Sirpa (signal-regulatory protein alpha) - Rat Genome Database

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Gene: Sirpa (signal-regulatory protein alpha) Rattus norvegicus
Analyze
Symbol: Sirpa
Name: signal-regulatory protein alpha
RGD ID: 3449
Description: Enables GTPase regulator activity; enzyme binding activity; and protein binding activity involved in heterotypic cell-cell adhesion. Involved in several processes, including cellular response to cytokine stimulus; monocyte extravasation; and regulation of cytokine production. Located in cell surface. Orthologous to several human genes including SIRPA (signal regulatory protein alpha); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Bit; brain Ig-like molecule with tyrosine-based activation motifs; Brain immunoglobulin like protein with tyrosine - based activation motifs; CD172 antigen-like family member A; inhibitory receptor SHPS-1; macrophage fusion receptor; macrophage membrane protein MFP150; protein tyrosine phosphatase non-receptor type substrate 1; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); protein tyrosine phosphatase, non-receptor type substrate 1; Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1); Ptpns1; SHP substrate 1; SHPS-1; signal-regulatory protein alpha-1; sirp-alpha-1; tyrosine-protein phosphatase non-receptor type substrate 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83137,272,932 - 137,311,279 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3137,273,042 - 137,311,279 (+)EnsemblGRCr8
mRatBN7.23116,819,730 - 116,858,099 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3116,819,726 - 116,858,098 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3120,717,512 - 120,755,285 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03129,313,130 - 129,350,902 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03126,973,615 - 127,011,386 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03122,113,735 - 122,152,478 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3122,114,108 - 122,152,477 (+)Ensemblrn6Rnor6.0
Rnor_5.03127,864,145 - 127,902,598 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43117,210,116 - 117,247,840 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3115,635,887 - 115,673,609 (+)NCBICelera
RGSC_v3.13117,115,688 - 117,153,412 (+)NCBI
Cytogenetic Map3q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyproconazole  (ISO)
D-gluconic acid  (EXP)
deoxycholic acid  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (EXP)
folic acid  (ISO)
fonofos  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
isotretinoin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP,ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosomorpholine  (EXP)
naled  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
NSC 23766  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
terbufos  (ISO)
Tesaglitazar  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
tungsten  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (ISO)
cell migration  (IDA)
cell motility  (ISO)
cell-cell adhesion  (IEA)
cell-matrix adhesion  (ISO)
cellular response to hydrogen peroxide  (IMP)
cellular response to interleukin-1  (IMP)
cellular response to interleukin-12  (ISO)
cellular response to type II interferon  (IMP)
cytoskeleton organization  (ISO)
granulocyte migration  (ISO)
hematopoietic progenitor cell differentiation  (ISO)
heterotypic cell-cell adhesion  (IEA)
monocyte extravasation  (IMP)
myeloid leukocyte migration  (IEA)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of chemokine (C-C motif) ligand 5 production  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interferon-beta production  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of JNK cascade  (ISO)
negative regulation of lipopolysaccharide-mediated signaling pathway  (ISO)
negative regulation of macrophage inflammatory protein 1 alpha production  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of phagocytosis  (IEA,IMP,ISO)
negative regulation of tumor necrosis factor production  (ISO)
phagocytosis, engulfment  (ISO)
phagocytosis, recognition  (ISO)
positive regulation of phagocytosis  (IBA,ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of T cell activation  (IBA)
regulation of gene expression  (ISO)
regulation of interleukin-1 beta production  (IMP)
regulation of interleukin-6 production  (IEA,IMP)
regulation of nitric oxide biosynthetic process  (IEA,IMP)
regulation of tumor necrosis factor production  (IEA,IMP,ISO)
regulation of type II interferon production  (ISO)

Cellular Component
cell surface  (IDA,ISO)
membrane  (IEA)
plasma membrane  (IBA,ISO,TAS)

References

References - curated
# Reference Title Reference Citation
1. Signal-regulatory protein is selectively expressed by myeloid and neuronal cells. Adams S, etal., J Immunol 1998 Aug 15;161(4):1853-9.
2. Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways. Alblas J, etal., Mol Cell Biol. 2005 Aug;25(16):7181-92. doi: 10.1128/MCB.25.16.7181-7192.2005.
3. Signal-regulatory protein alpha-CD47 interactions are required for the transmigration of monocytes across cerebral endothelium. de Vries HE, etal., J Immunol 2002 Jun 1;168(11):5832-9.
4. A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Fujioka Y, etal., Mol Cell Biol 1996 Dec;16(12):6887-99.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPa (signal regulatory protein-a) on phagocytes. Gitik M, etal., J Neuroinflammation. 2011 Mar 15;8:24. doi: 10.1186/1742-2094-8-24.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. SIRPalpha interacts with nephrin at the podocyte slit diaphragm. Kajiho Y, etal., FEBS J. 2012 Sep;279(17):3010-21. doi: 10.1111/j.1742-4658.2012.08682.x. Epub 2012 Jul 23.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. BIT (Bit) maps to mouse chromosome 2. Ohnishi H, etal., Genomics 1997 Mar 15;40(3):504-6.
12. Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule. Ohnishi H, etal., J Biol Chem 1996 Oct 11;271(41):25569-74.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. MFR, a putative receptor mediating the fusion of macrophages. Saginario C, etal., Mol Cell Biol 1998 Nov;18(11):6213-23.
16. BIT, an immune antigen receptor-like molecule in the brain. Sano S, etal., FEBS Lett 1997 Jul 14;411(2-3):327-34.
17. Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activation. Takada T, etal., J Biol Chem. 1998 Apr 10;273(15):9234-42.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:9344856   PMID:10082587   PMID:11118207   PMID:11509594   PMID:12393607   PMID:12477932   PMID:12763253   PMID:12807424   PMID:14634079   PMID:14741368   PMID:15047126   PMID:15158458  
PMID:15858173   PMID:16159885   PMID:16371655   PMID:16511298   PMID:16920950   PMID:17954568   PMID:17999719   PMID:19056867   PMID:20207740   PMID:20554646   PMID:21553247   PMID:22193512  
PMID:22871113   PMID:23562609   PMID:24026300   PMID:24029230   PMID:38279488  


Genomics

Comparative Map Data
Sirpa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83137,272,932 - 137,311,279 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3137,273,042 - 137,311,279 (+)EnsemblGRCr8
mRatBN7.23116,819,730 - 116,858,099 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3116,819,726 - 116,858,098 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3120,717,512 - 120,755,285 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03129,313,130 - 129,350,902 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03126,973,615 - 127,011,386 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03122,113,735 - 122,152,478 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3122,114,108 - 122,152,477 (+)Ensemblrn6Rnor6.0
Rnor_5.03127,864,145 - 127,902,598 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43117,210,116 - 117,247,840 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3115,635,887 - 115,673,609 (+)NCBICelera
RGSC_v3.13117,115,688 - 117,153,412 (+)NCBI
Cytogenetic Map3q36NCBI
SIRPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38201,894,167 - 1,940,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl201,892,726 - 1,940,592 (+)Ensemblhg38GRCh38
GRCh37201,874,813 - 1,921,238 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36201,822,813 - 1,868,540 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34201,823,424 - 1,868,535NCBI
Celera201,938,791 - 1,984,521 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef201,824,406 - 1,870,408 (+)NCBIHuRef
CHM1_1201,875,015 - 1,920,758 (+)NCBICHM1_1
T2T-CHM13v2.0201,924,358 - 1,970,769 (+)NCBIT2T-CHM13v2.0
Sirpa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392129,432,962 - 129,474,148 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2129,434,755 - 129,474,148 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382129,591,042 - 129,632,228 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2129,592,835 - 129,632,228 (+)Ensemblmm10GRCm38
MGSCv372129,418,575 - 129,457,964 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362129,284,759 - 129,322,373 (+)NCBIMGSCv36mm8
Celera2130,820,643 - 130,860,425 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.19NCBI
Sirpa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541513,031,947 - 13,072,786 (+)Ensembl
ChiLan1.0NW_00495541513,030,752 - 13,072,735 (+)NCBIChiLan1.0ChiLan1.0
SIRPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2212,887,607 - 2,933,424 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1202,884,271 - 2,930,254 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0202,006,994 - 2,052,894 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1201,773,271 - 1,818,106 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl201,773,271 - 1,818,106 (+)EnsemblpanPan2panpan1.1
SIRPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12419,094,930 - 19,136,655 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2418,923,276 - 18,964,758 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02419,551,905 - 19,593,551 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2419,551,911 - 19,593,056 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12419,108,428 - 19,149,479 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02419,218,798 - 19,260,377 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02419,547,368 - 19,588,981 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sirpa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640168,176,954 - 168,219,753 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648516,608,318 - 16,649,450 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648516,608,317 - 16,654,552 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11733,566,270 - 33,611,375 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21737,961,460 - 37,968,581 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103215732
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1254,590,151 - 54,636,381 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660871,006,396 - 1,052,664 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirpa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247413,157,734 - 3,202,018 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Sirpa
473 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:313
Count of miRNA genes:185
Interacting mature miRNAs:226
Transcripts:ENSRNOT00000006408
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3136091420155634702Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF055065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D38468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U62328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000006408   ⟹   ENSRNOP00000006408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3137,273,042 - 137,311,271 (+)Ensembl
mRatBN7.2 Ensembl3116,820,372 - 116,858,098 (+)Ensembl
Rnor_6.0 Ensembl3122,114,754 - 122,152,477 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091935   ⟹   ENSRNOP00000069024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3116,819,726 - 116,856,803 (+)Ensembl
Rnor_6.0 Ensembl3122,114,108 - 122,151,182 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095684   ⟹   ENSRNOP00000092321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3137,277,241 - 137,311,279 (+)Ensembl
mRatBN7.2 Ensembl3116,823,799 - 116,858,098 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103247   ⟹   ENSRNOP00000082474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3137,273,787 - 137,311,279 (+)Ensembl
mRatBN7.2 Ensembl3116,820,605 - 116,858,098 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109073   ⟹   ENSRNOP00000087384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3137,289,229 - 137,311,279 (+)Ensembl
mRatBN7.2 Ensembl3116,836,048 - 116,858,098 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117905   ⟹   ENSRNOP00000083855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3137,273,042 - 137,311,271 (+)Ensembl
mRatBN7.2 Ensembl3116,820,372 - 116,858,098 (+)Ensembl
RefSeq Acc Id: NM_013016   ⟹   NP_037148
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,273,554 - 137,311,279 (+)NCBI
mRatBN7.23116,820,372 - 116,858,099 (+)NCBI
Rnor_6.03122,114,754 - 122,152,478 (+)NCBI
Rnor_5.03127,864,145 - 127,902,598 (-)NCBI
RGSC_v3.43117,210,116 - 117,247,840 (+)RGD
Celera3115,635,887 - 115,673,609 (+)RGD
Sequence:
RefSeq Acc Id: XM_006234952   ⟹   XP_006235014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,272,932 - 137,311,279 (+)NCBI
mRatBN7.23116,819,730 - 116,858,099 (+)NCBI
Rnor_6.03122,113,910 - 122,152,478 (+)NCBI
Rnor_5.03127,864,145 - 127,902,598 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234953   ⟹   XP_006235015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,273,108 - 137,311,279 (+)NCBI
mRatBN7.23116,819,928 - 116,858,099 (+)NCBI
Rnor_6.03122,113,910 - 122,152,478 (+)NCBI
Rnor_5.03127,864,145 - 127,902,598 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591496   ⟹   XP_017446985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,273,037 - 137,311,279 (+)NCBI
mRatBN7.23116,819,859 - 116,858,099 (+)NCBI
Rnor_6.03122,113,910 - 122,152,478 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591497   ⟹   XP_017446986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,273,108 - 137,311,279 (+)NCBI
mRatBN7.23116,819,928 - 116,858,099 (+)NCBI
Rnor_6.03122,113,911 - 122,152,478 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104381   ⟹   XP_038960309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,273,108 - 137,311,279 (+)NCBI
mRatBN7.23116,819,928 - 116,858,099 (+)NCBI
RefSeq Acc Id: XM_063283159   ⟹   XP_063139229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,272,932 - 137,311,279 (+)NCBI
RefSeq Acc Id: XM_063283160   ⟹   XP_063139230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,273,037 - 137,311,279 (+)NCBI
RefSeq Acc Id: XM_063283161   ⟹   XP_063139231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,275,156 - 137,311,279 (+)NCBI
RefSeq Acc Id: XM_063283162   ⟹   XP_063139232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,272,932 - 137,311,279 (+)NCBI
RefSeq Acc Id: NP_037148   ⟸   NM_013016
- Peptide Label: precursor
- UniProtKB: P97710 (UniProtKB/Swiss-Prot),   O70426 (UniProtKB/Swiss-Prot),   O08951 (UniProtKB/Swiss-Prot),   Q9QWI5 (UniProtKB/Swiss-Prot),   A6HQ65 (UniProtKB/TrEMBL),   A0A8I6ADR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235014   ⟸   XM_006234952
- Peptide Label: isoform X1
- UniProtKB: Q499T3 (UniProtKB/TrEMBL),   A0A8I6ADR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235015   ⟸   XM_006234953
- Peptide Label: isoform X1
- UniProtKB: Q499T3 (UniProtKB/TrEMBL),   A0A8I6ADR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446985   ⟸   XM_017591496
- Peptide Label: isoform X1
- UniProtKB: Q499T3 (UniProtKB/TrEMBL),   A0A8I6ADR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446986   ⟸   XM_017591497
- Peptide Label: isoform X2
- UniProtKB: O70426 (UniProtKB/Swiss-Prot),   O08951 (UniProtKB/Swiss-Prot),   Q9QWI5 (UniProtKB/Swiss-Prot),   P97710 (UniProtKB/Swiss-Prot),   A6HQ65 (UniProtKB/TrEMBL),   A0A8I6ADR4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006408   ⟸   ENSRNOT00000006408
Ensembl Acc Id: ENSRNOP00000069024   ⟸   ENSRNOT00000091935
RefSeq Acc Id: XP_038960309   ⟸   XM_039104381
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A0T2 (UniProtKB/TrEMBL),   A6HQ67 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083855   ⟸   ENSRNOT00000117905
Ensembl Acc Id: ENSRNOP00000092321   ⟸   ENSRNOT00000095684
Ensembl Acc Id: ENSRNOP00000087384   ⟸   ENSRNOT00000109073
Ensembl Acc Id: ENSRNOP00000082474   ⟸   ENSRNOT00000103247
RefSeq Acc Id: XP_063139229   ⟸   XM_063283159
- Peptide Label: isoform X2
- UniProtKB: Q9QWI5 (UniProtKB/Swiss-Prot),   P97710 (UniProtKB/Swiss-Prot),   O70426 (UniProtKB/Swiss-Prot),   O08951 (UniProtKB/Swiss-Prot),   A6HQ65 (UniProtKB/TrEMBL),   A0A8I6ADR4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139232   ⟸   XM_063283162
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063139230   ⟸   XM_063283160
- Peptide Label: isoform X2
- UniProtKB: Q9QWI5 (UniProtKB/Swiss-Prot),   P97710 (UniProtKB/Swiss-Prot),   O70426 (UniProtKB/Swiss-Prot),   O08951 (UniProtKB/Swiss-Prot),   A6HQ65 (UniProtKB/TrEMBL),   A0A8I6ADR4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139231   ⟸   XM_063283161
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ADR4 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   Ig-like C1-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97710-F1-model_v2 AlphaFold P97710 1-509 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692430
Promoter ID:EPDNEW_R2949
Type:initiation region
Name:Sirpa_1
Description:signal-regulatory protein alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03122,114,200 - 122,114,260EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3449 AgrOrtholog
BioCyc Gene G2FUF-47901 BioCyc
Ensembl Genes ENSRNOG00000004763 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006408 ENTREZGENE
  ENSRNOT00000006408.7 UniProtKB/Swiss-Prot
  ENSRNOT00000095684 ENTREZGENE
  ENSRNOT00000117905 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro Ig-like_CS_Receptor UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig/MHC_CS UniProtKB/Swiss-Prot
  Ig_C1-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
KEGG Report rno:25528 UniProtKB/Swiss-Prot
NCBI Gene 25528 ENTREZGENE
PANTHER SIGNAL-REGULATORY PROTEIN BETA UniProtKB/Swiss-Prot
Pfam C1-set UniProtKB/Swiss-Prot
  V-set UniProtKB/Swiss-Prot
PhenoGen Sirpa PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
  IG_MHC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004763 RatGTEx
SMART IGc1 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
TIGR TC228492
UniProt A0A8I5ZU69_RAT UniProtKB/TrEMBL
  A0A8I6A0T2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7V6_RAT UniProtKB/TrEMBL
  A0A8I6ADR4 ENTREZGENE, UniProtKB/TrEMBL
  A6HQ65 ENTREZGENE, UniProtKB/TrEMBL
  A6HQ67 ENTREZGENE, UniProtKB/TrEMBL
  O08951 ENTREZGENE
  O70426 ENTREZGENE
  P97710 ENTREZGENE
  Q499T3 ENTREZGENE, UniProtKB/TrEMBL
  Q9QWI5 ENTREZGENE
  SHPS1_RAT UniProtKB/Swiss-Prot
UniProt Secondary O08951 UniProtKB/Swiss-Prot
  O70426 UniProtKB/Swiss-Prot
  Q9QWI5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Sirpa  signal-regulatory protein alpha  Ptpns1  protein tyrosine phosphatase, non-receptor type substrate 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Ptpns1  protein tyrosine phosphatase, non-receptor type substrate 1      Symbol and Name updated 629477 APPROVED
2003-03-06 Ptpns1  protein tyrosine phosphatase, non-receptor type substrate 1  Bit  Brain immunoglobulin like protein with tyrosine - based activation motifs  Data merged from RGD:2210 628472 PROVISIONAL
2002-06-10 Ptpns1  Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1)      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Bit  Brain immunoglobulin like protein with tyrosine - based activation motifs      Symbol and Name status set to approved 70586 APPROVED