Rnase1 (ribonuclease A family member 1, pancreatic) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Rnase1 (ribonuclease A family member 1, pancreatic) Rattus norvegicus
Analyze
Symbol: Rnase1
Name: ribonuclease A family member 1, pancreatic
RGD ID: 3574
Description: Predicted to enable RNA nuclease activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to act upstream of or within response to bacterium. Predicted to be located in cytosol and lysosomal lumen. Orthologous to human RNASE1 (ribonuclease A family member 1, pancreatic); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103690354; pancreatic ribonuclease; Rib1; ribonuclease 1 pancreatic; ribonuclease 1, pancreatic; ribonuclease pancreatic beta-type; ribonuclease RNase A family 1; ribonuclease, RNase A family, 1; ribonuclease, RNase A family, 1 (pancreatic); RL1; RNase 1 gamma; RNase A
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,835,436 - 26,837,145 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1526,835,463 - 26,837,248 (-)EnsemblGRCr8
mRatBN7.21524,361,924 - 24,363,633 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,361,927 - 24,363,624 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1527,133,082 - 27,134,791 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,092,239 - 28,093,948 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,341,641 - 26,343,350 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,073,963 - 28,075,677 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,074,953 - 28,075,411 (+)NCBIrn6Rnor6.0
Rnor_5.01531,897,124 - 31,898,675 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41527,123,440 - 27,124,991NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1524,679,524 - 24,681,067 (-)NCBICelera
RGSC_v3.11527,139,139 - 27,140,691NCBI
Cytogenetic Map15p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Pancreatic-type ribonuclease 1 gene duplications in rat species. Dubois JY, etal., J Mol Evol 2002 Nov;55(5):522-33.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat pancreatic ribonuclease messenger RNA. The nucleotide sequence of the entire mRNA and the derived amino acid sequence of the pre-enzyme. MacDonald RJ, etal., J Biol Chem 1982 Dec 25;257(24):14582-5.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:4710592   PMID:6873294   PMID:9826755   PMID:10090281   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Rnase1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,835,436 - 26,837,145 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1526,835,463 - 26,837,248 (-)EnsemblGRCr8
mRatBN7.21524,361,924 - 24,363,633 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,361,927 - 24,363,624 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1527,133,082 - 27,134,791 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,092,239 - 28,093,948 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,341,641 - 26,343,350 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,073,963 - 28,075,677 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,074,953 - 28,075,411 (+)NCBIrn6Rnor6.0
Rnor_5.01531,897,124 - 31,898,675 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41527,123,440 - 27,124,991NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1524,679,524 - 24,681,067 (-)NCBICelera
RGSC_v3.11527,139,139 - 27,140,691NCBI
Cytogenetic Map15p14NCBI
RNASE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,801,228 - 20,802,844 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,801,228 - 20,802,884 (-)Ensemblhg38GRCh38
GRCh371421,269,387 - 21,271,003 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,339,355 - 20,340,876 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341420,339,355 - 20,340,876NCBI
Celera141,130,381 - 1,131,902 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,390,522 - 1,392,043 (-)NCBIHuRef
CHM1_11421,271,658 - 21,273,179 (-)NCBICHM1_1
T2T-CHM13v2.01414,998,670 - 15,000,286 (-)NCBIT2T-CHM13v2.0
Rnase1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,382,459 - 51,384,224 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,382,455 - 51,384,242 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381451,145,002 - 51,146,767 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,144,998 - 51,146,785 (-)Ensemblmm10GRCm38
MGSCv371451,764,677 - 51,766,442 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361450,066,953 - 50,068,718 (-)NCBIMGSCv36mm8
Celera1447,439,042 - 47,440,804 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.4NCBI
RNASE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,298,976 - 22,300,905 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,515,463 - 21,517,392 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,663,595 - 1,665,121 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,719,885 - 19,746,621 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,720,127 - 19,720,597 (-)EnsemblpanPan2panpan1.1
LOC475395
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11518,034,337 - 18,065,925 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1518,037,298 - 18,066,333 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1518,522,914 - 18,524,349 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01518,281,909 - 18,326,869 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1518,298,180 - 18,299,615 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11517,979,542 - 17,980,977 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01518,035,593 - 18,037,028 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01518,163,424 - 18,164,859 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rnase1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864032,181,705 - 32,183,432 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493688091,088 - 92,720 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493688091,085 - 92,743 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNASE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,213,005 - 78,214,821 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1778,199,007 - 78,214,832 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103231361
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,312,858 - 21,314,712 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,313,095 - 21,313,553 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605925,116,644 - 25,118,609 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Rnase1
1 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:32
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000041822
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151691152132439851Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 20 10 23 25 14 25 14 6 75 48 2 10 39 11

Sequence


Ensembl Acc Id: ENSRNOT00000082938   ⟹   ENSRNOP00000072263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,361,927 - 24,363,624 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086427   ⟹   ENSRNOP00000068653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1526,835,463 - 26,837,248 (-)Ensembl
Rnor_6.0 Ensembl1528,074,953 - 28,075,411 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000124045   ⟹   ENSRNOP00000110345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1526,835,513 - 26,837,093 (-)Ensembl
RefSeq Acc Id: NM_001029904   ⟹   NP_001025075
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,835,436 - 26,837,145 (-)NCBI
mRatBN7.21524,361,924 - 24,363,633 (-)NCBI
Rnor_5.01531,897,124 - 31,898,675 (-)NCBI
RGSC_v3.41527,123,440 - 27,124,991 (-)RGD
Celera1524,679,524 - 24,681,067 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001025075 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAB41484 (Get FASTA)   NCBI Sequence Viewer  
  EDL88443 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068653
  ENSRNOP00000072263.2
GenBank Protein P00684 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001025075   ⟸   NM_001029904
- Peptide Label: precursor
- UniProtKB: P00684 (UniProtKB/Swiss-Prot),   A6KED8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068653   ⟸   ENSRNOT00000086427
Ensembl Acc Id: ENSRNOP00000072263   ⟸   ENSRNOT00000082938
Ensembl Acc Id: ENSRNOP00000110345   ⟸   ENSRNOT00000124045
Protein Domains
Ribonuclease A-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00684-F1-model_v2 AlphaFold P00684 1-152 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3574 AgrOrtholog
BioCyc Gene G2FUF-14025 BioCyc
Ensembl Genes ENSRNOG00000053633 Ensembl
  ENSRNOG00000063584 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000082938.2 UniProtKB/Swiss-Prot
  ENSRNOT00000086427 ENTREZGENE
Gene3D-CATH 3.10.130.10 UniProtKB/Swiss-Prot
InterPro RNaseA UniProtKB/Swiss-Prot
  RNaseA-like_dom_sf UniProtKB/Swiss-Prot
  RNaseA_AS UniProtKB/Swiss-Prot
  RNaseA_domain UniProtKB/Swiss-Prot
NCBI Gene Rnase1 ENTREZGENE
PANTHER PTHR11437 UniProtKB/Swiss-Prot
  RIBONUCLEASE PANCREATIC UniProtKB/Swiss-Prot
Pfam RnaseA UniProtKB/Swiss-Prot
PhenoGen Rnase1 PhenoGen
PRINTS RIBONUCLEASE UniProtKB/Swiss-Prot
PROSITE RNASE_PANCREATIC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000053633 RatGTEx
  ENSRNOG00000063584 RatGTEx
SMART RNAse_Pc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54076 UniProtKB/Swiss-Prot
UniProt A6KED8 ENTREZGENE, UniProtKB/TrEMBL
  P00684 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Rnase1  ribonuclease A family member 1, pancreatic  LOC103690354  ribonuclease pancreatic beta-type  Data merged from RGD:9117758 737654 PROVISIONAL
2016-01-27 Rnase1  ribonuclease A family member 1, pancreatic  Rnase1  ribonuclease, RNase A family, 1 (pancreatic)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103690354  ribonuclease pancreatic beta-type      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Rnase1  ribonuclease, RNase A family, 1 (pancreatic)  Rib1  ribonuclease, RNase A family, 1  Symbol and Name updated 1299863 APPROVED
2002-06-10 Rib1  ribonuclease, RNase A family, 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein synthesized as a secretory pre-ribonuclease of 152 amino acids 69967