Serpina3l (serine (or cysteine) peptidase inhibitor, clade A, member 3L) - Rat Genome Database

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Gene: Serpina3l (serine (or cysteine) peptidase inhibitor, clade A, member 3L) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Serpina3l (Ensembl: Serpina3n)
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3L (Ensembl:serpin family A member 3N)
RGD ID: 3745
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in response to cytokine. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3); INTERACTS WITH 17beta-estradiol; 2,5-hexanedione; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ab1-021; contrapsin-like protease inhibitor 3; contrapsin-like protease inhibitor-related protein; CPi-23; liver regeneration protein lrryan; LOC299282; Serine protease inhibitor; serine protease inhibitor 1; serine protease inhibitor 2.1; serine protease inhibitor 2a; serine protease inhibitor A3L; serpin A3L; SPI-1; SPI-2.1; SPI1; Spin1; Spin2a
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86129,063,145 - 129,079,465 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6129,063,206 - 129,077,298 (+)EnsemblGRCr8
mRatBN7.26123,298,365 - 123,305,804 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,298,437 - 123,312,529 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6123,429,228 - 123,436,588 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,724,522 - 123,731,882 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06123,095,657 - 123,103,028 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06128,046,780 - 128,062,241 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,941,526 - 128,080,889 (+)Ensemblrn6Rnor6.0
Rnor_5.06137,256,803 - 137,272,264 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46128,435,211 - 128,450,672 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6120,774,322 - 120,789,776 (+)NCBICelera
RGSC_v3.16128,438,957 - 128,454,419 (+)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. Molecular cloning and characterization of rat contrapsin-like protease inhibitor and related proteins. Ohkubo K, etal., J Biochem (Tokyo) 1991 Feb;109(2):243-50.
4. Molecular characterization of three rat liver serine-protease inhibitors affected by inflammation and hypophysectomy. Protein and mRNA analysis and cDNA cloning. Pages G, etal., Eur J Biochem 1990 Jun 20;190(2):385-91.
5. Primary structure and assignment to chromosome 6 of three related rat genes encoding liver serine protease inhibitors. Pages G, etal., Gene 1990 Oct 15;94(2):273-82.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:3493437   PMID:3494016   PMID:12477932   PMID:15489334   PMID:15638460  


Genomics

Variants

.
Variants in Serpina3l
117 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
4 11 44 83 57 60 41 20 41 170 76 1 74 41 63 19

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001389215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_182474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY298742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY325133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000013961   ⟹   ENSRNOP00000013961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6123,300,439 - 123,312,529 (+)Ensembl
Rnor_6.0 Ensembl6128,050,311 - 128,062,241 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000014073   ⟹   ENSRNOP00000014073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6128,073,344 - 128,080,878 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000033897   ⟹   ENSRNOP00000029694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6127,941,526 - 127,964,588 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077517   ⟹   ENSRNOP00000075693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6128,050,250 - 128,080,220 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078064   ⟹   ENSRNOP00000070684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6123,300,371 - 123,312,529 (+)Ensembl
Rnor_6.0 Ensembl6128,046,780 - 128,062,238 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082680   ⟹   ENSRNOP00000074930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6123,300,538 - 123,312,486 (+)Ensembl
Rnor_6.0 Ensembl6127,946,686 - 128,080,217 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084685   ⟹   ENSRNOP00000071980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6128,048,099 - 128,080,889 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087017   ⟹   ENSRNOP00000070308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6123,298,437 - 123,305,803 (+)Ensembl
Rnor_6.0 Ensembl6128,048,174 - 128,055,509 (+)Ensembl
RefSeq Acc Id: NM_001389215   ⟹   NP_001376144
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86129,063,206 - 129,070,573 (+)NCBI
mRatBN7.26123,298,437 - 123,305,804 (+)NCBI
RefSeq Acc Id: XM_039112075   ⟹   XP_038968003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86129,063,166 - 129,070,572 (+)NCBI
mRatBN7.26123,298,398 - 123,305,803 (+)NCBI
RefSeq Acc Id: XM_039112076   ⟹   XP_038968004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86129,063,200 - 129,070,572 (+)NCBI
mRatBN7.26123,298,440 - 123,305,803 (+)NCBI
RefSeq Acc Id: XM_039112077   ⟹   XP_038968005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86129,063,156 - 129,070,572 (+)NCBI
mRatBN7.26123,298,387 - 123,305,803 (+)NCBI
RefSeq Acc Id: XM_063261769   ⟹   XP_063117839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86129,063,145 - 129,079,465 (+)NCBI
Ensembl Acc Id: ENSRNOP00000074930   ⟸   ENSRNOT00000082680
Ensembl Acc Id: ENSRNOP00000029694   ⟸   ENSRNOT00000033897
Ensembl Acc Id: ENSRNOP00000071980   ⟸   ENSRNOT00000084685
Ensembl Acc Id: ENSRNOP00000075693   ⟸   ENSRNOT00000077517
Ensembl Acc Id: ENSRNOP00000070308   ⟸   ENSRNOT00000087017
Ensembl Acc Id: ENSRNOP00000014073   ⟸   ENSRNOT00000014073
Ensembl Acc Id: ENSRNOP00000070684   ⟸   ENSRNOT00000078064
Ensembl Acc Id: ENSRNOP00000013961   ⟸   ENSRNOT00000013961
RefSeq Acc Id: XP_038968005   ⟸   XM_039112077
- Peptide Label: isoform X1
- UniProtKB: P05544 (UniProtKB/Swiss-Prot),   A0A0G2JXK5 (UniProtKB/TrEMBL),   A6JEQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968003   ⟸   XM_039112075
- Peptide Label: isoform X1
- UniProtKB: P05544 (UniProtKB/Swiss-Prot),   A0A0G2JXK5 (UniProtKB/TrEMBL),   A6JEQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001376144   ⟸   NM_001389215
- Peptide Label: precursor
- UniProtKB: P05544 (UniProtKB/Swiss-Prot),   A0A0G2JXK5 (UniProtKB/TrEMBL),   A6JEQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968004   ⟸   XM_039112076
- Peptide Label: isoform X1
- UniProtKB: P05544 (UniProtKB/Swiss-Prot),   A0A0G2JXK5 (UniProtKB/TrEMBL),   A6JEQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117839   ⟸   XM_063261769
- Peptide Label: isoform X2
- UniProtKB: F1LM05 (UniProtKB/TrEMBL)
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09005-F1-model_v2 AlphaFold P09005 1-214 view protein structure
AF-P05544-F1-model_v2 AlphaFold P05544 1-413 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694807
Promoter ID:EPDNEW_R5330
Type:multiple initiation site
Name:LOC299282_2
Description:Serine protease inhibitor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5331  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06128,048,149 - 128,048,209EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3745 AgrOrtholog
BioCyc Gene G2FUF-36384 BioCyc
Ensembl Genes ENSRNOG00000010478 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000087017 ENTREZGENE
  ENSRNOT00000087017.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot
  3.30.497.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7372979 IMAGE-MGC_LOAD
InterPro Serpin_CS UniProtKB/Swiss-Prot
  Serpin_dom UniProtKB/Swiss-Prot
  Serpin_fam UniProtKB/Swiss-Prot
  Serpin_sf UniProtKB/Swiss-Prot
  Serpin_sf_1 UniProtKB/Swiss-Prot
  Serpin_sf_2 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108539 IMAGE-MGC_LOAD
NCBI Gene Serpina3l ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot
  SERINE PROTEASE INHIBITOR A3A-RELATED UniProtKB/Swiss-Prot
Pfam Serpin UniProtKB/Swiss-Prot
PhenoGen Serpina3l PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010478 RatGTEx
SMART SERPIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot
UniProt A0A0G2JXK5 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JYK0_RAT UniProtKB/TrEMBL
  A6JEQ7 ENTREZGENE, UniProtKB/TrEMBL
  F1LM05 ENTREZGENE
  P05544 ENTREZGENE
  P09005 ENTREZGENE
  Q7TMB9_RAT UniProtKB/TrEMBL
  SPA3L_RAT UniProtKB/Swiss-Prot
  SPI21_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-24 Serpina3l  serine (or cysteine) peptidase inhibitor, clade A, member 3L  LOC299282  Serine protease inhibitor  Name and Symbol changed 629549 APPROVED
2006-11-30 LOC299282  serine (or cysteine) peptidase inhibitor, clade A, member 3K  Spin2a  Serine protease inhibitor  Symbol and Name updated 1299863 APPROVED
2002-06-10 Spin2a  Serine protease inhibitor      Symbol and Name status set to approved 70586 APPROVED