Slc18a1 (solute carrier family 18 member A1) - Rat Genome Database

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Gene: Slc18a1 (solute carrier family 18 member A1) Rattus norvegicus
Analyze
Symbol: Slc18a1
Name: solute carrier family 18 member A1
RGD ID: 3693
Description: Enables enzyme binding activity; monoamine:proton antiporter activity; and serotonin:sodium:chloride symporter activity. Involved in several processes, including cellular response to lithium ion; positive regulation of dopamine secretion; and serotonin uptake. Predicted to be located in endoplasmic reticulum membrane and secretory granule membrane. Predicted to be active in synaptic vesicle membrane and terminal bouton. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human SLC18A1 (solute carrier family 18 member A1); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CGAT; chromaffin granule amine transporter; LOC684870; similar to solute carrier family 18 (vesicular monoamine), member 1; solute carrier family 18 (vesicular monoamine transporter), member 1; solute carrier family 18 (vesicular monoamine), member 1; solute carrier family 18 member 1; solute carrier family 18, member 1; Solute carrier family18 (vesicular monoamine) member 1 (chromaffin granule amine transporter); VAT1; vesicular amine transporter 1; vesicular monoamine transporter 1; VMAT-1; VMAT1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81625,408,485 - 25,453,786 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1625,420,243 - 25,453,786 (+)EnsemblGRCr8
mRatBN7.21620,653,268 - 20,687,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1620,653,508 - 20,687,051 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1624,022,654 - 24,055,924 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01627,452,714 - 27,485,111 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01623,387,959 - 23,421,230 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01622,358,646 - 22,395,183 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1622,361,998 - 22,395,183 (+)Ensemblrn6Rnor6.0
Rnor_5.01622,256,523 - 22,289,704 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41622,356,304 - 22,389,827 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1620,629,165 - 20,846,643 (+)NCBICelera
RGSC_v3.11622,356,297 - 22,389,825 (+)NCBI
RH 3.4 Map16253.67RGD
Cytogenetic Map16p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The first luminal domain of vesicular monoamine transporters mediates G-protein-dependent regulation of transmitter uptake. Brunk I, etal., J Biol Chem. 2006 Nov 3;281(44):33373-85. Epub 2006 Aug 22.
2. Ca2+-dependent activator proteins of secretion promote vesicular monoamine uptake. Brunk I, etal., J Biol Chem. 2009 Jan 9;284(2):1050-6. Epub 2008 Nov 13.
3. A biochemical and functional protein complex involving dopamine synthesis and transport into synaptic vesicles. Cartier EA, etal., J Biol Chem. 2010 Jan 15;285(3):1957-66. Epub 2009 Nov 10.
4. Lithium ions Up-regulate mRNAs encoding dense-core vesicle proteins in nerve growth factor-differentiated PC12 cells. Cordeiro ML, etal., J Neurochem. 2000 Dec;75(6):2622-5.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Different expression of catecholamine transporters in phaeochromocytomas from patients with von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2. Huynh TT, etal., Eur J Endocrinol. 2005 Oct;153(4):551-63.
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter. Liu Y, etal., Cell 1992 Aug 21;70(4):539-51.
10. Association between polymorphisms in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) on chromosome 8p and schizophrenia. Lohoff FW, etal., Neuropsychobiology. 2008;57(1-2):55-60. Epub 2008 May 2.
11. Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorder. Lohoff FW, etal., Neuropsychopharmacology. 2006 Dec;31(12):2739-47. Epub 2006 Aug 23.
12. Vesicular monoamine transporter 1 mediates dopamine secretion in rat proximal tubular cells. Maurel A, etal., Am J Physiol Renal Physiol. 2007 May;292(5):F1592-8. Epub 2007 Jan 23.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. The chromaffin granule and synaptic vesicle amine transporters differ in substrate recognition and sensitivity to inhibitors. Peter D, etal., J Biol Chem. 1994 Mar 11;269(10):7231-7.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12534970   PMID:22253933   PMID:23201251   PMID:31955909  


Genomics

Comparative Map Data
Slc18a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81625,408,485 - 25,453,786 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1625,420,243 - 25,453,786 (+)EnsemblGRCr8
mRatBN7.21620,653,268 - 20,687,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1620,653,508 - 20,687,051 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1624,022,654 - 24,055,924 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01627,452,714 - 27,485,111 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01623,387,959 - 23,421,230 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01622,358,646 - 22,395,183 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1622,361,998 - 22,395,183 (+)Ensemblrn6Rnor6.0
Rnor_5.01622,256,523 - 22,289,704 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41622,356,304 - 22,389,827 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1620,629,165 - 20,846,643 (+)NCBICelera
RGSC_v3.11622,356,297 - 22,389,825 (+)NCBI
RH 3.4 Map16253.67RGD
Cytogenetic Map16p14NCBI
SLC18A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38820,144,855 - 20,183,136 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl820,144,855 - 20,183,206 (-)Ensemblhg38GRCh38
GRCh37820,002,366 - 20,040,647 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36820,046,652 - 20,084,997 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34820,046,651 - 20,084,997NCBI
Celera818,964,997 - 19,003,346 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef818,542,580 - 18,580,897 (-)NCBIHuRef
CHM1_1820,204,176 - 20,242,504 (-)NCBICHM1_1
T2T-CHM13v2.0820,409,985 - 20,448,250 (-)NCBIT2T-CHM13v2.0
Slc18a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39869,490,360 - 69,547,951 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl869,490,363 - 69,541,887 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38869,037,708 - 69,089,238 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl869,037,711 - 69,089,235 (-)Ensemblmm10GRCm38
MGSCv37871,561,607 - 71,613,121 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36871,966,697 - 72,018,211 (-)NCBIMGSCv36mm8
Celera871,585,811 - 71,639,074 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map833.88NCBI
Slc18a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540343,821,296 - 43,848,399 (-)Ensembl
ChiLan1.0NW_00495540343,821,978 - 43,848,403 (-)NCBIChiLan1.0ChiLan1.0
SLC18A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2738,626,188 - 38,662,488 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1814,351,749 - 14,388,069 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0819,369,843 - 19,408,412 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1816,318,744 - 16,353,708 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl816,318,744 - 16,353,708 (-)EnsemblpanPan2panpan1.1
SLC18A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12536,859,047 - 36,904,057 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2536,872,636 - 36,904,056 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2537,453,565 - 37,498,544 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02537,085,789 - 37,130,930 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2537,105,537 - 37,130,929 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12537,021,486 - 37,066,607 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02536,869,997 - 36,915,036 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02537,038,820 - 37,083,968 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc18a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494314,299,001 - 14,321,190 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365554,249,821 - 4,271,379 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365554,249,821 - 4,271,379 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC18A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl144,243,557 - 4,275,243 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1144,243,553 - 4,279,341 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2144,278,115 - 4,313,822 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC18A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1818,214,703 - 18,250,025 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl818,214,701 - 18,249,731 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605224,002,943 - 24,037,546 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc18a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475815,864,204 - 15,894,529 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475815,863,410 - 15,894,958 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc18a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11320,369,625 - 20,400,078 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc18a1
376 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:50
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000016193
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161574800625801629Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)161627818427244292Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338679026128267Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat

Markers in Region
RH94391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21620,686,870 - 20,687,031 (+)MAPPERmRatBN7.2
Rnor_6.01622,395,003 - 22,395,163NCBIRnor6.0
Rnor_5.01622,289,524 - 22,289,684UniSTSRnor5.0
RGSC_v3.41622,389,647 - 22,389,807UniSTSRGSC3.4
Celera1620,846,463 - 20,846,623UniSTS
RH 3.4 Map16253.67UniSTS
Cytogenetic Map16p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 2 59 133 67 60 41 21 41 6 228 102 6 108 67 69 19 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000016193   ⟹   ENSRNOP00000016193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1625,420,243 - 25,453,786 (+)Ensembl
mRatBN7.2 Ensembl1620,653,508 - 20,687,051 (+)Ensembl
Rnor_6.0 Ensembl1622,361,998 - 22,395,183 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106291   ⟹   ENSRNOP00000082299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1625,420,243 - 25,453,786 (+)Ensembl
mRatBN7.2 Ensembl1620,653,508 - 20,687,051 (+)Ensembl
RefSeq Acc Id: NM_013152   ⟹   NP_037284
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81625,420,247 - 25,453,786 (+)NCBI
mRatBN7.21620,653,512 - 20,687,051 (+)NCBI
Rnor_6.01622,362,002 - 22,395,183 (+)NCBI
Rnor_5.01622,256,523 - 22,289,704 (+)NCBI
RGSC_v3.41622,356,304 - 22,389,827 (+)RGD
Celera1620,629,165 - 20,846,643 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094220   ⟹   XP_038950148
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81625,408,485 - 25,453,786 (+)NCBI
mRatBN7.21620,653,268 - 20,687,051 (+)NCBI
RefSeq Acc Id: XM_063275099   ⟹   XP_063131169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81625,408,485 - 25,453,786 (+)NCBI
RefSeq Acc Id: XM_063275100   ⟹   XP_063131170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81625,408,534 - 25,453,786 (+)NCBI
RefSeq Acc Id: XM_063275101   ⟹   XP_063131171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81625,408,523 - 25,453,786 (+)NCBI
RefSeq Acc Id: XM_063275102   ⟹   XP_063131172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81625,408,528 - 25,453,786 (+)NCBI
RefSeq Acc Id: XM_063275103   ⟹   XP_063131173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81625,408,485 - 25,453,786 (+)NCBI
RefSeq Acc Id: XM_063275104   ⟹   XP_063131174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81625,408,485 - 25,443,565 (+)NCBI
RefSeq Acc Id: XR_010058277
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81625,408,485 - 25,451,602 (+)NCBI
RefSeq Acc Id: XR_010058278
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81625,408,485 - 25,449,553 (+)NCBI
RefSeq Acc Id: NP_037284   ⟸   NM_013152
- UniProtKB: Q01818 (UniProtKB/Swiss-Prot),   F1LSA7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016193   ⟸   ENSRNOT00000016193
RefSeq Acc Id: XP_038950148   ⟸   XM_039094220
- Peptide Label: isoform X2
- UniProtKB: Q01818 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000082299   ⟸   ENSRNOT00000106291
RefSeq Acc Id: XP_063131169   ⟸   XM_063275099
- Peptide Label: isoform X1
- UniProtKB: Q01818 (UniProtKB/Swiss-Prot),   F1LSA7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131173   ⟸   XM_063275103
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063131174   ⟸   XM_063275104
- Peptide Label: isoform X4
- UniProtKB: A6KU71 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131171   ⟸   XM_063275101
- Peptide Label: isoform X1
- UniProtKB: Q01818 (UniProtKB/Swiss-Prot),   F1LSA7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131172   ⟸   XM_063275102
- Peptide Label: isoform X1
- UniProtKB: Q01818 (UniProtKB/Swiss-Prot),   F1LSA7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131170   ⟸   XM_063275100
- Peptide Label: isoform X1
- UniProtKB: Q01818 (UniProtKB/Swiss-Prot),   F1LSA7 (UniProtKB/TrEMBL)
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01818-F1-model_v2 AlphaFold Q01818 1-521 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3693 AgrOrtholog
BioCyc Gene G2FUF-11702 BioCyc
Ensembl Genes ENSRNOG00000011992 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016193 ENTREZGENE
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
InterPro MFS UniProtKB/Swiss-Prot
  MFS_dom UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  MFS_Vesicular_Transporter UniProtKB/Swiss-Prot
  Multidrug-R UniProtKB/Swiss-Prot
KEGG Report rno:25693 UniProtKB/Swiss-Prot
NCBI Gene 25693 ENTREZGENE
PANTHER CHROMAFFIN GRANULE AMINE TRANSPORTER UniProtKB/Swiss-Prot
  PTHR23506 UniProtKB/Swiss-Prot
Pfam MFS_1 UniProtKB/Swiss-Prot
PhenoGen Slc18a1 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011992 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
TIGR TC216694
UniProt A0A8I5ZTW4_RAT UniProtKB/TrEMBL
  A6KU71 ENTREZGENE, UniProtKB/TrEMBL
  F1LSA7 ENTREZGENE, UniProtKB/TrEMBL
  Q01818 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Slc18a1  solute carrier family 18 member A1  Slc18a1  solute carrier family 18 member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Slc18a1  solute carrier family 18 member 1  Slc18a1  solute carrier family 18 (vesicular monoamine transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc18a1  solute carrier family 18 (vesicular monoamine transporter), member 1  Slc18a1  solute carrier family 18 (vesicular monoamine), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-12 Slc18a1  solute carrier family 18 (vesicular monoamine), member 1  LOC684870  similar to solute carrier family 18 (vesicular monoamine), member 1  Data merged from RGD:1585526 737654 PROVISIONAL
2006-11-19 LOC684870  similar to solute carrier family 18 (vesicular monoamine), member 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Slc18a1  solute carrier family 18 (vesicular monoamine), member 1    solute carrier family 18, member 1  Name updated 1299863 APPROVED
2003-04-09 Slc18a1  solute carrier family 18, member 1    Solute carrier family18 (vesicular monoamine) member 1 (chromaffin granule amine transporter)  Name updated 629478 APPROVED
2002-06-10 Slc18a1  Solute carrier family18 (vesicular monoamine) member 1 (chromaffin granule amine transporter)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed exclusively in adrenal gland 729674