Urod (uroporphyrinogen decarboxylase) - Rat Genome Database

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Gene: Urod (uroporphyrinogen decarboxylase) Rattus norvegicus
Analyze
Symbol: Urod
Name: uroporphyrinogen decarboxylase
RGD ID: 3946
Description: Enables ferrous iron binding activity and uroporphyrinogen decarboxylase activity. Involved in several processes, including response to estradiol; response to fungicide; and uroporphyrinogen III metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Biomarker of porphyria and porphyria cutanea tarda. Human ortholog(s) of this gene implicated in porphyria cutanea tarda. Orthologous to human UROD (uroporphyrinogen decarboxylase); PARTICIPATES IN heme biosynthetic pathway; acute intermittent porphyria pathway; erythropoietic porphyria pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: porphyrinogen carboxy-lyase; porphyrinogen carboxylase; UPD; URO-D; uroporphyrinogen III decarboxylase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,701,294 - 135,705,380 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5135,701,296 - 135,705,380 (-)EnsemblGRCr8
mRatBN7.25130,464,695 - 130,468,783 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,455,217 - 130,468,808 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5133,095,323 - 133,099,413 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,849,929 - 134,854,019 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,872,344 - 134,876,434 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,855,429 - 135,859,515 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,855,433 - 135,859,643 (-)Ensemblrn6Rnor6.0
Rnor_5.05139,650,563 - 139,654,649 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45137,296,410 - 137,300,496 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5128,991,227 - 128,995,309 (-)NCBICelera
RGSC_v3.15137,301,638 - 137,305,678 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,5-hexanedione  (EXP)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aminolevulinic acid  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
alcohol  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
barium(0)  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diuron  (EXP)
enzyme inhibitor  (ISO)
Evodiamine  (ISO)
folic acid  (ISO)
fomesafen  (ISO)
hexachlorobenzene  (EXP,ISO)
iron atom  (EXP,ISO)
iron dextran  (ISO)
iron(0)  (EXP,ISO)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
magnesium atom  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
naphthalenes  (EXP)
nitrofen  (EXP)
Nodakenin  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pirinixic acid  (ISO)
polysulfur  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
scopolin  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfur atom  (ISO)
sunitinib  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
topotecan  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Arsenite alters heme synthesis in long-term cultures of adult rat hepatocytes. Aguilar-Gonzalez MG, etal., Toxicol Sci. 1999 Jun;49(2):281-9.
2. Biosynthesis of heme in mammals. Ajioka RS, etal., Biochim Biophys Acta. 2006 Jul;1763(7):723-36. Epub 2006 Jun 3.
3. Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors. Barupala DP, etal., Arch Biochem Biophys. 2016 Feb 15;592:60-75. doi: 10.1016/j.abb.2016.01.010. Epub 2016 Jan 16.
4. Rat-liver porphyrinogen carboxy-lyase inhibition as a function of the degree of hexachlorobenzene-induced porphyria. Billi SC, etal., IARC Sci Publ. 1986;(77):487-91.
5. Activation of uroporphyrinogen decarboxylase by ferrous iron in porphyria cutanea tarda. Blekkenhorst GH, etal., S Afr Med J. 1979 Nov 24;56(22):918-20.
6. Effects of iron overload on bile secretion and hepatic porphyrin metabolism in ethinyl estradiol-treated rats. Cantoni L, etal., Toxicology. 1986 Feb;38(2):187-96.
7. Comparison between crab hepatopancreas and rat liver uroporphyrinogen decarboxylase. Chaufan G, etal., Comp Biochem Physiol B Biochem Mol Biol. 2002 Oct;133(2):251-6.
8. Abnormal kinetic behavior of uroporphyrinogen decarboxylase obtained from rats with hexachlorobenzene-induced porphyria. Chaufan G, etal., J Biochem Mol Toxicol. 2005;19(1):19-24.
9. Decreased activity of hepatic uroporphyrinogen decarboxylase in sporadic porphyria cutanea tarda. Elder GH, etal., N Engl J Med. 1978 Aug 10;299(6):274-8.
10. A point mutation in the coding region of uroporphyrinogen decarboxylase associated with familial porphyria cutanea tarda. Garey JR, etal., Blood. 1989 Mar;73(4):892-5.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. GenMAPP: Gene Map Annotator and Pathway Profiler GenMAPP
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Effects of hexachlorobenzene feeding and iron overload on enzymes of haem biosynthesis and cytochrome P 450 in rat liver. Louw M, etal., Clin Sci Mol Med. 1977 Aug;53(2):111-5.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Heme biosynthesis in human breast cancer--mimetic "in vitro" studies and some heme enzymic activity levels. Navone NM, etal., Int J Biochem. 1990;22(12):1407-11.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. Effect of in vivo administered hexachlorobenzene on epidermal growth factor receptor levels, protein tyrosine kinase activity, and phosphotyrosine content in rat liver. Randi AS, etal., Biochem Pharmacol. 2003 May 1;65(9):1495-506.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Comprehensive gene review and curation RGD comprehensive gene curation
26. The decrease in uroporphyrinogen decarboxylase activity induced by ethanol predisposes rats to the development of porphyria and accelerates xenobiotic-triggered porphyria, regardless of hepatic damage. Rios de Molina MC, etal., Braz J Med Biol Res. 2002 Nov;35(11):1273-83.
27. Rat uroporphyrinogen decarboxylase cDNA: nucleotide sequence and comparison to human uroporphyrinogen decarboxylase. Romana M, etal., Nucleic Acids Res 1987 Sep 11;15(17):7211.
28. Distinction between octachlorostyrene and hexachlorobenzene in their potentials to induce ethoxyphenoxazone deethylase and cause porphyria in rats and mice. Smith AG, etal., J Biochem Toxicol. 1986 Mar;1(1):105-17.
29. Hexachlorobenzene treatment on hepatic mitochondrial function parameters and intracellular coproporphyrinogen oxidase location. Sopena YE, etal., Int J Toxicol. 2008 Nov;27(6):455-65.
30. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
31. Effect of alpha lipoic acid amide on hexachlorobenzene porphyria. Vilas GL, etal., Biochem Mol Biol Int. 1999 May;47(5):815-23.
32. Mechanism of hexachlorobenzene-induced porphyria in rats. Effect of phenobarbitone pretreatment. Wainstok de Calmanovici R, etal., Biochem J. 1984 Mar 15;218(3):753-63.
33. Metal alteration of uroporphyrinogen decarboxylase and coproporphyrinogen oxidase. Woods JS and Fowler BA, Ann N Y Acad Sci. 1987;514:55-64.
34. Developmental aspects of hepatic heme biosynthetic capability and hematotoxicity-II. Studies on uroporphyrinogen decarboxylase. Woods JS and Kardish RM, Biochem Pharmacol. 1983 Jan 1;32(1):73-8.
35. Response of uroporphyrinogen decarboxylase to the hematopoietic demands of the spleen. Woods JS and Kardish RM, Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):389-400.
36. Studies on porphyrin metabolism in the kidney. Effects of trace metals and glutathione on renal uroporphyrinogen decarboxylase. Woods JS, etal., Mol Pharmacol. 1984 Sep;26(2):336-41.
Additional References at PubMed
PMID:8661721   PMID:8889548   PMID:11134514   PMID:12477932   PMID:17360334   PMID:18004775  


Genomics

Comparative Map Data
Urod
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,701,294 - 135,705,380 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5135,701,296 - 135,705,380 (-)EnsemblGRCr8
mRatBN7.25130,464,695 - 130,468,783 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,455,217 - 130,468,808 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5133,095,323 - 133,099,413 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,849,929 - 134,854,019 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,872,344 - 134,876,434 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,855,429 - 135,859,515 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,855,433 - 135,859,643 (-)Ensemblrn6Rnor6.0
Rnor_5.05139,650,563 - 139,654,649 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45137,296,410 - 137,300,496 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5128,991,227 - 128,995,309 (-)NCBICelera
RGSC_v3.15137,301,638 - 137,305,678 (-)NCBI
Cytogenetic Map5q36NCBI
UROD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38145,012,254 - 45,015,575 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl145,010,950 - 45,015,575 (+)Ensemblhg38GRCh38
GRCh37145,477,926 - 45,481,247 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36145,250,417 - 45,253,928 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34145,147,012 - 45,150,434NCBI
Celera143,760,589 - 43,764,125 (+)NCBICelera
Cytogenetic Map1p34.1NCBI
HuRef143,589,865 - 43,593,401 (+)NCBIHuRef
CHM1_1145,594,383 - 45,597,919 (+)NCBICHM1_1
T2T-CHM13v2.0144,882,726 - 44,887,169 (+)NCBIT2T-CHM13v2.0
Urod
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394116,847,161 - 116,851,561 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4116,847,162 - 116,851,610 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384116,989,965 - 116,994,436 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,989,965 - 116,994,413 (-)Ensemblmm10GRCm38
MGSCv374116,662,822 - 116,666,980 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364116,488,150 - 116,492,292 (-)NCBIMGSCv36mm8
Celera4115,725,715 - 115,729,873 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.41NCBI
Urod
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546413,221,551 - 13,229,253 (-)Ensembl
ChiLan1.0NW_00495546413,226,271 - 13,228,908 (-)NCBIChiLan1.0ChiLan1.0
UROD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21181,792,058 - 181,795,527 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11180,933,533 - 180,936,999 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,315,912 - 44,319,356 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1145,679,744 - 45,683,185 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl145,679,744 - 45,683,185 (+)EnsemblpanPan2panpan1.1
UROD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11515,313,808 - 15,317,130 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1515,312,674 - 15,320,010 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1515,434,370 - 15,437,815 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01515,468,964 - 15,472,409 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1515,468,979 - 15,472,392 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11515,265,932 - 15,269,377 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01515,333,857 - 15,337,302 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01515,406,026 - 15,409,471 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Urod
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505860,382,374 - 60,385,817 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647426,207,169 - 26,210,623 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647426,207,169 - 26,210,599 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UROD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6166,327,247 - 166,330,614 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16166,327,243 - 166,330,558 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26153,911,652 - 153,914,966 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UROD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12087,772,685 - 87,776,110 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2087,772,261 - 87,775,978 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603329,169,582 - 29,173,007 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Urod
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624906910,313 - 914,898 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624906910,306 - 914,898 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Urod
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1140,621,204 - 40,625,481 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Urod
18 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:63
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000024719
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133308734140009902Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
Urod  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q36UniSTS
RH135227  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25130,465,465 - 130,465,682 (+)MAPPERmRatBN7.2
Rnor_6.05135,856,200 - 135,856,416NCBIRnor6.0
Rnor_5.05139,651,334 - 139,651,550UniSTSRnor5.0
RGSC_v3.45137,297,181 - 137,297,397UniSTSRGSC3.4
Celera5128,991,998 - 128,992,214UniSTS
RH 3.4 Map5836.1UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC119459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF414694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI282626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY314066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV767503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000024719   ⟹   ENSRNOP00000024719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5135,701,296 - 135,705,380 (-)Ensembl
mRatBN7.2 Ensembl5130,464,697 - 130,468,783 (-)Ensembl
Rnor_6.0 Ensembl5135,855,433 - 135,859,643 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106708   ⟹   ENSRNOP00000093051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5130,464,697 - 130,468,536 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114152   ⟹   ENSRNOP00000091280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5130,455,217 - 130,468,808 (-)Ensembl
RefSeq Acc Id: NM_019209   ⟹   NP_062082
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,701,294 - 135,705,380 (-)NCBI
mRatBN7.25130,464,695 - 130,468,783 (-)NCBI
Rnor_6.05135,855,429 - 135,859,515 (-)NCBI
Rnor_5.05139,650,563 - 139,654,649 (-)NCBI
RGSC_v3.45137,296,410 - 137,300,496 (-)RGD
Celera5128,991,227 - 128,995,309 (-)RGD
Sequence:
RefSeq Acc Id: XM_039109371   ⟹   XP_038965299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,701,297 - 135,704,279 (-)NCBI
mRatBN7.25130,464,696 - 130,467,861 (-)NCBI
Protein Sequences
Protein RefSeqs NP_062082 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965299 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58691 (Get FASTA)   NCBI Sequence Viewer  
  CAB50784 (Get FASTA)   NCBI Sequence Viewer  
  EDL90239 (Get FASTA)   NCBI Sequence Viewer  
  EDL90240 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024719
GenBank Protein P32362 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062082   ⟸   NM_019209
- UniProtKB: P32362 (UniProtKB/Swiss-Prot),   B0BN55 (UniProtKB/TrEMBL),   F1LMP0 (UniProtKB/TrEMBL),   A0A9K3Y7K6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024719   ⟸   ENSRNOT00000024719
RefSeq Acc Id: XP_038965299   ⟸   XM_039109371
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000091280   ⟸   ENSRNOT00000114152
Ensembl Acc Id: ENSRNOP00000093051   ⟸   ENSRNOT00000106708
Protein Domains
Uroporphyrinogen decarboxylase (URO-D)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P32362-F1-model_v2 AlphaFold P32362 1-364 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693944
Promoter ID:EPDNEW_R4469
Type:multiple initiation site
Name:Urod_1
Description:uroporphyrinogen decarboxylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05135,859,492 - 135,859,552EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3946 AgrOrtholog
BioCyc Gene G2FUF-40224 BioCyc
Ensembl Genes ENSRNOG00000018211 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024719 ENTREZGENE
Gene3D-CATH 3.20.20.210 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8376316 IMAGE-MGC_LOAD
InterPro UROD/MetE-like_sf UniProtKB/Swiss-Prot
  Uroporphyrinogen_deCO2ase_HemE UniProtKB/Swiss-Prot
  Uroporphyrinogen_deCOase UniProtKB/Swiss-Prot
MGC_CLONE MGC:187707 IMAGE-MGC_LOAD
NCBI Gene 29421 ENTREZGENE
PANTHER METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED UniProtKB/Swiss-Prot
  UROPORPHYRINOGEN DECARBOXYLASE UniProtKB/Swiss-Prot
Pfam URO-D UniProtKB/Swiss-Prot
PhenoGen Urod PhenoGen
PROSITE UROD_1 UniProtKB/Swiss-Prot
  UROD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018211 RatGTEx
Superfamily-SCOP SSF51726 UniProtKB/Swiss-Prot
TIGR TC228421
UniProt A0A9K3Y7K6 ENTREZGENE, UniProtKB/TrEMBL
  A6JZB4_RAT UniProtKB/TrEMBL
  B0BN55 ENTREZGENE, UniProtKB/TrEMBL
  DCUP_RAT UniProtKB/Swiss-Prot
  F1LMP0 ENTREZGENE
  P32362 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Urod  uroporphyrinogen decarboxylase      Name updated 70584 APPROVED