Tfec (transcription factor EC) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tfec (transcription factor EC) Rattus norvegicus
Analyze
Symbol: Tfec
Name: transcription factor EC
RGD ID: 3846
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human TFEC (transcription factor EC); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: rTFEC; Tcfec; TFE-C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8446,072,093 - 46,146,200 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl446,073,605 - 46,146,200 (-)EnsemblGRCr8
mRatBN7.2445,106,129 - 45,180,236 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl445,107,641 - 45,180,236 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx450,100,101 - 50,172,609 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0446,021,794 - 46,094,161 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0444,447,122 - 44,519,608 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0444,063,533 - 44,136,815 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl444,065,045 - 44,136,815 (-)Ensemblrn6Rnor6.0
Rnor_5.0444,670,886 - 44,744,984 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4442,422,172 - 42,495,654 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera440,398,740 - 40,470,786 (-)NCBICelera
RGSC_v3.1442,541,818 - 42,615,301 (-)NCBI
RH 3.4 Map4258.81RGD
Cytogenetic Map4q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
decabromodiphenyl ether  (EXP)
Dibutyl phosphate  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
folic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydroxyurea  (ISO)
L-methionine  (ISO)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
styrene  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
tremolite asbestos  (ISO)
triptonide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation. Zhao GQ, etal., Mol Cell Biol 1993 Aug;13(8):4505-12.
Additional References at PubMed
PMID:18755693  


Genomics

Comparative Map Data
Tfec
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8446,072,093 - 46,146,200 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl446,073,605 - 46,146,200 (-)EnsemblGRCr8
mRatBN7.2445,106,129 - 45,180,236 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl445,107,641 - 45,180,236 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx450,100,101 - 50,172,609 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0446,021,794 - 46,094,161 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0444,447,122 - 44,519,608 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0444,063,533 - 44,136,815 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl444,065,045 - 44,136,815 (-)Ensemblrn6Rnor6.0
Rnor_5.0444,670,886 - 44,744,984 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4442,422,172 - 42,495,654 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera440,398,740 - 40,470,786 (-)NCBICelera
RGSC_v3.1442,541,818 - 42,615,301 (-)NCBI
RH 3.4 Map4258.81RGD
Cytogenetic Map4q22NCBI
TFEC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387115,935,152 - 116,159,896 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7115,935,148 - 116,159,896 (-)Ensemblhg38GRCh38
GRCh377115,575,206 - 115,670,817 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367115,362,438 - 115,458,034 (-)NCBIBuild 36Build 36hg18NCBI36
Build 347115,173,976 - 115,264,746NCBI
Celera7110,382,578 - 110,478,171 (-)NCBICelera
Cytogenetic Map7q31.2NCBI
HuRef7109,941,132 - 110,036,927 (-)NCBIHuRef
CHM1_17115,508,483 - 115,604,121 (-)NCBICHM1_1
T2T-CHM13v2.07117,250,129 - 117,474,879 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27114,970,614 - 115,066,276 (-)NCBI
Tfec
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39616,830,926 - 16,898,463 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl616,833,372 - 16,898,440 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38616,830,927 - 16,898,464 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl616,833,373 - 16,898,441 (-)Ensemblmm10GRCm38
MGSCv37616,783,381 - 16,848,441 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36616,783,392 - 16,848,441 (-)NCBIMGSCv36mm8
Celera616,915,029 - 16,979,927 (-)NCBICelera
Cytogenetic Map6A2NCBI
cM Map67.61NCBI
Tfec
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543221,752,044 - 21,813,292 (-)Ensembl
ChiLan1.0NW_00495543221,751,697 - 21,813,199 (-)NCBIChiLan1.0ChiLan1.0
TFEC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26152,760,399 - 152,937,498 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan174,770,655 - 4,947,754 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07107,900,876 - 107,996,752 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17120,598,588 - 120,823,338 (-)NCBIPanPan1.1PanPan1.1panPan2
TFEC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11454,977,603 - 55,194,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1454,979,110 - 55,105,323 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1454,368,445 - 54,589,602 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01455,011,659 - 55,232,717 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1455,016,421 - 55,192,923 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11455,043,051 - 55,264,294 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01454,731,988 - 54,953,053 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01455,102,571 - 55,323,323 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tfec
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511843,684,480 - 43,749,006 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365892,971,417 - 3,000,694 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365892,971,350 - 3,001,480 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TFEC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1830,122,494 - 30,175,484 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11829,980,394 - 30,260,226 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21832,094,390 - 32,287,701 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TFEC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12184,655,653 - 84,858,828 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2184,654,538 - 84,680,786 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604219,026,239 - 19,107,511 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tfec
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248273,426,277 - 3,496,989 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248273,472,157 - 3,498,689 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tfec
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16122,078,479 - 122,143,840 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tfec
343 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:182
Count of miRNA genes:128
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000008156
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)41308014658080146Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41564430960644309Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42228845363245191Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41891315163913151Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42786220462997402Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43353881653719714Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat

Markers in Region
RH94544  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2445,108,142 - 45,108,330 (+)MAPPERmRatBN7.2
Rnor_6.0444,065,547 - 44,065,734NCBIRnor6.0
Rnor_5.0444,672,900 - 44,673,087UniSTSRnor5.0
RGSC_v3.4442,422,674 - 42,422,861UniSTSRGSC3.4
Celera440,399,242 - 40,399,429UniSTS
RH 3.4 Map4258.81UniSTS
Cytogenetic Map4q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 61 156 91 90 59 83 59 6 339 175 11 133 81 92 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000086810   ⟹   ENSRNOP00000073175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl446,073,605 - 46,146,200 (-)Ensembl
mRatBN7.2 Ensembl445,107,641 - 45,180,236 (-)Ensembl
Rnor_6.0 Ensembl444,065,045 - 44,136,815 (-)Ensembl
RefSeq Acc Id: NM_022379   ⟹   NP_071774
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8446,073,605 - 46,146,200 (-)NCBI
mRatBN7.2445,107,641 - 45,180,236 (-)NCBI
Rnor_6.0444,065,045 - 44,136,815 (-)NCBI
Rnor_5.0444,670,886 - 44,744,984 (-)NCBI
RGSC_v3.4442,422,172 - 42,495,654 (-)RGD
Celera440,398,740 - 40,470,786 (-)RGD
Sequence:
RefSeq Acc Id: XM_006236128   ⟹   XP_006236190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8446,072,093 - 46,105,600 (-)NCBI
mRatBN7.2445,106,129 - 45,139,671 (-)NCBI
Rnor_6.0444,063,533 - 44,096,185 (-)NCBI
Rnor_5.0444,670,886 - 44,744,984 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_071774 (Get FASTA)   NCBI Sequence Viewer  
  XP_006236190 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41523 (Get FASTA)   NCBI Sequence Viewer  
  EDM15100 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073175
  ENSRNOP00000073175.1
GenBank Protein Q63302 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071774   ⟸   NM_022379
- UniProtKB: Q63302 (UniProtKB/Swiss-Prot),   A6IE13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236190   ⟸   XM_006236128
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000073175   ⟸   ENSRNOT00000086810
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63302-F1-model_v2 AlphaFold Q63302 1-317 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692889
Promoter ID:EPDNEW_R3413
Type:initiation region
Name:Tfec_1
Description:transcription factor EC
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0444,136,826 - 44,136,886EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3846 AgrOrtholog
BioCyc Gene G2FUF-45586 BioCyc
Ensembl Genes ENSRNOG00000061595 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000086810 ENTREZGENE
  ENSRNOT00000086810.2 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  MiT/TFE_C UniProtKB/Swiss-Prot
KEGG Report rno:26296 UniProtKB/Swiss-Prot
NCBI Gene Tfec ENTREZGENE
PANTHER MIP04163P UniProtKB/Swiss-Prot
  PTHR45776:SF1 UniProtKB/Swiss-Prot
Pfam DUF3371 UniProtKB/Swiss-Prot
  HLH UniProtKB/Swiss-Prot
PhenoGen Tfec PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000061595 RatGTEx
SMART HLH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
UniProt A6IE13 ENTREZGENE, UniProtKB/TrEMBL
  Q63302 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tfec  transcription factor EC  Tcfec  transcription factor EC  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Tcfec  transcription factor EC  Tfec  transcription factor EC  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Tfec  transcription factor EC      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer 70037