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Gene: Rab12 (RAB12, member RAS oncogene family) Rattus norvegicus

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Symbol:

Rab12

Name:

RAB12, member RAS oncogene family

RGD ID:

3527

Description:

Predicted to enable GDP binding activity and GTPase activity. Predicted to be involved in several processes, including endocytic recycling; endosome to lysosome transport; and positive regulation of macroautophagy. Predicted to act upstream of or within cellular response to type II interferon. Located in secretory granule. Orthologous to human RAB12 (RAB12, member RAS oncogene family); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

hypothetical protein LOC680714; LOC100362985; LOC102551479; LOC680714; ras-related protein Rab-12; ras-related protein Rab-12-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RAB12 (RAB12, member RAS oncogene family)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Rab12 (RAB12, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rab12 (RAB12, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RAB12 (RAB12, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RAB12 (RAB12, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rab12 (RAB12, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RAB12 (RAB12, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RAB12 (RAB12, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rab12 (RAB12, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rab12 (RAB12, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PNMA8C (PNMA family member 8C)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Rab12 (RAB12, member RAS oncogene family)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rab12 (RAB12, member RAS oncogene family)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	RAB12 (RAB12, member RAS oncogene family)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rab12 (RAB12, member RAS oncogene family)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SEC4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	SEC4	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	rab12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	113,927,119 - 113,953,722 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	113,927,119 - 113,953,695 (-)	Ensembl				GRCr8
mRatBN7.2	9	106,480,301 - 106,506,895 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	106,480,301 - 106,506,910 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	114,869,871 - 114,895,129 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	119,992,575 - 120,018,922 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	118,335,731 - 118,360,989 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	114,683,985 - 114,709,613 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	114,684,039 - 114,709,546 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	114,153,790 - 114,211,219 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	79,369,269 - 79,370,038 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	103,654,511 - 103,681,028 (-)	NCBI		Celera
RGSC_v3.1	9	105,834,937 - 105,854,349 (-)	NCBI
Cytogenetic Map	9	q37	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Myocardial Ischemia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

7,12-dimethyltetraphene (ISO)

ammonium chloride (EXP)

Aroclor 1254 (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

chlorpyrifos (ISO)

choline (ISO)

chromium(6+) (ISO)

clozapine (EXP)

cocaine (EXP)

doxorubicin (ISO)

ethanol (ISO)

folic acid (ISO)

FR900359 (ISO)

furan (EXP)

genistein (EXP)

gentamycin (EXP)

GSK-J4 (ISO)

haloperidol (EXP)

ivermectin (ISO)

L-methionine (ISO)

lead(0) (ISO)

lithocholic acid (EXP)

Methylazoxymethanol acetate (EXP)

methylmercury chloride (ISO)

phenol red (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

resveratrol (ISO)

sodium fluoride (ISO)

sunitinib (ISO)

testosterone (EXP,ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

valproic acid (ISO)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagy (IEA)

cellular response to type II interferon (ISO)

endocytic recycling (IBA)

endosome to lysosome transport (ISO,ISS)

exocytosis (IBA)

positive regulation of macroautophagy (ISO)

protein catabolic process (ISO,ISS)

protein transport (IEA)

Rab protein signal transduction (IEA)

Cellular Component

autophagosome (IEA,ISO)

cytoplasm (IEA)

cytoplasmic vesicle (IEA)

endosome (IBA)

Golgi membrane (IEA)

lysosomal membrane (IEA)

lysosome (ISO,ISS)

phagocytic vesicle (ISO)

plasma membrane (IBA)

recycling endosome membrane (IEA,ISO,ISS)

secretory granule (IDA)

synaptic vesicle (IBA)

trans-Golgi network transport vesicle (IBA)

Molecular Function

G protein activity (IEA)

GDP binding (ISO,ISS)

GTP binding (IEA,TAS)

GTPase activity (IBA,IEA)

hydrolase activity (IEA)

metal ion binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain.	Elferink LA, etal., J Biol Chem 1992 Mar 25;267(9):5768-75.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Identification of rab12 as a secretory granule-associated small GTP-binding protein in atrial myocytes.	Iida H, etal., Circ Res 1996 Feb;78(2):343-7.
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:8889548	PMID:19144319	PMID:20937701	PMID:21718402	PMID:23357852	PMID:26740112

Genomics

Comparative Map Data

Rab12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	113,927,119 - 113,953,722 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	113,927,119 - 113,953,695 (-)	Ensembl				GRCr8
mRatBN7.2	9	106,480,301 - 106,506,895 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	106,480,301 - 106,506,910 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	114,869,871 - 114,895,129 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	119,992,575 - 120,018,922 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	118,335,731 - 118,360,989 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	114,683,985 - 114,709,613 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	114,684,039 - 114,709,546 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	114,153,790 - 114,211,219 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	79,369,269 - 79,370,038 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	103,654,511 - 103,681,028 (-)	NCBI		Celera
RGSC_v3.1	9	105,834,937 - 105,854,349 (-)	NCBI
Cytogenetic Map	9	q37	NCBI

RAB12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	8,609,437 - 8,639,383 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	8,609,437 - 8,639,383 (+)	Ensembl			hg38	GRCh38
GRCh37	18	8,609,435 - 8,639,381 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	8,599,443 - 8,629,380 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	18	8,493,793 - 8,523,729 (+)	NCBI		Celera
Cytogenetic Map	18	p11.22	NCBI
HuRef	18	8,573,832 - 8,603,702 (+)	NCBI		HuRef
CHM1_1	18	8,609,630 - 8,639,561 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	8,772,604 - 8,802,430 (+)	NCBI		T2T-CHM13v2.0

Rab12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	66,801,507 - 66,826,712 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	66,801,507 - 66,826,724 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	66,494,512 - 66,519,750 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	66,494,512 - 66,519,729 (-)	Ensembl			mm10	GRCm38
MGSCv37	17	66,843,852 - 66,869,010 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	66,399,903 - 66,403,053 (-)	NCBI		MGSCv36	mm8
Celera	17	70,794,697 - 70,819,774 (-)	NCBI		Celera
Cytogenetic Map	17	E1.1	NCBI
cM Map	17	37.88	NCBI

Rab12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	3,103,708 - 3,110,701 (-)	Ensembl
ChiLan1.0	NW_004955402	3,102,709 - 3,109,701 (-)	NCBI	ChiLan1.0	ChiLan1.0

RAB12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	29,812,893 - 29,842,802 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	15,505,488 - 15,535,394 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	5,646,023 - 5,675,920 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	7,972,938 - 8,002,396 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	7,972,938 - 8,027,500 (-)	Ensembl			panPan2	panpan1.1

RAB12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	74,752,697 - 74,791,872 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	74,156,331 - 74,183,601 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	74,816,718 - 74,843,988 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	74,816,718 - 74,843,152 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	74,519,047 - 74,546,312 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	74,537,542 - 74,564,800 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	74,843,119 - 74,870,370 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rab12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	71,800,038 - 71,822,597 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936670	2,315,442 - 2,338,509 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936670	2,315,930 - 2,338,489 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RAB12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	99,216,228 - 99,244,868 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	99,216,225 - 99,244,627 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

RAB12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	67,572,529 - 67,600,646 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	67,572,519 - 67,601,428 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666050	42,507,756 - 42,535,934 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rab12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624770	17,635,901 - 17,653,919 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624770	17,636,031 - 17,654,863 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rab12
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	176,165,321 - 176,191,384 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rab12
386 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	41
Count of miRNA genes:	38
Interacting mature miRNAs:	39
Transcripts:	ENSRNOT00000026177
Prediction methods:	Microtar, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	44458256	121768150	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	68875497	121768150	Rat
1354626	Bvd1	Brain ventricular dilatation QTL 1	3.73	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	9	83161999	118999486	Rat
7794784	Mcs31	Mammary carcinoma susceptibility QTL 31	2.98		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	9	85262459	118999486	Rat
2303178	Bp334	Blood pressure QTL 334	3.7	0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	86720043	121768150	Rat

Markers in Region

RH129245

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Celera	9	103,654,577 - 103,654,786	UniSTS
Cytogenetic Map	9	q37	UniSTS

RH138031

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	106,505,613 - 106,505,837 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	114,708,428 - 114,708,651	NCBI	Rnor6.0
Rnor_5.0	9	114,210,034 - 114,210,257	UniSTS	Rnor5.0
RGSC_v3.4	9	105,643,888 - 105,644,111	UniSTS	RGSC3.4
Celera	9	103,679,846 - 103,680,069	UniSTS
Cytogenetic Map	9	q37	UniSTS

RH129304

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Celera	9	103,654,596 - 103,654,814	UniSTS
Cytogenetic Map	9	q37	UniSTS

RH135112

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Celera	9	103,655,190 - 103,655,384	UniSTS
Cytogenetic Map	9	q37	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_013017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063266705	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005488852	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AI029303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI706856	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB692926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK841014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DY310463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213691	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M83676	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026177 ⟹ ENSRNOP00000059602

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	113,929,321 - 113,953,616 (-)	Ensembl
mRatBN7.2 Ensembl	9	106,482,503 - 106,506,799 (-)	Ensembl
Rnor_6.0 Ensembl	9	114,684,039 - 114,709,546 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098588 ⟹ ENSRNOP00000076702

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	113,927,119 - 113,953,695 (-)	Ensembl
mRatBN7.2 Ensembl	9	106,480,301 - 106,506,910 (-)	Ensembl

RefSeq Acc Id:

NM_013017 ⟹ NP_037149

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	113,927,119 - 113,953,616 (-)	NCBI
mRatBN7.2	9	106,480,301 - 106,506,799 (-)	NCBI
Rnor_6.0	9	114,683,985 - 114,709,613 (-)	NCBI
Rnor_5.0	9	114,153,790 - 114,211,219 (-)	NCBI
Celera	9	103,654,511 - 103,681,028 (-)	RGD

Sequence:

show sequence

GCGGGTGGAGGGTGCGCGGGGGCCCGGGGCGCGCGGACGGCGGCCCGAGCGCGAGCCGTATGCG
TGCATGGATCCGAGCGCCGCGCTGCACCGGCGGCCCGCGGGCGGCGGCCTGGGCGCGGTCTCCC
CGGCGCTGTCCGGCGGCCAGGCCCGTCGGAGGAAGCAGCCCCCCAGGCCGGCCGACTTCAAGCT
GCAGGTCATCATCATCGGCTCCCGCGGCGTGGGCAAGACCAGCCTGATGGAGCGCTTCACCGAC
GACACGTTCTGCGAGGCCTGCAAGTCCACCGTGGGTGTTGACTTTAAAATCAAGACTGTAGAAC
TAAGAGGGAAGAAAATTAGATTACAGATCTGGGACACAGCAGGGCAGGAGCGATTCAACAGCAT
TACCTCAGCCTATTACAGAAGTGCCAAGGGGATCATACTCGTGTATGACATCACCAAGAAAGAG
ACGTTCGATGACTTGCCAAAGTGGATGAAGATGATCGATAAGTATGCTTCAGAAGACGCTGAGC
TTCTCCTGGTCGGAAATAAGCTGGACTGTGAAACAGACAGAGAAATCTCCAGGCAGCAAGGAGA
AAAGTTTGCACAGCAGATAACCGGGATGCGGTTCTGCGAAGCCAGTGCCAAGGACAATTTCAAC
GTGGATGAGATCTTTCTGAAACTCGTTGATGATATTTTGAAAAAGATGCCTCTCGATGTTTTGA
GAAGCGAGTTATCCAATAGCATCCTCTCTCTACAACCAGAGCCTGAGATCCCACCAGAGCTGCC
TCCACCCAGACCACACGTCCGATGCTGTTGATTTGATACTTTGGAGATGGTGCAAGCCATTGCT
AGAAGGGGAAAGCATTCTGCTCTGCACTACAATCACGTGACAACTTCCTTTCGCACTTTGTAAC
CCAAGTCAGCTACACACTAACTTGTAAATATGCAAATATGCAATCCTGGGTGAGGTCGGGTTAT
AGGTTACACACGTCCCTTCAGATTATATTTCCTCCTTATCCCAGTGTCTAGTGTACATACACTG
GGAGACGTAGTACTTCTAATATGAAGAATGGGAGAGAAACGTCCTTGTTAACTACACTATAAGG
CAGACACTCCGATGAGAAGACAGGACCTGGTGCTTCGCTTGCTGTTTCAACGAAAATCTACAAA
AACTGAAGATTTTTTTGAAAAGGAAGACAAGACAACTGCCTTTTCTTTATTTATGAGGCTTTCT
CCATGTAGCATCTCAAGGTTTGGAGTGTCTCTGCCCCAAAGCAAAGCTTCCTTCACAGCCACCA
GTGAGATTACATATGGCTATGAATTGAGAAGGTTTTCCTAGATAGGGGACTGGATTGGACTTGG
TCCTGCGGCTGCAGAACCTGGGGTTTTCCCACTGGCTGCAACCTTCTTTTAAGAATGAAAAAGA
TTCAATCGAGAAAGACCTGAAGGGCTGGGATTGTAGCTCAGTAATTGAGCATTTTTCCAGCGTA
CGTGAGGCTCTGGGTTCAATCCCTGTCATCACAAGGAAAGGAAAAAGAGAAAGAAAAAGAAGCA
TTTTGAAAACTATAGAAAAGATTTTAAAATCATACTGCTGTCCTACAGAAATCCTGTTTAAAGG
GATTTTAAGAGTTACATTTTAGTATATCAAAGAATACACATGCATTTGCCTAAACACTCTGTAT
CTTTGTAACGATAAACTTCTCCCCTTGGTGGTGAAGCTTATGCCTATTTAGCCTAGACTGTGTT
CAAGTTTTCTTGTTTTGTTTTGTTTTTTTCTTGAGGGTTTTTTTTCCTGGTCTGATAAGGAATT
TGTGAACTCTATCTTTGGTATACCTTTTATTAAACTGCACCGTTTTGTTTAGTCGAGGTAAATA
AGTATGTATTTGAATAACTTGGCGTGTCCTGAGTGTTGTGGTATGAGAAGCATCGTGGTCTTTC
TACACTAATGAAGTGCAAATAAAGTTTTGTATTTATGAATGACAGTTAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063266705 ⟹ XP_063122775

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	113,938,261 - 113,953,722 (-)	NCBI

RefSeq Acc Id:

XR_005488852

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	113,928,356 - 113,953,719 (-)	NCBI
mRatBN7.2	9	106,481,279 - 106,506,895 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_037149	(Get FASTA)	NCBI Sequence Viewer
	XP_063122775	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41992	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000076702
GenBank Protein	P35284	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_037149 ⟸ NM_013017

- UniProtKB:

P35284 (UniProtKB/Swiss-Prot), A6KF57 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDPSAALHRRPAGGGLGAVSPALSGGQARRRKQPPRPADFKLQVIIIGSRGVGKTSLMERFTDD
TFCEACKSTVGVDFKIKTVELRGKKIRLQIWDTAGQERFNSITSAYYRSAKGIILVYDITKKET
FDDLPKWMKMIDKYASEDAELLLVGNKLDCETDREISRQQGEKFAQQITGMRFCEASAKDNFNV
DEIFLKLVDDILKKMPLDVLRSELSNSILSLQPEPEIPPELPPPRPHVRCC

hide sequence

Ensembl Acc Id:

ENSRNOP00000059602 ⟸ ENSRNOT00000026177

Ensembl Acc Id:

ENSRNOP00000076702 ⟸ ENSRNOT00000098588

RefSeq Acc Id:	XP_063122775 ⟸ XM_063266705
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P35284-F1-model_v2	AlphaFold	P35284	1-243	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3527	AgrOrtholog
BioCyc Gene	G2FUF-26407	BioCyc
Ensembl Genes	ENSRNOG00000019295	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000098588	ENTREZGENE
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot
InterPro	P-loop_NTPase	UniProtKB/Swiss-Prot
	Rab12	UniProtKB/Swiss-Prot
	Small_GTP-bd_dom	UniProtKB/Swiss-Prot
	Small_GTPase	UniProtKB/Swiss-Prot
	Small_GTPase_Rab	UniProtKB/Swiss-Prot
KEGG Report	rno:25530	UniProtKB/Swiss-Prot
NCBI Gene	25530	ENTREZGENE
PANTHER	LD44762P	UniProtKB/Swiss-Prot
Pfam	Ras	UniProtKB/Swiss-Prot
PhenoGen	Rab12	PhenoGen
PRINTS	RASTRNSFRMNG	UniProtKB/Swiss-Prot
PROSITE	RAB	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000019295	RatGTEx
SMART	RAB	UniProtKB/Swiss-Prot
	RAN	UniProtKB/Swiss-Prot
	RAS	UniProtKB/Swiss-Prot
	RHO	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
TIGR	TC208980
UniProt	A0A8I5Y4W3_RAT	UniProtKB/TrEMBL
	A6KF57	ENTREZGENE, UniProtKB/TrEMBL
	D4A376_RAT	UniProtKB/TrEMBL
	P35284	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Rab12	RAB12, member RAS oncogene family	LOC102551479	ras-related protein Rab-12-like	Data merged from RGD:7652518	737654	PROVISIONAL
2015-07-29	LOC102551479	ras-related protein Rab-12-like	LOC680714	hypothetical protein LOC680714	Data merged from RGD:1588252	737654	PROVISIONAL
2013-12-18	LOC102551479	ras-related protein Rab-12-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2013-04-12	Rab12	RAB12, member RAS oncogene family	LOC100362985	ras-related protein Rab-12-like	Data merged from RGD:2323709	737654	PROVISIONAL
2010-05-06	LOC100362985	ras-related protein Rab-12-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC680714	hypothetical protein LOC680714			Symbol and Name status set to provisional	70820	PROVISIONAL
2002-06-10	Rab12	RAB12, member RAS oncogene family			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to secretory granules in atrial myocytes	734515

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD