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Gene: Tnfrsf8 (TNF receptor superfamily member 8) Rattus norvegicus

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Symbol:

Tnfrsf8

Name:

TNF receptor superfamily member 8

RGD ID:

3879

Description:

Predicted to enable protease binding activity. Predicted to be involved in cellular response to mechanical stimulus; positive regulation of apoptotic process; and positive regulation of tumor necrosis factor superfamily cytokine production. Predicted to be located in plasma membrane. Orthologous to human TNFRSF8 (TNF receptor superfamily member 8); PARTICIPATES IN cytokine mediated signaling pathway; INTERACTS WITH acetamide; ammonium chloride; arsenous acid.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Cd30; CD30L receptor; lymphocyte activation antigen CD30; tumor necrosis factor receptor superfamily member 8; tumor necrosis factor receptor superfamily, member 8; Tumor necrosis factor superfamily member 8; tumor necrosis factor superfamily member CD30; tumor necrosis factor superfamily, member CD30

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	162,406,387 - 162,451,620 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	162,406,387 - 162,451,620 (-)	Ensembl				GRCr8
mRatBN7.2	5	157,123,183 - 157,168,421 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	157,123,185 - 157,168,421 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	159,825,817 - 159,871,349 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	161,599,104 - 161,644,643 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	161,555,455 - 161,600,991 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	163,186,349 - 163,231,578 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	163,186,349 - 163,231,578 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	166,864,886 - 166,910,671 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	163,716,462 - 163,762,235 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	155,412,388 - 155,457,954 (-)	NCBI		Celera
RGSC_v3.1	5	163,726,649 - 163,772,415 (-)	NCBI
RH 3.4 Map	5	1065.7	RGD
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

anaplastic large cell lymphoma (ISO)

chronic obstructive pulmonary disease (ISO)

diabetes mellitus (ISO)

dilated cardiomyopathy (ISO)

embryonal carcinoma (ISO)

Emphysema (ISO)

gingivitis (ISO)

graft-versus-host disease (ISO)

Graves' disease (ISO)

Hashimoto Disease (ISO)

Hemorrhage (ISO)

Hodgkin's lymphoma (ISO)

human immunodeficiency virus infectious disease (ISO)

Infectious Ectromelia (ISO)

malignant mesothelioma (ISO)

Mycobacterium Infections (ISO)

myocarditis (ISO)

prostate cancer (ISO)

viral infectious disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (ISO)

4-aminobenzohydrazide (ISO)

acetamide (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

aphidicolin (ISO)

aripiprazole (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (EXP,ISO)

benzene-1,2,4-triol (ISO)

benzo[a]pyrene (EXP,ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

Butylbenzyl phthalate (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

chlordecone (ISO)

cisplatin (ISO)

cycloheximide (ISO)

dextran sulfate (ISO)

diarsenic trioxide (EXP,ISO)

dioxygen (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

FR900359 (ISO)

furosemide (EXP)

genistein (EXP)

isoflurane (EXP)

lipopolysaccharide (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nitroglycerin (EXP)

okadaic acid (ISO)

ozone (ISO)

p-menthan-3-ol (ISO)

paclitaxel (ISO)

paracetamol (ISO)

paraquat (EXP)

PCB138 (ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

quinidine (ISO)

SB 431542 (ISO)

silicon dioxide (EXP)

sodium arsenate (ISO)

sodium arsenite (ISO)

streptozocin (ISO)

trichloroethene (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

usnic acid (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to mechanical stimulus (ISO)

obsolete positive regulation of NF-kappaB transcription factor activity (IMP)

positive regulation of apoptotic process (ISO)

positive regulation of TRAIL production (ISO)

positive regulation of tumor necrosis factor production (ISO)

signal transduction (IEA)

Cellular Component

plasma membrane (IEA,ISO)

Molecular Function

protease binding (ISO)

protein binding (ISO)

transmembrane signaling receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

cytokine mediated signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Cloning and characterization of a cDNA for rat CD30 homolog and chromosomal assignment of the genomic gene.	Aizawa S, etal., Gene 1996 Dec 5;182(1-2):155-62.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells.	Kurts C, etal., Nature. 1999 Mar 25;398(6725):341-4.
5.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:8999898	PMID:16108830	PMID:19593445	PMID:20458337

Genomics

Comparative Map Data

Tnfrsf8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	162,406,387 - 162,451,620 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	162,406,387 - 162,451,620 (-)	Ensembl				GRCr8
mRatBN7.2	5	157,123,183 - 157,168,421 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	157,123,185 - 157,168,421 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	159,825,817 - 159,871,349 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	161,599,104 - 161,644,643 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	161,555,455 - 161,600,991 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	163,186,349 - 163,231,578 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	163,186,349 - 163,231,578 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	166,864,886 - 166,910,671 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	163,716,462 - 163,762,235 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	155,412,388 - 155,457,954 (-)	NCBI		Celera
RGSC_v3.1	5	163,726,649 - 163,772,415 (-)	NCBI
RH 3.4 Map	5	1065.7	RGD
Cytogenetic Map	5	q36	NCBI

TNFRSF8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	12,063,303 - 12,144,207 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	12,063,303 - 12,144,207 (+)	Ensembl			hg38	GRCh38
GRCh37	1	12,123,360 - 12,204,264 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	12,046,021 - 12,126,851 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	12,120,221 - 12,138,528	NCBI
Celera	1	11,236,734 - 11,317,553 (+)	NCBI		Celera
Cytogenetic Map	1	p36.22	NCBI
HuRef	1	11,277,612 - 11,357,523 (+)	NCBI		HuRef
CHM1_1	1	12,111,329 - 12,192,169 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	11,607,442 - 11,688,342 (+)	NCBI		T2T-CHM13v2.0

Tnfrsf8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	144,993,702 - 145,041,734 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	144,993,707 - 145,041,734 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	145,267,132 - 145,315,164 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	145,267,137 - 145,315,164 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	144,858,879 - 144,905,050 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	144,535,663 - 144,581,834 (-)	NCBI		MGSCv36	mm8
Celera	4	146,859,235 - 146,903,716 (-)	NCBI		Celera
Cytogenetic Map	4	E1	NCBI
cM Map	4	78.17	NCBI

Tnfrsf8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955486	1,839,642 - 1,910,080 (-)	NCBI	ChiLan1.0	ChiLan1.0

TNFRSF8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	216,093,002 - 216,172,889 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	214,739,970 - 214,819,867 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	10,813,111 - 10,893,005 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	12,029,038 - 12,108,495 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	12,029,038 - 12,108,495 (+)	Ensembl			panPan2	panpan1.1

TNFRSF8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	84,185,445 - 84,225,986 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	84,186,961 - 84,232,675 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	80,718,898 - 80,759,203 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	84,846,192 - 84,886,695 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	84,847,766 - 84,936,785 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	81,596,265 - 81,636,510 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	82,596,295 - 82,636,747 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	83,661,577 - 83,702,020 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tnfrsf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	35,006,667 - 35,066,082 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936474	814,510 - 889,851 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TNFRSF8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	72,103,309 - 72,174,882 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	66,086,273 - 66,128,007 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TNFRSF8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	119,656,183 - 119,736,151 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	119,657,614 - 119,715,078 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666054	23,512,780 - 23,552,347 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tnfrsf8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624818	957,597 - 996,565 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tnfrsf8
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	13,514,359 - 13,558,747 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tnfrsf8
295 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	239
Count of miRNA genes:	153
Interacting mature miRNAs:	187
Transcripts:	ENSRNOT00000022968
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	141212838	172190305	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	149642129	171146538	Rat
1549904	Neuinf1	Neuroinflammation QTL 1	3	0	nervous system integrity trait (VT:0010566)	blood T lymphocyte count (CMO:0000110)	5	160111176	171146538	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	156396728	172190305	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
631263	Cm24	Cardiac mass QTL 24	3.5		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	149805999	162987697	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138002522	170842766	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	160071170	172129029	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	141764300	172190305	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	148093485	172129029	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	156396728	167181764	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	149661912	166600247	Rat
1298090	Bp155	Blood pressure QTL 155	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	156289283	171137955	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat

Markers in Region

RH94435

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	5	162,406,390 - 162,406,581 (+)	Marker Load Pipeline
mRatBN7.2	5	157,123,186 - 157,123,377 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	163,186,351 - 163,186,541	NCBI	Rnor6.0
Rnor_5.0	5	166,864,890 - 166,865,080	UniSTS	Rnor5.0
RGSC_v3.4	5	163,716,464 - 163,716,654	UniSTS	RGSC3.4
Celera	5	155,412,390 - 155,412,580	UniSTS
RH 3.4 Map	5	1065.7	UniSTS
Cytogenetic Map	5	q36.2	UniSTS

AU049470

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	5	162,417,537 - 162,417,770 (+)	Marker Load Pipeline
mRatBN7.2	5	157,134,335 - 157,134,568 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	163,197,498 - 163,197,730	NCBI	Rnor6.0
Rnor_5.0	5	166,875,933 - 166,876,191	UniSTS	Rnor5.0
RGSC_v3.4	5	163,727,562 - 163,728,357	UniSTS	RGSC3.4
Celera	5	155,423,448 - 155,424,106	UniSTS
Cytogenetic Map	5	q36.2	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
15	12	37	115	55	56	25	85	25	6	245	152	10	90	45	81	31	13	13

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287165	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC127855	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D42117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000022968 ⟹ ENSRNOP00000022967

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	162,406,387 - 162,451,620 (-)	Ensembl
mRatBN7.2 Ensembl	5	157,123,185 - 157,168,421 (-)	Ensembl
Rnor_6.0 Ensembl	5	163,186,349 - 163,231,578 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000085929 ⟹ ENSRNOP00000074409

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	163,188,170 - 163,231,494 (-)	Ensembl

RefSeq Acc Id:

NM_019135 ⟹ NP_062008

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	162,406,387 - 162,451,620 (-)	NCBI
mRatBN7.2	5	157,123,183 - 157,168,421 (-)	NCBI
Rnor_6.0	5	163,186,349 - 163,231,578 (-)	NCBI
Rnor_5.0	5	166,864,886 - 166,910,671 (-)	NCBI
RGSC_v3.4	5	163,716,462 - 163,762,235 (-)	RGD
Celera	5	155,412,388 - 155,457,954 (-)	RGD

Sequence:

show sequence

GGCCCACACATTAGAAGTGATTTCACCACGGAGAGTCAGGGTGCCGGCAGTGGCCAGGCGCTGG
AGACCCGGGAAGCCAAGATGAGCATCCTACTCAAGGCAGCCGGGTTGCTGTTCCTGGGGATGCT
TCAAGCCTTCCCAAAGGATCGACCACTGGACACTACCTGTACCGGAGACCTCAGCTACTACCCC
GGGGAGGCTGCCAGGAACTGCTGTTACCAGTGCCCCTCAGGGTTGTCTCCTACACAGCCATGCC
CACAGGGCCCTGCCACTGCCAGAAACAGTGTGATCCTGACTACTACATCAAACGAAGACGGGAA
GTGCACAGCCTGCGTGACCTGTTTGCCAGGCCTCGTGGAGAAGGCTCCATGTTCTGGGAACTCT
CCTCGAATCTGTGAGTGTCAGCCCGGCATGTACTGCTCCACACCAGCTGTCAATTCCTGTGCCC
GATGTTCTGAAAAGACGGTTGTCAAGTTCCCAGACACAGCAGAAAAGAACACTATCTGTGAGCT
GCCCTCCCCAGGATCTGGCCCCAATGGCTCCAATCCAGACGACTGCAAAACACTTACTAGCCAT
ACCACTCCTCAGGCCATACCTACTCTAGAATCTCCAGCCAATGACAGTGTGAGGAGCTTGCTGC
CAAAACAGGTCACTGACTTTGTGAACGAAGGTGCTACTAAGCTGGTGAAGGTTCCTGAGTCTTC
CTCTTCCAAGGCAAGCATGCCTAGTCCAGATCCAGGTAATGCAGAGATGAATATGACCTTGAAG
CTTCCACCTCCAGGGACAGTCCCTGACATCAGTACTTCAGAAAACAGCATGGAGCCTGCCAGTA
CCGCCTCCACCCTAAGCCTCTTGGTAGATGCCCGGACCAGCAGCAGGATGCAGCCTACATCTCC
CTTGTCCACAGGAACACCGTTTCTGGATCCAGGGACCATGCTCTTCTGGGTGGCCATGGTGGTG
CTGCTGGTTGGCTCTGCCTCCTTCCTCCTGTGTTACTGGAAGGCCTGCTGGAGGCGGTTCCAGC
GGAAGTTTCACCTGAACTATCTACAGCAGACCTTCCAGCCCAAGATGGAGCAGGTAGATTCCTG
TCCTACTGAAAAGCTAACTCAGCTGCAGAGAAGTGGGTCAGTGACAGATTCCAGCGCTGGACAC
ACGTTGAGCCCACTGAGCCCTCCAGCTGTAGAGACTGGTGCCAGTGTTGGAACCGCCTGCCTGG
AGACCCTGCCGCTGCTGGATGACAGCATAACTGGGAACTCTTTTGCTCCCAGAGAACCTCCAGA
GCCACGGGTATCCACCGAACACACCAACAACAGGATTGAGAAAATCTACATCATGAAGGCTGAC
ACAGCGATTGTGGGCTCAGTAAAAACTGAAGTCCCTGAGGGCCGGGCTCCAGTAGGGTCTACAG
AGTCTGAGTTGGAAGCTGAACTAGAAGTGGACCATACCCCCCATTACCCGGAGCAGGAGACAGA
ACCACCTCTGGGCAGCTGCACTGAGGTCATGTTCTCCGTGGAGGAAGGAGGAAAAGAAGACCAT
GAGCCCACAACTGTCTCTGAGAAGTAACACCCAATGTTAGCGGGGGCTAGAGTACAGCTGAGTG
TTCAGTTTGAGATCAGGTTAATACCTGGGAAGCTACCACGGCTTGAACTGAAGCCCGGCATCCA
GGGTAGCACAGAATGAAGCTTCAGCTGCTACCAAGAACACTGGCCCCTGGACCCCAGCAGTGCG
CACTCACCATCAGGCTGTTGTCTACTGGGGGAGAAGCTACAGGTTGGGTCCAAGCCTCCTTGCC
CACACCCCTGTGCCCTGCCTTCTCTCCTTGGGTCTCAAGTGATGGCTTTACTGACATGCTACCA
GCCTTCAGCTATACACATGGCTCCCTGGAACAGAACCAACACCTAATTGCTTCTACTCCTGAGG
AAGAGGGAAGTTAAAGGATGAATGCTCATCATCACTGGCACAATGATAGCCTGTGCCCATCACA
CAGGGAGGGCGAAATGAGACCCTTCTGGCATGGCCTCCCTGTTCTGTGGACTCCCTCAGCAGCT
GCAGGTGATCCCACCCACTAAATGATGCTGGAGACTCTACTTTGCCACAGGAGTTCCTGTCATG
TGGTGATGGGAGTACTGTAGTCCTGGCCGTCCTTAACACATTGTGCCTCTATCTGTTCTGCCCT
GGAAATGAAGAACCATTGTCCCTAAGCCACCAGGATCAGGCCTGACACCTAGGAGGTTTGGAGC
CTATCTTTGAAGGCACCCTGCTGCTCACGCTGCTTGCCTTACCCTGCGGCCCACTCTGAGGAGG
CAGTGCTGCTGAACTTACCTGAAGTTCCGCTTTTAATGTTTTGTTTTGTTTTTTTCCTTTCGAG
GTAGTGAGAATTGAACCCATGGCCTTGTGCATGCCAGGAAAAGGTTGCAGGGCTGATCAACCCC
AGCCTAGCATTTCATACTAAGCACTAAAAGCTGCTGTCACTCCCAGCCTGGCTCACTCCCTGGC
ATTTGCGTACTCTTGTAACAAACGAGCAGCCAACTGGATGACACATCTGCTCTGTGGCAGCCAG
GGGACTCTGGACTTACCCTTGGGCCAGGCAGGGAGAATTCTGTTTACTCACTAGCTGTTTGCTG
TGTGGAGGAAGTTGGGACCCTGTCAAGAATCACGAGGGGAGTTTCTGAAACTGCTTGAATCTAT
GGGGAAAAGTTGGAGTGGCTGAGTACCACCAGAGGCGTTAAATCACAGTCTAGATACTAGCCAG
AAGGGATGTGTGGGGGCTGGATAGTTGCCCATTTTTCTTGTACAAGGACACAGTAGATATGTGG
GCATGCATAGTGTTCCCAAAGCCATGTCACAATGACCACATGGATTCCACACTTTTGGAAGATA
TTTCCCAACTTTTTCTTCTTCTTCTTTTTTTTTTCTAAGATCTTGTTCTGTATCCTAGGATAGA
TTCGAACTTGATATGGCTGACCCTGAACCTGTGACCCTCCTATCTTAACTTCCCAAGGAAGGAC
AGGCTTCAGCCACTATGCCAGACTGCCACACATTTCAACAAAGGGACATATTCCCTTGCAAAAG
ATGCTCTTCACACAATTTTTTGACCCTCTAAAAATCCCTACGTGGCCTGTAAAAATTAATGGAT
TTGTGAGGCCGAAAACTGATCAGAGAGATGAGTAGTGGGAGGCCCTGAACACAAAGACTGTCAG
GGGTCTGGTCTATTCTCTCTAGACAGGGCTGTTCTCTTTGTGCAAAGCACCCACAGCCAAGGGC
AGGAGCCCATGACCAGCTGTGTGCCCTTTAAATCTCTCCTTGTCCATCTGGGCAGTCCCTTCTT
CCCCTGTTCAAGGCCTGCCCTCCAAGGATGCTGGGAATAAAGGATCTCTGCTCAC

hide sequence

RefSeq Acc Id:

XM_063287165 ⟹ XP_063143235

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	162,406,387 - 162,427,830 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_062008	(Get FASTA)	NCBI Sequence Viewer
	XP_063143235	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA07699	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000022967
GenBank Protein	P97525	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_062008 ⟸ NM_019135
- Peptide Label:	precursor
- UniProtKB:	P97525 (UniProtKB/Swiss-Prot), A0A0G2K7Z6 (UniProtKB/Swiss-Prot), F1LNN5 (UniProtKB/TrEMBL), A6IU17 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSILLKAAGLLFLGMLQAFPKDRPLDTTCTGDLSYYPGEAARNCCYQCPSGLSPTQPCPQGPAT ARNSVILTTTSNEDGKCTACVTCLPGLVEKAPCSGNSPRICECQPGMYCSTPAVNSCARCSEKT VVKFPDTAEKNTICELPSPGSGPNGSNPDDCKTLTSHTTPQAIPTLESPANDSVRSLLPKQVTD FVNEGATKLVKVPESSSSKASMPSPDPGNAEMNMTLKLPPPGTVPDISTSENSMEPASTASTLS LLVDARTSSRMQPTSPLSTGTPFLDPGTMLFWVAMVVLLVGSASFLLCYWKACWRRFQRKFHLN YLQQTFQPKMEQVDSCPTEKLTQLQRSGSVTDSSAGHTLSPLSPPAVETGASVGTACLETLPLL DDSITGNSFAPREPPEPRVSTEHTNNRIEKIYIMKADTAIVGSVKTEVPEGRAPVGSTESELEA ELEVDHTPHYPEQETEPPLGSCTEVMFSVEEGGKEDHEPTTVSEK hide sequence

Ensembl Acc Id:

ENSRNOP00000074409 ⟸ ENSRNOT00000085929

Ensembl Acc Id:

ENSRNOP00000022967 ⟸ ENSRNOT00000022968

RefSeq Acc Id:	XP_063143235 ⟸ XM_063287165
- Peptide Label:	isoform X1
- UniProtKB:	A6IU18 (UniProtKB/TrEMBL)

Protein Domains

TNFR-Cys

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P97525-F1-model_v2	AlphaFold	P97525	1-492	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3879	AgrOrtholog
BioCyc Gene	G2FUF-39250	BioCyc
Ensembl Genes	ENSRNOG00000016782	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000022968	ENTREZGENE
Gene3D-CATH	Tumor Necrosis Factor Receptor, subunit A, domain 2	UniProtKB/Swiss-Prot
InterPro	TNFR/NGFR_Cys_rich_reg	UniProtKB/Swiss-Prot
	TNFR_8	UniProtKB/Swiss-Prot
	TNFR_superfamily_member_8	UniProtKB/Swiss-Prot
KEGG Report	rno:25069	UniProtKB/Swiss-Prot
NCBI Gene	25069	ENTREZGENE
PANTHER	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 8	UniProtKB/Swiss-Prot
	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 8	UniProtKB/Swiss-Prot
PhenoGen	Tnfrsf8	PhenoGen
PRINTS	TNFACTORR8	UniProtKB/Swiss-Prot
PROSITE	TNFR_NGFR_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000016782	RatGTEx
SMART	TNFR	UniProtKB/Swiss-Prot
Superfamily-SCOP	TNF receptor-like	UniProtKB/Swiss-Prot
TIGR	TC212021
UniProt	A0A0G2K7Z6	ENTREZGENE
	A6IU17	ENTREZGENE, UniProtKB/TrEMBL
	A6IU18	ENTREZGENE, UniProtKB/TrEMBL
	F1LNN5	ENTREZGENE, UniProtKB/TrEMBL
	P97525	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	A0A0G2K7Z6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-05	Tnfrsf8	TNF receptor superfamily member 8	Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2001-06-22	Tnfrsf8	Tumor necrosis factor superfamily, member 8			Name updated	67952	APPROVED
2001-06-22	Cd30	tumor necrosis factor superfamily, member CD30			Symbol withdrawn, duplicate of Tnfrsf8 (RGD:3879)	67952	WITHDRAWN

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains a single transmembrane domain	730027
gene_protein	493 amino acids	730027

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)