Gene:	Ptprc ( Rattus norvegicus ) protein tyrosine phosphatase, receptor type, C
Description:	member of a family of heavily glycosylated leukocyte cell surface glycoproteins; displays extensive O-glycosylation
Synonyms:	RT7; CD45; T200; L-CA; Lca;
ArrayIDs:	6652371; 6634075; 6387745; 5816230; 6528377; 6737043; 6403337; 6271065; 5887672; 6266765; 6477915; 5757988; 6278837; 5688710; 6023832; 6023640; 6386012; 6111821; 6733066; 6057249; 6439202; 6097112; 6604629; 5754417; M18349cds#1_s_at; 6186734; K03039mRNA_s_at; 5874903; 6603945; 6413950; M25823_s_at; 5832541; 1390798_at; 6209735; 1370603_a_at; 6079212; 5977098; 5880967; rc_AI177752_at; 6718496; 6211845; M10072mRNA_s_at; 5688090;  (details...)
Gene Type:	protein-coding
Strain:	BBDP.WF-(D13Rat124-D13Mgh5)/Sunn
Additional Data
Markers:	D13Mit7
Homologs
Homo sapiens: PTPRC     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Ptprc     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Ptprc genome assembly 3.1 13 51261097 - 51309893     Rat Celera Assembly 13 49881478 - 49993142     RGSC genome assembly v3.4 13 51246163 - 51357995     Cytogenetic 13 q13 Mus musculus Ptprc Mouse genome assembly build 36.1 1 139959992 - 140071843     Cytogenetic 1 1 E4 Homo sapiens PTPRC human genome assembly 1 195339881 - 195393989     Human genome assembly build 36.2 1 196874848 - 196992953     Cytogenetic 1 q31-q32   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Other Map Data:	Associated SSLP Map Locations No mapping information currently available in RGD for D13Mit7
Annotation
Molecular Function	Gene Ontology protein kinase binding,  protein tyrosine phosphatase activity,  transmembrane receptor protein tyrosine phosphatase activity ...  (details...)
Biological Process	Gene Ontology positive regulation of isotype switching to IgG isotypes,  B cell receptor signaling pathway,  positive regulation of apoptosis ...  (details...)
Cellular Component	Gene Ontology focal adhesion,  integral to membrane,  external side of plasma membrane ...  (details...)
Disease	Ontology Severe Combined Immunodeficiency,  Multiple Sclerosis (details...)
External Links
Databases	DATABASE ID SOURCE SMART: PTPc IPI SMART: FN3 IPI PROSITE: TYR_PHOSPHATASE_PTP IPI PROSITE: TYR_PHOSPHATASE_2 IPI PROSITE: TYR_PHOSPHATASE_1 IPI PROSITE: FN3 IPI UNIPARC: UPI0001529A16 IPI UNIPARC: UPI0001529A14 IPI UNIPARC: UPI0001B7A5A0 IPI UNIPARC: UPI0001529A15 IPI UNIPARC: UPI0001529A17 IPI UNIPARC: UPI0000186826 IPI KEGG Report: rno:24699 ENTREZGENE HomoloGene Group ID: 2126 ENTREZGENE Germonline: 3451 Pfam: fn3 IPI Pfam: Y_phosphatase IPI KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 05340 ENTREZGENE KEGG Pathway: 04666 ENTREZGENE KEGG Pathway: 04514 ENTREZGENE InterPro: Tyr_Pase_rcpt/non-rcpt. IPI InterPro: Dual-sp/Tyr_phosphatase. IPI InterPro: Fibronectin_typ-III-like_fold. IPI InterPro: Tyr_Pase_AS. IPI InterPro: FN_III. IPI IPI: IPI00389957 IPI IPI: IPI00515862 IPI IPI: IPI00231601 IPI IPI: IPI00851132 IPI IPI: IPI00950717 IPI IPI: IPI00851110 IPI Ensembl Protein: ENSRNOP00000057042 IPI Ensembl Protein: ENSRNOP00000063859 IPI Ensembl Protein: ENSRNOP00000029889 IPI Ensembl Protein: ENSRNOP00000000814 IPI Ensembl Protein: ENSRNOP00000057043 IPI Ensembl Protein: ENSRNOP00000030503 IPI Gene3D-CATH: FN_III-like IPI Entrez Gene: Ptprc ENTREZGENE UniProt: Q9JK90_RAT IPI UniProt: Q6LDZ3_RAT IPI UniProt: CD45_RAT IPI UniProt: Q5R3Z5_RAT IPI UniProt: CD45_RAT IPI UniProt: CD45_RAT IPI UniProt: Q5R3Z3_RAT IPI UniProt: CD45_RAT IPI UniProt: Q5R3Z4_RAT IPI UniProt: CD45_RAT IPI Ensembl Genes: ENSRNOG00000000655 IPI RatMap: 34344 ENTREZGENE Superfamily-SCOP: FN_III-like IPI PRINTS: PRTYPHPHTASE. IPI
Sequences	Nucleotide: Y00065 Get FASTA Search GEO Profiles Nucleotide: M25823 Get FASTA Search GEO Profiles Nucleotide: M25822 Get FASTA Search GEO Profiles Nucleotide: M25821 Get FASTA Search GEO Profiles Nucleotide: M25820 Get FASTA Search GEO Profiles Nucleotide: M10072 Get FASTA Search GEO Profiles Nucleotide: CV080346 Get FASTA Search GEO Profiles Nucleotide: CN541893 Get FASTA Search GEO Profiles Nucleotide: CK364357 Get FASTA Search GEO Profiles Nucleotide: CB788988 Get FASTA Search GEO Profiles Nucleotide: CA508247 Get FASTA Search GEO Profiles Nucleotide: BF556033 Get FASTA Search GEO Profiles Nucleotide: BF288130 Get FASTA Search GEO Profiles Nucleotide: AF251010 Get FASTA Search GEO Profiles Nucleotide: M18349 Get FASTA Search GEO Profiles Nucleotide: M18348 Get FASTA Search GEO Profiles Nucleotide: M18347 Get FASTA Search GEO Profiles Nucleotide: CH473958 Get FASTA Search GEO Profiles Nucleotide: NM_138507 Get FASTA Search GEO Profiles Nucleotide: NM_001109890 Get FASTA Search GEO Profiles Nucleotide: NM_001109889 Get FASTA Search GEO Profiles Nucleotide: NM_001109888 Get FASTA Search GEO Profiles Nucleotide: NM_001109887 Get FASTA Search GEO Profiles Nucleotide: XM_001063971 Get FASTA Search GEO Profiles Nucleotide: XM_001062978 Get FASTA Search GEO Profiles (View all 25 Nucleotide Accessions) Protein: Q9JK90 Get FASTA Protein: Q6LDZ3 Get FASTA Protein: Q5R3Z5 Get FASTA Protein: Q5R3Z4 Get FASTA Protein: Q5R3Z3 Get FASTA Protein: P04157 Get FASTA Protein: CAA68275 Get FASTA Protein: CAA68274 Get FASTA Protein: CAA68273 Get FASTA Protein: CAA68272 Get FASTA Protein: AAA41521 Get FASTA Protein: AAA41520 Get FASTA Protein: AAA41519 Get FASTA Protein: AAA41518 Get FASTA Protein: AAA41513 Get FASTA Protein: AAF72179 Get FASTA Protein: AAA41517 Get FASTA Protein: AAA41516 Get FASTA Protein: AAA41515 Get FASTA Protein: EDM09643 Get FASTA Protein: NP_612516 Get FASTA Protein: NP_001103360 Get FASTA Protein: NP_001103359 Get FASTA Protein: NP_001103358 Get FASTA Protein: NP_001103357 Get FASTA Protein: XP_001063971 Get FASTA Protein: XP_001062978 Get FASTA (View all 27 Protein Accessions)
Clusters	UniGene: 90166
References
Curated References	11 references in RGD related to Ptprc
Other References	11 other references at PubMed related to Ptprc
Database Information
RGD ID	3451
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-JUN-02: Ptprc Protein tyrosine phosphatase, receptor-type, c polypeptide (antigen Cd45, leukocyte-common antigen/T200 glycoprotein) also RT7 APPROVED Symbol and Name status set to approved 70586