Slc9a2 (solute carrier family 9 member A2) - Rat Genome Database

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Gene: Slc9a2 (solute carrier family 9 member A2) Rattus norvegicus
Analyze
Symbol: Slc9a2
Name: solute carrier family 9 member A2
RGD ID: 3719
Description: Enables sodium:proton antiporter activity. Involved in sodium ion transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Orthologous to human SLC9A2 (solute carrier family 9 member A2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: H7; na(+)/H(+) exchanger 2; Na/H ion exchanger; NHE-2; Nhe2; sodium/hydrogen exchanger 2; Solute carrier family 9 (sodium/hydrogen exchanger 2) antiporter 2 Na+/H+ (Na+/H+ exchanger 2); Solute carrier family 9 (sodium/hydrogen exchanger 2), antiporter 2, Na+/H+ (Na+/H+ exchanger 2); solute carrier family 9 (sodium/hydrogen exchanger), member 2; solute carrier family 9 member 2; solute carrier family 9, member 2; solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8950,427,612 - 50,510,043 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl950,426,798 - 50,510,040 (+)EnsemblGRCr8
mRatBN7.2942,932,001 - 43,014,447 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl942,931,346 - 43,014,444 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx951,431,897 - 51,514,356 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0956,554,607 - 56,637,069 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0954,832,669 - 54,915,087 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0947,386,581 - 47,491,813 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl947,386,626 - 47,491,907 (+)Ensemblrn6Rnor6.0
Rnor_5.0947,069,252 - 47,174,869 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4939,832,184 - 39,916,242 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera940,674,586 - 40,756,808 (+)NCBICelera
RGSC_v3.1939,864,431 - 39,917,653 (+)NCBI
RH 3.4 Map9416.79RGD
Cytogenetic Map9q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IEA,ISO,ISS,TAS)
cell junction  (ISO)
membrane  (IEA)
plasma membrane  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2). Collins JF, etal., Proc Natl Acad Sci U S A 1993 May 1;90(9):3938-42.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5. Metabolic acidosis in rats increases intestinal NHE2 and NHE3 expression and function. Lucioni A, etal., Am J Physiol Gastrointest Liver Physiol 2002 Jul;283(1):G51-6.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Region-specific adaptation of apical Na/H exchangers after extensive proximal small bowel resection. Musch MW, etal., Am J Physiol Gastrointest Liver Physiol 2002 Oct;283(4):G975-85.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Evidence for involvement of the putative first extracellular loop in differential volume sensitivity of the Na+/H+ exchangers NHE1 and NHE2. Su X, etal., Biochemistry 2003 Feb 4;42(4):1086-94.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron. Wang T, etal., Am J Physiol Renal Physiol 2001 Dec;281(6):F1117-22.
14. Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells. Yu FH, etal., J Biol Chem. 1993 Dec 5;268(34):25536-41.
Additional References at PubMed
PMID:7685026   PMID:8595899   PMID:8889548   PMID:9804979   PMID:10666043   PMID:15238256   PMID:15800055   PMID:17018119   PMID:17303069   PMID:17379926   PMID:19458287   PMID:23509787  
PMID:26078707   PMID:26350456   PMID:27191152   PMID:28019659   PMID:28493993  


Genomics

Comparative Map Data
Slc9a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8950,427,612 - 50,510,043 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl950,426,798 - 50,510,040 (+)EnsemblGRCr8
mRatBN7.2942,932,001 - 43,014,447 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl942,931,346 - 43,014,444 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx951,431,897 - 51,514,356 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0956,554,607 - 56,637,069 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0954,832,669 - 54,915,087 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0947,386,581 - 47,491,813 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl947,386,626 - 47,491,907 (+)Ensemblrn6Rnor6.0
Rnor_5.0947,069,252 - 47,174,869 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4939,832,184 - 39,916,242 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera940,674,586 - 40,756,808 (+)NCBICelera
RGSC_v3.1939,864,431 - 39,917,653 (+)NCBI
RH 3.4 Map9416.79RGD
Cytogenetic Map9q22NCBI
SLC9A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382102,619,553 - 102,711,355 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2102,619,553 - 102,711,355 (+)Ensemblhg38GRCh38
GRCh372103,236,012 - 103,327,814 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362102,602,598 - 102,694,241 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342102,694,683 - 102,786,325NCBI
Celera297,437,331 - 97,528,969 (+)NCBICelera
Cytogenetic Map2q12.1NCBI
HuRef297,000,460 - 97,092,035 (+)NCBIHuRef
CHM1_12103,240,476 - 103,332,120 (+)NCBICHM1_1
T2T-CHM13v2.02103,078,521 - 103,170,032 (+)NCBIT2T-CHM13v2.0
Slc9a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39140,720,872 - 40,808,045 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl140,719,734 - 40,808,433 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38140,681,712 - 40,768,885 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl140,680,574 - 40,769,273 (+)Ensemblmm10GRCm38
MGSCv37140,738,557 - 40,825,730 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36140,626,258 - 40,713,431 (+)NCBIMGSCv36mm8
Celera140,497,312 - 40,580,915 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map119.66NCBI
Slc9a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554708,083,641 - 8,137,372 (+)Ensembl
ChiLan1.0NW_0049554708,083,737 - 8,137,372 (+)NCBIChiLan1.0ChiLan1.0
SLC9A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21224,998,994 - 25,089,855 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A25,001,759 - 25,092,620 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A99,112,174 - 99,202,890 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A103,716,909 - 103,808,140 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A103,717,055 - 103,806,141 (+)EnsemblpanPan2panpan1.1
SLC9A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11040,334,417 - 40,394,438 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1040,338,284 - 40,394,470 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1040,259,042 - 40,355,812 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01041,199,202 - 41,296,164 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1041,204,618 - 41,296,196 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11040,914,179 - 41,010,959 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01041,194,951 - 41,291,464 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01041,387,298 - 41,484,088 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc9a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629289,792,543 - 89,876,241 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367131,256,692 - 1,342,229 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367131,256,678 - 1,340,338 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC9A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl351,535,798 - 51,623,057 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1351,535,798 - 51,623,003 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2353,962,479 - 54,047,324 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC9A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,274,887 - 6,368,183 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041173,959,230 - 174,051,533 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc9a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247497,100,607 - 7,189,494 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247497,100,585 - 7,188,744 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc9a2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14116,900,210 - 116,983,266 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc9a2
492 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:569
Count of miRNA genes:182
Interacting mature miRNAs:218
Transcripts:ENSRNOT00000021270, ENSRNOT00000066000
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat

Markers in Region
D9Rat125  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2942,930,419 - 42,930,620 (+)MAPPERmRatBN7.2
Rnor_6.0947,384,998 - 47,385,200NCBIRnor6.0
Rnor_5.0947,067,669 - 47,067,871UniSTSRnor5.0
RGSC_v3.4939,830,600 - 39,830,803RGDRGSC3.4
RGSC_v3.4939,830,601 - 39,830,803UniSTSRGSC3.4
Celera940,673,003 - 40,673,205UniSTS
RGSC_v3.1939,832,014 - 39,832,217RGD
RH 2.0 Map9416.4RGD
SHRSP x BN Map937.6898RGD
Cytogenetic Map9q21UniSTS
RH94565  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2943,013,197 - 43,013,356 (+)MAPPERmRatBN7.2
Rnor_6.0947,490,564 - 47,490,722NCBIRnor6.0
Rnor_5.0947,173,620 - 47,173,778UniSTSRnor5.0
RGSC_v3.4939,914,993 - 39,915,151UniSTSRGSC3.4
Celera940,755,559 - 40,755,717UniSTS
RH 3.4 Map9416.79UniSTS
Cytogenetic Map9q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 20 124 43 44 13 35 13 6 203 86 11 102 80 89 31 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000021270   ⟹   ENSRNOP00000021270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl950,427,530 - 50,510,036 (+)Ensembl
mRatBN7.2 Ensembl942,932,001 - 43,014,440 (+)Ensembl
Rnor_6.0 Ensembl947,386,626 - 47,491,907 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096863   ⟹   ENSRNOP00000088725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl950,426,798 - 50,510,040 (+)Ensembl
mRatBN7.2 Ensembl942,931,346 - 43,014,444 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134379   ⟹   ENSRNOP00000107537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl950,426,798 - 50,510,036 (+)Ensembl
RefSeq Acc Id: NM_001113335   ⟹   NP_001106806
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,427,612 - 50,510,043 (+)NCBI
mRatBN7.2942,932,001 - 43,014,447 (+)NCBI
Rnor_6.0947,386,581 - 47,491,813 (+)NCBI
Rnor_5.0947,069,252 - 47,174,869 (+)NCBI
RGSC_v3.4939,832,184 - 39,916,242 (+)RGD
Celera940,674,586 - 40,756,808 (+)RGD
Sequence:
RefSeq Acc Id: NM_012653   ⟹   NP_036785
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,458,441 - 50,510,043 (+)NCBI
mRatBN7.2942,962,845 - 43,014,447 (+)NCBI
Rnor_6.0947,417,415 - 47,491,813 (+)NCBI
Rnor_5.0947,069,252 - 47,174,869 (+)NCBI
RGSC_v3.4939,832,184 - 39,916,242 (+)RGD
Celera940,705,420 - 40,756,808 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036785   ⟸   NM_012653
- Peptide Label: isoform 2
- UniProtKB: A6INP4 (UniProtKB/TrEMBL),   A0A8I6A8M9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001106806   ⟸   NM_001113335
- Peptide Label: isoform 1 precursor
- UniProtKB: Q16434 (UniProtKB/Swiss-Prot),   P48763 (UniProtKB/Swiss-Prot),   A6INP3 (UniProtKB/TrEMBL),   A0A8I6A8M9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021270   ⟸   ENSRNOT00000021270
Ensembl Acc Id: ENSRNOP00000088725   ⟸   ENSRNOT00000096863
Ensembl Acc Id: ENSRNOP00000107537   ⟸   ENSRNOT00000134379
Protein Domains
Cation/H+ exchanger transmembrane   Sodium/hydrogen exchanger regulatory region

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48763-F1-model_v2 AlphaFold P48763 1-813 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696634
Promoter ID:EPDNEW_R7159
Type:initiation region
Name:Slc9a2_1
Description:solute carrier family 9 member A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0947,386,537 - 47,386,597EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3719 AgrOrtholog
BioCyc Gene G2FUF-27719 BioCyc
Ensembl Genes ENSRNOG00000015567 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021270 ENTREZGENE
  ENSRNOT00000021270.7 UniProtKB/Swiss-Prot
  ENSRNOT00000096863 ENTREZGENE
Gene3D-CATH 6.10.140.1330 UniProtKB/Swiss-Prot
  6.10.250.1040 UniProtKB/Swiss-Prot
  6.10.250.2020 UniProtKB/Swiss-Prot
InterPro Cation/H_exchanger UniProtKB/Swiss-Prot
  Cation/H_exchanger_CPA1 UniProtKB/Swiss-Prot
  Na/H_exchanger_2 UniProtKB/Swiss-Prot
  NaH_exchanger UniProtKB/Swiss-Prot
  NHE_CaM-bd UniProtKB/Swiss-Prot
KEGG Report rno:24783 UniProtKB/Swiss-Prot
NCBI Gene 24783 ENTREZGENE
PANTHER PTHR10110 UniProtKB/Swiss-Prot
  SODIUM/HYDROGEN EXCHANGER 2 UniProtKB/Swiss-Prot
Pfam Na_H_Exchanger UniProtKB/Swiss-Prot
  NEXCaM_BD UniProtKB/Swiss-Prot
PhenoGen Slc9a2 PhenoGen
PRINTS NAHEXCHNGR UniProtKB/Swiss-Prot
  NAHEXCHNGR2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015567 RatGTEx
TIGR TC220961
UniProt A0A8I6A8M9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LZX1_RAT UniProtKB/TrEMBL
  A6INP3 ENTREZGENE, UniProtKB/TrEMBL
  A6INP4 ENTREZGENE, UniProtKB/TrEMBL
  P48763 ENTREZGENE
  Q16434 ENTREZGENE
  SL9A2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q16434 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Slc9a2  solute carrier family 9 member A2  Slc9a2  solute carrier family 9 member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-24 Slc9a2  solute carrier family 9 member 2  Slc9a2  solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Slc9a2  solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2  Slc9a2  solute carrier family 9 (sodium/hydrogen exchanger), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Slc9a2  solute carrier family 9 (sodium/hydrogen exchanger), member 2    solute carrier family 9, member 2  Name updated 1299863 APPROVED
2003-04-09 Slc9a2  solute carrier family 9, member 2    Solute carrier family 9 (sodium/hydrogen exchanger 2), antiporter 2, Na+/H+ (Na+/H+ exchanger 2)  Name updated 629478 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease associated with chronic metabolic acidosis 625757
gene_expression expressed in the small and large intestine 625757
gene_process facilitates increased absorption of NaCl in the intestine 625757
gene_regulation enhanced exchanger activity and increased acidosis reported in rats after 6 days of treatment with ammonium chloride 625757
gene_regulation activity is regulated by protein kinase C, cAMP, cGMP and intracellular calcium signal transduction pathways and accessory proteins such as NHE regulatory factor and E3KARP 625757