Slc14a1 (solute carrier family 14 member 1 (Kidd blood group)) - Rat Genome Database

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Gene: Slc14a1 (solute carrier family 14 member 1 (Kidd blood group)) Rattus norvegicus
Analyze
Symbol: Slc14a1
Name: solute carrier family 14 member 1 (Kidd blood group)
RGD ID: 3688
Description: Enables urea transmembrane transporter activity. Involved in urea transport. Predicted to be located in basolateral plasma membrane. Orthologous to human SLC14A1 (solute carrier family 14 member 1 (Kidd blood group)); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: HUT11; solute carrier family 14 (urea transporter), member 1; solute carrier family 14 (urea transporter), member 1 (Kidd blood group); solute carrier family 14 member 1; solute carrier family 14, member 1; Urea transporter; urea transporter 1; urea transporter B; urea transporter, erythrocyte; UrT2; UT-B; UT3; UTB1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81873,840,568 - 73,883,925 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1873,840,569 - 73,870,489 (-)EnsemblGRCr8
mRatBN7.21871,565,453 - 71,608,807 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1871,565,454 - 71,595,146 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1873,667,014 - 73,688,961 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01874,336,292 - 74,358,236 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01872,192,863 - 72,214,807 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01874,461,064 - 74,504,475 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1874,461,055 - 74,485,139 (-)Ensemblrn6Rnor6.0
Rnor_5.01874,136,472 - 74,181,806 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41875,024,200 - 75,048,481 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1870,085,031 - 70,106,502 (-)NCBICelera
RGSC_v3.11875,097,598 - 75,121,754 (-)NCBI
Cytogenetic Map18q12.3NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxyacetamide  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamic acid  (ISO)
carbon nanotube  (ISO)
carbonyl dihydrazine  (ISO)
carmustine  (ISO)
chromium(6+)  (ISO)
clothianidin  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dimethylarsinic acid  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
endosulfan  (EXP)
ethanol  (ISO)
formamide  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
GSK-J4  (ISO)
hydroxyurea  (ISO)
malathion  (ISO)
mancozeb  (ISO)
melphalan  (ISO)
methapyrilene  (ISO)
methylarsonic acid  (ISO)
methylseleninic acid  (ISO)
N-methyl urea  (ISO)
N-methylformamide  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phloretin  (EXP)
poly(I:C)  (EXP)
progesterone  (ISO)
propanal  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thiourea  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
urea  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
urea transmembrane transport  (IBA,IEA,ISO,ISS)
urea transport  (IDA,ISO)
water transport  (IEA,ISO)

Cellular Component
basolateral plasma membrane  (IEA,ISO,ISS)
membrane  (IEA)
plasma membrane  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cloning and functional characterization of a rat urea transporter: expression in the brain. Couriaud C, etal., Biochim Biophys Acta 1996 Dec 11;1309(3):197-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Cloning and characterization of two new isoforms of the rat kidney urea transporter: UT-A3 and UT-A4. Karakashian A, etal., J Am Soc Nephrol 1999 Feb;10(2):230-7.
5. Expression of urea transporters in the developing rat kidney. Kim YH, etal., Am J Physiol Renal Physiol 2002 Mar;282(3):F530-40.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Molecular characterization of a novel urea transporter from kidney inner medullary collecting ducts. Shayakul C, etal., Am J Physiol Renal Physiol 2001 Mar;280(3):F487-94.
12. Localization of the urea transporter UT-B protein in human and rat erythrocytes and tissues. Timmer RT, etal., Am J Physiol Cell Physiol 2001 Oct;281(4):C1318-25.
Additional References at PubMed
PMID:11792714   PMID:12133842   PMID:18945830   PMID:19865084   PMID:22871113   PMID:23486518   PMID:25613743   PMID:25869070   PMID:26414230  


Genomics

Comparative Map Data
Slc14a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81873,840,568 - 73,883,925 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1873,840,569 - 73,870,489 (-)EnsemblGRCr8
mRatBN7.21871,565,453 - 71,608,807 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1871,565,454 - 71,595,146 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1873,667,014 - 73,688,961 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01874,336,292 - 74,358,236 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01872,192,863 - 72,214,807 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01874,461,064 - 74,504,475 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1874,461,055 - 74,485,139 (-)Ensemblrn6Rnor6.0
Rnor_5.01874,136,472 - 74,181,806 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41875,024,200 - 75,048,481 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1870,085,031 - 70,106,502 (-)NCBICelera
RGSC_v3.11875,097,598 - 75,121,754 (-)NCBI
Cytogenetic Map18q12.3NCBI
SLC14A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381845,724,181 - 45,752,520 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1845,687,025 - 45,752,521 (+)Ensemblhg38GRCh38
GRCh371843,304,146 - 43,332,485 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361841,558,155 - 41,585,297 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341841,558,156 - 41,585,297NCBI
Celera1840,112,419 - 40,140,815 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
HuRef1840,161,204 - 40,189,605 (+)NCBIHuRef
CHM1_11843,231,331 - 43,259,727 (+)NCBICHM1_1
T2T-CHM13v2.01845,915,156 - 45,943,497 (+)NCBIT2T-CHM13v2.0
Slc14a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391878,143,306 - 78,185,334 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1878,143,306 - 78,185,334 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381878,100,091 - 78,142,119 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1878,100,091 - 78,142,119 (-)Ensemblmm10GRCm38
MGSCv371878,296,830 - 78,338,858 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361878,262,167 - 78,285,398 (-)NCBIMGSCv36mm8
Celera1879,241,320 - 79,283,362 (-)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1852.49NCBI
Slc14a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540231,320,591 - 31,343,829 (+)Ensembl
ChiLan1.0NW_00495540231,320,897 - 31,343,774 (+)NCBIChiLan1.0ChiLan1.0
SLC14A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21763,150,083 - 63,178,412 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11848,842,683 - 48,871,012 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01839,007,475 - 39,035,489 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11842,547,609 - 42,575,723 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1842,550,210 - 42,575,723 (+)EnsemblpanPan2panpan1.1
SLC14A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1745,378,744 - 45,409,068 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl745,380,239 - 45,408,829 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha744,859,588 - 44,908,859 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0745,330,772 - 45,379,595 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl745,332,491 - 45,361,129 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1745,030,313 - 45,079,568 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0745,083,750 - 45,132,793 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0745,368,374 - 45,417,245 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc14a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494441,687,947 - 41,712,136 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365171,015,036 - 1,039,529 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365171,015,069 - 1,039,474 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC14A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl195,355,016 - 95,381,489 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1195,354,848 - 95,381,492 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21105,417,779 - 105,442,766 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC14A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11835,148,552 - 35,176,121 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1835,146,190 - 35,174,948 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660509,519,200 - 9,547,144 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc14a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247789,403,405 - 9,419,841 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247789,397,773 - 9,419,604 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc14a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11554,026,589 - 54,051,027 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc14a1
143 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:889
Count of miRNA genes:297
Interacting mature miRNAs:370
Transcripts:ENSRNOT00000022598, ENSRNOT00000074572
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186289225779484461Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)186438376279484311Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185782524385493247Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
7794793Mcs34Mammary carcinoma susceptibility QTL 341.54mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)186563556785897775Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)186584644786134022Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186198220476619168Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186289225779484461Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)186144685386134022Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat

Markers in Region
BE102916  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21871,581,681 - 71,581,836 (+)MAPPERmRatBN7.2
Rnor_6.01874,477,292 - 74,477,446NCBIRnor6.0
Rnor_5.01874,152,563 - 74,152,717UniSTSRnor5.0
RGSC_v3.41875,039,834 - 75,039,988UniSTSRGSC3.4
Celera1870,098,655 - 70,098,809UniSTS
RH 3.4 Map18770.1UniSTS
Cytogenetic Map18q12.3UniSTS
RH137664  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21871,565,613 - 71,565,774 (+)MAPPERmRatBN7.2
Rnor_6.01874,461,225 - 74,461,385NCBIRnor6.0
Rnor_5.01874,136,633 - 74,136,793UniSTSRnor5.0
RGSC_v3.41875,022,228 - 75,022,388UniSTSRGSC3.4
Celera1870,083,059 - 70,083,219UniSTS
Cytogenetic Map18q12.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 58 158 91 90 59 92 59 6 346 182 11 129 81 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000022598   ⟹   ENSRNOP00000022598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1873,840,569 - 73,864,675 (-)Ensembl
mRatBN7.2 Ensembl1871,565,454 - 71,589,561 (-)Ensembl
Rnor_6.0 Ensembl1874,463,197 - 74,485,139 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000074572   ⟹   ENSRNOP00000065722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1873,840,569 - 73,870,489 (-)Ensembl
mRatBN7.2 Ensembl1871,565,454 - 71,595,146 (-)Ensembl
Rnor_6.0 Ensembl1874,461,055 - 74,478,341 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109500   ⟹   ENSRNOP00000083480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1873,840,569 - 73,864,668 (-)Ensembl
mRatBN7.2 Ensembl1871,565,454 - 71,589,727 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114974   ⟹   ENSRNOP00000088113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1873,840,569 - 73,864,675 (-)Ensembl
mRatBN7.2 Ensembl1871,565,454 - 71,589,561 (-)Ensembl
RefSeq Acc Id: NM_019346   ⟹   NP_062219
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81873,842,701 - 73,864,643 (-)NCBI
mRatBN7.21871,567,586 - 71,589,529 (-)NCBI
Rnor_6.01874,463,197 - 74,485,139 (-)NCBI
Rnor_5.01874,136,472 - 74,181,806 (-)NCBI
RGSC_v3.41875,024,200 - 75,048,481 (-)RGD
Celera1870,085,031 - 70,106,502 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772168   ⟹   XP_008770390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81873,840,568 - 73,865,175 (-)NCBI
mRatBN7.21871,565,453 - 71,590,061 (-)NCBI
Rnor_6.01874,461,064 - 74,485,155 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772169   ⟹   XP_008770391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81873,840,568 - 73,870,463 (-)NCBI
mRatBN7.21871,565,453 - 71,595,231 (-)NCBI
Rnor_6.01874,461,064 - 74,491,895 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772170   ⟹   XP_008770392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81873,840,568 - 73,883,925 (-)NCBI
mRatBN7.21871,565,453 - 71,608,807 (-)NCBI
Rnor_6.01874,461,064 - 74,504,475 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097052   ⟹   XP_038952980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81873,840,568 - 73,865,175 (-)NCBI
mRatBN7.21871,565,453 - 71,590,061 (-)NCBI
RefSeq Acc Id: NP_062219   ⟸   NM_019346
- UniProtKB: P97689 (UniProtKB/Swiss-Prot),   P70633 (UniProtKB/Swiss-Prot),   E9PSP0 (UniProtKB/Swiss-Prot),   A0A8J8XP37 (UniProtKB/TrEMBL),   A6KMX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770392   ⟸   XM_008772170
- Peptide Label: isoform X3
- UniProtKB: P97689 (UniProtKB/Swiss-Prot),   P70633 (UniProtKB/Swiss-Prot),   E9PSP0 (UniProtKB/Swiss-Prot),   A0A8J8XP37 (UniProtKB/TrEMBL),   A6KMX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770391   ⟸   XM_008772169
- Peptide Label: isoform X2
- UniProtKB: P97689 (UniProtKB/Swiss-Prot),   P70633 (UniProtKB/Swiss-Prot),   E9PSP0 (UniProtKB/Swiss-Prot),   H9KVF0 (UniProtKB/TrEMBL),   M0R8C6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770390   ⟸   XM_008772168
- Peptide Label: isoform X1
- UniProtKB: P97689 (UniProtKB/Swiss-Prot),   P70633 (UniProtKB/Swiss-Prot),   E9PSP0 (UniProtKB/Swiss-Prot),   A0A8I5ZWN6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022598   ⟸   ENSRNOT00000022598
Ensembl Acc Id: ENSRNOP00000065722   ⟸   ENSRNOT00000074572
RefSeq Acc Id: XP_038952980   ⟸   XM_039097052
- Peptide Label: isoform X1
- UniProtKB: P97689 (UniProtKB/Swiss-Prot),   P70633 (UniProtKB/Swiss-Prot),   E9PSP0 (UniProtKB/Swiss-Prot),   A0A8I5ZWN6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083480   ⟸   ENSRNOT00000109500
Ensembl Acc Id: ENSRNOP00000088113   ⟸   ENSRNOT00000114974

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97689-F1-model_v2 AlphaFold P97689 1-384 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700883
Promoter ID:EPDNEW_R11407
Type:single initiation site
Name:Slc14a1_1
Description:solute carrier family 14 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01874,485,122 - 74,485,182EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3688 AgrOrtholog
BioCyc Gene G2FUF-6925 BioCyc
Ensembl Genes ENSRNOG00000016753 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000022598 ENTREZGENE
  ENSRNOT00000074572 ENTREZGENE
  ENSRNOT00000109500 ENTREZGENE
  ENSRNOT00000114974 ENTREZGENE
Gene3D-CATH 1.10.3430.10 UniProtKB/Swiss-Prot
InterPro Ammonium/urea_transptr UniProtKB/Swiss-Prot
  Urea_transporter UniProtKB/Swiss-Prot
KEGG Report rno:54301 UniProtKB/Swiss-Prot
NCBI Gene 54301 ENTREZGENE
PANTHER PTHR10464 UniProtKB/Swiss-Prot
  UREA TRANSPORTER 1 UniProtKB/Swiss-Prot
Pfam PF03253 UniProtKB/Swiss-Prot
PhenoGen Slc14a1 PhenoGen
PIRSF Urea_transporter UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016753 RatGTEx
UniProt A0A8I5ZWN6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A939_RAT UniProtKB/TrEMBL
  A0A8J8XP37 ENTREZGENE, UniProtKB/TrEMBL
  A6KMX6 ENTREZGENE, UniProtKB/TrEMBL
  E9PSP0 ENTREZGENE
  H9KVF0 ENTREZGENE
  M0R8C6 ENTREZGENE, UniProtKB/TrEMBL
  P70633 ENTREZGENE
  P97689 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary E9PSP0 UniProtKB/Swiss-Prot
  P70633 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 Slc14a1  solute carrier family 14 member 1 (Kidd blood group)  Slc14a1  solute carrier family 14 member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-01-17 Slc14a1  solute carrier family 14 member 1  Slc14a1  solute carrier family 14 (urea transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Slc14a1  solute carrier family 14 (urea transporter), member 1    solute carrier family 14 (urea transporter), member 1 (Kidd blood group)  Name updated 1299863 APPROVED
2004-09-10 Slc14a1  solute carrier family 14 (urea transporter), member 1 (Kidd blood group)    solute carrier family 14, member 1  Name updated 1299863 APPROVED
2003-04-14 Slc14a1  solute carrier family 14, member 1  UrT2    Data merged from RGD:69059 628472 APPROVED
2002-06-10 Slc14a1  solute carrier family 14, member 1      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 UrT2        Symbol and Name status set to provisional 70585 PROVISIONAL
2002-02-20 Slc14a1  solute carrier family 14 (urea transporter), member 1      Name updated to reflect Human and Mouse nomenclature 70282 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the descending vasa recta of kidney, pelvic epithelium, red blood cells, brain astrocytes and sertoli cells 67999
gene_expression expressed in the descending vasa recta of kidney, pelvic epithelium, red blood cells, brain astrocytes and sertoli cells 70002
gene_expression expressed in renal medulla; both mRNA and protein observed in brain, colon, heart,liver, lung, testis and erythrocytes 628434
gene_function transports urea 68904
gene_process plays a role in regulating urea accumulation in the kidney inner medulla and in maintaining water and nitrogen balance 68904