Slc14a2 (solute carrier family 14 member 2)

Gene: Slc14a2 (solute carrier family 14 member 2) Rattus norvegicus

Analyze

Symbol:

Slc14a2

Name:

solute carrier family 14 member 2

RGD ID:

3689

Description:

Enables urea transmembrane transporter activity. Involved in urea transport. Located in apical plasma membrane. Orthologous to human SLC14A2 (solute carrier family 14 member 2); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH (R)-noradrenaline; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

plasma membrane urea transporter; Slc14a1_v3; Slc14a1_v4; Slc14a2_v4; Slc14a2T; solute carrier family 14 (urea transporter), member 2; solute carrier family 14 (urea transporter), member 2, variant 4; solute carrier family 14 (urea transporter), member 2T; solute carrier family 14, member 2; testName; testSymbol; urea transport protein; Urea transporter; urea transporter 2; urea transporter UT-A2c; urea transporter UT-A2d; urea transporter, kidney; UrT1-C; UrT1-D; UT-A1; UT-A2; UT-A4; UTA3

RGD Orthologs

Alliance Genes

More Info

more info ...

Allele / Splice:

Slc14a2_v1 Slc14a2_v2 Slc14a2_v3

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

NCBI Annotation Information:

Annotation category: suggests misassembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	18	71,612,460 - 72,039,462 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	71,612,460 - 71,792,968 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	73,711,878 - 74,138,787 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	74,381,161 - 74,808,122 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	72,237,749 - 72,664,708 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	74,508,070 - 74,941,389 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	74,508,069 - 74,542,077 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	18	74,546,220 - 74,688,551 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	74,185,426 - 74,617,691 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	75,071,416 - 75,499,738 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	75,144,693 - 75,325,630 (-)	NCBI
Celera	18	70,129,421 - 70,555,892 (-)	NCBI		Celera
Cytogenetic Map	18	q12.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

intellectual disability (ISO)

Microcephaly, Epilepsy, and Diabetes Syndrome (ISO)

Vici syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(R)-noradrenaline (EXP)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

Allylamine (EXP)

amiodarone (ISO)

ammonium chloride (EXP)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroquine (ISO)

cocaine (EXP)

decabromodiphenyl ether (EXP)

diarsenic trioxide (ISO)

dichlorine (EXP)

doxorubicin (EXP)

fenvalerate (EXP)

flavonoids (EXP)

folic acid (ISO)

fulvestrant (ISO)

hydroxyurea (ISO)

indole-3-methanol (EXP)

lipopolysaccharide (ISO)

lithium atom (ISO)

lithium hydride (ISO)

methamphetamine (ISO)

methapyrilene (ISO)

methoxychlor (EXP)

N-acetyl-L-cysteine (EXP)

N-nitrosodiethylamine (EXP)

ozone (EXP,ISO)

paracetamol (ISO)

phenethyl caffeate (EXP)

phloretin (EXP)

pirinixic acid (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP)

thiourea (EXP)

titanium dioxide (ISO)

toluene (EXP)

urea (EXP,ISO)

valproic acid (ISO)

vanadium atom (ISO)

vanadium(0) (ISO)

vancomycin (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

urea transmembrane transport (IBA,IEA,ISO)

urea transport (IDA,NAS)

Cellular Component

apical plasma membrane (IDA,ISO)

basolateral plasma membrane (ISO)

plasma membrane (IDA,IEA,ISO)

Molecular Function

cell adhesion molecule binding (ISO)

protein binding (IPI,ISO)

urea transmembrane transporter activity (IDA,IEA,ISO,NAS)

Molecular Pathway Annotations Click to see Annotation Detail View

amiloride pharmacodynamics pathway (ISO)

bendroflumethiazide pharmacodynamics pathway (ISO)

bumetanide pharmacodynamics pathway (ISO)

chlorothiazide pharmacodynamics pathway (ISO)

chlorthalidone pharmacodynamics pathway (ISO)

cystinuria pathway (ISO)

eplerenone pharmacodynamics pathway (ISO)

etacrynic acid pharmacodynamics pathway (ISO)

furosemide pharmacodynamics pathway (ISO)

Hartnup disease pathway (ISO)

hydrochlorothiazide pharmacodynamics pathway (ISO)

hydroflumethiazide pharmacodynamics pathway (ISO)

iminoglycinuria pathway (ISO)

lysinuric protein intolerance pathway (ISO)

metolazone pharmacodynamics pathway (ISO)

spironolactone pharmacodynamics pathway (ISO)

torasemide pharmacodynamics pathway (ISO)

triamterene pharmacodynamics pathway (ISO)

trichlormethiazide pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Molecular characterization of a novel UT-A urea transporter isoform (UT-A5) in testis.	Fenton RA, etal., Am J Physiol Cell Physiol 2000 Nov;279(5):C1425-31.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Cloning and characterization of two new isoforms of the rat kidney urea transporter: UT-A3 and UT-A4.	Karakashian A, etal., J Am Soc Nephrol 1999 Feb;10(2):230-7.
5.	Expression of urea transporters in the developing rat kidney.	Kim YH, etal., Am J Physiol Renal Physiol 2002 Mar;282(3):F530-40.
6.	Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts.	Klein JD, etal., J Am Soc Nephrol. 2006 Oct;17(10):2680-6. doi: 10.1681/ASN.2006030246. Epub 2006 Sep 7.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein.	Mistry AC, etal., J Biol Chem. 2007 Oct 12;282(41):30097-106. Epub 2007 Aug 16.
9.	Cloning of the rat Slc14a2 gene and genomic organization of the UT-A urea transporter.	Nakayama Y, etal., Biochim Biophys Acta 2001 Mar 19;1518(1-2):19-26.
10.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
11.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
12.	GOA pipeline	RGD automated data pipeline
13.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
15.	Molecular characterization of a novel urea transporter from kidney inner medullary collecting ducts.	Shayakul C, etal., Am J Physiol Renal Physiol 2001 Mar;280(3):F487-94.
16.	Molecular cloning and characterization of the vasopressin-regulated urea transporter of rat kidney collecting ducts.	Shayakul C, etal., J Clin Invest 1996 Dec 1;98(11):2580-7.
17.	Cloning and regulation of expression of the rat kidney urea transporter (rUT2).	Smith CP, etal., J Clin Invest 1995 Sep;96(3):1556-63.
18.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:8889548	PMID:11547347	PMID:15251864	PMID:15886274	PMID:16788141	PMID:17264983	PMID:18448630	PMID:18495802	PMID:18715940	PMID:18784257	PMID:19034881	PMID:19369293
PMID:19661162	PMID:20071460	PMID:20457831	PMID:21127847	PMID:21965602	PMID:22535801	PMID:23620790	PMID:25377918	PMID:25613743	PMID:25995111	PMID:26423860	PMID:29046292

Genomics

Comparative Map Data

Slc14a2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	18	71,612,460 - 72,039,462 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	71,612,460 - 71,792,968 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	73,711,878 - 74,138,787 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	74,381,161 - 74,808,122 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	72,237,749 - 72,664,708 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	74,508,070 - 74,941,389 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	74,508,069 - 74,542,077 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	18	74,546,220 - 74,688,551 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	74,185,426 - 74,617,691 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	75,071,416 - 75,499,738 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	75,144,693 - 75,325,630 (-)	NCBI
Celera	18	70,129,421 - 70,555,892 (-)	NCBI		Celera
Cytogenetic Map	18	q12.3	NCBI

SLC14A2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	45,167,963 - 45,683,688 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	45,212,995 - 45,683,688 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	42,747,928 - 43,263,653 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	41,448,764 - 41,517,070 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	41,448,763 - 41,517,056	NCBI
Celera	18	40,003,033 - 40,071,376 (+)	NCBI		Celera
Cytogenetic Map	18	q12.3	NCBI
HuRef	18	39,650,605 - 40,120,200 (+)	NCBI		HuRef
CHM1_1	18	42,719,963 - 43,190,313 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	45,359,240 - 45,874,622 (+)	NCBI		T2T-CHM13v2.0

Slc14a2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	78,189,359 - 78,640,165 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	78,189,363 - 78,640,157 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	78,146,144 - 78,596,950 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	78,146,148 - 78,596,942 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	78,342,883 - 78,793,689 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	78,308,224 - 78,759,020 (-)	NCBI		MGSCv36	mm8
Celera	18	79,287,387 - 79,738,811 (-)	NCBI		Celera
Cytogenetic Map	18	E3	NCBI
cM Map	18	52.53	NCBI

Slc14a2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	31,115,937 - 31,285,228 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	30,877,808 - 31,283,983 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC14A2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	63,050,743 - 63,110,153 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	48,743,343 - 48,802,753 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	38,766,994 - 38,966,124 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	42,034,675 - 42,506,485 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	42,448,067 - 42,506,485 (+)	Ensembl	panpan1.1		panPan2

SLC14A2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	45,435,387 - 45,868,977 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	45,431,450 - 45,490,430 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	45,019,276 - 45,354,276 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	45,413,685 - 45,883,152 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	7	45,113,465 - 45,589,519 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	45,166,683 - 45,635,665 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	45,451,135 - 45,920,415 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101965929
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	41,732,909 - 41,759,360 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936517	1,061,119 - 1,104,768 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936517	1,060,311 - 1,104,775 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC14A2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	95,255,632 - 95,320,542 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	94,838,955 - 95,322,748 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	105,368,929 - 105,382,578 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC14A2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	35,209,672 - 35,684,142 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	35,209,267 - 35,404,626 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	9,581,381 - 9,639,922 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc14a2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624778	9,330,064 - 9,379,942 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624778	8,943,209 - 9,379,942 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc14a2
1763 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	277
Count of miRNA genes:	149
Interacting mature miRNAs:	171
Transcripts:	ENSRNOT00000022417, ENSRNOT00000071290, ENSRNOT00000072665
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	24796977	79788953	Rat
2293704	Bss35	Bone structure and strength QTL 35	4.59	0.0002	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	18	28964853	73964853	Rat
2300157	Bmd66	Bone mineral density QTL 66	13.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	18	28964853	73964853	Rat
2300177	Bmd65	Bone mineral density QTL 65	19.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	18	28964853	73964853	Rat
9589816	Gluco68	Glucose level QTL 68	7.25	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	29792965	74792965	Rat
8694378	Bw157	Body weight QTL 157	3.59	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	29792965	74792965	Rat
9590318	Scort22	Serum corticosterone level QTL 22	7.64	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	29792965	74792965	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	29792965	74792965	Rat
738005	Anxrr11	Anxiety related response QTL 11	3.4		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	18	30039813	75039813	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	31359408	83218561	Rat
631274	Sprol1	Serum protein level QTL 1	5.3		blood total protein amount (VT:0005567)	serum total protein level (CMO:0000661)	18	31393320	77209694	Rat
631518	Bw11	Body weight QTL 11	2.8		body mass (VT:0001259)	body weight (CMO:0000012)	18	35870723	80870723	Rat
61367	Iddm4	Insulin dependent diabetes mellitus QTL 4	2.33	0.0074	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	38192455	83192455	Rat
1598826	Anxrr20	Anxiety related response QTL 20	3.04		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	18	41432971	83828827	Rat
6893683	Bw110	Body weight QTL 110	2.7	0.002	body mass (VT:0001259)	body weight (CMO:0000012)	18	43345022	83828827	Rat
8694366	Abfw8	Abdominal fat weight QTL 8	6.38	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	18	46640675	83828827	Rat
8694432	Bw165	Body weight QTL 165	3.81	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	46640675	83828827	Rat
9589041	Epfw12	Epididymal fat weight QTL 12	17.08	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	18	46640675	83828827	Rat
2303571	Bw92	Body weight QTL 92	3		body mass (VT:0001259)	body weight (CMO:0000012)	18	48520044	83828827	Rat
2303584	Gluco55	Glucose level QTL 55	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	18	48520044	83828827	Rat
738008	Hcar14	Hepatocarcinoma resistance QTL 14	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion number (CMO:0001462)	18	51464733	83218561	Rat
1359020	Ppulsi2	Prepulse inhibition QTL 2	2.71		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	18	52292875	73997283	Rat
12880368	Bw187	Body weight QTL 187		0.045	body mass (VT:0001259)	body weight (CMO:0000012)	18	52539763	76104388	Rat
12904067	Cm122	Cardiac mass QTL 122		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	52539763	76104388	Rat
12904069	Cm123	Cardiac mass QTL 123		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	52539763	76104388	Rat
12904070	Cm124	Cardiac mass QTL 124		0.01	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	52539763	76104388	Rat
12904071	Am18	Aortic mass QTL 18		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	52539763	76104388	Rat
12904073	Kidm71	Kidney mass QTL 71		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	52539763	76104388	Rat
2301417	Bp319	Blood pressure QTL 319		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	52539763	76104388	Rat
1298072	Cia26	Collagen induced arthritis QTL 26	3.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	54709769	83828827	Rat
724542	Kidm2	Kidney mass QTL 2	2.6		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	18	59172115	83828827	Rat
2301969	Bp324	Blood pressure QTL 324	4.05		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	59712417	76477814	Rat
70185	BpQTLcluster15	Blood pressure QTL cluster 15	4.61		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	59712417	76477814	Rat
70185	BpQTLcluster15	Blood pressure QTL cluster 15	4.61		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	59712417	76477814	Rat
70185	BpQTLcluster15	Blood pressure QTL cluster 15	4.61		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	18	59712417	76477814	Rat
70185	BpQTLcluster15	Blood pressure QTL cluster 15	4.61		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	18	59712417	76477814	Rat
1331770	Bp234	Blood pressure QTL 234	3.807		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	59796478	71893566	Rat
6903353	Bp353	Blood pressure QTL 353	2.8		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	59796478	83828827	Rat
6903356	Bp354	Blood pressure QTL 354	4.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	59796478	83828827	Rat
61384	Bp48	Blood pressure QTL 48	19.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	60622311	77209844	Rat
631675	Iddm15	Insulin dependent diabetes mellitus QTL 15			urine glucose amount (VT:0001758)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	18	60622311	77209844	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium										19
Low	1								15	47	33
Below cutoff	2	12	15	3	15	3	6	8	48	4	26	6	6

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001110270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_019347	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_177962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC114093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC120683	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC129683	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF031642	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF041788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF042167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF214484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474069	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK483468	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK844529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000301	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KT598256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KT598257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U09957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U77971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000078016 ⟹ ENSRNOP00000073854

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	71,650,629 - 71,792,968 (-)	Ensembl
Rnor_6.0 Ensembl	18	74,546,220 - 74,688,551 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000078519 ⟹ ENSRNOP00000074116

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	71,619,933 - 71,646,486 (-)	Ensembl
Rnor_6.0 Ensembl	18	74,508,069 - 74,542,077 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000079899 ⟹ ENSRNOP00000068708

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	71,612,460 - 71,792,968 (-)	Ensembl
Rnor_6.0 Ensembl	18	74,546,441 - 74,574,052 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000091439 ⟹ ENSRNOP00000071655

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	18	74,546,474 - 74,574,052 (-)	Ensembl

RefSeq Acc Id:

NM_001110270 ⟹ NP_001103740

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	18	71,612,460 - 71,646,486 (-)	NCBI
Rnor_6.0	18	74,508,070 - 74,542,077 (-)	NCBI
Rnor_5.0	18	74,185,426 - 74,617,691 (-)	NCBI
RGSC_v3.4	18	75,071,416 - 75,499,738 (-)	RGD
Celera	18	70,129,421 - 70,163,429 (-)	NCBI

Sequence:

show sequence

GCCCTTCTTAATTTGAGAGGGCCTTGGTGAGTTACCAGGAGACCCTGGTCAACAAGAGTTGGGG
GGAGAAGGTATGAAATTTTCCACAGAAAGCCCACATTTAGTATTAGGCTGTGCAAAACTTTCCG
TTGAGGTACTGATGGTAAGCACTAGTCCCCAGCCTATGCACTGCCTGTTGGGGAATTAAGTGAG
TATATTGAGGTTGGAAGGCAAATTAGGCCCCCAAGGAGACAACGCCTAGGTAACTGTTCATAGA
CCAATACTGGAGCTAGAATTCTTATGAGACGTGAATAACTCCTGTGAGACAACAAGGAAGCAGC
TAGACAGTTGCCAGAGCTGCCCTGTCAGGGAAGTTACCTGATTCAGCTGGTGGGGAGACCATGG
AAGCTAGACTACATCTTCCCTGAGGCGCGTAGGGAATTATCTTTAGTCAAGAAGGCCAGAGTGC
AGGAGAGCCGCCGAGAGATGTTTGTCCTTCTTCTTCCTCCATTGGCAGACCCATGGTAGGCATG
GGTTCAGGGGTGATACTTAGTGGGTTCATAGAAAGTTGTCAAAAGGAAAGGCTGGAAGATGCAG
GACAGTGAGGGGGATCGGGCATAGGAGACTTCACAGCGCCTGACGCTGAGGACCAGCTTGGCGA
GAGGCTTCTTCTCAAGTCTGATGACCTAGACTTCTCCAGTCCCATCTAGGACTCCAAAGAAGCC
CAGGTGGCGGTGGAGAACAGTCACACGGAGGAGGCCAGCGGAAGGCAGAGGAGGGCTCCGAGAC
CGTGTTCCCCAGGCGTAAGAGCGTGTTCCATATCGAGTGGTCATCCATCCGGAGGAGGAGCAAA
GTGTTTGGAAAAAGTGAACACCAAGAGAGACAAACCAAAGAGCCACTCCCCTACCTGTATCGGA
AGCCCACAGTGGAACTCTTGGACCTGAACACCATGGAGGAGAGCTCTGAGATAAAGGTAGAAAC
CAACACAACCAGGACTACCTGGATCCAGAGCTCCATGATCGCTGGGGGGAAGAGAGTCAGCAAA
GCCCTCAGCTACATCACAGGAGAGATGAAGGAGTGCGGCGAGGGACTTAAAGACAAATCTCCAG
TGTTCCAGTTTCTTGACTGGGTGCTCCGAGGCACGTCTCAGGTGATGTTTGTGAACAACCCTCT
CAGTGGCATCCTCATCGTTCTTGGCCTCTTCGTGCAGAATCCCTGGTGGGCCATCTCCGGTTGC
TTGGGCACCATCATGTCCACCTTGACTGCCCTCATCCTGAGCCAGGACAAGTCGGCCATTGCAG
CAGGACTCCATGGCTACAATGGGGTGCTTGTGGGGCTCCTGATGGCCGTGTTCTCAGACAAGGG
CAATTACTACTGGTGGCTGCTGCTCCCGGTCATCGTCATGTCCATGACTTGCCCCATCCTCTCC
AGTGCTCTGAGCACCGTCTTCAGCAAATGGGACCTCCCAGTCTTCACACTGCCCTTCAACATCG
CCGTGACCCTGTACCTGGCAGCCACGGGCCACTACAATCTCTTCTTCCCCACGAAGCTGCTGCA
GCCTGCAGTTACCACACCCAACATCACCTGGTCAGATGTCCAAGTGCCTTTGCTTCTGAGAGCC
ATCCCCGTTGGAATCGGCCAAGTGTATGGCTGTGACAATCCCTGGACTGGAGGCATCTTCCTCG
TTGCTCTGTTCGTCTCTTCACCTCTCATCTGCTTGCACGCTGCCATCGGATCCACGATAGGGAT
GTTAGCAGCACTCAGCATTGCCACACCATTTGACTCCATCTACTTTGGCCTGTGTGGCTTCAAT
AGCACTCTGGCCTGTATCGCTATTGGTGGCATGTTCTACGTCATCACCTGGCAGACGCACCTGC
TCGCCATTGCCTGTGCCCTGTTTGCAGCCTACCTGGGTGCTGCCCTGGCCAACATGCTGTCTGT
GTTTGGATTACCACCCTGCACCTGGCCCTTCTGCCTCTCAGCGCTCACCTTCCTCCTCCTCACA
ACCAACAACCCTGGCATCTACAAGCTCCCGCTCAGCAAAGTCACCTACCCAGAGGCCAACCGCA
TCTACTTCCTGTCCCAGGAGAAAAACAGAAGGGCATCGATGATAACAAAGTACCAGGCCTACGA
CGTCTCCTAAGCTGCCCTTTCTAAGCTCGTCTGGTAAATGCAGCCTCCAGAACCCACCCTGCAC
CCCAGGCTAAATCTAAGTCACTCAACCACCCTTCTTCCTAATATGCGAGTGGCTGCTATTTGGA
GCCCTCAATGAGATGTGCAGCGCTCATCAAAGCCACGCTAGTTTAAACTAAATACCCACCGATG
GCTCTTTGGGAACTCTCTGTGGGGGGAACTTGCTAGTCACCTCTTTCAGTTATTTAGTGGCGCA
AATCATGATTCCAGGAAATGTTCATTAGCCTGCCATGCAAGAGGGCTGGGTTCACTAATGAGTT
CCAACTGTCTCAGGCCAGTCTTCTCCCTACCCCATCCCCACCCCTATCCACACCCACCCCACCC
CTCATCTCAGCCTGGGTGTTTTGTTGCCAAGGATTTCTTTACCATGACAAGGAAGGACTCCAAA
GTCCTTCCACCTCAGAAGCATTTATTCTTTTCCATATCCTGTAAACTAACCAACTCAGCATGGC
CAGCAAGTAATTATTCTGACTTGAGTTACTTATGGAATGGCTCTCAGAGGAGAGAGGAAAATGT
TAGTGCCCTGTGGAAGTTTATTCTTAGATATCTGGGAGATGCTCTAAGGCTTGGGACCGGACAC
CTGAATTCATTGAAAATGCCAATGTATCTTCTTTGCACCATAGAAATATTTCCAGAAACATCAT
CTGGTAAGGAGTGACCTTTTCCAACATCCAATCATAGTGTAAGCAAACGTCTTTGCTTGTGTAA
TATTCAAAATCAGTAGTCATTAAACTTGAAATTTGCACGTTAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_019347 ⟹ NP_062220

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	18	71,612,460 - 72,039,462 (-)	NCBI
Rnor_6.0	18	74,508,070 - 74,941,389 (-)	NCBI
Rnor_5.0	18	74,185,426 - 74,617,691 (-)	NCBI
RGSC_v3.4	18	75,071,416 - 75,499,738 (-)	RGD
Celera	18	70,129,421 - 70,555,892 (-)	RGD

Sequence:

show sequence

AAAAAGAGGAAAGACAGAGCCGGCCTAGACAGCAGACATCAGGACACCCTTCTAGGCCAGCTCT
GTTTTCTGCCTTAATGCTCAAGGAAGACTGCAAGATCATCTGAGGTGGGCTCTGTAACAGCGTC
AGCTCCACAAAGTCATCGCTGCAAAGTTCAGGAGATGGGAGATCTTTCCTGTTTTCTTACTGAG
TGTTTCCGGGTGTGAGTGCATGCCATTGACATCTTCCTACCTCTGTGGACAAACAAGGACAAGG
CTCGAATCCCCTCAGTCTACTTCATCAGCCGGACCTGCATGACTGGCTATTTTGACCACTTGAA
GTCATCTAAATAGAAGTTCTCAAGACCACCAAGACCAAGGACACTTCACATGACAGATGAGCGA
CCATCCCCTGAAGGAGATGTCTGACAACAACCGCAGCCCCCTCTTGCCAGAGCCTCTTTCCAGC
AGATACAAGTTGTATGAGTCAGAGCTAAGCAGCCCTACCTGGCCTTCAAGCTCCCAGGATACAC
ACCCAGCCCTTCCCCTGCTGGAAATGCCTGAAGAAAAGGATCTCCGATCATCGGATGAAGACAG
CCACATAGTGAAGATTGAAAAGCCCAACGAGCGGAGTAAACGGAGAGAAAGCGAGTTGCCCCGC
AGGGCTTCTGCAGGCCGGGGAGGCTTCAGCCTCTTCCAAGCTGTGAGCTACCTCACTGGTGACA
TGAAGGAATGCAAGAACTGGCTGAAAGATAAGCCCCTGGTCCTTCAGTTCCTAGACTGGGTCCT
GCGGGGAGCAGCTCAGGTGATGTTTGTCAACAACCCCCTTAGTGGGCTCATCATCTTCATAGGG
CTCCTGATCCAGAATCCCTGGTGGACGATTGCTGGGGCACTGGGGACAGTGGTCTCAACCTTGG
CTGCCCTTGCCTTGAGCCAGGACAGGTCAGCCATCGCCTCTGGACTCCATGGGTACAACGGGAT
GCTGGTGGGACTCCTGGTGGCTGTCTTCTCAGAGAAGTTAGACTACTACTGGTGGCTTCTGTTT
CCTGTGACCTTCGCATCCATGGCCTGCCCAGTTATTTCTAGTGCCTTGAGCACCGTCTTCGCCA
AGTGGGACCTGCCAGTCTTCACACTGCCCTTCAACATCGCCTTAACACTGTACCTGGCAGCTAC
GGGCCACTACAACCTTTTCTTCCCCACGACGCTTGTGAAGCCTGCGTCTTCAGCGCCCAACATC
ACCTGGTCAGAGATTGAGATGCCTTTGCTGTTACAAACCATCCCCGTTGGGGTGGGCCAGGTCT
ACGGCTGTGACAACCCCTGGACAGGCGGCGTGATCCTGGTGGCTCTGTTTATCTCCTCTCCCCT
CATCTGTTTGCACGCAGCCATAGGATCCATTGTGGGGCTGCTGGCAGCACTGACGGTGGCCACT
CCCTTCGAGACGATCTACACGGGCCTTTGGAGCTACAACTGTGTCCTCTCCTGTGTCGCCATTG
GAGGCATGTTCTACGTACTCACCTGGCAGACACACCTGTTGGCACTTGTCTGTGCCCTGTTCTG
TGCGTACACGGGAGCGGCCCTCTCCAATATGATGGCAGTGGTTGGTGTGCCACCGGGCACCTGG
GCCTTCTGTCTCTCCACCCTCACCTTCCTTCTCCTCACAAGCAACAACCCTGGCATCCACAAGC
TCCCACTCAGCAAAGTCACCTACCCAGAGGCCAACCGCATCTACTTCCTGACAGCGAAACGCAG
TGACGAGCAGAAGCCCCCCAATGGTGGCGGTGGAGAACAGTCACACGGAGGAGGCCAGCGGAAG
GCAGAGGAGGGCTCCGAGACCGTGTTCCCCAGGCGTAAGAGCGTGTTCCATATCGAGTGGTCAT
CCATCCGGAGGAGGAGCAAAGTGTTTGGAAAAAGTGAACACCAAGAGAGACAAACCAAAGAGCC
ACTCCCCTACCTGTATCGGAAGCCCACAGTGGAACTCTTGGACCTGAACACCATGGAGGAGAGC
TCTGAGATAAAGGTAGAAACCAACACAACCAGGACTACCTGGATCCAGAGCTCCATGATCGCTG
GGGGGAAGAGAGTCAGCAAAGCCCTCAGCTACATCACAGGAGAGATGAAGGAGTGCGGCGAGGG
ACTTAAAGACAAATCTCCAGTGTTCCAGTTTCTTGACTGGGTGCTCCGAGGCACGTCTCAGGTG
ATGTTTGTGAACAACCCTCTCAGTGGCATCCTCATCGTTCTTGGCCTCTTCGTGCAGAATCCCT
GGTGGGCCATCTCCGGTTGCTTGGGCACCATCATGTCCACCTTGACTGCCCTCATCCTGAGCCA
GGACAAGTCGGCCATTGCAGCAGGACTCCATGGCTACAATGGGGTGCTTGTGGGGCTCCTGATG
GCCGTGTTCTCAGACAAGGGCAATTACTACTGGTGGCTGCTGCTCCCGGTCATCGTCATGTCCA
TGACTTGCCCCATCCTCTCCAGTGCTCTGAGCACCGTCTTCAGCAAATGGGACCTCCCAGTCTT
CACACTGCCCTTCAACATCGCCGTGACCCTGTACCTGGCAGCCACGGGCCACTACAATCTCTTC
TTCCCCACGAAGCTGCTGCAGCCTGCAGTTACCACACCCAACATCACCTGGTCAGATGTCCAAG
TGCCTTTGCTTCTGAGAGCCATCCCCGTTGGAATCGGCCAAGTGTATGGCTGTGACAATCCCTG
GACTGGAGGCATCTTCCTCGTTGCTCTGTTCGTCTCTTCACCTCTCATCTGCTTGCACGCTGCC
ATCGGATCCACGATAGGGATGTTAGCAGCACTCAGCATTGCCACACCATTTGACTCCATCTACT
TTGGCCTGTGTGGCTTCAATAGCACTCTGGCCTGTATCGCTATTGGTGGCATGTTCTACGTCAT
CACCTGGCAGACGCACCTGCTCGCCATTGCCTGTGCCCTGTTTGCAGCCTACCTGGGTGCTGCC
CTGGCCAACATGCTGTCTGTGTTTGGATTACCACCCTGCACCTGGCCCTTCTGCCTCTCAGCGC
TCACCTTCCTCCTCCTCACAACCAACAACCCTGGCATCTACAAGCTCCCGCTCAGCAAAGTCAC
CTACCCAGAGGCCAACCGCATCTACTTCCTGTCCCAGGAGAAAAACAGAAGGGCATCGATGATA
ACAAAGTACCAGGCCTACGACGTCTCCTAAGCTGCCCTTTCTAAGCTCGTCTGGTAAATGCAGC
CTCCAGAACCCACCCTGCACCCCAGGCTAAATCTAAGTCACTCAACCACCCTTCTTCCTAATAT
GCGAGTGGCTGCTATTTGGAGCCCTCAATGAGATGTGCAGCGCTCATCAAAGCCACGCTAGTTT
AAACTAAATACCCACCGATGGCTCTTTGGGAACTCTCTGTGGGGGGAACTTGCTAGTCACCTCT
TTCAGTTATTTAGTGGCGCAAATCATGATTCCAGGAAATGTTCATTAGCCTGCCATGCAAGAGG
GCTGGGTTCACTAATGAGTTCCAACTGTCTCAGGCCAGTCTTCTCCCTACCCCATCCCCACCCC
TATCCACACCCACCCCACCCCTCATCTCAGCCTGGGTGTTTTGTTGCCAAGGATTTCTTTACCA
TGACAAGGAAGGACTCCAAAGTCCTTCCACCTCAGAAGCATTTATTCTTTTCCATATCCTGTAA
ACTAACCAACTCAGCATGGCCAGCAAGTAATTATTCTGACTTGAGTTACTTATGGAATGGCTCT
CAGAGGAGAGAGGAAAATGTTAGTGCCCTGTGGAAGTTTATTCTTAGATATCTGGGAGATGCTC
TAAGGCTTGGGACCGGACACCTGAATTCATTGAAAATGCCAATGTATCTTCTTTGCACCATAGA
AATATTTCCAGAAACATCATCTGGTAAGGAGTGACCTTTTCCAACATCCAATCATAGTGTAAGC
AAACGTCTTTGCTTGTGTAATATTCAAAATCAGTAGTCATTAAACTTGAAATTTGCACGTTAAA
AAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_177962 ⟹ NP_808877

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	18	71,650,627 - 72,039,462 (-)	NCBI
Rnor_6.0	18	74,546,218 - 74,941,389 (-)	NCBI
Rnor_5.0	18	74,185,426 - 74,617,691 (-)	NCBI
RGSC_v3.4	18	75,071,416 - 75,499,738 (-)	RGD
Celera	18	70,167,570 - 70,555,892 (-)	NCBI

Sequence:

show sequence

AAAAAGAGGAAAGACAGAGCCGGCCTAGACAGCAGACATCAGGACACCCTTCTAGGCCAGCTCT
GTTTTCTGCCTTAATGCTCAAGGAAGACTGCAAGATCATCTGAGGTGGGCTCTGTAACAGCGTC
AGCTCCACAAAGTCATCGCTGCAAAGTTCAGGAGATGGGAGATCTTTCCTGTTTTCTTACTGAG
TGTTTCCGGGTGTGAGTGCATGCCATTGACATCTTCCTACCTCTGTGGACAAACAAGGACAAGG
CTCGAATCCCCTCAGTCTACTTCATCAGCCGGACCTGCATGACTGGCTATTTTGACCACTTGAA
GTCATCTAAATAGAAGTTCTCAAGACCACCAAGACCAAGGACACTTCACATGACAGATGAGCGA
CCATCCCCTGAAGGAGATGTCTGACAACAACCGCAGCCCCCTCTTGCCAGAGCCTCTTTCCAGC
AGATACAAGTTGTATGAGTCAGAGCTAAGCAGCCCTACCTGGCCTTCAAGCTCCCAGGATACAC
ACCCAGCCCTTCCCCTGCTGGAAATGCCTGAAGAAAAGGATCTCCGATCATCGGATGAAGACAG
CCACATAGTGAAGATTGAAAAGCCCAACGAGCGGAGTAAACGGAGAGAAAGCGAGTTGCCCCGC
AGGGCTTCTGCAGGCCGGGGAGGCTTCAGCCTCTTCCAAGCTGTGAGCTACCTCACTGGTGACA
TGAAGGAATGCAAGAACTGGCTGAAAGATAAGCCCCTGGTCCTTCAGTTCCTAGACTGGGTCCT
GCGGGGAGCAGCTCAGGTGATGTTTGTCAACAACCCCCTTAGTGGGCTCATCATCTTCATAGGG
CTCCTGATCCAGAATCCCTGGTGGACGATTGCTGGGGCACTGGGGACAGTGGTCTCAACCTTGG
CTGCCCTTGCCTTGAGCCAGGACAGGTCAGCCATCGCCTCTGGACTCCATGGGTACAACGGGAT
GCTGGTGGGACTCCTGGTGGCTGTCTTCTCAGAGAAGTTAGACTACTACTGGTGGCTTCTGTTT
CCTGTGACCTTCGCATCCATGGCCTGCCCAGTTATTTCTAGTGCCTTGAGCACCGTCTTCGCCA
AGTGGGACCTGCCAGTCTTCACACTGCCCTTCAACATCGCCTTAACACTGTACCTGGCAGCTAC
GGGCCACTACAACCTTTTCTTCCCCACGACGCTTGTGAAGCCTGCGTCTTCAGCGCCCAACATC
ACCTGGTCAGAGATTGAGATGCCTTTGCTGTTACAAACCATCCCCGTTGGGGTGGGCCAGGTCT
ACGGCTGTGACAACCCCTGGACAGGCGGCGTGATCCTGGTGGCTCTGTTTATCTCCTCTCCCCT
CATCTGTTTGCACGCAGCCATAGGATCCATTGTGGGGCTGCTGGCAGCACTGACGGTGGCCACT
CCCTTCGAGACGATCTACACGGGCCTTTGGAGCTACAACTGTGTCCTCTCCTGTGTCGCCATTG
GAGGCATGTTCTACGTACTCACCTGGCAGACACACCTGTTGGCACTTGTCTGTGCCCTGTTCTG
TGCGTACACGGGAGCGGCCCTCTCCAATATGATGGCAGTGGTTGGTGTGCCACCGGGCACCTGG
GCCTTCTGTCTCTCCACCCTCACCTTCCTTCTCCTCACAAGCAACAACCCTGGCATCCACAAGC
TCCCACTCAGCAAAGTCACCTACCCAGAGGCCAACCGCATCTACTTCCTGACAGCGAAACGCAG
TGACGAGCAGAAGCCCCCCAATGGTGACTAGTTCAGCGCCAAGCCAAAATGTTCTGCTTTGTCT
GCATCCCTATGGTCTCAACTCTGGGCCAAGCGACCCGGCCAGCACTCACTTTCCTCGCCTCTCC
TTGCACCTGTTTCAAATCAAACCCACCTATTCCTCCCTAATCCCGAGGCTGATTCGTTCCCTCT
GCCCAGATCTTTATAACAACCCCTTGTAGCATTAAAGGAAGCTGGTACGACATAAAAAAAAAAA
AAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001103740	(Get FASTA)	NCBI Sequence Viewer
	NP_062220	(Get FASTA)	NCBI Sequence Viewer
	NP_808877	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA84392	(Get FASTA)	NCBI Sequence Viewer
	AAB50197	(Get FASTA)	NCBI Sequence Viewer
	AAD01938	(Get FASTA)	NCBI Sequence Viewer
	AAD23098	(Get FASTA)	NCBI Sequence Viewer
	AAD23099	(Get FASTA)	NCBI Sequence Viewer
	AMD39458	(Get FASTA)	NCBI Sequence Viewer
	AMD39459	(Get FASTA)	NCBI Sequence Viewer
	EDL84678	(Get FASTA)	NCBI Sequence Viewer
	EDL84679	(Get FASTA)	NCBI Sequence Viewer
	EDL84680	(Get FASTA)	NCBI Sequence Viewer
	EDL84681	(Get FASTA)	NCBI Sequence Viewer
	EDL84682	(Get FASTA)	NCBI Sequence Viewer
	EDL84683	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000068708
	ENSRNOP00000068708.2
	ENSRNOP00000073854
	ENSRNOP00000073854.2
	ENSRNOP00000074116.2
GenBank Protein	Q62668	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_062220 ⟸ NM_019347
- Peptide Label:	isoform 1
- UniProtKB:	Q9Z2R3 (UniProtKB/Swiss-Prot), Q9WTT8 (UniProtKB/Swiss-Prot), Q9R1Y7 (UniProtKB/Swiss-Prot), Q62668 (UniProtKB/Swiss-Prot), A6KMY1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSDHPLKEMSDNNRSPLLPEPLSSRYKLYESELSSPTWPSSSQDTHPALPLLEMPEEKDLRSSD EDSHIVKIEKPNERSKRRESELPRRASAGRGGFSLFQAVSYLTGDMKECKNWLKDKPLVLQFLD WVLRGAAQVMFVNNPLSGLIIFIGLLIQNPWWTIAGALGTVVSTLAALALSQDRSAIASGLHGY NGMLVGLLVAVFSEKLDYYWWLLFPVTFASMACPVISSALSTVFAKWDLPVFTLPFNIALTLYL AATGHYNLFFPTTLVKPASSAPNITWSEIEMPLLLQTIPVGVGQVYGCDNPWTGGVILVALFIS SPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVLSCVAIGGMFYVLTWQTHLLALVCA LFCAYTGAALSNMMAVVGVPPGTWAFCLSTLTFLLLTSNNPGIHKLPLSKVTYPEANRIYFLTA KRSDEQKPPNGGGGEQSHGGGQRKAEEGSETVFPRRKSVFHIEWSSIRRRSKVFGKSEHQERQT KEPLPYLYRKPTVELLDLNTMEESSEIKVETNTTRTTWIQSSMIAGGKRVSKALSYITGEMKEC GEGLKDKSPVFQFLDWVLRGTSQVMFVNNPLSGILIVLGLFVQNPWWAISGCLGTIMSTLTALI LSQDKSAIAAGLHGYNGVLVGLLMAVFSDKGNYYWWLLLPVIVMSMTCPILSSALSTVFSKWDL PVFTLPFNIAVTLYLAATGHYNLFFPTKLLQPAVTTPNITWSDVQVPLLLRAIPVGIGQVYGCD NPWTGGIFLVALFVSSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIAIGGMF YVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPGIYKLPLS KVTYPEANRIYFLSQEKNRRASMITKYQAYDVS hide sequence

RefSeq Acc Id:	NP_808877 ⟸ NM_177962
- Peptide Label:	isoform 2
- UniProtKB:	A0A0G2K6L0 (UniProtKB/TrEMBL), A6KMY3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSDHPLKEMSDNNRSPLLPEPLSSRYKLYESELSSPTWPSSSQDTHPALPLLEMPEEKDLRSSD EDSHIVKIEKPNERSKRRESELPRRASAGRGGFSLFQAVSYLTGDMKECKNWLKDKPLVLQFLD WVLRGAAQVMFVNNPLSGLIIFIGLLIQNPWWTIAGALGTVVSTLAALALSQDRSAIASGLHGY NGMLVGLLVAVFSEKLDYYWWLLFPVTFASMACPVISSALSTVFAKWDLPVFTLPFNIALTLYL AATGHYNLFFPTTLVKPASSAPNITWSEIEMPLLLQTIPVGVGQVYGCDNPWTGGVILVALFIS SPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVLSCVAIGGMFYVLTWQTHLLALVCA LFCAYTGAALSNMMAVVGVPPGTWAFCLSTLTFLLLTSNNPGIHKLPLSKVTYPEANRIYFLTA KRSDEQKPPNGD hide sequence

RefSeq Acc Id:	NP_001103740 ⟸ NM_001110270
- Peptide Label:	isoform 3
- UniProtKB:	A6KMY2 (UniProtKB/TrEMBL), A0A120KA92 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEESSEIKVETNTTRTTWIQSSMIAGGKRVSKALSYITGEMKECGEGLKDKSPVFQFLDWVLRG TSQVMFVNNPLSGILIVLGLFVQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGLHGYNGVLV GLLMAVFSDKGNYYWWLLLPVIVMSMTCPILSSALSTVFSKWDLPVFTLPFNIAVTLYLAATGH YNLFFPTKLLQPAVTTPNITWSDVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLVALFVSSPLIC LHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALFAAY LGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPGIYKLPLSKVTYPEANRIYFLSQEKNRR ASMITKYQAYDVS hide sequence

RefSeq Acc Id:

ENSRNOP00000068708 ⟸ ENSRNOT00000079899

RefSeq Acc Id:

ENSRNOP00000073854 ⟸ ENSRNOT00000078016

RefSeq Acc Id:

ENSRNOP00000071655 ⟸ ENSRNOT00000091439

RefSeq Acc Id:

ENSRNOP00000074116 ⟸ ENSRNOT00000078519

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q62668-F1-model_v2	AlphaFold	Q62668	1-929	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3689	AgrOrtholog
BioCyc Gene	G2FUF-6922	BioCyc
Ensembl Genes	ENSRNOG00000056021	Ensembl
	ENSRNOG00000061714	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000078016	ENTREZGENE
	ENSRNOT00000078016.2	UniProtKB/TrEMBL
	ENSRNOT00000078519.2	UniProtKB/TrEMBL
	ENSRNOT00000079899	ENTREZGENE
	ENSRNOT00000079899.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.3430.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Ammonium/urea_transptr	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Urea_transporter	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:54302	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	54302	ENTREZGENE
PANTHER	PTHR10464	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UREA TRANSPORTER 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PF03253	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc14a2	PhenoGen
PIRSF	Urea_transporter	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000056021	RatGTEx
	ENSRNOG00000061714	RatGTEx
TIGR	TC235944
UniProt	A0A0G2JTG8_RAT	UniProtKB/TrEMBL
	A0A0G2K6L0	ENTREZGENE, UniProtKB/TrEMBL
	A0A120KA92	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2UR79_RAT	UniProtKB/TrEMBL
	A6KMX9_RAT	UniProtKB/TrEMBL
	A6KMY0_RAT	UniProtKB/TrEMBL
	A6KMY1	ENTREZGENE, UniProtKB/TrEMBL
	A6KMY2	ENTREZGENE, UniProtKB/TrEMBL
	A6KMY3	ENTREZGENE, UniProtKB/TrEMBL
	A6KMY4_RAT	UniProtKB/TrEMBL
	Q62668	ENTREZGENE
	Q9R1Y7	ENTREZGENE
	Q9WTT8	ENTREZGENE
	Q9Z2R3	ENTREZGENE
	UT2_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q9R1Y7	UniProtKB/Swiss-Prot
	Q9WTT8	UniProtKB/Swiss-Prot
	Q9Z2R3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-25	Slc14a2	solute carrier family 14 member 2	Slc14a2	solute carrier family 14 (urea transporter), member 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-04-17	Slc14a2	solute carrier family 14 (urea transporter), member 2	Slc14a2_v4	solute carrier family 14 (urea transporter), member 2, variant 4	Data merged from RGD:70071	737654	PROVISIONAL
2008-06-23	Slc14a2	solute carrier family 14 (urea transporter), member 2	Slc14a2T	solute carrier family 14 (urea transporter), member 2T	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-06-23	Slc14a2T	solute carrier family 14 (urea transporter), member 2T	Slc14a2	solute carrier family 14 (urea transporter), member 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-06-10	Slc14a2	solute carrier family 14 (urea transporter), member 2	testSymbol	testName	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-06-10	testSymbol	testName	Slc14a2	solute carrier family 14 (urea transporter), member 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Slc14a2_v4	solute carrier family 14, member 2, variant 4			Symbol and Name status set to approved	1299863	APPROVED
2004-09-10	Slc14a2	solute carrier family 14 (urea transporter), member 2		solute carrier family 14, member 2	Name updated	1299863	APPROVED
2003-03-12	Slc14a1_v4	solute carrier family 14, member 1, variant 4	UrT1-D		Data merged from RGD:620582	628472	PROVISIONAL
2002-11-06	Slc14a1_v4	solute carrier family 14, member 1, variant 4			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	UrT1-D				Symbol and Name status set to provisional	70820	PROVISIONAL
2002-06-10	Slc14a2	solute carrier family 14, member 2			Symbol and Name status set to approved	70586	APPROVED
2002-06-10	Slc14a1_v4	solute carrier family 14, member 1, variant 4			Symbol and Name updated	70585	PROVISIONAL
2002-02-20	Slc14a2	solute carrier family 14 (urea transporter), member 2			Name updated to reflect Human and Mouse nomenclature	70282	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in the renal outer and inner medulla but not in the cortex	68904
gene_function	transports urea	68889
gene_function	transports urea	68904
gene_process	plays a role in regulating urea accumulation in the kidney inner medulla and in maintaining water and nitrogen balance	68904
gene_protein	466 amino acids	68904

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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