Slc4a2 (solute carrier family 4 member 2) - Rat Genome Database

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Gene: Slc4a2 (solute carrier family 4 member 2) Rattus norvegicus
Analyze
Symbol: Slc4a2
Name: solute carrier family 4 member 2
RGD ID: 3711
Description: Enables chloride:bicarbonate antiporter activity and enzyme binding activity. Involved in digestive tract development; regulation of intracellular pH; and spermatogenesis. Located in apical plasma membrane and basolateral plasma membrane. Biomarker of autosomal recessive polycystic kidney disease and prediabetes syndrome. Human ortholog(s) of this gene implicated in osteopetrosis. Orthologous to human SLC4A2 (solute carrier family 4 member 2); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic AMP; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AE 2; Ae2; AE2 Cl-/HCO3-exchanger, variant AE2b; Aep2; anion exchange protein 2; anion exchanger 2; B3RP-2; band 3-related protein 2; non-erythroid band 3-like protein; solute carrier family 4 (anion exchanger), member 2; Solute carrier family 4 member 2 anion exchange protein 2; solute carrier family 4, member 2; Solute carrier family 4, member 2, anion exchange protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   BpQTLcluster5  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,628,860 - 11,646,961 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl411,628,862 - 11,645,402 (-)EnsemblGRCr8
mRatBN7.2410,736,419 - 10,754,407 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,736,425 - 10,752,965 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx415,882,663 - 15,899,242 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,702,854 - 11,719,435 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,054,638 - 10,071,219 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,264,677 - 7,282,355 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,264,683 - 7,281,223 (-)Ensemblrn6Rnor6.0
Rnor_5.047,276,041 - 7,294,088 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.446,100,783 - 6,117,982 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera46,350,986 - 6,367,533 (-)NCBICelera
RGSC_v3.146,100,782 - 6,117,982 (-)NCBI
Cytogenetic Map4q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic AMP  (EXP)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
alachlor  (EXP)
ammonium chloride  (EXP)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzoic acid  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Boldine  (EXP)
boric acid  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dapsone  (EXP)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
diquat  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
fenamidone  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
glycoursodeoxycholic acid  (ISO)
hydrogencarbonate  (EXP,ISO)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP)
nicotinic acid  (ISO)
nitric oxide  (EXP)
ozone  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (EXP)
propionic acid  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triptonide  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IBA,IDA,IEA)
basolateral plasma membrane  (IBA,IDA,IEA,ISO)
membrane  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats. Aitman TJ, etal., Nat Genet 1997 Jun;16(2):197-201
2. Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease. Banales JM, etal., Am J Pathol. 2008 Dec;173(6):1637-46. Epub 2008 Nov 6.
3. Bicarbonate-rich choleresis induced by secretin in normal rat is taurocholate-dependent and involves AE2 anion exchanger. Banales JM, etal., Hepatology. 2006 Feb;43(2):266-75.
4. Effect of prediabetes on membrane bicarbonate transporters in testis and epididymis. Bernardino RL, etal., J Membr Biol. 2013 Dec;246(12):877-83. doi: 10.1007/s00232-013-9601-4. Epub 2013 Oct 9.
5. Regulation of AE2 Cl-/HCO3- exchanger during intestinal development. Chow A, etal., Am J Physiol. 1996 Aug;271(2 Pt 1):G330-7.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Primary structure of a sperm cell anion exchanger and its messenger ribonucleic acid expression during spermatogenesis. Holappa K, etal., Biol Reprod. 1999 Oct;61(4):981-6.
9. cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3- exchanger. Kudrycki KE, etal., J Biol Chem 1990 Jan 5;265(1):462-71.
10. Functional expression and subcellular localization of an anion exchanger cloned from choroid plexus. Lindsey AE, etal., Proc Natl Acad Sci U S A. 1990 Jul;87(14):5278-82. doi: 10.1073/pnas.87.14.5278.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters. Morgan PE, etal., Am J Physiol Cell Physiol. 2007 Aug;293(2):C738-48. Epub 2007 Jul 25.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. A SCL4A10 gene product maps selectively to the basolateral plasma membrane of choroid plexus epithelial cells. Praetorius J, etal., Am J Physiol Cell Physiol. 2004 Mar;286(3):C601-10. Epub 2003 Oct 30.
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Immunolocalization of anion exchanger AE2 and Na(+)-HCO(-)(3) cotransporter in rat parotid and submandibular glands. Roussa E, etal., Am J Physiol. 1999 Dec;277(6 Pt 1):G1288-96.
19. Guanylin and functional coupling proteins in the hepatobiliary system of rat and guinea pig. Schwabe K and Cetin Y, Histochem Cell Biol. 2012 May;137(5):589-97. doi: 10.1007/s00418-012-0927-2. Epub 2012 Feb 7.
20. Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3. Simon JS, etal., Mamm Genome 1996 May;7(5):380-2.
21. Vacuolar H+-ATPase expression is increased in acid-secreting intercalated cells in kidneys of rats with hypercalcaemia-induced alkalosis. Wang W, etal., Acta Physiol (Oxf). 2007 Apr;189(4):359-68.
Additional References at PubMed
PMID:8631828   PMID:14749257   PMID:15184086   PMID:15579501   PMID:16575514   PMID:17690150   PMID:19946888   PMID:21423176   PMID:21705333   PMID:22871113   PMID:23059814   PMID:24192602  
PMID:26319954  


Genomics

Comparative Map Data
Slc4a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,628,860 - 11,646,961 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl411,628,862 - 11,645,402 (-)EnsemblGRCr8
mRatBN7.2410,736,419 - 10,754,407 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,736,425 - 10,752,965 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx415,882,663 - 15,899,242 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,702,854 - 11,719,435 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,054,638 - 10,071,219 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,264,677 - 7,282,355 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,264,683 - 7,281,223 (-)Ensemblrn6Rnor6.0
Rnor_5.047,276,041 - 7,294,088 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.446,100,783 - 6,117,982 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera46,350,986 - 6,367,533 (-)NCBICelera
RGSC_v3.146,100,782 - 6,117,982 (-)NCBI
Cytogenetic Map4q11NCBI
SLC4A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387151,058,200 - 151,076,527 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7151,057,210 - 151,076,527 (+)Ensemblhg38GRCh38
GRCh377150,755,287 - 150,773,614 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,387,590 - 150,404,547 (+)NCBIBuild 36Build 36hg18NCBI36
Build 347150,194,386 - 150,211,257NCBI
Celera7145,313,966 - 145,330,946 (+)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,567,635 - 144,585,988 (+)NCBIHuRef
CHM1_17150,763,647 - 150,782,011 (+)NCBICHM1_1
T2T-CHM13v2.07152,231,288 - 152,249,645 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27150,084,838 - 150,103,154 (+)NCBI
Slc4a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39524,628,834 - 24,645,945 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl524,628,835 - 24,645,948 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38524,423,761 - 24,440,947 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,423,837 - 24,440,950 (+)Ensemblmm10GRCm38
MGSCv37523,931,050 - 23,946,765 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36523,935,384 - 23,951,010 (+)NCBIMGSCv36mm8
Celera521,375,044 - 21,390,745 (+)NCBICelera
Cytogenetic Map5A3NCBI
cM Map511.74NCBI
Slc4a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,499,033 - 5,517,319 (+)Ensembl
ChiLan1.0NW_0049554915,498,472 - 5,513,389 (+)NCBIChiLan1.0ChiLan1.0
SLC4A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26187,481,654 - 187,498,469 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1739,494,100 - 39,508,738 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07142,646,413 - 142,663,376 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17154,799,256 - 154,815,919 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7154,799,256 - 154,815,919 (+)EnsemblpanPan2panpan1.1
SLC4A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11615,111,078 - 15,126,618 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1615,111,116 - 15,126,617 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1615,719,293 - 15,734,862 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01616,833,273 - 16,848,983 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1616,833,256 - 16,848,981 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11615,205,711 - 15,221,294 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,787,162 - 15,802,688 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,837,873 - 15,853,424 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc4a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,403,528 - 6,418,117 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,485,511 - 6,499,924 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365276,485,566 - 6,499,901 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC4A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,149,459 - 6,165,212 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1186,149,459 - 6,166,622 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,513,563 - 6,532,069 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC4A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,240,352 - 119,258,920 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21119,241,490 - 119,263,193 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607215,211,406 - 15,229,713 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc4a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248005,545,380 - 5,560,789 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc4a2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16153,617,165 - 153,634,464 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc4a2
67 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:62
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000019666
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4132668025Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4128392287Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4132668025Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4134142783Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4134142783Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4131106810Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4128392287Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4132668025Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4128392287Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4842855130449094Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4133538816Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4132668025Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41075870140490708Rat

Markers in Region
D4Bro1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8411,642,701 - 11,642,865 (+)Marker Load Pipeline
mRatBN7.2410,750,264 - 10,750,427 (+)MAPPERmRatBN7.2
Rnor_6.047,278,523 - 7,278,685NCBIRnor6.0
Rnor_5.047,289,887 - 7,290,049UniSTSRnor5.0
RGSC_v3.446,115,281 - 6,115,444RGDRGSC3.4
RGSC_v3.446,115,282 - 6,115,444UniSTSRGSC3.4
Celera46,364,827 - 6,364,989UniSTS
RGSC_v3.146,115,281 - 6,115,444RGD
RH 3.4 Map45.3RGD
Cytogenetic Map4q11UniSTS
D4Wox29  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2410,750,268 - 10,750,383 (+)MAPPERmRatBN7.2
Rnor_6.047,278,527 - 7,278,641NCBIRnor6.0
Rnor_5.047,289,891 - 7,290,005UniSTSRnor5.0
RGSC_v3.446,115,286 - 6,115,400UniSTSRGSC3.4
Celera46,364,831 - 6,364,945UniSTS
Cytogenetic Map4q11UniSTS
d4bro1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8411,642,701 - 11,642,864 (+)Marker Load Pipeline
mRatBN7.2410,750,264 - 10,750,427 (+)MAPPERmRatBN7.2
Rnor_6.047,278,523 - 7,278,685NCBIRnor6.0
Rnor_5.047,289,887 - 7,290,049UniSTSRnor5.0
RGSC_v3.446,115,282 - 6,115,444UniSTSRGSC3.4
Celera46,364,827 - 6,364,989UniSTS
RH 3.4 Map45.3UniSTS
Cytogenetic Map4q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC099360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ288902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U45885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U45886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U45887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000019666   ⟹   ENSRNOP00000019666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl411,628,862 - 11,645,402 (-)Ensembl
mRatBN7.2 Ensembl410,736,425 - 10,752,965 (-)Ensembl
Rnor_6.0 Ensembl47,264,683 - 7,281,223 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108170   ⟹   ENSRNOP00000096662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl411,628,862 - 11,641,906 (-)Ensembl
mRatBN7.2 Ensembl410,736,425 - 10,749,469 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109153   ⟹   ENSRNOP00000077917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl411,628,862 - 11,641,386 (-)Ensembl
mRatBN7.2 Ensembl410,736,425 - 10,748,949 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111245   ⟹   ENSRNOP00000077442
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl411,628,862 - 11,642,834 (-)Ensembl
mRatBN7.2 Ensembl410,736,425 - 10,750,071 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118763   ⟹   ENSRNOP00000076462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,736,425 - 10,749,130 (-)Ensembl
RefSeq Acc Id: NM_017048   ⟹   NP_058744
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,628,862 - 11,645,402 (-)NCBI
mRatBN7.2410,736,425 - 10,752,965 (-)NCBI
Rnor_6.047,264,683 - 7,281,223 (-)NCBI
Rnor_5.047,276,041 - 7,294,088 (-)NCBI
RGSC_v3.446,100,783 - 6,117,982 (-)RGD
Celera46,350,986 - 6,367,533 (-)RGD
Sequence:
RefSeq Acc Id: XM_006235874   ⟹   XP_006235936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,628,860 - 11,646,961 (-)NCBI
mRatBN7.2410,736,419 - 10,754,082 (-)NCBI
Rnor_6.047,264,677 - 7,282,355 (-)NCBI
Rnor_5.047,276,041 - 7,294,088 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235875   ⟹   XP_006235937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,628,860 - 11,645,161 (-)NCBI
mRatBN7.2410,736,419 - 10,752,562 (-)NCBI
Rnor_6.047,264,677 - 7,280,986 (-)NCBI
Rnor_5.047,276,041 - 7,294,088 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235877   ⟹   XP_006235939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,628,860 - 11,642,606 (-)NCBI
mRatBN7.2410,736,419 - 10,750,170 (-)NCBI
Rnor_6.047,264,677 - 7,278,900 (-)NCBI
Rnor_5.047,276,041 - 7,294,088 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107064   ⟹   XP_038962992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,628,860 - 11,646,915 (-)NCBI
mRatBN7.2410,736,419 - 10,754,407 (-)NCBI
RefSeq Acc Id: XM_039107065   ⟹   XP_038962993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,628,860 - 11,645,142 (-)NCBI
mRatBN7.2410,736,419 - 10,752,581 (-)NCBI
RefSeq Acc Id: NP_058744   ⟸   NM_017048
- UniProtKB: P23347 (UniProtKB/Swiss-Prot),   A6K551 (UniProtKB/TrEMBL),   A0A8I6AM83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235936   ⟸   XM_006235874
- Peptide Label: isoform X1
- UniProtKB: P23347 (UniProtKB/Swiss-Prot),   A6K551 (UniProtKB/TrEMBL),   A0A8I6AM83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235937   ⟸   XM_006235875
- Peptide Label: isoform X1
- UniProtKB: P23347 (UniProtKB/Swiss-Prot),   A6K551 (UniProtKB/TrEMBL),   A0A8I6AM83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235939   ⟸   XM_006235877
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y5U0 (UniProtKB/TrEMBL),   A0A8I6AM83 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019666   ⟸   ENSRNOT00000019666
RefSeq Acc Id: XP_038962992   ⟸   XM_039107064
- Peptide Label: isoform X1
- UniProtKB: P23347 (UniProtKB/Swiss-Prot),   A6K551 (UniProtKB/TrEMBL),   A0A8I6AM83 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962993   ⟸   XM_039107065
- Peptide Label: isoform X1
- UniProtKB: P23347 (UniProtKB/Swiss-Prot),   A6K551 (UniProtKB/TrEMBL),   A0A8I6AM83 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077442   ⟸   ENSRNOT00000111245
Ensembl Acc Id: ENSRNOP00000096662   ⟸   ENSRNOT00000108170
Ensembl Acc Id: ENSRNOP00000077917   ⟸   ENSRNOT00000109153
Ensembl Acc Id: ENSRNOP00000076462   ⟸   ENSRNOT00000118763
Protein Domains
Band 3 cytoplasmic   Bicarbonate transporter-like transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23347-F1-model_v2 AlphaFold P23347 1-1234 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692789
Promoter ID:EPDNEW_R3314
Type:initiation region
Name:Slc4a2_1
Description:solute carrier family 4 member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.047,281,248 - 7,281,308EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3711 AgrOrtholog
BioCyc Gene G2FUF-46043 BioCyc
Ensembl Genes ENSRNOG00000014347 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019666 ENTREZGENE
  ENSRNOT00000019666.3 UniProtKB/Swiss-Prot
  ENSRNOT00000111245 ENTREZGENE
Gene3D-CATH Helical hairpin bin UniProtKB/Swiss-Prot
  Mannitol-specific EII, Chain A UniProtKB/Swiss-Prot
InterPro Anion_exchange UniProtKB/Swiss-Prot
  Anion_exchange_2 UniProtKB/Swiss-Prot
  Anion_exchange_CS UniProtKB/Swiss-Prot
  Band3_cytoplasmic_dom UniProtKB/Swiss-Prot
  HCO3_transpt_C UniProtKB/Swiss-Prot
  HCO3_transpt_euk UniProtKB/Swiss-Prot
  PTrfase/Anion_transptr UniProtKB/Swiss-Prot
KEGG Report rno:24780 UniProtKB/Swiss-Prot
NCBI Gene 24780 ENTREZGENE
PANTHER PTHR11453 UniProtKB/Swiss-Prot
  PTHR11453:SF14 UniProtKB/Swiss-Prot
Pfam Band_3_cyto UniProtKB/Swiss-Prot
  HCO3_cotransp UniProtKB/Swiss-Prot
PhenoGen Slc4a2 PhenoGen
PRINTS ANIONEXCHNGR UniProtKB/Swiss-Prot
  ANIONEXHNGR2 UniProtKB/Swiss-Prot
  HCO3TRNSPORT UniProtKB/Swiss-Prot
PROSITE ANION_EXCHANGER_1 UniProtKB/Swiss-Prot
  ANION_EXCHANGER_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014347 RatGTEx
Superfamily-SCOP SSF55804 UniProtKB/Swiss-Prot
UniProt A0A8I5Y267_RAT UniProtKB/TrEMBL
  A0A8I5Y5U0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AM83 ENTREZGENE, UniProtKB/TrEMBL
  A6K551 ENTREZGENE, UniProtKB/TrEMBL
  A6K553_RAT UniProtKB/TrEMBL
  A6K554_RAT UniProtKB/TrEMBL
  A6K555_RAT UniProtKB/TrEMBL
  B3A2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc4a2  solute carrier family 4 member 2  Slc4a2  solute carrier family 4 (anion exchanger), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Slc4a2  solute carrier family 4 (anion exchanger), member 2  Slc4a2  solute carrier family 4, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Slc4a2  solute carrier family 4, member 2    Solute carrier family 4, member 2, anion exchange protein 2  Name updated 629478 APPROVED
2002-06-10 Slc4a2  Solute carrier family 4, member 2, anion exchange protein 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed highly in stomach 729955
gene_function may contribute in the development of hypertension in SHRSP and SHR rats 1342444
gene_protein predicted protein consists of 1234 aa residues and masses 135 kDa 729955