Pcsk1n (proprotein convertase subtilisin/kexin type 1 inhibitor) - Rat Genome Database

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Gene: Pcsk1n (proprotein convertase subtilisin/kexin type 1 inhibitor) Rattus norvegicus
Analyze
Symbol: Pcsk1n
Name: proprotein convertase subtilisin/kexin type 1 inhibitor
RGD ID: 3617
Description: Enables endopeptidase inhibitor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within peptide hormone processing; response to cold; and response to dietary excess. Located in extracellular space. Used to study obesity. Orthologous to human PCSK1N (proprotein convertase subtilisin/kexin type 1 inhibitor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: granin-like neuroendocrine peptide; granin-like neuroendocrine peptide precursor; LOC100911286; LOC108348172; pro-SAAS; proprotein convertase 1 inhibitor; proSAAS; proSAAS-like; Saas
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,251,963 - 17,255,405 (-)NCBIGRCr8
mRatBN7.2X14,580,036 - 14,583,478 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,580,038 - 14,583,566 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,393,585 - 19,397,012 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,686,099 - 20,689,526 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,951,269 - 16,954,696 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,324,263 - 15,327,705 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,324,400 - 15,327,684 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,324,400 - 15,327,684 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,425,078 - 15,428,518 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,425,078 - 15,428,518 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0X16,104,504 - 16,107,946 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,614,585 - 26,618,027 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X26,668,055 - 26,671,496 (-)NCBI
CeleraX14,664,791 - 14,668,241 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
extracellular space  (IBA,IDA,IEA,ISO)
secretory granule  (IEA,ISO)
trans-Golgi network  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of incompletely processed potential carboxypeptidase E substrates from CpEfat/CpEfat mice. Bures EJ, etal., Proteomics. 2001 Jan;1(1):79-92.
2. Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing. Fricker LD, etal., J Neurosci 2000 Jan 15;20(2):639-48.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Dehydration-induced proteome changes in the rat hypothalamo-neurohypophyseal system. Gouraud SS, etal., Endocrinology. 2007 Jul;148(7):3041-52. Epub 2007 Apr 5.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Embryonic gene expression and pro-protein processing of proSAAS during rodent development. Morgan DJ, etal., J Neurochem. 2005 Jun;93(6):1454-62.
8. Processing of proSAAS in neuroendocrine cell lines. Mzhavia N, etal., Biochem J. 2002 Jan 1;361(Pt 1):67-76.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam. Wada M, etal., Neurosci Lett. 2004 Feb 6;356(1):49-52.
14. Obesity and diabetes in transgenic mice expressing proSAAS. Wei S, etal., J Endocrinol. 2004 Mar;180(3):357-68.
Additional References at PubMed
PMID:9630436   PMID:10816562   PMID:16631141   PMID:23376485   PMID:25002582  


Genomics

Comparative Map Data
Pcsk1n
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,251,963 - 17,255,405 (-)NCBIGRCr8
mRatBN7.2X14,580,036 - 14,583,478 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,580,038 - 14,583,566 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,393,585 - 19,397,012 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,686,099 - 20,689,526 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,951,269 - 16,954,696 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,324,263 - 15,327,705 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,324,400 - 15,327,684 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,324,400 - 15,327,684 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,425,078 - 15,428,518 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,425,078 - 15,428,518 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0X16,104,504 - 16,107,946 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,614,585 - 26,618,027 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X26,668,055 - 26,671,496 (-)NCBI
CeleraX14,664,791 - 14,668,241 (-)NCBICelera
Cytogenetic MapXq12NCBI
PCSK1N
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,831,096 - 48,835,610 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX48,831,096 - 48,835,610 (-)EnsemblGRCh38hg38GRCh38
GRCh37X48,689,506 - 48,694,012 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,574,450 - 48,578,904 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X48,445,755 - 48,450,209NCBI
CeleraX52,969,569 - 52,974,023 (+)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,349,219 - 46,353,523 (-)NCBIHuRef
CHM1_1X48,720,646 - 48,725,174 (-)NCBICHM1_1
T2T-CHM13v2.0X48,241,591 - 48,246,097 (-)NCBIT2T-CHM13v2.0
Pcsk1n
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,786,061 - 7,790,649 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,786,061 - 7,790,649 (+)EnsemblGRCm39 Ensembl
GRCm38X7,919,822 - 7,924,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,919,822 - 7,924,410 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X7,496,948 - 7,501,536 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X7,076,781 - 7,080,194 (+)NCBIMGSCv36mm8
CeleraX3,544,922 - 3,549,511 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.57NCBI
Pcsk1n
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955543384,123 - 387,744 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955543383,984 - 387,885 (-)NCBIChiLan1.0ChiLan1.0
PCSK1N
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X50,320,252 - 50,324,769 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,323,624 - 50,328,141 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X41,128,785 - 41,133,284 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X48,988,782 - 48,994,021 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX48,988,948 - 48,990,028 (-)Ensemblpanpan1.1panPan2
PCSK1N
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X42,030,708 - 42,036,363 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,962,524 - 42,036,586 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,406,140 - 16,411,765 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,166,878 - 42,172,506 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,166,878 - 42,172,740 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,153,141 - 42,158,765 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,141,418 - 42,147,043 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,235,574 - 42,241,199 (-)NCBIUU_Cfam_GSD_1.0
Pcsk1n
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,543,584 - 34,547,318 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936721782,032 - 787,952 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936721783,973 - 787,712 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK1N
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,947,692 - 42,949,024 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,947,688 - 42,952,222 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,889,000 - 47,893,572 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PCSK1N
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X45,957,760 - 45,962,588 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX45,957,715 - 45,962,601 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607611,437,561 - 11,442,355 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcsk1n
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893632,930 - 636,664 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624893632,514 - 636,656 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pcsk1n
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:66
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000009794, ENSRNOT00000075774
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat

Markers in Region
BI283701  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 MapX165.3UniSTS
Cytogenetic MapXq13UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000009794   ⟹   ENSRNOP00000009794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX15,324,400 - 15,327,684 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000075774   ⟹   ENSRNOP00000066891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,580,038 - 14,583,566 (-)Ensembl
Rnor_6.0 EnsemblX15,425,078 - 15,428,518 (-)Ensembl
RefSeq Acc Id: NM_019279   ⟹   NP_062152
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X17,251,963 - 17,255,405 (-)NCBI
mRatBN7.2X14,580,036 - 14,583,478 (-)NCBI
Rnor_6.0X15,324,263 - 15,327,705 (-)NCBI
Rnor_5.0X16,104,504 - 16,107,946 (-)NCBI
RGSC_v3.4X26,614,585 - 26,618,027 (-)RGD
CeleraX14,664,791 - 14,668,241 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062152 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF22642 (Get FASTA)   NCBI Sequence Viewer  
  EDL83811 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066891.1
GenBank Protein Q9QXU9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062152   ⟸   NM_019279
- Peptide Label: precursor
- UniProtKB: Q9QXU9 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066891   ⟸   ENSRNOT00000075774
Ensembl Acc Id: ENSRNOP00000009794   ⟸   ENSRNOT00000009794

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QXU9-F1-model_v2 AlphaFold Q9QXU9 1-260 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701738
Promoter ID:EPDNEW_R12259
Type:initiation region
Name:Pcsk1n_1
Description:proprotein convertase subtilisin/kexin type 1 inhibitor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X15,327,754 - 15,327,814EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3617 AgrOrtholog
BioCyc Gene G2FUF-2931 BioCyc
Ensembl Genes ENSRNOG00000007112 Ensembl
  ENSRNOG00000046021 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075774.3 UniProtKB/TrEMBL
InterPro ProSAAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246333 UniProtKB/Swiss-Prot
NCBI Gene Pcsk1n ENTREZGENE
PANTHER PROSAAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15531 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ProSAAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pcsk1n PhenoGen
RatGTEx ENSRNOG00000007112 RatGTEx
  ENSRNOG00000046021 RatGTEx
  ENSRNOG00055027142 RatGTEx
  ENSRNOG00060025182 RatGTEx
  ENSRNOG00065011262 RatGTEx
TIGR TC205564
UniProt A6KP63_RAT UniProtKB/TrEMBL
  G3V6X7_RAT UniProtKB/TrEMBL
  PCSK1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Pcsk1n  proprotein convertase subtilisin/kexin type 1 inhibitor  LOC108348172  proSAAS  Data merged from RGD:11409911 737654 PROVISIONAL
2016-08-02 LOC108348172  proSAAS      Symbol and Name status set to provisional 70820 PROVISIONAL
2015-07-29 Pcsk1n  proprotein convertase subtilisin/kexin type 1 inhibitor  LOC100911286  proSAAS-like  Data merged from RGD:6493991 737654 PROVISIONAL
2012-07-05 LOC100911286  proSAAS-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Pcsk1n  proprotein convertase subtilisin/kexin type 1 inhibitor      Symbol and Name updated 629477 APPROVED
2003-03-06 Pcsk1n  proprotein convertase subtilisin/kexin type 1 inhibitor  Saas  granin-like neuroendocrine peptide precursor  Data merged from RGD:620567 628472 PROVISIONAL
2002-08-07 Saas  granin-like neuroendocrine peptide precursor      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-02-20 Pcsk1n  proprotein convertase subtilisin/kexin type 1 inhibitor      Symbol and Name updated to reflect Human and Mouse nomenclature 70282 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process inhibits prohormone convertase 1 activity 69973