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Gene: Rgs1 (regulator of G-protein signaling 1) Rattus norvegicus

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Symbol:

Rgs1

Name:

regulator of G-protein signaling 1

RGD ID:

3561

Description:

Predicted to enable G-protein alpha-subunit binding activity and GTPase activator activity. Predicted to be involved in leukotriene signaling pathway and positive regulation of GTPase activity. Predicted to act upstream of or within response to bacterium. Predicted to be located in cytoplasmic side of plasma membrane and cytosol. Orthologous to human RGS1 (regulator of G protein signaling 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

MGC112645

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RGS1 (regulator of G protein signaling 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Rgs1 (regulator of G-protein signaling 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rgs1 (regulator of G protein signaling 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RGS1 (regulator of G protein signaling 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RGS1 (regulator of G protein signaling 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rgs1 (regulator of G protein signaling 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RGS1 (regulator of G protein signaling 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RGS1 (regulator of G protein signaling 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rgs1 (regulator of G protein signaling 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rgs1 (regulator of G protein signaling 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RGS1 (regulator of G protein signaling 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rgs1 (regulator of G-protein signaling 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rgs1 (regulator of G protein signaling 1)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	rgs1 (regulator of G protein signaling 1)	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	si:ch211-117l17.5	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Danio rerio (zebrafish):	si:ch211-117l17.5	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|SonicParanoid)
Danio rerio (zebrafish):	rgs13 (regulator of G protein signaling 13)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Danio rerio (zebrafish):	rgs13 (regulator of G protein signaling 13)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rgs-10	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	rgs-8.1	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	rgs-8.2	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	rgs1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SST2	Alliance	DIOPT (OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	58,568,844 - 58,573,187 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	58,568,844 - 58,573,187 (-)	Ensembl				GRCr8
mRatBN7.2	13	56,018,546 - 56,022,889 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	56,018,554 - 56,022,984 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	58,589,584 - 58,593,926 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	59,843,245 - 59,847,588 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	57,127,442 - 57,131,783 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	61,066,196 - 61,070,772 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	61,066,153 - 61,070,599 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	66,051,575 - 66,055,971 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	58,121,188 - 58,125,514 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	56,094,754 - 56,099,080 (-)	NCBI		Celera
RGSC_v3.1	13	58,135,995 - 58,136,925 (-)	NCBI
Cytogenetic Map	13	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic contact dermatitis (ISO)

Arsenic Poisoning (ISO)

COVID-19 (ISO)

osteosarcoma (ISO)

skin disease (ISO)

Tendon Injuries (IDA)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(-)-demecolcine (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

1,3-benzothiazole-2-thiol (ISO)

1,4-dioxane (ISO)

1,4-phenylenediamine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-butoxyethanol (ISO)

2-naphthylamine (ISO)

3,7-dihydropurine-6-thione (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

4-hydroxynon-2-enal (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

Butylbenzyl phthalate (EXP,ISO)

calcitriol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (EXP)

Cuprizon (EXP)

cytarabine (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

dimethylarsinic acid (ISO)

dinitrogen (ISO)

diuron (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

eugenol (ISO)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

fulvestrant (ISO)

graphite (EXP)

GSK-J4 (ISO)

iodoacetic acid (ISO)

irinotecan (ISO)

iron atom (ISO)

iron(0) (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

mercaptopurine (EXP)

methamphetamine (EXP)

methimazole (EXP)

methotrexate (ISO)

methylarsonic acid (ISO)

methylmercury chloride (ISO)

microcystin-LR (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

nicotine (ISO)

nitrofen (EXP)

octreotide (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pioglitazone (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

purine-6-thiol (EXP)

quercetin (ISO)

SCH 23390 (EXP)

silicon dioxide (EXP,ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

T-2 toxin (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

triclosan (ISO)

triphenyl phosphate (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

vincristine (ISO)

vitamin D (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

G protein-coupled receptor signaling pathway (IEA,ISO,ISS)

leukotriene signaling pathway (IEA,ISO,ISS)

negative regulation of G protein-coupled receptor signaling pathway (IBA)

negative regulation of signal transduction (IEA)

positive regulation of GTPase activity (ISO,ISS)

response to bacterium (ISO)

signal transduction (IEA,ISO,ISS)

Cellular Component

cytoplasmic side of plasma membrane (IBA,IEA,ISO,ISS)

cytosol (IEA,ISO,ISS)

plasma membrane (IEA)

Molecular Function

G-protein alpha-subunit binding (IEA,ISO)

GTPase activator activity (IBA,IEA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Primary gene response to mechanical loading in healing rat Achilles tendons.	Eliasson P, etal., J Appl Physiol (1985). 2013 Jun;114(11):1519-26. doi: 10.1152/japplphysiol.01500.2012. Epub 2013 Mar 21.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10480894	PMID:12477932	PMID:15489334	PMID:18434541	PMID:23012479	PMID:31012109

Genomics

Comparative Map Data

Rgs1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	58,568,844 - 58,573,187 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	58,568,844 - 58,573,187 (-)	Ensembl				GRCr8
mRatBN7.2	13	56,018,546 - 56,022,889 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	56,018,554 - 56,022,984 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	58,589,584 - 58,593,926 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	59,843,245 - 59,847,588 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	57,127,442 - 57,131,783 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	61,066,196 - 61,070,772 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	61,066,153 - 61,070,599 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	66,051,575 - 66,055,971 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	58,121,188 - 58,125,514 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	56,094,754 - 56,099,080 (-)	NCBI		Celera
RGSC_v3.1	13	58,135,995 - 58,136,925 (-)	NCBI
Cytogenetic Map	13	q21	NCBI

RGS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	192,575,773 - 192,580,024 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	192,575,763 - 192,580,024 (+)	Ensembl			hg38	GRCh38
GRCh37	1	192,544,903 - 192,549,154 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	190,811,480 - 190,815,782 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	189,276,513 - 189,280,816	NCBI
Celera	1	165,654,672 - 165,658,974 (+)	NCBI		Celera
Cytogenetic Map	1	q31.2	NCBI
HuRef	1	163,781,164 - 163,785,466 (+)	NCBI		HuRef
CHM1_1	1	193,966,658 - 193,970,960 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	191,922,968 - 191,927,219 (+)	NCBI		T2T-CHM13v2.0

Rgs1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	144,120,407 - 144,124,862 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	144,118,034 - 144,124,980 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	144,244,669 - 144,249,104 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	144,242,296 - 144,249,242 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	146,091,799 - 146,096,234 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	146,006,887 - 146,011,253 (-)	NCBI		MGSCv36	mm8
Celera	1	146,807,094 - 146,811,529 (-)	NCBI		Celera
Cytogenetic Map	1	F	NCBI
cM Map	1	62.56	NCBI

Rgs1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	30,041,870 - 30,047,752 (+)	Ensembl
ChiLan1.0	NW_004955406	30,042,354 - 30,047,172 (+)	NCBI	ChiLan1.0	ChiLan1.0

RGS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	57,209,527 - 57,213,812 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	56,873,541 - 56,877,824 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	168,039,235 - 168,043,516 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	172,333,842 - 172,338,105 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	172,333,866 - 172,337,401 (+)	Ensembl			panPan2	panpan1.1

RGS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	6,372,451 - 6,376,427 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	6,372,558 - 6,376,315 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	6,469,308 - 6,473,654 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	6,389,651 - 6,393,997 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	6,390,151 - 6,393,923 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	6,388,350 - 6,392,690 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	6,754,006 - 6,758,352 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	6,989,727 - 6,994,072 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rgs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	81,261,527 - 81,265,779 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936638	879,287 - 883,169 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936638	879,241 - 883,423 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RGS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	1,147,458 - 1,151,738 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	1,147,439 - 1,151,733 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	2,731,386 - 2,735,619 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RGS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	36,853,413 - 36,868,599 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	36,853,340 - 36,857,663 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666055	37,822,366 - 37,826,704 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rgs1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624814	1,041,784 - 1,045,954 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624814	1,041,812 - 1,045,961 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rgs1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	24,151,464 - 24,155,812 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rgs1
125 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	239
Count of miRNA genes:	169
Interacting mature miRNAs:	195
Transcripts:	ENSRNOT00000005251
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	48639634	93639634	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	48749814	87285480	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	24853925	69853925	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	39968211	83286298	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	17468282	62468282	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37087983	82087983	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	40983585	85983585	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	47354258	94285672	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	26244808	71244808	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	33794096	78794096	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	34834947	79834947	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	33794096	60914504	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	39814726	84814726	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	39968211	84968211	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	26244808	71244808	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	38286298	83286298	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	17711336	62711336	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	10	61	157	91	90	59	92	59	6	347	184	11	136	81	85	31	9	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001401277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_019336	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC098681	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U77698	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000005251 ⟹ ENSRNOP00000005251

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	58,568,844 - 58,573,187 (-)	Ensembl
mRatBN7.2 Ensembl	13	56,018,554 - 56,022,984 (-)	Ensembl
Rnor_6.0 Ensembl	13	61,066,153 - 61,070,599 (-)	Ensembl

RefSeq Acc Id:

NM_001401277 ⟹ NP_001388206

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	58,568,844 - 58,573,187 (-)	NCBI
mRatBN7.2	13	56,018,546 - 56,022,889 (-)	NCBI

RefSeq Acc Id:

NM_019336 ⟹ NP_062209

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	58,568,844 - 58,573,187 (-)	NCBI
mRatBN7.2	13	56,018,546 - 56,022,889 (-)	NCBI
Rnor_6.0	13	61,066,196 - 61,070,522 (-)	NCBI
Rnor_5.0	13	66,051,575 - 66,055,971 (-)	NCBI
RGSC_v3.4	13	58,121,188 - 58,125,514 (-)	RGD
Celera	13	56,094,754 - 56,099,080 (-)	RGD

Sequence:

show sequence

GGACCATGAGAGCTGCAGCCATCTCCATGCCAAGGTTGAACAAAATGCCAGGAATGTTCTTCTC
TGCTAGCCCAAAGGATTCAAAAGAACCAAGCCATTCTCTTCTAGATGACAACAAGCAAAAAAAG
AGGCCAAAGACTTTATAAAGGGGAACTCTTCTAGAGAATTATGAATTTTTGCTGTCTTTTGTAG
TGGAATGGACATGAAAGCATATCTAAGATCTATGATCCCTCATCTGGAATCTGGGATGAAATCG
TCCAAGTCCAAAGACATACTTTCGGCTGAGGAAGTAATGCAGTGGTCTCAGTCTCTGGAAAAAC
TCCTTGCCAACCAGATGGGTCAAAATGTCTTTGGGAAATTCCTAAAGTCTGAATTCAGTGAAGA
GAACATTGAATTCTGGTTGGCTTGTGAAGACTATAAGAAAACAGAGACTGATCTTTTGCATAAC
AAAGCAGAGCATATATACAAAGCATTTGTGCACTCAGATGCTGTGAAACAAATCAATATTGACT
TTCATACTCGGGAATCGACAGCCAAGAAGATCAAAACACCAACTCCCACATGTTTTGATGAAGC
ACAAAAAGTCATATACGCACTTATGGAAAAGGATTCTTATCCCAGGTTCCTGAAATCAAATATT
TACTTAAATCTTCTAAATGACCTTCAGGCGAATACCTTAAAGTGAGTGGTTCCTTGCTGACAGG
AATTCAAAGATAGTATCAAGGACAGAAGGAACATGAGACTGCCTACAGGATCAGTCTGGCCTGC
AGAGGAGACTCATCAGTCCGGAGAAGTGCAGATGAACGGATTCACACAGAATGTATCTCGGTGG
AGACTTGAGGAAACATCGCAAGAAGAACAGGGTGAGGCAAGTGGAAGGAGAAACTGTGGTACTG
TCATGAAATACAGTGGGACTCTATTAGACAACCCTCCCAACTGGGGAGGTCAGCTGACTCTGGC
AACACAGAAACTGTGAATAATTTGTATGAGACTGATTACTATGTGCTATAAGCTTCAAGAACAG
CAGACGTGTATGCTACATGCTGTTGTGTACAATGTGTTGAACTCTGACAATCTCCTTCCTGTAC
ATAATCAGTCCAAAAGTATATATTGCAAATAGGAGTTGCTATTATAGACATGAAGAACTTTTTA
TTTGTTTATTTAATTGTATTTGGCTTGGAGTTGAGAAAGACAATTATATATTTAACCTATTTTT
TAATCTAAGAAGTTATAACACATCTGTAAAGTAAATTATCACTGTGGCAATAATAAATGTGGGC
ATTACATTAAAATAGAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001388206	(Get FASTA)	NCBI Sequence Viewer
	NP_062209	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB48300	(Get FASTA)	NCBI Sequence Viewer
	AAH98681	(Get FASTA)	NCBI Sequence Viewer
	EDM09598	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005251
	ENSRNOP00000005251.5
GenBank Protein	P97844	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_062209 ⟸ NM_019336
- Peptide Label:	isoform 2
- UniProtKB:	P97844 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MDMKAYLRSMIPHLESGMKSSKSKDILSAEEVMQWSQSLEKLLANQMGQNVFGKFLKSEFSEEN IEFWLACEDYKKTETDLLHNKAEHIYKAFVHSDAVKQINIDFHTRESTAKKIKTPTPTCFDEAQ KVIYALMEKDSYPRFLKSNIYLNLLNDLQANTLK hide sequence

Ensembl Acc Id:

ENSRNOP00000005251 ⟸ ENSRNOT00000005251

RefSeq Acc Id:	NP_001388206 ⟸ NM_001401277
- Peptide Label:	isoform 1
- UniProtKB:	P97844 (UniProtKB/Swiss-Prot), A0A0H2UHC4 (UniProtKB/Swiss-Prot), Q4KM99 (UniProtKB/Swiss-Prot)

Protein Domains

RGS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P97844-F1-model_v2	AlphaFold	P97844	1-209	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698876

Promoter ID:

EPDNEW_R9401

Type:

single initiation site

Name:

Rgs1_1

Description:

regulator of G-protein signaling 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	61,070,535 - 61,070,595	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3561	AgrOrtholog
BioCyc Gene	G2FUF-18000	BioCyc
Ensembl Genes	ENSRNOG00000003895	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000005251	ENTREZGENE
	ENSRNOT00000005251.8	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.167.10	UniProtKB/Swiss-Prot
	1.10.196.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7385088	IMAGE-MGC_LOAD
InterPro	RGS	UniProtKB/Swiss-Prot
	RGS_sf	UniProtKB/Swiss-Prot
	RGS_subdom1/3	UniProtKB/Swiss-Prot
	RGS_subdomain_2	UniProtKB/Swiss-Prot
KEGG Report	rno:54289	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112645	IMAGE-MGC_LOAD
NCBI Gene	54289	ENTREZGENE
PANTHER	PTHR10845:SF34	UniProtKB/Swiss-Prot
	REGULATOR OF G PROTEIN SIGNALING	UniProtKB/Swiss-Prot
Pfam	RGS	UniProtKB/Swiss-Prot
PhenoGen	Rgs1	PhenoGen
PRINTS	RGSPROTEIN	UniProtKB/Swiss-Prot
PROSITE	RGS	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000003895	RatGTEx
SMART	RGS	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48097	UniProtKB/Swiss-Prot
UniProt	A0A0H2UHC4	ENTREZGENE
	P97844	ENTREZGENE
	Q4KM99	ENTREZGENE
	RGS1_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	A0A0H2UHC4	UniProtKB/Swiss-Prot
	Q4KM99	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Rgs1	regulator of G-protein signaling 1			Name updated	70584	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD