamide (EXP)

thiram (ISO)

trichostatin A (ISO)

triptonide (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

venlafaxine hydrochloride (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bile acid biosynthetic process (ISO)

biological_process (ND)

cellular response to reactive oxygen species (IEA,ISO)

cholesterol homeostasis (ISO)

fatty acid beta-oxidation (IBA,IEA,ISO)

negative regulation of epithelial cell proliferation (IEA,ISO)

negative regulation of fibroblast proliferation (IEA,ISO)

nervous system development (ISO)

neuron migration (ISO)

peroxisome organization (IBA,IEA,ISO)

pexophagy (IEA,ISO,ISS)

protein destabilization (IEA,ISO)

protein import into peroxisome matrix (IEA,ISO)

protein import into peroxisome matrix, receptor recycling (IEA,ISO,ISS)

protein monoubiquitination (IEA,ISO)

protein transport (IEA)

protein ubiquitination (IEA)

regulation of cholesterol biosynthetic process (ISO)

response to amino acid starvation (IEA,ISO,ISS)

very long-chain fatty acid metabolic process (IBA,IEA,ISO)

Cellular Component

Cdc73/Paf1 complex (IBA,IEA,ISO)

peroxisomal membrane (IBA,IDA,IEA,ISO)

peroxisome (IDA)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

transferase activity (IEA)

ubiquitin protein ligase activity (IEA,ISO,ISS)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	A mouse model for Zellweger syndrome.	Baes M, etal., Nat Genet. 1997 Sep;17(1):49-57.
2.	Targeted deletion of the PEX2 peroxisome assembly gene in mice provides a model for Zellweger syndrome, a human neuronal migration disorder.	Faust PL and Hatten ME, J Cell Biol. 1997 Dec 1;139(5):1293-305.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Transmembrane topology of the peroxin, Pex2p, an essential component for the peroxisome assembly.	Harano T, etal., J Biochem (Tokyo). 1999 Jun;125(6):1168-74.
5.	Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease.	Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15.	Peroxisome assembly factor 1: nonsense mutation in a peroxisome-deficient Chinese hamster ovary cell mutant and deletion analysis.	Tsukamoto T, etal., Mol Cell Biol 1994 Aug;14(8):5458-65.

Additional References at PubMed

PMID:1546315	PMID:1750930	PMID:9765053	PMID:10528859	PMID:12746876	PMID:12751901	PMID:14673138	PMID:15489334	PMID:18359941	PMID:18987311	PMID:19208625	PMID:19946888
PMID:21525035	PMID:21554508	PMID:27597759

Genomics

Comparative Map Data

Pex2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	97,957,479 - 97,973,767 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	97,948,443 - 97,981,092 (+)	Ensembl				GRCr8
mRatBN7.2	2	96,050,380 - 96,072,928 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	96,045,958 - 96,073,404 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	102,587,325 - 102,603,512 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	100,708,411 - 100,724,598 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	95,763,317 - 95,779,508 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	98,251,756 - 98,269,185 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	98,252,925 - 98,269,184 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	117,990,545 - 118,007,746 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	98,361,891 - 98,378,715 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	91,566,959 - 91,583,216 (+)	NCBI		Celera
RGSC_v3.1	2	98,306,852 - 98,323,677 (+)	NCBI
Cytogenetic Map	2	q23	NCBI

PEX2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	76,980,258 - 77,001,044 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	76,980,258 - 77,001,044 (-)	Ensembl			hg38	GRCh38
GRCh37	8	77,892,494 - 77,913,280 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	78,055,049 - 78,075,079 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	8	78,057,712 - 78,074,994	NCBI
Celera	8	73,885,870 - 73,906,661 (-)	NCBI		Celera
Cytogenetic Map	8	q21.13	NCBI
HuRef	8	73,378,964 - 73,399,755 (-)	NCBI		HuRef
CHM1_1	8	77,944,088 - 77,964,880 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	77,409,691 - 77,430,483 (-)	NCBI		T2T-CHM13v2.0

Pex2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	5,625,248 - 5,643,655 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	5,625,248 - 5,641,299 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	5,560,188 - 5,578,596 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	5,560,188 - 5,576,239 (-)	Ensembl			mm10	GRCm38
MGSCv37	3	5,560,188 - 5,576,239 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	5,543,577 - 5,559,201 (-)	NCBI		MGSCv36	mm8
Celera	3	5,637,555 - 5,653,606 (-)	NCBI		Celera
Cytogenetic Map	3	A1	NCBI
cM Map	3	1.96	NCBI

Pex2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955444	3,811,973 - 3,830,666 (+)	Ensembl
ChiLan1.0	NW_004955444	3,811,972 - 3,830,666 (+)	NCBI	ChiLan1.0	ChiLan1.0

PEX2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	92,717,778 - 92,735,460 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	68,345,570 - 68,363,805 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	73,508,349 - 73,526,560 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	75,145,061 - 75,163,338 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	75,146,255 - 75,147,172 (-)	Ensembl			panPan2	panpan1.1

PEX2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	24,943,563 - 24,960,834 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	25,206,108 - 25,223,363 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	25,055,730 - 25,073,096 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	25,055,743 - 25,073,046 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	25,130,967 - 25,148,201 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	25,148,141 - 25,165,401 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	25,500,349 - 25,517,613 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pex2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	54,180,390 - 54,197,777 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936702	1,573,650 - 1,591,004 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936702	1,573,616 - 1,626,323 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PEX2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	59,252,337 - 59,270,116 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	59,252,330 - 59,270,117 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	64,716,680 - 64,745,314 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PEX2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	72,513,975 - 72,532,399 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	72,514,307 - 72,517,003 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666039	68,748,476 - 68,767,273 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pex2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624744	14,240,570 - 14,245,183 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624744	14,227,430 - 14,245,082 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pex2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	139,527,305 - 139,543,448 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pex2
96 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	153
Count of miRNA genes:	120
Interacting mature miRNAs:	134
Transcripts:	ENSRNOT00000011579
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578777	Stresp15	Stress response QTL 15	2	0.05	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	2	61556902	106556902	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1598865	Bp296	Blood pressure QTL 296	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	82947902	127947902	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1578772	Stresp14	Stress response QTL 14	5	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	2	84056790	132859658	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1581576	Pur7	Proteinuria QTL 7		0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	80396178	220931218	Rat
152025242	Bw191	Body weight QTL 191	3.62		body mass (VT:0001259)		2	40306867	124537199	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	78269809	208420281	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	27148328	145807373	Rat
61465	Bp13	Blood pressure QTL 13	3.3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	78269809	104744824	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	80396178	220931218	Rat
2317886	Alcrsp23	Alcohol response QTL 23	2.4	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	95142371	140142371	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	41801363	104744824	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
2317058	Aia13	Adjuvant induced arthritis QTL 13	2.9		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	2	78269809	123269809	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1300155	Bp174	Blood pressure QTL 174	4.09		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	44537979	112567334	Rat
5684990	Bmd82	Bone mineral density QTL 82	2.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	2	61051541	105724065	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	7605533	104774005	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845182	205135428	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83400752	223709938	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	28652666	139067443	Rat
2299162	Iddm32	Insulin dependent diabetes mellitus QTL 32	2.36		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	93602631	145807373	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	80396034	220931416	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78269809	205135428	Rat
631500	Bp99	Blood pressure QTL 99	2.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	61051883	104684275	Rat
61392	Bp6	Blood pressure QTL 6	7		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	82214549	127214549	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
5684996	Bmd85	Bone mineral density QTL 85	4.7	0.024	tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	2	61051541	105724065	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	159440891	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83465462	225110681	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	60861391	105861391	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
2306903	Bp336	Blood pressure QTL 336		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	38426449	111295694	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	76328396	209350714	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	61051541	143746880	Rat

Markers in Region

BE111495

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	96,049,755 - 96,049,915 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	98,252,415 - 98,252,574	NCBI	Rnor6.0
Rnor_5.0	2	117,990,974 - 117,991,133	UniSTS	Rnor5.0
RGSC_v3.4	2	98,361,381 - 98,361,540	UniSTS	RGSC3.4
Celera	2	91,566,449 - 91,566,608	UniSTS
RH 3.4 Map	2	679.6	UniSTS
Cytogenetic Map	2	q24	UniSTS

AI043801

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	96,065,305 - 96,065,397 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	98,267,968 - 98,268,059	NCBI	Rnor6.0
Rnor_5.0	2	118,006,527 - 118,006,618	UniSTS	Rnor5.0
RGSC_v3.4	2	98,377,499 - 98,377,590	UniSTS	RGSC3.4
Celera	2	91,582,000 - 91,582,091	UniSTS
RH 3.4 Map	2	730.8	UniSTS
Cytogenetic Map	2	q24	UniSTS

AI233233

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	96,066,119 - 96,066,333 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	98,268,782 - 98,268,995	NCBI	Rnor6.0
Rnor_5.0	2	118,007,341 - 118,007,554	UniSTS	Rnor5.0
RGSC_v3.4	2	98,378,313 - 98,378,526	UniSTS	RGSC3.4
Celera	2	91,582,814 - 91,583,027	UniSTS
RH 3.4 Map	2	622.4	UniSTS
Cytogenetic Map	2	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001388504	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001388505	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001388506	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_017234	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006232157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006232158	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006232159	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006232160	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006232161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760865	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC063169	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D30616	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D30617	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM078955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM104606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219520	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011579 ⟹ ENSRNOP00000011579

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	96,050,187 - 96,066,523 (+)	Ensembl
Rnor_6.0 Ensembl	2	98,252,925 - 98,269,184 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095560 ⟹ ENSRNOP00000076831

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	97,954,870 - 97,980,497 (+)	Ensembl
mRatBN7.2 Ensembl	2	96,045,958 - 96,073,404 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000131413 ⟹ ENSRNOP00000100149

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	97,956,964 - 97,980,945 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000151330 ⟹ ENSRNOP00000108095

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	97,948,443 - 97,981,092 (+)	Ensembl

RefSeq Acc Id:

NM_001388504 ⟹ NP_001375433

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	97,957,630 - 97,973,767 (+)	NCBI
mRatBN7.2	2	96,050,386 - 96,066,523 (+)	NCBI

RefSeq Acc Id:

NM_001388505 ⟹ NP_001375434

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	97,957,630 - 97,973,767 (+)	NCBI
mRatBN7.2	2	96,050,386 - 96,066,523 (+)	NCBI

RefSeq Acc Id:

NM_001388506 ⟹ NP_001375435

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	97,957,630 - 97,973,767 (+)	NCBI
mRatBN7.2	2	96,050,386 - 96,066,523 (+)	NCBI

RefSeq Acc Id:

NM_017234 ⟹ NP_058930

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	97,957,630 - 97,973,767 (+)	NCBI
mRatBN7.2	2	96,050,386 - 96,066,523 (+)	NCBI
Rnor_6.0	2	98,252,925 - 98,269,184 (+)	NCBI
Rnor_5.0	2	117,990,545 - 118,007,746 (+)	NCBI
RGSC_v3.4	2	98,361,891 - 98,378,715 (+)	RGD
Celera	2	91,566,959 - 91,583,216 (+)	RGD

Sequence:

show sequence

ATCCATCGTCCCTTCGGTTCCTCGGCTCCTCGGCTCCTCGGCATTTTCCGCCGTTGGGCCGTAT
GCAGCTTTCCTCTAAACCACTGACTGTAATTTCCCAGGTTTCTTTCAGCCACTTCCGGGTCTTC
CGTCGTTCCGGAAGCCCGCGAATTCCGGAAGCGAGGGCTACCCAGATTCGGCTAGGAAAAGCCC
AGCTTGCCAGAGAATGTTTGAGAAAAGTTTGCGCGGCGCTGGTGTGTTCCGCAGACCCTGCAGC
TCTTGACAAGTATGAGGCAAAAGCCTCTTGAAGCAGATGTGCAGCAGAATTCTCCACCACCTTT
TGATAGGCCGCTGAGTGCTGAGGGGACCACAGGATCCAAGGAAAGACAGCATCAGAGAAGATAT
GGCTGCCAGAGAAGAGAGTACACAAAGTGCCAACAGAGTGCTGAGGATAAGTCAGCTGGATGCA
CTGGAACTGAATAAGGCCCTGGAGCAGCTCGTGTGGTCCCAGTTTACTCAGTGTTTTCATGGAT
TTAAGCCAGGACTGTTAGCTCGCTTTGAGCCAGAAGTGAAAGCATTTCTGTGGCTTTTCCTGTG
GAGGTTCACCATCTATTCCAAAAATGCCACTGTGGGGCAGTCGGTTTTAAATATTCAGTACAAA
AATGATTCTTCTCCCAACCCAGTATACCAACCACCAAGTAAAAATCAGAAACTGTTGTATGCTG
TGTGCACTATTGGGGGGAGGTGGTTAGAAGAACGATGTTACGATTTGTTTCCAAACCGACATTT
AGCATCTTTCGGGAAAGCCAAACAGTGCATGAATTTTGTGGTTGGACTTTTAAAATTAGGTGAG
TTGATGAACTTCTTGATTTTTCTACAAAAAGGAAAGTTTGCAACTTTGACAGAACGCCTCCTTG
GCATTCATTCTGTATTTTGCAAGCCCCAGAGCATGCGTGAAGTTGGCTTCGAGTACATGAATAG
GGAACTTCTCTGGCATGGCTTTGCCGAATTTCTGGTTTTCCTCTTACCGCTCATCAATATCCAG
AAGTTGAAAGCCAAGTTGTCTTCCTGGTGCATCCCCCTTACCAGCACTGCTGGTAGTGACAGTA
CACTAGGCAGCAGTGGAAAAGAGTGTGCTCTATGTGGAGAGTGGCCCACAATGCCTCATACTAT
TGGATGTGAGCATGTATTTTGTTACTACTGTGTTAAGAGTAGCTTCCTATTTGACATGTACTTT
ACGTGCCCTAAGTGTGGCACAGAAGTGCACAGTGTGCAGCCACTGAAATCAGGAATTGAAATGT
CAGAAGTGAATGCTCTTTAAAACCAAGTTGTTTCCTCTGAGGAAAGTGTATTGTATCCAATTCC
TTGGAATTCGTCATCTTCAGTGTCATCTGTAGGTGGCTTTTAGCAGGAGTGTGCTGTGCGGCCA
CTCTCTTCCTTTCCAAGCACAACTCAGTTCTAATCACTGGAAACCAAGTGATTCTAGAGAATCT
TATAAATCCTCATGTTATTTTTTGATCCCTAATACAATTTTTAATGTCAAGAATAATGGAAAAT
TTTGTCAGATGAATACTAAGAATGACTAAGAATGCTCCTTCATAGAAAAAGGTCAGACTCTAAA
AATAAAACATTTTTGAGGCTCTG

hide sequence

RefSeq Acc Id:

XM_006232159 ⟹ XP_006232221

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	97,957,479 - 97,973,767 (+)	NCBI
mRatBN7.2	2	96,050,380 - 96,072,928 (+)	NCBI
Rnor_6.0	2	98,253,101 - 98,269,185 (+)	NCBI
Rnor_5.0	2	117,990,545 - 118,007,746 (+)	NCBI

Sequence:

show sequence

GGCTAGGAAAAGCCCAGCTTGCCAGAGAATGTTTGAGAAAAGTTTGCGCGGCGCTGGTGTGTTC
CGCAGACCCTGCAGGTCAGTGTCCGCTCGGAGGCGGTCCGGCGTGCGGGCCCCGCGCTCTCGGA
GGACGGCCTGGCGACGTTCGCCTTGGCTGCAGGCCGCTGTGGCTTCCTGTCTTTCTGGAAGGAG
CCAGCCTGTCTCTGGGTTTCCGGAAAGGCAGTAAAACAAATCCAAACTCCTAGTTTTCCCCTAG
TTTAATGCCATCACACAAACAAAGCGACTCTGCAGGGAACCAACCTCTGCATTCCCCGGGGCGA
CGTTGCAGACAGCCCCGAAAGCGCCTCCTCGCCATTAACAGTACTAGCTCTTGACAAGTATGAG
GCAAAAGCCTCTTGAAGCAGATGTGCAGCAGAATTCTCCACCACCTTTTGATAGGCCGCTGAGT
GCTGAGGGGACCACAGGATCCAAGGAAAGCATCAGAGAAGATATGGCTGCCAGAGAAGAGAGTA
CACAAAGTGCCAACAGAGTGCTGAGGATAAGTCAGCTGGATGCACTGGAACTGAATAAGGCCCT
GGAGCAGCTCGTGTGGTCCCAGTTTACTCAGTGTTTTCATGGATTTAAGCCAGGACTGTTAGCT
CGCTTTGAGCCAGAAGTGAAAGCATTTCTGTGGCTTTTCCTGTGGAGGTTCACCATCTATTCCA
AAAATGCCACTGTGGGGCAGTCGGTTTTAAATATTCAGTACAAAAATGATTCTTCTCCCAACCC
AGTATACCAACCACCAAGTAAAAATCAGAAACTGTTGTATGCTGTGTGCACTATTGGGGGGAGG
TGGTTAGAAGAACGATGTTACGATTTGTTTCGAAACCGACATTTAGCATCTTTCGGGAAAGCCA
AACAGTGCATGAATTTTGTGGTTGGACTTTTAAAATTAGGTGAGTTGATGAACTTCTTGATTTT
TCTACAAAAAGGAAAGTTTGCAACTTTGACAGAACGCCTCCTTGGCATTCATTCTGTATTTTGC
AAGCCCCAGAGCATGCGTGAAGTTGGCTTCGAGTACATGAATAGGGAACTTCTCTGGCATGGCT
TTGCCGAATTTCTGGTTTTCCTCTTACCGCTCATCAATATCCAGAAGTTGAAAGCCAAGTTGTC
TTCCTGGTGCATCCCCCTTACCAGCACTGCTGGTAGTGACAGTACACTAGGCAGCAGTGGAAAA
GAGTGTGCTCTATGTGGAGAGTGGCCCACAATGCCTCATACTATTGGATGTGAGCATGTATTTT
GTTACTACTGTGTTAAGAGTAGCTTCCTATTTGACATGTACTTTACGTGCCCTAAGTGTGGCAC
AGAAGTGCACAGTGTGCAGCCACTGAAATCAGGAATTGAAATGTCAGAAGTGAATGCTCTTTAG
AAACCAAGTTGTTTCCTCTGAGGAAAGTGTATTGTATCCAATTCCTTGGAATTCGTCATCTTCA
GTGTCATCTGTAGGTGGCTTTTAGCAGGAGTGTGCTGTGCGGCCACTCTCTTCCTTTCCAAGCA
CAACTCAGTTCTAATCACTGGAAACCAAGTGATTCTAGAGAATCTTATAAATCCTCATGTTATT
TTTTGATCCCTAATACAATTTTTAATGTCAAGAATAATGGAAAATTTTGTCAGATGAATACTAA
GAATGACTAAGAATGCTCCTTCATAGAAAAAGGTCAGACTCTAAAAATAAAACATTTTTGAGGC
TCTGG

hide sequence

RefSeq Acc Id:

XM_008760865 ⟹ XP_008759087

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	97,958,071 - 97,973,767 (+)	NCBI
mRatBN7.2	2	96,050,827 - 96,072,928 (+)	NCBI
Rnor_6.0	2	98,253,474 - 98,269,185 (+)	NCBI

Sequence:

show sequence

TTAACTCTTAAATAAGAATCTCTCGGGGTTTATGAAAAAGTTTTTTTTTTTTTCTCAATGTTTT
GGAGTTTCAACCCTTTCTAGGGCCCATTCACTTAAAATCTCGGTCTTGGTCTCCGTTGGAAGAG
CTCTTGACAAGTATGAGGCAAAAGCCTCTTGAAGCAGATGTGCAGCAGAATTCTCCACCACCTT
TTGATAGGCCGCTGAGTGCTGAGGGGACCACAGGATCCAAGGAAAGCATCAGAGAAGATATGGC
TGCCAGAGAAGAGAGTACACAAAGTGCCAACAGAGTGCTGAGGATAAGTCAGCTGGATGCACTG
GAACTGAATAAGGCCCTGGAGCAGCTCGTGTGGTCCCAGTTTACTCAGTGTTTTCATGGATTTA
AGCCAGGACTGTTAGCTCGCTTTGAGCCAGAAGTGAAAGCATTTCTGTGGCTTTTCCTGTGGAG
GTTCACCATCTATTCCAAAAATGCCACTGTGGGGCAGTCGGTTTTAAATATTCAGTACAAAAAT
GATTCTTCTCCCAACCCAGTATACCAACCACCAAGTAAAAATCAGAAACTGTTGTATGCTGTGT
GCACTATTGGGGGGAGGTGGTTAGAAGAACGATGTTACGATTTGTTTCGAAACCGACATTTAGC
ATCTTTCGGGAAAGCCAAACAGTGCATGAATTTTGTGGTTGGACTTTTAAAATTAGGTGAGTTG
ATGAACTTCTTGATTTTTCTACAAAAAGGAAAGTTTGCAACTTTGACAGAACGCCTCCTTGGCA
TTCATTCTGTATTTTGCAAGCCCCAGAGCATGCGTGAAGTTGGCTTCGAGTACATGAATAGGGA
ACTTCTCTGGCATGGCTTTGCCGAATTTCTGGTTTTCCTCTTACCGCTCATCAATATCCAGAAG
TTGAAAGCCAAGTTGTCTTCCTGGTGCATCCCCCTTACCAGCACTGCTGGTAGTGACAGTACAC
TAGGCAGCAGTGGAAAAGAGTGTGCTCTATGTGGAGAGTGGCCCACAATGCCTCATACTATTGG
ATGTGAGCATGTATTTTGTTACTACTGTGTTAAGAGTAGCTTCCTATTTGACATGTACTTTACG
TGCCCTAAGTGTGGCACAGAAGTGCACAGTGTGCAGCCACTGAAATCAGGAATTGAAATGTCAG
AAGTGAATGCTCTTTAGAAACCAAGTTGTTTCCTCTGAGGAAAGTGTATTGTATCCAATTCCTT
GGAATTCGTCATCTTCAGTGTCATCTGTAGGTGGCTTTTAGCAGGAGTGTGCTGTGCGGCCACT
CTCTTCCTTTCCAAGCACAACTCAGTTCTAATCACTGGAAACCAAGTGATTCTAGAGAATCTTA
TAAATCCTCATGTTATTTTTTGATCCCTAATACAATTTTTAATGTCAAGAATAATGGAAAATTT
TGTCAGATGAATACTAAGAATGACTAAGAATGCTCCTTCATAGAAAAAGGTCAGACTCTAAAAA
TAAAACATTTTTGAGGCTCTGG

hide sequence

RefSeq Acc Id:

XM_063281639 ⟹ XP_063137709

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	97,970,399 - 97,973,767 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001375433	(Get FASTA)	NCBI Sequence Viewer
	NP_001375434	(Get FASTA)	NCBI Sequence Viewer
	NP_001375435	(Get FASTA)	NCBI Sequence Viewer
	NP_058930	(Get FASTA)	NCBI Sequence Viewer
	XP_006232221	(Get FASTA)	NCBI Sequence Viewer
	XP_008759087	(Get FASTA)	NCBI Sequence Viewer
	XP_063137709	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH63169	(Get FASTA)	NCBI Sequence Viewer
	BAA06306	(Get FASTA)	NCBI Sequence Viewer
	BAA06307	(Get FASTA)	NCBI Sequence Viewer
	EDM01038	(Get FASTA)	NCBI Sequence Viewer
	EDM01039	(Get FASTA)	NCBI Sequence Viewer
	EDM01040	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000076831
	ENSRNOP00000076831.1
	ENSRNOP00000108095
GenBank Protein	P24392	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_058930 ⟸ NM_017234
- Peptide Label:	isoform 1
- UniProtKB:	P24392 (UniProtKB/Swiss-Prot), Q63733 (UniProtKB/Swiss-Prot), A6IH90 (UniProtKB/TrEMBL), A0A8L2Q557 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAREESTQSANRVLRISQLDALELNKALEQLVWSQFTQCFHGFKPGLLARFEPEVKAFLWLFL WRFTIYSKNATVGQSVLNIQYKNDSSPNPVYQPPSKNQKLLYAVCTIGGRWLEERCYDLFPNRH LASFGKAKQCMNFVVGLLKLGELMNFLIFLQKGKFATLTERLLGIHSVFCKPQSMREVGFEYMN RELLWHGFAEFLVFLLPLINIQKLKAKLSSWCIPLTSTAGSDSTLGSSGKECALCGEWPTMPHT IGCEHVFCYYCVKSSFLFDMYFTCPKCGTEVHSVQPLKSGIEMSEVNAL hide sequence

RefSeq Acc Id:	XP_006232221 ⟸ XM_006232159
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2Q557 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRQKPLEADVQQNSPPPFDRPLSAEGTTGSKESIREDMAAREESTQSANRVLRISQLDALELNK ALEQLVWSQFTQCFHGFKPGLLARFEPEVKAFLWLFLWRFTIYSKNATVGQSVLNIQYKNDSSP NPVYQPPSKNQKLLYAVCTIGGRWLEERCYDLFRNRHLASFGKAKQCMNFVVGLLKLGELMNFL IFLQKGKFATLTERLLGIHSVFCKPQSMREVGFEYMNRELLWHGFAEFLVFLLPLINIQKLKAK LSSWCIPLTSTAGSDSTLGSSGKECALCGEWPTMPHTIGCEHVFCYYCVKSSFLFDMYFTCPKC GTEVHSVQPLKSGIEMSEVNAL hide sequence

RefSeq Acc Id:	XP_008759087 ⟸ XM_008760865
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2Q557 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRQKPLEADVQQNSPPPFDRPLSAEGTTGSKESIREDMAAREESTQSANRVLRISQLDALELNK ALEQLVWSQFTQCFHGFKPGLLARFEPEVKAFLWLFLWRFTIYSKNATVGQSVLNIQYKNDSSP NPVYQPPSKNQKLLYAVCTIGGRWLEERCYDLFRNRHLASFGKAKQCMNFVVGLLKLGELMNFL IFLQKGKFATLTERLLGIHSVFCKPQSMREVGFEYMNRELLWHGFAEFLVFLLPLINIQKLKAK LSSWCIPLTSTAGSDSTLGSSGKECALCGEWPTMPHTIGCEHVFCYYCVKSSFLFDMYFTCPKC GTEVHSVQPLKSGIEMSEVNAL hide sequence

Ensembl Acc Id:

ENSRNOP00000011579 ⟸ ENSRNOT00000011579

RefSeq Acc Id:	NP_001375434 ⟸ NM_001388505
- Peptide Label:	isoform 1
- UniProtKB:	P24392 (UniProtKB/Swiss-Prot), Q63733 (UniProtKB/Swiss-Prot), A6IH90 (UniProtKB/TrEMBL), A0A8L2Q557 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001375435 ⟸ NM_001388506
- Peptide Label:	isoform 2
- UniProtKB:	A0A8L2Q557 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001375433 ⟸ NM_001388504
- Peptide Label:	isoform 1
- UniProtKB:	P24392 (UniProtKB/Swiss-Prot), Q63733 (UniProtKB/Swiss-Prot), A6IH90 (UniProtKB/TrEMBL), A0A8L2Q557 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000076831 ⟸ ENSRNOT00000095560

RefSeq Acc Id:	XP_063137709 ⟸ XM_063281639
- Peptide Label:	isoform X2
- UniProtKB:	Q63733 (UniProtKB/Swiss-Prot), P24392 (UniProtKB/Swiss-Prot), A6IH90 (UniProtKB/TrEMBL), A0A8L2Q557 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000108095 ⟸ ENSRNOT00000151330

Ensembl Acc Id:

ENSRNOP00000100149 ⟸ ENSRNOT00000131413

Protein Domains

RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P24392-F1-model_v2	AlphaFold	P24392	1-305	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691247

Promoter ID:

EPDNEW_R1771

Type:

initiation region

Name:

Pex2_1

Description:

peroxisomal biogenesis factor 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	98,253,056 - 98,253,116	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61814	AgrOrtholog
BioCyc Gene	G2FUF-53669	BioCyc
Ensembl Genes	ENSRNOG00000008748	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000095560	ENTREZGENE
	ENSRNOT00000095560.1	UniProtKB/Swiss-Prot
	ENSRNOT00000151330	ENTREZGENE
Gene3D-CATH	3.30.40.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:6886755	IMAGE-MGC_LOAD
InterPro	PEX2/10	UniProtKB/Swiss-Prot
	Pex_N	UniProtKB/Swiss-Prot
	RING-HC_PEX2	UniProtKB/Swiss-Prot
	Znf_RING	UniProtKB/Swiss-Prot
	Znf_RING/FYVE/PHD	UniProtKB/Swiss-Prot
	Znf_RING_CS	UniProtKB/Swiss-Prot
KEGG Report	rno:29534	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72871	IMAGE-MGC_LOAD
NCBI Gene	29534	ENTREZGENE
PANTHER	PEROXISOME BIOGENESIS FACTOR 2	UniProtKB/Swiss-Prot
	PEROXISOME BIOGENESIS FACTOR 2	UniProtKB/Swiss-Prot
Pfam	Pex2_Pex12	UniProtKB/Swiss-Prot
PhenoGen	Pex2	PhenoGen
PROSITE	ZF_RING_1	UniProtKB/Swiss-Prot
	ZF_RING_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000008748	RatGTEx
SMART	RING	UniProtKB/Swiss-Prot
Superfamily-SCOP	RING/U-box	UniProtKB/Swiss-Prot
TIGR	TC206361
UniProt	A0A8L2Q557	ENTREZGENE
	A6IH90	ENTREZGENE, UniProtKB/TrEMBL
	A6IHR8_RAT	UniProtKB/TrEMBL
	P24392	ENTREZGENE, UniProtKB/Swiss-Prot
	Q63733	ENTREZGENE
UniProt Secondary	Q63733	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-01-26	Pex2	peroxisomal biogenesis factor 2	Pxmp3	peroxisomal membrane protein 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-18	Pxmp3	peroxisomal membrane protein 3	Pex2	peroxisome biogenesis factor 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-01-09	Pex2	peroxisome biogenesis factor 2	Pxmp3	peroxisomal membrane protein 3	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2002-06-10	Pxmp3	peroxisomal membrane protein 3			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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