Pygm (glycogen phosphorylase, muscle associated) - Rat Genome Database

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Gene: Pygm (glycogen phosphorylase, muscle associated) Rattus norvegicus
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Symbol: Pygm
Name: glycogen phosphorylase, muscle associated
RGD ID: 3461
Description: Enables carbohydrate binding activity; glycogen phosphorylase activity; and heterocyclic compound binding activity. Involved in several processes, including glycogen catabolic process; response to cAMP; and response to hypoxia. Located in sarcoplasmic reticulum. Used to study cholestasis. Human ortholog(s) of this gene implicated in glycogen storage disease V. Orthologous to human PYGM (glycogen phosphorylase, muscle associated); PARTICIPATES IN glycogen degradation pathway; insulin signaling pathway; starch and sucrose metabolic pathway; INTERACTS WITH (R)-noradrenaline; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glycogen phosphorylase, muscle form; muscle (McArdle syndrome); muscle glycogen phosphorylase; Muscpho; myophosphorylase; Phosphorylase glycogen; Phosphorylase, glycogen; phosphorylase, glycogen, muscle
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,119,805 - 213,134,622 (+)NCBIGRCr8
mRatBN7.21203,690,550 - 203,705,369 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1203,690,533 - 203,705,368 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,039,387 - 212,054,202 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,135,880 - 219,150,695 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,826,933 - 211,841,748 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01221,756,325 - 221,771,142 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,756,286 - 221,771,143 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01228,737,461 - 228,758,937 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,166,701 - 209,181,588 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11209,325,179 - 209,340,017 (+)NCBI
Celera1201,223,967 - 201,238,784 (+)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
PygmRatcholestasis  IDA 1599990mRNA:decreased expression:liverRGD 
PygmRatExperimental Diabetes Mellitus  IDA 1599897protein:increased expression:sarcoplasmic reticulumRGD 
PygmRatglycogen storage disease V  ISOPYGM (Homo sapiens)1599985DNA:deletion:exonRGD 
PygmRatLeft Ventricular Hypertrophy  HEP 1599987mRNA:increased expression:heart left ventricle and cardiac muscle cellRGD 
PygmRatMyocardial Ischemia  IDA 1599991 RGD 
PygmRatParalysis  IEP 1599993mRNA and protein:decreased expression:skeletal muscleRGD 
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Original Reference(s)
PygmRatBardet-Biedl syndrome  ISOPYGM (Homo sapiens)8554872ClinVar Annotator: match by term: Bardet-Biedl syndromeClinVarPMID:12118255 more ...
PygmRatgenetic disease  ISOPYGM (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:10450796 more ...
PygmRatglycogen storage disease  ISOPYGM (Homo sapiens)8554872ClinVar Annotator: match by term: Glycogen storage diseaseClinVarPMID:16924035 more ...
PygmRatglycogen storage disease V  ISOPYGM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10417800 more ...
PygmRatHigh Myopia  ISOPYGM (Homo sapiens)8554872ClinVar Annotator: match by term: Severe MyopiaClinVarPMID:25741868 more ...
PygmRatintellectual disability  ISOPYGM (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
PygmRatisolated elevated serum creatine phosphokinase levels  ISOPYGM (Homo sapiens)8554872ClinVar Annotator: match by term: HYPERCKEMIA and IDIOPATHICClinVarPMID:25741868 and PMID:28492532
PygmRatleukocyte adhesion deficiency 3  ISOPYGM (Homo sapiens)8554872ClinVar Annotator: match by term: Leukocyte adhesion deficiency 3ClinVarPMID:28492532
PygmRatmultiple endocrine neoplasia type 1  ISOPYGM (Homo sapiens)8554872ClinVar Annotator: match by term: Multiple endocrine neoplasia and type 1ClinVarPMID:17065424 more ...
PygmRatmyopathy  ISOPYGM (Homo sapiens)8554872ClinVar Annotator: match by term: MyopathyClinVarPMID:28492532
PygmRatRhabdomyolysis  ISOPYGM (Homo sapiens)8554872ClinVar Annotator: match by term: RhabdomyolysisClinVarPMID:25741868 and PMID:28492532
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Original Reference(s)
PygmRatglycogen storage disease V  ISOPYGM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12666117 and PMID:18380285
PygmRatmuscular disease  ISOPYGM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18380285
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Original Reference(s)
PygmRatglycogen storage disease V  ISSPygm (Mus musculus)13592920OMIM:232600MouseDO 
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Original Reference(s)
PygmRatglycogen storage disease V  ISOPYGM (Homo sapiens)7240710 OMIM 

1 to 20 of 117 rows

  
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Original Reference(s)
PygmRat(-)-epigallocatechin 3-gallate multiple interactionsISOPYGM (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PYGM mRNACTDPMID:22079256
PygmRat(R)-noradrenaline affects expressionEXP 6480464Norepinephrine affects the expression of PYGM mRNACTDPMID:14618266
PygmRat17alpha-ethynylestradiol affects expressionISOPygm (Mus musculus)6480464Ethinyl Estradiol affects the expression of PYGM mRNACTDPMID:17555576
PygmRat17alpha-ethynylestradiol increases expressionISOPygm (Mus musculus)6480464Ethinyl Estradiol results in increased expression of PYGM mRNACTDPMID:17942748
PygmRat17alpha-ethynylestradiol multiple interactionsISOPygm (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PYGM mRNACTDPMID:17942748
PygmRat17beta-estradiol decreases expressionISOPygm (Mus musculus)6480464Estradiol results in decreased expression of PYGM mRNACTDPMID:19484750
PygmRat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of PYGM mRNACTDPMID:32145629
PygmRat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOPYGM (Homo sapiens)64804642 more ...CTDPMID:31675489
PygmRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPygm (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PYGM mRNACTDPMID:17942748
PygmRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PYGM mRNACTDPMID:32109520
PygmRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPygm (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PYGM mRNACTDPMID:21570461
PygmRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPygm (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of PYGM mRNACTDPMID:17942748
PygmRat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
PygmRat2,4,6-tribromophenol increases expressionISOPYGM (Homo sapiens)64804642 more ...CTDPMID:31675489
PygmRat2,5-hexanedione decreases expressionEXP 64804642 and 5-hexanedione results in decreased expression of PYGM proteinCTDPMID:19033394
PygmRat3,3',5,5'-tetrabromobisphenol A increases expressionISOPYGM (Homo sapiens)6480464tetrabromobisphenol A results in increased expression of PYGM proteinCTDPMID:31675489
PygmRat4,4'-sulfonyldiphenol increases expressionISOPygm (Mus musculus)6480464bisphenol S results in increased expression of PYGM mRNACTDPMID:30951980
PygmRat4,4'-sulfonyldiphenol affects methylationISOPygm (Mus musculus)6480464bisphenol S affects the methylation of PYGM geneCTDPMID:31683443
PygmRat4-hydroxyphenyl retinamide decreases expressionISOPygm (Mus musculus)6480464Fenretinide results in decreased expression of PYGM mRNACTDPMID:16467112
PygmRat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of PYGM mRNACTDPMID:24780913

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Biological Process
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Original Reference(s)
PygmRatcarbohydrate metabolic process involved_inIEAInterPro:IPR000811 and InterPro:IPR0118331600115GO_REF:0000002InterProGO_REF:0000002
PygmRatglycogen catabolic process  IDA 1599897 RGD 
PygmRatglycogen catabolic process  IDA 1642811 RGD 
PygmRatglycogen catabolic process acts_upstream_of_or_withinIEAUniProtKB:Q9WUB3 and ensembl:ENSMUSP000000475641600115GO_REF:0000107EnsemblGO_REF:0000107
PygmRatglycogen catabolic process acts_upstream_of_or_withinISOPygm (Mus musculus)1624291 PMID:15282316 and PMID:17689562RGDPMID:15282316 and PMID:17689562
PygmRatglycogen catabolic process involved_inISOPygm (Mus musculus)1624291MGI:5696972 PMID:31511858RGDPMID:31511858
PygmRatglycogen catabolic process involved_inIBACGD:CAL0000189831 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PygmRatglycogen catabolic process involved_inIEAUniProtKB:P11217 and ensembl:ENSP000001641391600115GO_REF:0000107EnsemblGO_REF:0000107
PygmRatglycogen catabolic process involved_inIEAARBA:ARBA000341811600115GO_REF:0000117UniProtGO_REF:0000117
PygmRatglycogen catabolic process involved_inISOPYGM (Homo sapiens)1624291 PMID:1150650 and PMID:8316268RGDPMID:1150650 and PMID:8316268
PygmRatglycogen catabolic process  IDA 2304126 RGD 
PygmRatglycogen catabolic process  IDA 1642743 RGD 
PygmRatglycogen catabolic process  IDA 1599986 RGD 
PygmRatglycogen metabolic process  IDA 2304186 RGD 
PygmRatglycogen metabolic process involved_inIEAUniProtKB-KW:KW-03211600115GO_REF:0000043UniProtGO_REF:0000043
PygmRatglycogen metabolic process  IDA 1642811 RGD 
PygmRatglycogen metabolic process  IDA 2304119 RGD 
PygmRatintracellular calcium ion homeostasis  IDA 1599992 RGD 
PygmRatresponse to cAMP  IDA 1599988 RGD 
PygmRatresponse to hypoxia  IDA 1599986 RGD 
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Cellular Component

  
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Original Reference(s)
PygmRatcytoplasm is_active_inIBAFB:FBgn0004507 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PygmRatsarcoplasmic reticulum  IDA 1599897 RGD 
PygmRatsarcoplasmic reticulum  IDA 1599989 RGD 

Molecular Function
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PygmRat1,4-alpha-oligoglucan phosphorylase activity enablesIEAInterPro:IPR0118331600115GO_REF:0000002InterProGO_REF:0000002
PygmRat1,4-alpha-oligoglucan phosphorylase activity enablesIEARHEA:417321600115GO_REF:0000116RHEAGO_REF:0000116
PygmRat1,4-alpha-oligoglucan phosphorylase activity enablesIEAEC:2.4.1.11600115GO_REF:0000003UniProtGO_REF:0000003
PygmRatAMP binding  IDA 1599986 RGD 
PygmRatcarbohydrate binding  IDA 1599986 RGD 
PygmRatcarbohydrate binding  IDA 1642811 RGD 
PygmRatcarbohydrate binding  IDA 1642743 RGD 
PygmRatcatalytic activity enablesIEAUniProtKB-KW:KW-00211600115GO_REF:0000043UniProtGO_REF:0000043
PygmRatglycogen phosphorylase activity  TAS 729794 RGD 
PygmRatglycogen phosphorylase activity  IDA 1642811 RGD 
PygmRatglycogen phosphorylase activity enablesIEAUniProtKB:Q9WUB3 and ensembl:ENSMUSP000000475641600115GO_REF:0000107EnsemblGO_REF:0000107
PygmRatglycogen phosphorylase activity enablesIEAUniProtKB:P11217 and ensembl:ENSP000001641391600115GO_REF:0000107EnsemblGO_REF:0000107
PygmRatglycogen phosphorylase activity enablesISOPygm (Mus musculus)1624291MGI:5696972 PMID:11785984 more ...RGDPMID:11785984 more ...
PygmRatglycogen phosphorylase activity enablesIBACGD:CAL0000189831 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PygmRatglycogen phosphorylase activity enablesIEAInterPro:IPR0008111600115GO_REF:0000002InterProGO_REF:0000002
PygmRatglycogen phosphorylase activity enablesIEAARBA:ARBA000342061600115GO_REF:0000117UniProtGO_REF:0000117
PygmRatglycogen phosphorylase activity enablesISOPYGM (Homo sapiens)1624291 PMID:1150650 and PMID:8316268RGDPMID:1150650 and PMID:8316268
PygmRatglycogen phosphorylase activity  IDA 2304186 RGD 
PygmRatglycogen phosphorylase activity  IDA 2304126 RGD 
PygmRatglycogen phosphorylase activity  IDA 1642743 RGD 
1 to 20 of 30 rows

RGD Manual Annotations


  
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Original Reference(s)
PygmRatglycogen degradation pathway   ISOPYGM (Homo sapiens)2304109 RGD 
PygmRatglycogen degradation pathway   ISOPYGM (Homo sapiens)1642822 RGD 
PygmRatglycogen degradation pathway   IDA 1599897 RGD 

Imported Annotations - KEGG (archival)

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PygmRatinsulin signaling pathway   IEA 6907045 KEGGrno:04910
PygmRatstarch and sucrose metabolic pathway  IEA 6907045 KEGGrno:00500

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#
Reference Title
Reference Citation
1. Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors. Birch AM, etal., Bioorg Med Chem Lett. 2007 Jan 15;17(2):394-9. Epub 2006 Oct 19.
2. Brain-specific regulator of G-protein signaling 9-2 selectively interacts with alpha-actinin-2 to regulate calcium-dependent inactivation of NMDA receptors. Bouhamdan M, etal., J Neurosci. 2006 Mar 1;26(9):2522-30.
3. Structural relationships among regulated and unregulated phosphorylases. Buchbinder JL, etal., Annu Rev Biophys Biomol Struct. 2001;30:191-209.
4. Epinephrine regulation of skeletal muscle glycogen metabolism. Studies utilizing the perfused rat hindlimb preparation. Dietz MR, etal., J Biol Chem. 1980 Mar 25;255(6):2301-7.
5. Effects of electrostimulation on glycogenolysis in cultured rat myotubes. Elsner P, etal., Pflugers Arch. 2003 Dec;447(3):356-62. Epub 2003 Oct 25.
6. Alteration of glycogen and glucose metabolism in ischaemic and post-ischaemic working rat hearts by adenosine A1 receptor stimulation. Fraser H, etal., Br J Pharmacol. 1999 Sep;128(1):197-205.
7. Regulation of the rat muscle glycogen phosphorylase-encoding gene during muscle cell development. Froman BE, etal., Gene 1994 Nov 18;149(2):245-52.
8. The content of glycogen phosphorylase and glycogen in preparations of sarcoplasmic reticulum-glycogenolytic complex is enhanced in diabetic rat skeletal muscle. Garduno E, etal., Diabetologia. 2001 Oct;44(10):1238-46.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Botulinum-induced muscle paralysis alters metabolic gene expression and fatigue recovery. Gorin F, etal., Am J Physiol. 1996 Jan;270(1 Pt 2):R238-45.
12. Comparative analysis of species-independent, isozyme-specific amino-acid substitutions in mammalian muscle, brain and liver glycogen phosphorylases. Hudson JW, etal., Biochim Biophys Acta 1993 Jul 10;1164(2):197-208.
13. Adrenaline-mediated glycogen phosphorylase activation is enhanced in rat soleus muscle with increased glycogen content. Jensen J, etal., Biochim Biophys Acta. 1999 Oct 18;1472(1-2):215-21.
14. Glycogen phosphorylase: control by phosphorylation and allosteric effectors. Johnson LN FASEB J. 1992 Mar;6(6):2274-82.
15. Differential expression of the regulator of G protein signaling RGS9 protein in nociceptive pathways of different age rats. Kim KJ, etal., Brain Res Dev Brain Res. 2005 Nov 7;160(1):28-39. Epub 2005 Sep 8.
16. Molecular diagnosis of McArdle disease: revised genomic structure of the myophosphorylase gene and identification of a novel mutation. Kubisch C, etal., Hum Mutat. 1998;12(1):27-32.
17. Hepatic and skeletal muscle glycogen metabolism in rats with short-term cholestasis. Lang C, etal., J Hepatol. 2002 Jan;36(1):22-9.
18. Skeletal muscle sarcoplasmic reticulum glycogen status influences Ca2+ uptake supported by endogenously synthesized ATP. Lees SJ and Williams JH, Am J Physiol Cell Physiol. 2004 Jan;286(1):C97-104. Epub 2003 Sep 10.
19. Gene expression profile of cardiomyocytes in hypertrophic heart induced by continuous norepinephrine infusion in the rats. Li P, etal., Cell Mol Life Sci. 2003 Oct;60(10):2200-9.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
1 to 20 of 34 rows
PMID:3209063   PMID:3840433   PMID:11596118   PMID:11785984   PMID:12477932   PMID:15282316   PMID:17689562   PMID:21700703   PMID:22206666   PMID:23533145   PMID:23904609   PMID:26945066  
PMID:27156240   PMID:30053369   PMID:32357304   PMID:33450132  



Pygm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,119,805 - 213,134,622 (+)NCBIGRCr8
mRatBN7.21203,690,550 - 203,705,369 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1203,690,533 - 203,705,368 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,039,387 - 212,054,202 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,135,880 - 219,150,695 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,826,933 - 211,841,748 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01221,756,325 - 221,771,142 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,756,286 - 221,771,143 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01228,737,461 - 228,758,937 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,166,701 - 209,181,588 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11209,325,179 - 209,340,017 (+)NCBI
Celera1201,223,967 - 201,238,784 (+)NCBICelera
Cytogenetic Map1q43NCBI
PYGM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381164,746,389 - 64,760,715 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1164,746,389 - 64,759,974 (-)EnsemblGRCh38hg38GRCh38
GRCh371164,513,861 - 64,528,187 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361164,270,606 - 64,284,763 (-)NCBINCBI36Build 36hg18NCBI36
Build 341164,270,605 - 64,284,763NCBI
Celera1161,840,305 - 61,854,685 (-)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1160,840,630 - 60,855,032 (-)NCBIHuRef
CHM1_11164,397,556 - 64,411,957 (-)NCBICHM1_1
T2T-CHM13v2.01164,739,618 - 64,754,020 (-)NCBIT2T-CHM13v2.0
Pygm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,434,438 - 6,448,494 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,434,429 - 6,448,489 (+)EnsemblGRCm39 Ensembl
GRCm38196,384,408 - 6,398,464 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,384,399 - 6,398,459 (+)EnsemblGRCm38mm10GRCm38
MGSCv37196,384,429 - 6,398,459 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36196,384,429 - 6,398,459 (+)NCBIMGSCv36mm8
Celera196,257,446 - 6,271,476 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.53NCBI
Pygm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,411,480 - 20,424,931 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542220,411,480 - 20,424,676 (+)NCBIChiLan1.0ChiLan1.0
PYGM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2965,972,186 - 65,987,376 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11167,015,183 - 67,028,876 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01160,101,810 - 60,115,813 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11163,443,609 - 63,457,012 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1163,443,609 - 63,457,430 (-)Ensemblpanpan1.1panPan2
PYGM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,398,192 - 52,410,731 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,398,056 - 52,410,464 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1851,005,808 - 51,018,059 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01853,439,715 - 53,451,957 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1853,439,257 - 53,451,957 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11852,534,631 - 52,546,873 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01852,120,553 - 52,132,799 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01852,904,684 - 52,916,934 (+)NCBIUU_Cfam_GSD_1.0
Pygm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,108,815 - 8,121,764 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365994,551,032 - 4,564,154 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365994,551,164 - 4,564,109 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PYGM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,409,116 - 7,421,254 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.127,409,330 - 7,421,256 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,540,079 - 6,553,856 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PYGM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,474,539 - 9,490,612 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl19,475,622 - 9,491,500 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038106,864,368 - 106,879,692 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pygm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476721,626,740 - 21,640,161 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476721,626,740 - 21,639,963 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Pygm
40 total Variants

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:116
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000028636
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 83 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat

1 to 10 of 83 rows
D1Mgh11  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map11537.2RGD
RH 3.4 Map11537.2UniSTS
FHH x ACI Map198.97UniSTS
FHH x ACI Map198.97RGD
Cytogenetic Map1q43UniSTS
D1Wox28  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map11523.1UniSTS
RH 3.4 Map11523.1RGD
RH 2.0 Map11152.8RGD
Cytogenetic Map1q43UniSTS
RH128350  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21203,705,131 - 203,705,337 (+)MAPPERmRatBN7.2
Rnor_6.01221,770,905 - 221,771,110NCBIRnor6.0
Rnor_5.01228,758,694 - 228,758,899UniSTSRnor5.0
RGSC_v3.41209,181,351 - 209,181,556UniSTSRGSC3.4
Celera1201,238,547 - 201,238,752UniSTS
RH 3.4 Map11536.3UniSTS
Cytogenetic Map1q43UniSTS
RH140670  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21203,696,040 - 203,697,095 (+)MAPPERmRatBN7.2
Rnor_6.01221,761,816 - 221,762,870NCBIRnor6.0
Rnor_5.01228,749,605 - 228,750,659UniSTSRnor5.0
RGSC_v3.41209,172,192 - 209,173,246UniSTSRGSC3.4
Celera1201,229,458 - 201,230,512UniSTS
RH 3.4 Map11537.7UniSTS
Cytogenetic Map1q43UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 17 of 17 rows
RefSeq Transcripts NM_012638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC128900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB766603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB803241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK357376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK358095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR754132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR754647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L10669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L18752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X03032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 17 of 17 rows

Ensembl Acc Id: ENSRNOT00000028636   ⟹   ENSRNOP00000028636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1203,690,533 - 203,705,360 (+)Ensembl
Rnor_6.0 Ensembl1221,756,286 - 221,771,143 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094854   ⟹   ENSRNOP00000089298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1203,690,597 - 203,705,368 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097542   ⟹   ENSRNOP00000085985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1203,690,533 - 203,705,360 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099163   ⟹   ENSRNOP00000081606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1203,690,533 - 203,704,922 (+)Ensembl
RefSeq Acc Id: NM_012638   ⟹   NP_036770
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,119,805 - 213,134,622 (+)NCBI
mRatBN7.21203,690,550 - 203,705,369 (+)NCBI
Rnor_6.01221,756,325 - 221,771,142 (+)NCBI
Rnor_5.01228,737,461 - 228,758,937 (+)NCBI
RGSC_v3.41209,166,701 - 209,181,588 (+)RGD
Celera1201,223,967 - 201,238,784 (+)RGD
Sequence:
Protein RefSeqs NP_036770 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41253 (Get FASTA)   NCBI Sequence Viewer  
  AAA62613 (Get FASTA)   NCBI Sequence Viewer  
  AAI61897 (Get FASTA)   NCBI Sequence Viewer  
  CAA26835 (Get FASTA)   NCBI Sequence Viewer  
  EDM12601 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028636
GenBank Protein P09812 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036770   ⟸   NM_012638
- UniProtKB: G3V8V3 (UniProtKB/TrEMBL),   A6HZH0 (UniProtKB/TrEMBL),   B1WBU9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028636   ⟸   ENSRNOT00000028636
Ensembl Acc Id: ENSRNOP00000081606   ⟸   ENSRNOT00000099163
Ensembl Acc Id: ENSRNOP00000085985   ⟸   ENSRNOT00000097542
Ensembl Acc Id: ENSRNOP00000089298   ⟸   ENSRNOT00000094854

Name Modeler Protein Id AA Range Protein Structure
AF-P09812-F1-model_v2 AlphaFold P09812 1-842 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690701
Promoter ID:EPDNEW_R1224
Type:single initiation site
Name:Pygm_1
Description:glycogen phosphorylase, muscle associated
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01221,756,235 - 221,756,295EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-56595 BioCyc
BioCyc Pathway PWY-5941 [glycogen degradation II] BioCyc
BioCyc Pathway Image PWY-5941 BioCyc
Ensembl Genes ENSRNOG00000021090 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028636 ENTREZGENE
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8366912 IMAGE-MGC_LOAD
InterPro Glycg_phsphrylas UniProtKB/Swiss-Prot
  Glyco_trans_35 UniProtKB/Swiss-Prot
  Pyridoxal_P_attach_site UniProtKB/Swiss-Prot
MGC_CLONE MGC:187616 IMAGE-MGC_LOAD
NCBI Gene 24701 ENTREZGENE
PANTHER GLYCOGEN PHOSPHORYLASE, MUSCLE FORM UniProtKB/Swiss-Prot
  PTHR11468 UniProtKB/Swiss-Prot
Pfam Phosphorylase UniProtKB/Swiss-Prot
PhenoGen Pygm PhenoGen
PIRSF Pprylas_GlgP UniProtKB/Swiss-Prot
PROSITE PHOSPHORYLASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021090 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot
TIGR TC204701
UniProt A0A8I6A2T3_RAT UniProtKB/TrEMBL
  A0A8I6A9J1_RAT UniProtKB/TrEMBL
  A0A8I6G867_RAT UniProtKB/TrEMBL
  A6HZH0 ENTREZGENE, UniProtKB/TrEMBL
  B1WBU9 ENTREZGENE, UniProtKB/TrEMBL
  G3V8V3 ENTREZGENE, UniProtKB/TrEMBL
  P09812 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-18 Pygm  glycogen phosphorylase, muscle associated  Pygm  phosphorylase, glycogen, muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-30 Pygm  phosphorylase, glycogen, muscle  Pygm  muscle glycogen phosphorylase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pygm  Phosphorylase, glycogen; muscle (McArdle syndrome)      Symbol and Name status set to approved 70586 APPROVED