Prss2 (protease, serine, 2) - Rat Genome Database

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Gene: Prss2 (protease, serine, 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prss2
Name: protease, serine, 2
RGD ID: 3418
Description: Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Involved in response to nutrient. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human PRSS3P2 (PRSS3 pseudogene 2); PRSS1 (serine protease 1); and PRSS2 (serine protease 2); PARTICIPATES IN influenza A pathway; .
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: anionic trypsin II; anionic trypsin-2; pancreatic trypsin 2; Pancreatic trypsin II; pretrypsinogen II; Ptryss2; serine protease 2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Candidate Gene For: Bp116
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8471,244,964 - 71,250,043 (+)NCBIGRCr8
mRatBN7.2470,278,304 - 70,283,385 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl470,278,304 - 70,283,385 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx475,187,220 - 75,192,253 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0471,101,091 - 71,106,156 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0469,517,199 - 69,522,232 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0470,689,737 - 70,694,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl470,689,737 - 70,694,761 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04135,480,753 - 135,485,777 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4469,088,288 - 69,093,312 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1469,288,085 - 69,369,442 (+)NCBI
Celera465,243,567 - 65,248,645 (+)NCBICelera
Cytogenetic Map4q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. X-ray structures of a designed binding site in trypsin show metal-dependent geometry. Brinen LS, etal., Biochemistry. 1996 May 14;35(19):5999-6009.
2. Structure of two related rat pancreatic trypsin genes. Craik CS, etal., J Biol Chem 1984 Nov 25;259(22):14255-64.
3. Regulation by a protein-free carbohydrate-rich diet of rat pancreatic mRNAs encoding trypsin and elastase isoenzymes. Dakka N, etal., Biochem J. 1990 Jun 1;268(2):471-4.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases. Gillmor SA, etal., J Mol Biol. 2000 Jun 16;299(4):993-1003.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Serum trypsinogen-2 and trypsin-2-alpha(1)-antitrypsin complex in malignant and benign digestive-tract diseases. Preferential elevation in patients with cholangiocarcinomas. Hedstrom J, etal., Int J Cancer. 1996 May 3;66(3):326-31.
8. Urinary matrix metalloproteinase -8, -9, -14 and their regulators (TRY-1, TRY-2, TATI) in patients with diabetic nephropathy. Lauhio A, etal., Ann Med. 2008;40(4):312-20.
9. The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma. Lucas JM, etal., J Pathol. 2008 Jun;215(2):118-25.
10. Two similar but nonallelic rat pancreatic trypsinogens. Nucleotide sequences of the cloned cDNAs. MacDonald RJ, etal., J Biol Chem 1982 Aug 25;257(16):9724-32.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Comparison of anionic and cationic trypsinogens: the anionic activation domain is more flexible in solution and differs in its mode of BPTI binding in the crystal structure. Pasternak A, etal., Protein Sci. 1999 Jan;8(1):253-8.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:1881877   PMID:3112942   PMID:11685246   PMID:18815551   PMID:23650361   PMID:31904090  


Genomics

Variants

.
Variants in Prss2
58 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:68
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000018852, ENSRNOT00000066789
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)46699318572752834Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)46738666970362197Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)46293350882490359Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat

Markers in Region
D4Mgh32  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2470,278,793 - 70,279,197 (+)MAPPERmRatBN7.2
Rnor_6.0470,690,227 - 70,690,630NCBIRnor6.0
Rnor_5.04135,420,192 - 135,420,595UniSTSRnor5.0
Rnor_5.04135,481,243 - 135,481,646UniSTSRnor5.0
RGSC_v3.4469,088,777 - 69,089,181RGDRGSC3.4
RGSC_v3.4469,088,778 - 69,089,181UniSTSRGSC3.4
RGSC_v3.1469,364,907 - 69,365,311RGD
Celera465,244,057 - 65,244,460UniSTS
RH 3.4 Map4419.12RGD
RH 3.4 Map4419.12UniSTS
RH 2.0 Map4470.7RGD
Cytogenetic Map4q22UniSTS
D4Wox23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2470,282,456 - 70,282,627 (+)MAPPERmRatBN7.2
Rnor_6.0470,693,890 - 70,694,058NCBIRnor6.0
Rnor_5.04135,416,764 - 135,416,932UniSTSRnor5.0
Rnor_5.04135,484,906 - 135,485,074UniSTSRnor5.0
RGSC_v3.4469,092,440 - 69,092,609RGDRGSC3.4
RGSC_v3.4469,092,441 - 69,092,609UniSTSRGSC3.4
RGSC_v3.1469,368,570 - 69,368,739RGD
Celera465,247,719 - 65,247,887UniSTS
RH 3.4 Map4403.82UniSTS
RH 3.4 Map4403.82RGD
RH 2.0 Map4440.8RGD
Cytogenetic Map4q22UniSTS
D4Arb9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2470,279,628 - 70,279,998 (+)MAPPERmRatBN7.2
Rnor_6.0470,691,062 - 70,691,431NCBIRnor6.0
Rnor_5.04135,482,078 - 135,482,447UniSTSRnor5.0
RGSC_v3.4469,089,613 - 69,089,982UniSTSRGSC3.4
Celera465,244,892 - 65,245,260UniSTS
FHH x ACI Map444.65RGD
FHH x ACI Map444.65UniSTS
Cytogenetic Map4q22UniSTS
D4Arb36  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2470,282,455 - 70,282,627 (+)MAPPERmRatBN7.2
Rnor_6.0470,693,889 - 70,694,058NCBIRnor6.0
Rnor_5.04135,416,764 - 135,416,933UniSTSRnor5.0
Rnor_5.04135,484,905 - 135,485,074UniSTSRnor5.0
RGSC_v3.4469,092,439 - 69,092,609RGDRGSC3.4
RGSC_v3.4469,092,440 - 69,092,609UniSTSRGSC3.4
RGSC_v3.1469,368,569 - 69,368,739RGD
Celera465,247,718 - 65,247,887UniSTS
SHRSP x BN Map434.06UniSTS
SHRSP x BN Map434.06RGD
FHH x ACI Map444.65RGD
Cytogenetic Map4q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 7 6 13 26 30 10 21 10 57 33 8 5 16 20

Sequence


Ensembl Acc Id: ENSRNOT00000018852   ⟹   ENSRNOP00000018853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl470,689,737 - 70,694,761 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095908   ⟹   ENSRNOP00000082459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl470,278,304 - 70,283,385 (+)Ensembl
RefSeq Acc Id: NM_012729   ⟹   NP_036861
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8471,244,964 - 71,250,043 (+)NCBI
mRatBN7.2470,278,304 - 70,283,385 (+)NCBI
Rnor_6.0470,689,737 - 70,694,816 (+)NCBI
Rnor_5.04135,480,753 - 135,485,777 (+)NCBI
RGSC_v3.4469,088,288 - 69,093,312 (+)RGD
Celera465,243,567 - 65,248,645 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_036861 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA98517 (Get FASTA)   NCBI Sequence Viewer  
  CAA24581 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000082459.1
GenBank Protein P00763 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036861   ⟸   NM_012729
- Peptide Label: precursor
- UniProtKB: P00763 (UniProtKB/Swiss-Prot),   A6IF27 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018853   ⟸   ENSRNOT00000018852
Ensembl Acc Id: ENSRNOP00000082459   ⟸   ENSRNOT00000095908
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00763-F1-model_v2 AlphaFold P00763 1-246 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692997
Promoter ID:EPDNEW_R3521
Type:single initiation site
Name:Prss2_1
Description:protease, serine, 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0470,689,724 - 70,689,784EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3418 AgrOrtholog
BioCyc Gene G2FUF-45121 BioCyc
Ensembl Genes ENSRNOG00000032916 Ensembl
  ENSRNOG00000064731 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000095908.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serine_Proteases_S1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25052 UniProtKB/Swiss-Prot
NCBI Gene 25052 ENTREZGENE
PANTHER PROTEASE, SERINE 1 (TRYPSIN 1)-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prss2 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032916 RatGTEx
  ENSRNOG00000064731 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IF27 ENTREZGENE, UniProtKB/TrEMBL
  P00763 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Prss2  protease, serine, 2    pancreatic trypsin 2  Name updated 1299863 APPROVED
2003-04-09 Prss2  pancreatic trypsin 1    Pancreatic trypsin II  Name updated 629478 APPROVED
2002-06-10 Prss2  Pancreatic trypsin II      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology nucleotide sequence is 88% homologous with that of trypsinogen I mRNA 633744
gene_homology preproenzyme has 89% amino acid sequence identity with trypsinogen I 633744