Thrb (thyroid hormone receptor beta) - Rat Genome Database

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Gene: Thrb (thyroid hormone receptor beta) Rattus norvegicus
Analyze
Symbol: Thrb
Name: thyroid hormone receptor beta
RGD ID: 3858
Description: Enables double-stranded DNA binding activity; identical protein binding activity; and nuclear receptor activity. Involved in several processes, including positive regulation of chondrocyte differentiation; positive regulation of ossification; and regulation of lipid metabolic process. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Used to study breast cancer. Human ortholog(s) of this gene implicated in several diseases, including cervix uteri carcinoma in situ; prostate cancer; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (thyroid hormone receptor beta); INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-erbA-2; C-erba-beta; ERBA2; Nr1a2; nuclear receptor subfamily 1 group A member 2; RATT3REC; T3rec; Thyroid hormone receptor beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2); thyroid hormone receptor beta 3; thyroid hormone receptor beta2delta; thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2); TRbeta; TRbeta2Delta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81510,115,954 - 10,465,231 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1510,115,954 - 10,313,680 (-)EnsemblGRCr8
mRatBN7.2157,685,180 - 8,031,920 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl157,685,180 - 7,882,916 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx159,830,939 - 10,169,014 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01510,743,731 - 11,081,799 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0159,044,158 - 9,382,240 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0158,890,578 - 9,239,815 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl158,890,578 - 9,086,282 (-)Ensemblrn6Rnor6.0
Rnor_5.01512,951,550 - 13,299,586 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4159,282,845 - 9,345,506 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera157,735,185 - 8,077,355 (-)NCBICelera
RGSC_v3.1159,279,949 - 9,685,583 (-)NCBI
Cytogenetic Map15p16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-citrinin  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(S)-colchicine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthol  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,4,6-trichlorophenol  (ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-diisopropylnaphthalene  (ISO)
2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol  (EXP)
2-acetamidofluorene  (ISO)
2-benzyl-4-chlorophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-naphthol  (ISO)
2-phenylpropan-2-ol  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-Dimethylbenzaldehyde  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-di-tert-Butyl-4-hydroxybenzaldehyde  (ISO)
3-acetyldeoxynivalenol  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-chloro-3,5-dimethylphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
9-phenanthrol  (ISO)
acetamide  (EXP)
acetochlor  (ISO)
acetylcholine  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP,ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
androst-4-ene-3,17-dione  (ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bezafibrate  (EXP)
bicalutamide  (ISO)
biochanin A  (ISO)
biphenyl-2-ol  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
Bisphenol Z  (EXP)
bithionol  (EXP)
bleomycin A2  (EXP)
butachlor  (ISO)
butyric acid  (EXP)
cadmium dichloride  (EXP)
calciol  (EXP)
calcitriol  (ISO)
camptothecin  (ISO)
carbaryl  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
clomiphene  (ISO)
closantel  (EXP)
clozapine  (EXP)
coumaphos  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cyhalothrin  (ISO)
daidzein  (ISO)
DDD  (ISO)
DDE  (EXP,ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
diethyl hydrogen phosphate  (EXP)
diethylstilbestrol  (ISO)
digitoxin  (ISO)
diiodine  (ISO)
diisobutyl phthalate  (ISO)
Diosbulbin B  (ISO)
dodecylamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
dronedarone  (EXP)
elemental selenium  (ISO)
emetine  (ISO)
entinostat  (ISO)
estrone  (ISO)
ethanol  (ISO)
ethyl myristate  (ISO)
Ethylenethiourea  (ISO)
fenarimol  (ISO)
fenitrothion  (ISO)
fenobucarb  (ISO)
fentin chloride  (ISO)
fentin hydroxide  (ISO)
fenvalerate  (EXP,ISO)
finasteride  (ISO)
Flumetralin  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glyphosate  (EXP)
hexestrol  (ISO)
hydroxyflutamide  (ISO)
imidacloprid  (ISO)
iprodione  (ISO)
isoprenaline  (EXP)
isotretinoin  (EXP)
kojic acid  (ISO)
kresoxim-methyl  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
Melengestrol acetate  (ISO)
mestranol  (ISO)
methoxyacetic acid  (ISO)
methyl laurate  (ISO)
metolcarb  (ISO)
mifepristone  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzoyl-L-alanine  (ISO)
N-desethylamiodarone  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
nilutamide  (ISO)
nitrofen  (EXP)
Nonylphenol  (EXP)
norethisterone  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oryzalin  (ISO)
Oxadiazon  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pazopanib  (ISO)
pendimethalin  (ISO)
pentachlorophenol  (EXP)
perchlorate  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
permethrin  (EXP,ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
procymidone  (ISO)
propanil  (ISO)
propylparaben  (ISO)
Ptaquiloside  (ISO)
pymetrozine  (ISO)
rac-lactic acid  (ISO)
rafoxanide  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
staurosporine  (ISO)
sulfasalazine  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
taurine  (ISO)
teniposide  (ISO)
testosterone  (ISO)
Testosterone propionate  (ISO)
Tetrachlorobisphenol A  (ISO)
thiazolidinediones  (EXP)
thioacetamide  (EXP)
thyroxine  (EXP,ISO)
tiratricol  (ISO)
titanium dioxide  (ISO)
trenbolone  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Presence of two members of c-erbA receptor gene family (c-erbA beta and c-erbA2) in smallest region of somatic homozygosity on chromosome 3p21-p25 in human breast carcinoma. Ali IU, etal., J Natl Cancer Inst. 1989 Dec 6;81(23):1815-20.
2. Microsatellite alterations in exfoliated cervical epithelia deoxyribonucleic acid as a marker for high-grade dysplasia. Chang CL, etal., Am J Obstet Gynecol. 2001 Jul;185(1):108-15.
3. HPV-associated cervical cancers show frequent allelic loss at 3p14 but no apparent aberration of FHIT mRNA. Chu TY, etal., Int J Cancer. 1998 Jan 19;75(2):199-204.
4. The thyroid hormone receptor-beta agonist GC-1 induces cell proliferation in rat liver and pancreas. Columbano A, etal., Endocrinology. 2006 Jul;147(7):3211-8. Epub 2006 Mar 30.
5. A method for efficient production of recombinant thyroid hormone receptors reveals that receptor homodimer-DNA binding is enhanced by the coactivator TIF2. Diallo EM, etal., Protein Expr Purif. 2005 Apr;40(2):292-8.
6. Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. Erion MD, etal., Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15490-5. Epub 2007 Sep 18.
7. The thyroid hormone receptor beta-specific agonist GC-1 selectively affects the bone development of hypothyroid rats. Freitas FR, etal., J Bone Miner Res. 2005 Feb;20(2):294-304. Epub 2004 Nov 22.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Expression of mutant thyroid hormone nuclear receptors is associated with human renal clear cell carcinoma. Kamiya Y, etal., Carcinogenesis. 2002 Jan;23(1):25-33.
11. Expression of thyroid hormone receptors A and B in developing rat tissues; evidence for extensive posttranscriptional regulation. Keijzer R, etal., J Mol Endocrinol. 2007 May;38(5):523-35.
12. Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor. Koenig RJ, etal., Proc Natl Acad Sci U S A 1988 Jul;85(14):5031-5.
13. DNA-based diagnosis of thyroid hormone resistance syndrome: a novel THRB mutation associated with mild resistance to thyroid hormone. Lam CW, etal., Clin Chim Acta. 2005 Aug;358(1-2):55-9.
14. Aberrant methylation of the THRB gene in tissue and plasma of breast cancer patients. Ling Y, etal., Cancer Genet Cytogenet. 2010 Jan 15;196(2):140-145.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors. Murray MB, etal., J Biol Chem 1988 Sep 5;263(25):12770-7.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Time-dependent changes in the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling. Pantos C, etal., Eur J Endocrinol. 2007 Apr;156(4):415-24.
20. Thyroid hormone regulates the hypotriglyceridemic gene APOA5. Prieur X, etal., J Biol Chem. 2005 Jul 29;280(30):27533-43. Epub 2005 Jun 7.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Microsatellite analysis of allelic imbalance in tumour and blood from patients with prostate cancer. Schwarzenbach H, etal., BJU Int. 2008 Jul;102(2):253-8. Epub 2008 Jul 1.
25. Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer. Silva JM, etal., Oncogene. 2002 Jun 20;21(27):4307-16.
Additional References at PubMed
PMID:2539642   PMID:7566114   PMID:7776974   PMID:8673137   PMID:9795230   PMID:9832432   PMID:9927422   PMID:10769387   PMID:11046130   PMID:11739747   PMID:12039952   PMID:12407160  
PMID:14657007   PMID:14767065   PMID:15062575   PMID:15180993   PMID:15466465   PMID:16549781   PMID:16645037   PMID:16803873   PMID:17218414   PMID:17952069   PMID:18000305   PMID:18299881  
PMID:19052228   PMID:19082768   PMID:19171649   PMID:19629520   PMID:20203194   PMID:20610536   PMID:20615868   PMID:20719854   PMID:20949361   PMID:21149577   PMID:22001906   PMID:22079090  
PMID:22930759   PMID:22985455   PMID:23148211   PMID:23376485   PMID:23384771   PMID:23629656   PMID:25156012   PMID:25666034   PMID:33255695   PMID:33834296  


Genomics

Comparative Map Data
Thrb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81510,115,954 - 10,465,231 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1510,115,954 - 10,313,680 (-)EnsemblGRCr8
mRatBN7.2157,685,180 - 8,031,920 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl157,685,180 - 7,882,916 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx159,830,939 - 10,169,014 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01510,743,731 - 11,081,799 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0159,044,158 - 9,382,240 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0158,890,578 - 9,239,815 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl158,890,578 - 9,086,282 (-)Ensemblrn6Rnor6.0
Rnor_5.01512,951,550 - 13,299,586 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4159,282,845 - 9,345,506 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera157,735,185 - 8,077,355 (-)NCBICelera
RGSC_v3.1159,279,949 - 9,685,583 (-)NCBI
Cytogenetic Map15p16NCBI
THRB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38324,117,153 - 24,495,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl324,117,153 - 24,495,756 (-)Ensemblhg38GRCh38
GRCh37324,158,644 - 24,537,199 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36324,134,709 - 24,511,317 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34324,139,235 - 24,511,317NCBI
Celera324,094,249 - 24,472,076 (-)NCBICelera
Cytogenetic Map3p24.2NCBI
HuRef324,104,526 - 24,481,917 (-)NCBIHuRef
CHM1_1324,110,176 - 24,487,912 (-)NCBICHM1_1
T2T-CHM13v2.0324,121,636 - 24,500,130 (-)NCBIT2T-CHM13v2.0
Thrb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39144,429,599 - 4,810,538 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl144,431,611 - 4,809,435 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381417,659,225 - 18,040,097 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1417,660,261 - 18,038,090 (+)Ensemblmm10GRCm38
MGSCv371418,493,474 - 18,870,602 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361416,774,842 - 16,827,040 (+)NCBIMGSCv36mm8
Celera1413,338,110 - 13,729,284 (+)NCBICelera
Cytogenetic Map14A1NCBI
cM Map147.08NCBI
Thrb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543015,992,146 - 16,323,238 (-)Ensembl
ChiLan1.0NW_00495543015,992,146 - 16,322,696 (-)NCBIChiLan1.0ChiLan1.0
THRB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2224,072,698 - 24,449,852 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1324,077,464 - 24,454,587 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0324,024,025 - 24,401,024 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1324,345,760 - 24,722,803 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl324,346,824 - 24,564,960 (-)EnsemblpanPan2panpan1.1
THRB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12319,278,650 - 19,648,547 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2319,277,493 - 19,660,283 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2319,274,402 - 19,646,202 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02319,582,486 - 19,954,456 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2319,582,797 - 19,954,439 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12319,398,045 - 19,769,727 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02319,507,580 - 19,879,481 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02319,616,877 - 19,988,327 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Thrb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118182,627,645 - 182,847,821 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647315,770,146 - 15,986,561 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647315,766,214 - 15,986,389 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THRB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1310,900,724 - 11,359,544 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11310,900,716 - 11,360,587 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21312,399,964 - 12,857,951 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THRB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11568,797,410 - 69,161,256 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1568,802,078 - 68,902,292 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604141,924,134 - 42,291,602 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thrb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247881,950,890 - 2,349,343 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247881,950,888 - 2,348,895 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Thrb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11287,040,043 - 87,133,169 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Thrb
2893 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir27arno-miR-27a-3pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//Western Functional MTI21149577

Predicted Target Of
Summary Value
Count of predictions:1311
Count of miRNA genes:282
Interacting mature miRNAs:361
Transcripts:ENSRNOT00000008752, ENSRNOT00000008989, ENSRNOT00000061402
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
1300142Bp191Blood pressure QTL 1913.14arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)15115177511Rat

Markers in Region
D15Wox5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2157,688,354 - 7,688,569 (+)MAPPERmRatBN7.2
Rnor_6.0158,893,753 - 8,893,967NCBIRnor6.0
Rnor_5.01512,954,725 - 12,954,939UniSTSRnor5.0
RGSC_v3.4159,281,524 - 9,281,738UniSTSRGSC3.4
Celera157,738,360 - 7,738,574UniSTS
Cytogenetic Map15p16UniSTS
D15Rat76  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2157,772,649 - 7,772,785 (+)MAPPERmRatBN7.2
Rnor_6.0158,977,237 - 8,977,372NCBIRnor6.0
Rnor_5.01513,038,226 - 13,038,361UniSTSRnor5.0
RGSC_v3.4159,366,823 - 9,367,294RGDRGSC3.4
RGSC_v3.4159,367,158 - 9,367,293UniSTSRGSC3.4
Celera157,822,410 - 7,822,545UniSTS
RGSC_v3.1159,367,158 - 9,367,293RGD
RH 3.4 Map21650.92RGD
RH 3.4 Map21650.92UniSTS
RH 2.0 Map21223.4RGD
SHRSP x BN Map153.9298RGD
Cytogenetic Map15p16UniSTS
PMC27204P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2157,686,060 - 7,686,242 (+)MAPPERmRatBN7.2
Rnor_6.0158,891,459 - 8,891,640NCBIRnor6.0
Rnor_5.01512,952,431 - 12,952,612UniSTSRnor5.0
RGSC_v3.4159,279,230 - 9,279,411UniSTSRGSC3.4
Celera157,736,066 - 7,736,247UniSTS
Cytogenetic Map15p16UniSTS
RH132907  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2157,686,287 - 7,686,472 (+)MAPPERmRatBN7.2
Rnor_6.0158,891,686 - 8,891,870NCBIRnor6.0
Rnor_5.01512,952,658 - 12,952,842UniSTSRnor5.0
RGSC_v3.4159,279,457 - 9,279,641UniSTSRGSC3.4
Celera157,736,293 - 7,736,477UniSTS
RH 3.4 Map1592.23UniSTS
Cytogenetic Map15p16UniSTS
BF399305  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2157,860,336 - 7,860,487 (+)MAPPERmRatBN7.2
Rnor_6.0159,063,703 - 9,063,853NCBIRnor6.0
Rnor_5.01513,124,710 - 13,124,860UniSTSRnor5.0
Celera157,907,834 - 7,907,984UniSTS
RH 3.4 Map1595.4UniSTS
Cytogenetic Map15p16UniSTS
BE119389  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2157,827,635 - 7,827,818 (+)MAPPERmRatBN7.2
Rnor_6.0159,031,434 - 9,031,616NCBIRnor6.0
Rnor_5.01513,092,423 - 13,092,605UniSTSRnor5.0
RGSC_v3.4159,422,139 - 9,422,321UniSTSRGSC3.4
Celera157,877,061 - 7,877,243UniSTS
RH 3.4 Map1593.21UniSTS
Cytogenetic Map15p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
18 12 70 189 91 90 59 115 59 6 409 220 13 168 104 99 31 23 23

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF239914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF239915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF239916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ191165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM043807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000008752   ⟹   ENSRNOP00000008752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl157,685,180 - 7,751,120 (-)Ensembl
Rnor_6.0 Ensembl158,890,578 - 8,914,501 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000008989   ⟹   ENSRNOP00000008989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1510,115,954 - 10,313,680 (-)Ensembl
mRatBN7.2 Ensembl157,685,180 - 7,882,916 (-)Ensembl
Rnor_6.0 Ensembl158,890,578 - 9,086,282 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000061402   ⟹   ENSRNOP00000058119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1510,115,954 - 10,181,892 (-)Ensembl
mRatBN7.2 Ensembl157,685,180 - 7,751,154 (-)Ensembl
Rnor_6.0 Ensembl158,894,875 - 8,989,580 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085322   ⟹   ENSRNOP00000073083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl157,685,180 - 7,727,455 (-)Ensembl
Rnor_6.0 Ensembl158,895,074 - 8,931,983 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114169   ⟹   ENSRNOP00000082752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1510,115,954 - 10,158,228 (-)Ensembl
mRatBN7.2 Ensembl157,685,180 - 7,727,455 (-)Ensembl
RefSeq Acc Id: NM_001270854   ⟹   NP_001257783
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,461,446 (-)NCBI
mRatBN7.2157,685,180 - 8,030,688 (-)NCBI
Rnor_6.0158,890,578 - 9,239,815 (-)NCBI
Rnor_5.01512,951,550 - 13,299,586 (-)NCBI
Celera157,735,185 - 8,077,355 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012672   ⟹   NP_036804
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,461,446 (-)NCBI
mRatBN7.2157,685,180 - 8,030,688 (-)NCBI
Rnor_6.0158,890,578 - 9,239,815 (-)NCBI
Rnor_5.01512,951,550 - 13,299,586 (-)NCBI
RGSC_v3.4159,282,845 - 9,345,506 (-)RGD
Celera157,735,185 - 8,077,355 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251709   ⟹   XP_006251771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,158,219 (-)NCBI
mRatBN7.2157,685,180 - 7,727,446 (-)NCBI
Rnor_6.0158,890,578 - 8,932,209 (-)NCBI
Rnor_5.01512,951,550 - 13,299,586 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092997   ⟹   XP_038948925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,461,544 (-)NCBI
mRatBN7.2157,685,180 - 8,030,794 (-)NCBI
RefSeq Acc Id: XM_039092998   ⟹   XP_038948926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,461,542 (-)NCBI
mRatBN7.2157,685,180 - 8,030,794 (-)NCBI
RefSeq Acc Id: XM_063273969   ⟹   XP_063130039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,465,231 (-)NCBI
RefSeq Acc Id: XM_063273970   ⟹   XP_063130040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,461,902 (-)NCBI
RefSeq Acc Id: XM_063273971   ⟹   XP_063130041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,462,927 (-)NCBI
RefSeq Acc Id: XM_063273972   ⟹   XP_063130042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,462,927 (-)NCBI
RefSeq Acc Id: XM_063273973   ⟹   XP_063130043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,461,542 (-)NCBI
RefSeq Acc Id: XM_063273974   ⟹   XP_063130044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,462,927 (-)NCBI
RefSeq Acc Id: XM_063273975   ⟹   XP_063130045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,462,927 (-)NCBI
RefSeq Acc Id: XM_063273976   ⟹   XP_063130046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,462,927 (-)NCBI
RefSeq Acc Id: XM_063273978   ⟹   XP_063130048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,462,927 (-)NCBI
RefSeq Acc Id: XM_063273979   ⟹   XP_063130049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,462,927 (-)NCBI
RefSeq Acc Id: XM_063273980   ⟹   XP_063130050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,461,902 (-)NCBI
RefSeq Acc Id: XM_063273981   ⟹   XP_063130051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,465,231 (-)NCBI
RefSeq Acc Id: XM_063273982   ⟹   XP_063130052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,465,231 (-)NCBI
RefSeq Acc Id: XM_063273983   ⟹   XP_063130053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,274,015 (-)NCBI
RefSeq Acc Id: XM_063273984   ⟹   XP_063130054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,461,542 (-)NCBI
RefSeq Acc Id: XM_063273985   ⟹   XP_063130055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,461,542 (-)NCBI
RefSeq Acc Id: XM_063273986   ⟹   XP_063130056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,461,542 (-)NCBI
RefSeq Acc Id: XM_063273988   ⟹   XP_063130058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,461,542 (-)NCBI
RefSeq Acc Id: XM_063273989   ⟹   XP_063130059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,461,542 (-)NCBI
RefSeq Acc Id: XM_063273990   ⟹   XP_063130060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81510,115,954 - 10,274,015 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001257783 (Get FASTA)   NCBI Sequence Viewer  
  NP_036804 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251771 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948925 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948926 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130039 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130040 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130041 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130042 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130043 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130044 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130045 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130046 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130048 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130049 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130050 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130051 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130052 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130053 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130054 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130055 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130056 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130058 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130059 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130060 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40916 (Get FASTA)   NCBI Sequence Viewer  
  AAA42200 (Get FASTA)   NCBI Sequence Viewer  
  AAA60743 (Get FASTA)   NCBI Sequence Viewer  
  AAG33351 (Get FASTA)   NCBI Sequence Viewer  
  AAG33352 (Get FASTA)   NCBI Sequence Viewer  
  ABA39294 (Get FASTA)   NCBI Sequence Viewer  
  ADH04374 (Get FASTA)   NCBI Sequence Viewer  
  EDL94087 (Get FASTA)   NCBI Sequence Viewer  
  EDL94088 (Get FASTA)   NCBI Sequence Viewer  
  EDL94089 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008989
  ENSRNOP00000058119
  ENSRNOP00000082752
GenBank Protein P18113 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036804   ⟸   NM_012672
- Peptide Label: isoform 1
- UniProtKB: Q3HW36 (UniProtKB/TrEMBL),   D3ZGG0 (UniProtKB/TrEMBL),   D7R7X1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257783   ⟸   NM_001270854
- Peptide Label: isoform 2
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   F1LQ07 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   A6K040 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251771   ⟸   XM_006251709
- Peptide Label: isoform X3
- UniProtKB: A6K042 (UniProtKB/TrEMBL),   A0A8I5ZV63 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008989   ⟸   ENSRNOT00000008989
Ensembl Acc Id: ENSRNOP00000008752   ⟸   ENSRNOT00000008752
Ensembl Acc Id: ENSRNOP00000073083   ⟸   ENSRNOT00000085322
Ensembl Acc Id: ENSRNOP00000058119   ⟸   ENSRNOT00000061402
RefSeq Acc Id: XP_038948926   ⟸   XM_039092998
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038948925   ⟸   XM_039092997
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL),   A6K040 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082752   ⟸   ENSRNOT00000114169
RefSeq Acc Id: XP_063130039   ⟸   XM_063273969
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   A6K040 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130051   ⟸   XM_063273981
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   A6K040 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130052   ⟸   XM_063273982
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   A6K040 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130049   ⟸   XM_063273979
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   A6K040 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130041   ⟸   XM_063273971
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   A6K040 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130044   ⟸   XM_063273974
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   A6K040 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130045   ⟸   XM_063273975
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   A6K040 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130042   ⟸   XM_063273972
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   A6K040 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130046   ⟸   XM_063273976
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   A6K040 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130048   ⟸   XM_063273978
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   A6K040 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130040   ⟸   XM_063273970
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   A6K040 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130050   ⟸   XM_063273980
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   A6K040 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130054   ⟸   XM_063273984
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   A6K040 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130058   ⟸   XM_063273988
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063130055   ⟸   XM_063273985
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   A6K040 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130059   ⟸   XM_063273989
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063130056   ⟸   XM_063273986
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   A6K040 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130043   ⟸   XM_063273973
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   A6K040 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130053   ⟸   XM_063273983
- Peptide Label: isoform X1
- UniProtKB: P37826 (UniProtKB/Swiss-Prot),   P18113 (UniProtKB/Swiss-Prot),   A6K040 (UniProtKB/TrEMBL),   F1LP32 (UniProtKB/TrEMBL),   F1LQ07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130060   ⟸   XM_063273990
- Peptide Label: isoform X4
- UniProtKB: Q3HW36 (UniProtKB/TrEMBL),   D3ZGG0 (UniProtKB/TrEMBL),   D7R7X1 (UniProtKB/TrEMBL)
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18113-F1-model_v2 AlphaFold P18113 1-461 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3858 AgrOrtholog
BioCyc Gene G2FUF-14456 BioCyc
Ensembl Genes ENSRNOG00000006649 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000008989 ENTREZGENE
  ENSRNOT00000061402 ENTREZGENE
  ENSRNOT00000114169 ENTREZGENE
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hormone_rcpt_NR1 UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  ThyrH_rcpt UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
NCBI Gene 24831 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot
  THYROID HORMONE RECEPTOR BETA UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PhenoGen Thrb PhenoGen
PRINTS STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
  THYROIDHORMR UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006649 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
UniProt A0A0G2QC48_RAT UniProtKB/TrEMBL
  A0A8I5ZV63 ENTREZGENE
  A0A8J8YM55_RAT UniProtKB/TrEMBL
  A6K040 ENTREZGENE, UniProtKB/TrEMBL
  A6K042 ENTREZGENE, UniProtKB/TrEMBL
  D3ZGG0 ENTREZGENE
  D7R7X1 ENTREZGENE
  F1LP32 ENTREZGENE
  F1LQ07 ENTREZGENE, UniProtKB/TrEMBL
  P18113 ENTREZGENE
  P37826 ENTREZGENE
  Q3HW36 ENTREZGENE, UniProtKB/TrEMBL
  THB_RAT UniProtKB/Swiss-Prot
UniProt Secondary P37826 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Thrb  Thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in liver, heart, kidney and brain 730099
gene_product member of the thyroid hormone nuclear receptor family 729962
gene_protein predicted protein is 52 kDa 729962