Rgs10 (regulator of G-protein signaling 10) - Rat Genome Database

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Gene: Rgs10 (regulator of G-protein signaling 10) Rattus norvegicus
Analyze
Symbol: Rgs10
Name: regulator of G-protein signaling 10
RGD ID: 3562
Description: Predicted to enable G-protein alpha-subunit binding activity and GTPase activator activity. Involved in response to amphetamine. Located in axon terminus; dendritic spine; and neuronal cell body. Biomarker of opioid abuse. Orthologous to human RGS10 (regulator of G protein signaling 10); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: regulator of G-protein signalling 10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Hc6
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,376,772 - 192,422,640 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1192,376,774 - 192,418,904 (-)EnsemblGRCr8
mRatBN7.21182,946,334 - 182,987,729 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,946,336 - 182,987,697 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1191,296,809 - 191,338,111 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,482,897 - 198,524,198 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01191,152,753 - 191,193,909 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,782,076 - 199,823,440 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,782,078 - 199,823,386 (-)Ensemblrn6Rnor6.0
Rnor_5.01206,829,264 - 206,870,593 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41187,622,488 - 187,664,295 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1180,591,534 - 180,632,893 (-)NCBICelera
RGSC_v3.11187,784,655 - 187,797,931 (-)NCBI
Cytogenetic Map1q37NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
diethylstilbestrol  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
Evodiamine  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
irinotecan  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
medroxyprogesterone acetate  (ISO)
methylseleninic acid  (ISO)
N-nitrosodimethylamine  (EXP)
niclosamide  (ISO)
nitrates  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reserpine  (EXP)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon terminus  (IDA)
cytosol  (IEA,ISO,ISS)
dendritic spine  (IDA)
neuronal cell body  (IDA)
nuclear body  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures. Gold SJ, etal., J Neurochem. 2002 Aug;82(4):828-38.
3. Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain. Gold SJ, etal., J Neurosci 1997 Oct 15;17(20):8024-37.
4. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Koelle MR and Horvitz HR, Cell 1996 Jan 12;84(1):115-25.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Differential regulation of RGS proteins in the prefrontal cortex of short- and long-term human opiate abusers. Rivero G, etal., Neuropharmacology. 2012 Feb;62(2):1044-51. doi: 10.1016/j.neuropharm.2011.10.015. Epub 2011 Oct 31.
11. The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration. Sun H, etal., Neuroscience. 2015 Oct 29;307:253-61. doi: 10.1016/j.neuroscience.2015.08.053. Epub 2015 Aug 28.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. Regional, cellular, and subcellular localization of RGS10 in rodent brain. Waugh JL, etal., J Comp Neurol. 2005 Jan 17;481(3):299-313.
Additional References at PubMed
PMID:8889548   PMID:10791963   PMID:11443111   PMID:12062898   PMID:18276732   PMID:18434541  


Genomics

Comparative Map Data
Rgs10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,376,772 - 192,422,640 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1192,376,774 - 192,418,904 (-)EnsemblGRCr8
mRatBN7.21182,946,334 - 182,987,729 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,946,336 - 182,987,697 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1191,296,809 - 191,338,111 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,482,897 - 198,524,198 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01191,152,753 - 191,193,909 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,782,076 - 199,823,440 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,782,078 - 199,823,386 (-)Ensemblrn6Rnor6.0
Rnor_5.01206,829,264 - 206,870,593 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41187,622,488 - 187,664,295 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1180,591,534 - 180,632,893 (-)NCBICelera
RGSC_v3.11187,784,655 - 187,797,931 (-)NCBI
Cytogenetic Map1q37NCBI
RGS10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810119,499,817 - 119,542,719 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10119,499,817 - 119,543,294 (-)Ensemblhg38GRCh38
GRCh3710121,259,329 - 121,302,231 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610121,249,329 - 121,292,212 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3410121,249,329 - 121,286,035NCBI
Celera10114,987,371 - 115,030,248 (-)NCBICelera
Cytogenetic Map10q26.11NCBI
HuRef10114,886,926 - 114,929,790 (-)NCBIHuRef
CHM1_110121,543,774 - 121,586,656 (-)NCBICHM1_1
T2T-CHM13v2.010120,395,411 - 120,438,320 (-)NCBIT2T-CHM13v2.0
Rgs10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,975,345 - 128,020,993 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,975,345 - 128,020,482 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387128,373,621 - 128,419,506 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7128,373,621 - 128,418,758 (-)Ensemblmm10GRCm38
MGSCv377135,517,139 - 135,561,686 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367128,164,773 - 128,209,320 (-)NCBIMGSCv36mm8
Celera7128,211,923 - 128,256,406 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map770.16NCBI
Rgs10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955551318,517 - 340,418 (-)Ensembl
ChiLan1.0NW_004955551318,229 - 348,578 (-)NCBIChiLan1.0ChiLan1.0
RGS10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28131,358,437 - 131,401,517 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110131,363,783 - 131,406,867 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010116,070,326 - 116,113,422 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110119,492,112 - 119,534,443 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10119,492,159 - 119,534,443 (-)EnsemblpanPan2panpan1.1
RGS10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12829,673,357 - 29,711,887 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2829,673,374 - 29,713,908 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2829,814,817 - 29,854,624 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02830,203,886 - 30,243,308 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2830,203,399 - 30,244,653 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12829,757,423 - 29,797,210 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02829,778,362 - 29,817,681 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02829,972,269 - 30,012,076 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rgs10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721316,657,115 - 16,693,971 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364868,866,474 - 8,904,744 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364868,867,327 - 8,904,161 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14129,381,208 - 129,423,702 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114129,386,717 - 129,424,150 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214140,910,188 - 140,948,437 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RGS10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19112,288,352 - 112,330,455 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9112,288,596 - 112,315,220 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604873,560,439 - 73,602,441 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgs10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473727,284,131 - 27,321,642 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473727,284,123 - 27,319,169 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rgs10
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1273,533,559 - 73,575,340 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rgs10
199 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:96
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000027375
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1191177449205813246Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1188241285197807511Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
RH132404  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,946,504 - 182,946,716 (+)MAPPERmRatBN7.2
Rnor_6.01199,782,247 - 199,782,458NCBIRnor6.0
Rnor_5.01206,829,435 - 206,829,646UniSTSRnor5.0
RGSC_v3.41187,622,659 - 187,622,870UniSTSRGSC3.4
Celera1180,591,705 - 180,591,916UniSTS
Cytogenetic Map1q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027375   ⟹   ENSRNOP00000027375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,376,774 - 192,418,077 (-)Ensembl
mRatBN7.2 Ensembl1182,946,337 - 182,987,697 (-)Ensembl
Rnor_6.0 Ensembl1199,782,078 - 199,823,386 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111253   ⟹   ENSRNOP00000083632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,376,774 - 192,403,732 (-)Ensembl
mRatBN7.2 Ensembl1182,946,336 - 182,973,296 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117000   ⟹   ENSRNOP00000087056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,376,774 - 192,412,373 (-)Ensembl
mRatBN7.2 Ensembl1182,946,336 - 182,981,965 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000121897   ⟹   ENSRNOP00000107202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,376,774 - 192,418,904 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000137492   ⟹   ENSRNOP00000111190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,376,774 - 192,412,014 (-)Ensembl
RefSeq Acc Id: NM_019337   ⟹   NP_062210
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,376,772 - 192,418,077 (-)NCBI
mRatBN7.21182,946,334 - 182,987,641 (-)NCBI
Rnor_6.01199,782,076 - 199,823,386 (-)NCBI
Rnor_5.01206,829,264 - 206,870,593 (-)NCBI
RGSC_v3.41187,622,488 - 187,664,295 (-)RGD
Celera1180,591,534 - 180,632,893 (-)RGD
Sequence:
RefSeq Acc Id: XM_006230325   ⟹   XP_006230387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,376,780 - 192,412,313 (-)NCBI
mRatBN7.21182,946,334 - 182,981,884 (-)NCBI
Rnor_6.01199,782,082 - 199,817,630 (-)NCBI
Rnor_5.01206,829,264 - 206,870,593 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006230326   ⟹   XP_006230388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,376,780 - 192,422,640 (-)NCBI
mRatBN7.21182,946,334 - 182,987,729 (-)NCBI
Rnor_6.01199,782,416 - 199,823,440 (-)NCBI
Rnor_5.01206,829,264 - 206,870,593 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088606   ⟹   XP_038944534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,376,780 - 192,412,037 (-)NCBI
mRatBN7.21182,946,334 - 182,981,600 (-)NCBI
RefSeq Acc Id: XM_063271970   ⟹   XP_063128040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,376,780 - 192,401,873 (-)NCBI
RefSeq Acc Id: NP_062210   ⟸   NM_019337
- UniProtKB: A0A8I5ZZL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230387   ⟸   XM_006230325
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A7A9 (UniProtKB/TrEMBL),   A0A8I5ZZL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230388   ⟸   XM_006230326
- Peptide Label: isoform X3
- UniProtKB: A6IA02 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027375   ⟸   ENSRNOT00000027375
RefSeq Acc Id: XP_038944534   ⟸   XM_039088606
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZZL9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087056   ⟸   ENSRNOT00000117000
Ensembl Acc Id: ENSRNOP00000083632   ⟸   ENSRNOT00000111253
RefSeq Acc Id: XP_063128040   ⟸   XM_063271970
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000111190   ⟸   ENSRNOT00000137492
Ensembl Acc Id: ENSRNOP00000107202   ⟸   ENSRNOT00000121897
Protein Domains
RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49806-F1-model_v2 AlphaFold P49806 1-181 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690458
Promoter ID:EPDNEW_R983
Type:multiple initiation site
Name:Rgs10_1
Description:regulator of G-protein signaling 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01199,823,429 - 199,823,489EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3562 AgrOrtholog
BioCyc Gene G2FUF-57297 BioCyc
Ensembl Genes ENSRNOG00000042592 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027375 ENTREZGENE
  ENSRNOT00000027375.6 UniProtKB/Swiss-Prot
  ENSRNOT00000117000 ENTREZGENE
  ENSRNOT00000137492 ENTREZGENE
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot
  1.10.196.10 UniProtKB/Swiss-Prot
InterPro RGS UniProtKB/Swiss-Prot
  RGS10/12/14-like UniProtKB/Swiss-Prot
  RGS10_RGS UniProtKB/Swiss-Prot
  RGS_sf UniProtKB/Swiss-Prot
  RGS_subdom1/3 UniProtKB/Swiss-Prot
  RGS_subdomain_2 UniProtKB/Swiss-Prot
NCBI Gene 54290 ENTREZGENE
PANTHER REGULATOR OF G-PROTEIN SIGNALING LOCO UniProtKB/Swiss-Prot
  REGULATOR OF G-PROTEIN SIGNALING LOCO UniProtKB/Swiss-Prot
Pfam RGS UniProtKB/Swiss-Prot
PhenoGen Rgs10 PhenoGen
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot
PROSITE RGS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000042592 RatGTEx
SMART RGS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot
TIGR TC231169
UniProt A0A8I5ZZL9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7A9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LTM1_RAT UniProtKB/TrEMBL
  A0ABK0M230_RAT UniProtKB/TrEMBL
  A6IA02 ENTREZGENE, UniProtKB/TrEMBL
  P49806 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary G3V8Q0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Rgs10  regulator of G-protein signaling 10  Rgs10  regulator of G-protein signalling 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Rgs10  regulator of G-protein signalling 10    regulator of G-protein signaling 10  Name updated 1299863 APPROVED
2002-06-10 Rgs10  regulator of G-protein signaling 10      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression in hippocampus increases in response to seizure 737641