Slc22a3 (solute carrier family 22 member 3) - Rat Genome Database

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Gene: Slc22a3 (solute carrier family 22 member 3) Rattus norvegicus
Analyze
Symbol: Slc22a3
Name: solute carrier family 22 member 3
RGD ID: 3701
Description: Enables several functions, including dopamine:sodium symporter activity; organic cation transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including epinephrine transport; monoamine transport; and spermidine transport. Located in apical plasma membrane; endomembrane system; and mitochondrial membrane. Orthologous to human SLC22A3 (solute carrier family 22 member 3); PARTICIPATES IN lamivudine pharmacokinetics pathway; metformin pharmacokinetics pathway; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; 1,1'-diethyl-2,2'-cyanine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: EMT; extraneuronal monoamine transporter; OCT3; organic cation transporter 3; solute carrier family 22 (extraneuronal monoamine transporter), member 3; solute carrier family 22 (organic cation transporter), member 3; solute carrier family 22, member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,783,218 - 50,872,358 (+)NCBIGRCr8
mRatBN7.2148,235,476 - 48,324,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,235,476 - 48,324,612 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,927,055 - 49,016,211 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,912,824 - 55,001,976 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,002,573 - 49,091,712 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,433,079 - 48,521,261 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,433,079 - 48,521,256 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,234,467 - 51,321,364 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,690,158 - 42,781,895 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,693,102 - 42,784,835 (+)NCBI
Celera144,028,160 - 44,116,659 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
1,1'-diethyl-2,2'-cyanine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-methylnicotinamide  (ISO)
11-deoxycorticosterone  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-[2-(ethylamino)-1-hydroxyethyl]phenol  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
atorvastatin calcium  (ISO)
atropine  (ISO)
barium(0)  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-carboline  (ISO)
bisphenol A  (EXP,ISO)
budesonide  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carvedilol  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
cimetidine  (ISO)
cisplatin  (ISO)
clobenpropit  (EXP,ISO)
clonidine  (EXP,ISO)
clonidine (amino form)  (EXP,ISO)
clonidine (imino form)  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
desipramine  (EXP,ISO)
dextran sulfate  (ISO)
digoxin  (ISO)
diiodine  (ISO)
dioxygen  (ISO)
diphenhydramine  (ISO)
diquat  (ISO)
dopamine  (EXP,ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enzalutamide  (ISO)
ethanol  (ISO)
ethidium  (ISO)
famotidine  (ISO)
flecainide  (ISO)
fluticasone  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
Glu-P-1  (ISO)
Glu-P-2  (ISO)
glucose  (ISO)
guanidine  (EXP,ISO)
histamine  (EXP,ISO)
hydrogen peroxide  (ISO)
imipramine  (ISO)
Immepip  (EXP,ISO)
iodide salt  (EXP)
ipratropium  (ISO)
lamivudine  (ISO)
lead diacetate  (ISO)
lidocaine  (ISO)
MeIQ  (ISO)
MeIQx  (ISO)
menadione  (ISO)
mercaptopurine  (EXP)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP)
mifepristone  (ISO)
molsidomine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nifedipine  (ISO)
ozone  (ISO)
paclitaxel  (EXP,ISO)
papaverine  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
pentanal  (ISO)
perchlorate  (EXP)
phenobarbital  (ISO)
Phenoxybenzamine  (ISO)
phentolamine  (EXP,ISO)
phenylephrine  (EXP)
PhIP  (ISO)
pirinixic acid  (ISO)
potassium atom  (ISO)
prazosin  (ISO)
procainamide  (ISO)
progesterone  (EXP,ISO)
propafenone  (ISO)
propanal  (ISO)
propranolol  (ISO)
purine-6-thiol  (EXP)
quercetin  (EXP,ISO)
quinidine  (ISO)
quinine  (ISO)
quinolin-8-ol  (ISO)
ranitidine  (ISO)
Salmeterol xinafoate  (ISO)
serotonin  (EXP,ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
spironolactone  (ISO)
sulpiride  (ISO)
synephrine  (EXP)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetraethylammonium  (EXP,ISO)
thioacetamide  (EXP)
Thioperamide  (EXP,ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
trimazosin  (EXP,ISO)
trimethoprim  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
vincaleukoblastine  (ISO)
zearalenone  (ISO)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Amphoux A, etal., Neuropharmacology. 2006 Jun;50(8):941-52. doi: 10.1016/j.neuropharm.2006.01.005. Epub 2006 Mar 31.
2. Organic cation transporter 3 (OCT3) is localized to intracellular and surface membranes in select glial and neuronal cells within the basolateral amygdaloid complex of both rats and mice. Gasser PJ, etal., Brain Struct Funct. 2017 May;222(4):1913-1928. doi: 10.1007/s00429-016-1315-9. Epub 2016 Sep 22.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Metformin pathways: pharmacokinetics and pharmacodynamics. Gong L, etal., Pharmacogenet Genomics. 2012 Nov;22(11):820-7. doi: 10.1097/FPC.0b013e3283559b22.
6. Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Grundemann D, etal., Br J Pharmacol. 2002 Nov;137(6):910-8.
7. Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. Kekuda R, etal., J Biol Chem 1998 Jun 26;273(26):15971-9.
8. Lack of a primary physicochemical determinant in the direct transport of drugs to the brain after nasal administration in rats: potential involvement of transporters in the pathway. Lee KR, etal., Drug Metab Pharmacokinet. 2010;25(5):430-41. doi: 10.2133/dmpk.dmpk-10-rg-049. Epub 2010 Sep 30.
9. Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. Lips KS, etal., Am J Respir Cell Mol Biol. 2005 Jul;33(1):79-88. Epub 2005 Apr 7.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2, and OCT3. Sala-Rabanal M, etal., Mol Pharm. 2013 Apr 1;10(4):1450-8. doi: 10.1021/mp400024d. Epub 2013 Mar 19.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. Verhey KJ, etal., J Cell Biol. 2001 Mar 5;152(5):959-70.
19. Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. Wu X, etal., J Biol Chem. 1998 Dec 4;273(49):32776-86.
20. Renal tumours in a Tsc1(+)/(-) mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin. Yang J, etal., Eur J Cancer. 2013 Apr;49(6):1479-90. doi: 10.1016/j.ejca.2012.10.027. Epub 2012 Dec 7.
Additional References at PubMed
PMID:10966924   PMID:11390648   PMID:15028779   PMID:16024787   PMID:16061728   PMID:19141712   PMID:20858707   PMID:28543680  


Genomics

Comparative Map Data
Slc22a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,783,218 - 50,872,358 (+)NCBIGRCr8
mRatBN7.2148,235,476 - 48,324,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,235,476 - 48,324,612 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,927,055 - 49,016,211 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,912,824 - 55,001,976 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,002,573 - 49,091,712 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,433,079 - 48,521,261 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,433,079 - 48,521,256 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,234,467 - 51,321,364 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,690,158 - 42,781,895 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,693,102 - 42,784,835 (+)NCBI
Celera144,028,160 - 44,116,659 (+)NCBICelera
Cytogenetic Map1q11NCBI
SLC22A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386160,348,378 - 160,452,577 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6160,348,378 - 160,452,577 (+)EnsemblGRCh38hg38GRCh38
GRCh376160,769,410 - 160,873,609 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,689,415 - 160,796,004 (+)NCBINCBI36Build 36hg18NCBI36
Build 346160,739,835 - 160,846,425NCBI
Celera6161,420,905 - 161,527,486 (+)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6158,244,012 - 158,348,214 (+)NCBIHuRef
CHM1_16161,032,217 - 161,136,415 (+)NCBICHM1_1
T2T-CHM13v2.06161,598,508 - 161,702,771 (+)NCBIT2T-CHM13v2.0
Slc22a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391712,638,859 - 12,726,591 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1712,637,847 - 12,726,591 (-)EnsemblGRCm39 Ensembl
GRCm381712,419,972 - 12,507,704 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,418,960 - 12,507,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv371712,612,838 - 12,700,570 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,263,330 - 12,351,062 (-)NCBIMGSCv36mm8
Celera1712,450,734 - 12,539,105 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.52NCBI
Slc22a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543920,367,333 - 20,476,891 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543920,367,324 - 20,476,891 (-)NCBIChiLan1.0ChiLan1.0
SLC22A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25180,457,233 - 180,561,182 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16178,361,200 - 178,465,143 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06158,240,390 - 158,344,338 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16163,232,539 - 163,351,256 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6163,247,643 - 163,349,735 (+)Ensemblpanpan1.1panPan2
SLC22A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,407,949 - 49,496,627 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,407,966 - 49,496,620 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,250,859 - 50,339,627 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,593,106 - 49,681,894 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,593,126 - 49,681,430 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,475,470 - 49,564,251 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,347,643 - 49,435,978 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,962,647 - 50,051,070 (+)NCBIUU_Cfam_GSD_1.0
Slc22a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,441,761 - 144,522,387 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,693,755 - 11,772,628 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,693,755 - 11,774,380 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,110,074 - 7,207,401 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,105,486 - 7,207,395 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.218,787,403 - 8,885,452 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,971,305 - 88,076,468 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1387,971,392 - 88,074,946 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604060,348,130 - 60,452,975 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc22a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248552,399,671 - 2,516,237 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248552,402,096 - 2,516,249 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc22a3
658 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:255
Count of miRNA genes:166
Interacting mature miRNAs:204
Transcripts:ENSRNOT00000037369
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat

Markers in Region
RH132315  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,324,258 - 48,324,474 (+)MAPPERmRatBN7.2
Rnor_6.0148,520,903 - 48,521,118NCBIRnor6.0
Rnor_5.0151,234,610 - 51,234,825UniSTSRnor5.0
RGSC_v3.4142,781,537 - 42,781,752UniSTSRGSC3.4
Celera144,116,301 - 44,116,516UniSTS
RH 3.4 Map1586.6UniSTS
Cytogenetic Map1q11UniSTS
AU049521  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,303,745 - 48,303,907 (+)MAPPERmRatBN7.2
Rnor_6.0148,500,311 - 48,500,472NCBIRnor6.0
Rnor_5.0151,254,243 - 51,254,404UniSTSRnor5.0
RGSC_v3.4142,760,171 - 42,760,332UniSTSRGSC3.4
Celera144,095,535 - 44,095,696UniSTS
Cytogenetic Map1q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 9 8 2
Low 3 23 13 6 11 6 8 8 38 9 24 11 8
Below cutoff 18 23 23 23 3 16 18 17

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000037369   ⟹   ENSRNOP00000029748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl148,235,476 - 48,324,612 (+)Ensembl
Rnor_6.0 Ensembl148,433,079 - 48,521,256 (+)Ensembl
RefSeq Acc Id: NM_019230   ⟹   NP_062103
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,783,218 - 50,872,358 (+)NCBI
mRatBN7.2148,235,476 - 48,324,617 (+)NCBI
Rnor_6.0148,433,079 - 48,521,261 (+)NCBI
Rnor_5.0151,234,467 - 51,321,364 (-)NCBI
RGSC_v3.4142,690,158 - 42,781,895 (+)RGD
Celera144,028,160 - 44,116,659 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062103 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC40150 (Get FASTA)   NCBI Sequence Viewer  
  EDL83064 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029748
  ENSRNOP00000029748.2
  ENSRNOP00055039629
  ENSRNOP00060013024
  ENSRNOP00065041553
GenBank Protein O88446 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_062103   ⟸   NM_019230
- UniProtKB: O88446 (UniProtKB/Swiss-Prot),   A6KJX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000029748   ⟸   ENSRNOT00000037369
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88446-F1-model_v2 AlphaFold O88446 1-551 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3701 AgrOrtholog
BioCyc Gene G2FUF-61565 BioCyc
Ensembl Genes ENSRNOG00000022946 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055027821 UniProtKB/Swiss-Prot
  ENSRNOG00060009873 UniProtKB/Swiss-Prot
  ENSRNOG00065029272 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000037369 ENTREZGENE
  ENSRNOT00000037369.3 UniProtKB/Swiss-Prot
  ENSRNOT00055048168 UniProtKB/Swiss-Prot
  ENSRNOT00060016671 UniProtKB/Swiss-Prot
  ENSRNOT00065050567 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orgcat_transp/SVOP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29504 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29504 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 22 MEMBER 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sugar_tr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SLC22A3 RGD
PhenoGen Slc22a3 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022946 RatGTEx
  ENSRNOG00055027821 RatGTEx
  ENSRNOG00060009873 RatGTEx
  ENSRNOG00065029272 RatGTEx
Superfamily-SCOP MFS general substrate transporter UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC232883
UniProt A6KJX6 ENTREZGENE, UniProtKB/TrEMBL
  O88446 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Slc22a3  solute carrier family 22 member 3  Slc22a3  solute carrier family 22 (organic cation transporter), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc22a3  solute carrier family 22 (organic cation transporter), member 3  Slc22a3  solute carrier family 22 (extraneuronal monoamine transporter), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc22a3  solute carrier family 22 (extraneuronal monoamine transporter), member 3  Slc22a3  solute carrier family 22 (organic cation transporter), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-24 Slc22a3  solute carrier family 22 (organic cation transporter), member 3  Slc22a3  solute carrier family 22, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Slc22a3  solute carrier family 22, member 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression has highest mRNA expression in placenta 70010
gene_regulation transport activity is sensitive to membrane potential 70010