Tcrb (T-cell receptor beta chain) - Rat Genome Database

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Gene: Tcrb (T-cell receptor beta chain) Rattus norvegicus
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Symbol: Tcrb
Name: T-cell receptor beta chain
RGD ID: 3834
Description: INVOLVED IN cellular defense response; INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether; 4,4'-diaminodiphenylmethane
Type: protein-coding
Previously known as: MGC108929; MGC109620; MGC116333; RATTCB; RATTCBC1; T-cell receptor beta cluster; T-cell receptor, beta cluster; TCB; TCBC1; variable region-beta 8.5
Is Marker For: Strains:   WF.BBDR-(D4Rat93-D4Rat228)/Wor
Candidate Gene For: Eau1 Scwia1 Aia3
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Genome Annotation Status: not in current annotation release
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
RGSC_v3.1469,081,805 - 69,511,069 (+)NCBI
Cytogenetic Map4q22NCBI



Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. Alleles of highly homologous rat T cell receptor beta-chain variable segments 8.2 and 8.4: strain-specific expression, reactivity to superantigens, and binding of the mAb R78. Asmuss A, etal., J Immunol 1996 Nov 15;157(10):4436-41.
2. Alleles of the rat T-cell receptor beta chain gene complex. Blankenhorn EP, etal., Immunogenetics 1992;35(5):324-31.
3. Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. Burns FR, etal., J Exp Med 1989 Jan 1;169(1):27-39.
4. Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases. Kawahito Y, etal., J Immunol 1998 Oct 15;161(8):4411-9
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats. Sun SH, etal., Int Immunol 1999 Apr;11(4):529-34
8. Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases. Wilder RL, etal., Transplant Proc 1999 May;31(3):1585-8
9. Organization and nucleotide sequence of the rat T cell receptor beta-chain complex. Williams CB, etal., J Immunol 1991 Jun 15;146(12):4406-13.
Additional References at PubMed
PMID:1702803   PMID:12477932   PMID:15383583   PMID:17376830   PMID:19205800   PMID:34205929  


Genomics

Markers in Region
D4Mit4   No map positions available.
D4Arb12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2470,411,222 - 70,411,406 (+)MAPPERmRatBN7.2
Rnor_6.0470,822,505 - 70,822,688NCBIRnor6.0
Rnor_5.04135,612,869 - 135,613,052UniSTSRnor5.0
RGSC_v3.4469,235,630 - 69,235,813UniSTSRGSC3.4
Celera465,376,264 - 65,376,447UniSTS
Cytogenetic Map4q22UniSTS
Tcrb-C  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2470,417,960 - 70,418,727 (+)MAPPERmRatBN7.2
Rnor_6.0470,829,243 - 70,830,009NCBIRnor6.0
Rnor_5.04135,619,607 - 135,620,373UniSTSRnor5.0
RGSC_v3.4469,242,368 - 69,243,134UniSTSRGSC3.4
Celera465,383,002 - 65,383,768UniSTS
Cytogenetic Map4q22UniSTS


Related Rat Strains
The following Strains have been annotated to Tcrb
WF.BBDR-(D4Rat93-D4Rat228)/Wor    


Expression

RNA-SEQ Expression


Sequence



Additional Information

Database Acc Id Source(s)
IMAGE_CLONE IMAGE:7367078 IMAGE-MGC_LOAD
  IMAGE:7380746 IMAGE-MGC_LOAD
  IMAGE:7382105 IMAGE-MGC_LOAD
  IMAGE:7382821 IMAGE-MGC_LOAD
  IMAGE:7383431 IMAGE-MGC_LOAD
MGC_CLONE MGC:108929 IMAGE-MGC_LOAD
  MGC:109620 IMAGE-MGC_LOAD
  MGC:116333 IMAGE-MGC_LOAD
  MGC:125003 IMAGE-MGC_LOAD
  MGC:188284 IMAGE-MGC_LOAD
NCBI Gene 24820 ENTREZGENE
PhenoGen Tcrb PhenoGen


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Tcrb  T-cell receptor beta chain    T-cell receptor, beta cluster  Name updated 629478 APPROVED
2002-06-10 Tcrb  T-cell receptor, beta cluster      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains the hypervariable region 4 mediates binding of SAg to the P-chain of the TCR 724766