Rln1 (relaxin 1) - Rat Genome Database

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Gene: Rln1 (relaxin 1) Rattus norvegicus
Analyze
Symbol: Rln1
Name: relaxin 1
RGD ID: 3579
Description: Predicted to enable signaling receptor binding activity. Involved in negative regulation of apoptotic process and regulation of cell population proliferation. Acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway and regulation of nitric oxide mediated signal transduction. Predicted to be located in extracellular region. Orthologous to several human genes including RLN1 (relaxin 1); INTERACTS WITH ammonium chloride; berberine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: preprorelaxin; prorelaxin 1; RELAX; Relaxin 1 (H1)
RGD Orthologs
Human
Mouse
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,493,532 - 236,496,541 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1236,493,536 - 236,496,440 (-)EnsemblGRCr8
mRatBN7.21227,079,960 - 227,082,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,079,966 - 227,082,882 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1235,481,608 - 235,484,509 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,411,272 - 242,414,173 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,228,554 - 235,231,480 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,483,298 - 247,486,331 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,483,302 - 247,486,202 (-)Ensemblrn6Rnor6.0
Rnor_5.01254,731,580 - 254,734,531 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41233,000,540 - 233,003,444 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1224,231,880 - 224,234,784 (-)NCBICelera
RGSC_v3.11233,164,562 - 233,167,467 (-)NCBI
RH 3.4 Map11616.7RGD
Cytogenetic Map1q52NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Hypertrophy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and characterization of cDNA sequences coding for rat relaxin. Hudson P, etal., Nature 1981 May 14;291(5811):127-31.
2. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
3. The extent to which relaxin promotes proliferation and inhibits apoptosis of cervical epithelial and stromal cells is greatest during late pregnancy in rats. Lee HY, etal., Endocrinology. 2005 Jan;146(1):511-8. Epub 2004 Oct 21.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2. Mookerjee I, etal., FASEB J. 2009 Apr;23(4):1219-29. doi: 10.1096/fj.08-120857. Epub 2008 Dec 10.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Rat preprorelaxin: complete amino acid sequence derived from cDNA analysis. Niall H, etal., Ann N Y Acad Sci 1982;380:13-21.
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Circulating relaxin acts on subfornical organ neurons to stimulate water drinking in the rat. Sunn N, etal., Proc Natl Acad Sci U S A 2002 Feb 5;99(3):1701-1706.
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7004862   PMID:8216305   PMID:9886856   PMID:12861045   PMID:15155573   PMID:15198972   PMID:16926527   PMID:16956745   PMID:19261221   PMID:19542742   PMID:21272344   PMID:21410550  
PMID:22363579   PMID:22744867   PMID:23207895   PMID:24640565   PMID:24640566   PMID:28606038   PMID:28776188   PMID:31811156  


Genomics

Comparative Map Data
Rln1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,493,532 - 236,496,541 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1236,493,536 - 236,496,440 (-)EnsemblGRCr8
mRatBN7.21227,079,960 - 227,082,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,079,966 - 227,082,882 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1235,481,608 - 235,484,509 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,411,272 - 242,414,173 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,228,554 - 235,231,480 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,483,298 - 247,486,331 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,483,302 - 247,486,202 (-)Ensemblrn6Rnor6.0
Rnor_5.01254,731,580 - 254,734,531 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41233,000,540 - 233,003,444 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1224,231,880 - 224,234,784 (-)NCBICelera
RGSC_v3.11233,164,562 - 233,167,467 (-)NCBI
RH 3.4 Map11616.7RGD
Cytogenetic Map1q52NCBI
RLN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3895,334,930 - 5,340,916 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl95,334,930 - 5,339,876 (-)Ensemblhg38GRCh38
GRCh3795,334,930 - 5,339,876 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3695,324,969 - 5,329,873 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3495,324,968 - 5,329,873NCBI
Celera95,260,593 - 5,265,497 (-)NCBICelera
Cytogenetic Map9p24.1NCBI
HuRef95,290,420 - 5,295,595 (-)NCBIHuRef
CHM1_195,335,103 - 5,340,044 (-)NCBICHM1_1
T2T-CHM13v2.095,340,023 - 5,345,993 (-)NCBIT2T-CHM13v2.0
Rln1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,309,155 - 29,312,070 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1929,308,570 - 29,312,070 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381929,331,755 - 29,334,670 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,331,170 - 29,334,670 (-)Ensemblmm10GRCm38
MGSCv371929,406,245 - 29,409,160 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361929,397,695 - 29,400,593 (-)NCBIMGSCv36mm8
Celera1930,108,320 - 30,111,235 (-)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1923.83NCBI
LOC100982570
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211119,212,769 - 119,218,288 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19119,141,982 - 119,224,235 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v095,173,570 - 5,255,799 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.195,359,582 - 5,364,386 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl95,359,582 - 5,364,386 (-)EnsemblpanPan2panpan1.1

Variants

.
Variants in Rln1
26 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:30
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000021315
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367243666627Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
8693661Alc34Alcohol consumption QTL 342.20.611drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
6480786Bw97Body weight QTL 975.03body mass (VT:0001259)body weight (CMO:0000012)1234540191237018045Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
8693618Alc25Alcohol consumption QTL 2530.28drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
D1Bda60  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21227,080,097 - 227,080,297 (+)MAPPERmRatBN7.2
Rnor_6.01247,483,432 - 247,483,631NCBIRnor6.0
Rnor_5.01254,731,718 - 254,731,917UniSTSRnor5.0
RGSC_v3.41233,000,674 - 233,000,873UniSTSRGSC3.4
Celera1224,232,014 - 224,232,213UniSTS
Cytogenetic Map1q52UniSTS
RH94497  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81236,493,592 - 236,493,724 (+)Marker Load Pipeline
mRatBN7.21227,080,020 - 227,080,152 (+)MAPPERmRatBN7.2
Rnor_6.01247,483,355 - 247,483,486NCBIRnor6.0
Rnor_5.01254,731,641 - 254,731,772UniSTSRnor5.0
RGSC_v3.41233,000,597 - 233,000,728UniSTSRGSC3.4
Celera1224,231,937 - 224,232,068UniSTS
RH 3.4 Map11616.7UniSTS
Cytogenetic Map1q52UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 7 23 115 37 30 19 19 19 6 123 61 6 99 30 53 11 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000088193   ⟹   ENSRNOP00000072430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1236,493,536 - 236,496,440 (-)Ensembl
mRatBN7.2 Ensembl1227,079,966 - 227,082,882 (-)Ensembl
Rnor_6.0 Ensembl1247,483,302 - 247,486,202 (-)Ensembl
RefSeq Acc Id: NM_013413   ⟹   NP_038199
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81236,493,536 - 236,496,440 (-)NCBI
mRatBN7.21227,079,964 - 227,082,870 (-)NCBI
Rnor_6.01247,483,298 - 247,486,202 (-)NCBI
Rnor_5.01254,731,580 - 254,734,531 (-)NCBI
RGSC_v3.41233,000,540 - 233,003,444 (-)RGD
Celera1224,231,880 - 224,234,784 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231196   ⟹   XP_006231258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81236,493,532 - 236,496,541 (-)NCBI
mRatBN7.21227,079,960 - 227,082,960 (-)NCBI
Rnor_6.01247,483,320 - 247,486,331 (-)NCBI
Rnor_5.01254,731,580 - 254,734,531 (-)NCBI
Sequence:
RefSeq Acc Id: NP_038199   ⟸   NM_013413
- Peptide Label: precursor
- UniProtKB: Q78N50 (UniProtKB/Swiss-Prot),   P01347 (UniProtKB/Swiss-Prot),   A6I0V8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231258   ⟸   XM_006231196
- Peptide Label: isoform X1
- UniProtKB: Q7TQA2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072430   ⟸   ENSRNOT00000088193
Protein Domains
Insulin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01347-F1-model_v2 AlphaFold P01347 1-186 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3579 AgrOrtholog
BioCyc Gene G2FUF-55970 BioCyc
Ensembl Genes ENSRNOG00000060867 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000088193 ENTREZGENE
InterPro Insulin-like UniProtKB/Swiss-Prot
  Insulin-like_sf UniProtKB/Swiss-Prot
  Insulin_CS UniProtKB/Swiss-Prot
  Relaxin UniProtKB/Swiss-Prot
  Repro_Hormone_Insulin-like UniProtKB/Swiss-Prot
KEGG Report rno:25616 UniProtKB/Swiss-Prot
NCBI Gene 25616 ENTREZGENE
PANTHER PRORELAXIN H2 UniProtKB/Swiss-Prot
  RELAXIN UniProtKB/Swiss-Prot
Pfam Insulin UniProtKB/Swiss-Prot
PhenoGen Rln1 PhenoGen
PRINTS RELAXIN UniProtKB/Swiss-Prot
PROSITE INSULIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000060867 RatGTEx
SMART IlGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56994 UniProtKB/Swiss-Prot
TIGR TC220512
UniProt A6I0V8 ENTREZGENE, UniProtKB/TrEMBL
  P01347 ENTREZGENE
  Q78N50 ENTREZGENE
  Q7TQA2 ENTREZGENE, UniProtKB/TrEMBL
  REL1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q78N50 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Rln1  relaxin 1       Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process functions in pregnancy and body fluid balance 70239
gene_process stimulates subfornical organ neurons initiating water drinking; may stimulate organum vasculosum of the lamina terminalis neurons to secrete vasopressin 70239