Prss2 (protease, serine, 2) - Rat Genome Database

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Gene: Prss2 (protease, serine, 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prss2
Name: protease, serine, 2
RGD ID: 3418
Description: Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Involved in response to nutrient. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to several human genes including PRSS1 (serine protease 1) and PRSS2 (serine protease 2); PARTICIPATES IN influenza A pathway; .
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: anionic trypsin II; anionic trypsin-2; pancreatic trypsin 2; Pancreatic trypsin II; pretrypsinogen II; Ptryss2; serine protease 2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Candidate Gene For: Bp116
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8471,244,964 - 71,250,043 (+)NCBIGRCr8
mRatBN7.2470,278,304 - 70,283,385 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl470,278,304 - 70,283,385 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx475,187,220 - 75,192,253 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0471,101,091 - 71,106,156 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0469,517,199 - 69,522,232 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0470,689,737 - 70,694,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl470,689,737 - 70,694,761 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04135,480,753 - 135,485,777 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4469,088,288 - 69,093,312 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1469,288,085 - 69,369,442 (+)NCBI
Celera465,243,567 - 65,248,645 (+)NCBICelera
Cytogenetic Map4q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prss2Ratcholangiocarcinoma  ISOPRSS2 (Homo sapiens)2324908protein:increased expression:serumRGD 
Prss2RatDiabetic Nephropathies  ISOPRSS2 (Homo sapiens)2324899protein:increased expression:urineRGD 
Prss2RatProstatic Neoplasms  ISOPRSS2 (Homo sapiens)2324908protein:increased expression:serumRGD 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prss2Ratcollagen catabolic process involved_inISSUniProtKB:P074781600115GO_REF:0000024UniProtGO_REF:0000024
Prss2Ratdigestion involved_inIEAUniProtKB-KW:KW-02221600115GO_REF:0000043UniProtGO_REF:0000043
Prss2Ratproteolysis involved_inISSUniProtKB:P074781600115GO_REF:0000024UniProtGO_REF:0000024
Prss2Ratproteolysis involved_inIEAInterPro:IPR001254 and InterPro:IPR0181141600115GO_REF:0000002InterProGO_REF:0000002
Prss2Ratproteolysis involved_inIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Prss2Ratresponse to nutrient  IEP 1599973 RGD 

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prss2Ratextracellular region located_inISSUniProtKB:P074781600115GO_REF:0000024UniProtGO_REF:0000024
Prss2Ratextracellular region located_inIEAUniProtKB-SubCell:SL-01121600115GO_REF:0000044UniProtGO_REF:0000044
Prss2Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Prss2Ratextracellular space located_inISSUniProtKB:P074781600115GO_REF:0000024UniProtGO_REF:0000024
Prss2Ratextracellular space is_active_inIBAMGI:1891012 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prss2Ratcalcium ion binding enablesISSUniProtKB:P074781600115GO_REF:0000024UniProtGO_REF:0000024
Prss2Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Prss2Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Prss2Ratpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Prss2Ratprotein binding  IPIUniProtKB:P009741599969 RGD 
Prss2Ratprotein binding enablesIPIUniProtKB:P238278553322PMID:10843853IntAct 
Prss2Ratserine-type endopeptidase activity enablesISSUniProtKB:P074781600115GO_REF:0000024UniProtGO_REF:0000024
Prss2Ratserine-type endopeptidase activity enablesIEAEC:3.4.21.41600115GO_REF:0000003UniProtGO_REF:0000003
Prss2Ratserine-type endopeptidase activity enablesIBAMGI:102756 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Prss2Ratserine-type endopeptidase activity enablesIEAInterPro:IPR001254 and InterPro:IPR0181141600115GO_REF:0000002InterProGO_REF:0000002
Prss2Ratserine-type peptidase activity enablesIEAUniProtKB-KW:KW-07201600115GO_REF:0000043UniProtGO_REF:0000043
1 to 11 of 11 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prss2Ratinfluenza A pathway  IEA 6907045 KEGGrno:05164

1 to 18 of 18 rows
#
Reference Title
Reference Citation
1. X-ray structures of a designed binding site in trypsin show metal-dependent geometry. Brinen LS, etal., Biochemistry. 1996 May 14;35(19):5999-6009.
2. Structure of two related rat pancreatic trypsin genes. Craik CS, etal., J Biol Chem 1984 Nov 25;259(22):14255-64.
3. Regulation by a protein-free carbohydrate-rich diet of rat pancreatic mRNAs encoding trypsin and elastase isoenzymes. Dakka N, etal., Biochem J. 1990 Jun 1;268(2):471-4.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases. Gillmor SA, etal., J Mol Biol. 2000 Jun 16;299(4):993-1003.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Serum trypsinogen-2 and trypsin-2-alpha(1)-antitrypsin complex in malignant and benign digestive-tract diseases. Preferential elevation in patients with cholangiocarcinomas. Hedstrom J, etal., Int J Cancer. 1996 May 3;66(3):326-31.
8. Urinary matrix metalloproteinase -8, -9, -14 and their regulators (TRY-1, TRY-2, TATI) in patients with diabetic nephropathy. Lauhio A, etal., Ann Med. 2008;40(4):312-20.
9. The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma. Lucas JM, etal., J Pathol. 2008 Jun;215(2):118-25.
10. Two similar but nonallelic rat pancreatic trypsinogens. Nucleotide sequences of the cloned cDNAs. MacDonald RJ, etal., J Biol Chem 1982 Aug 25;257(16):9724-32.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Comparison of anionic and cationic trypsinogens: the anionic activation domain is more flexible in solution and differs in its mode of BPTI binding in the crystal structure. Pasternak A, etal., Protein Sci. 1999 Jan;8(1):253-8.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
1 to 18 of 18 rows
PMID:1881877   PMID:3112942   PMID:11685246   PMID:18815551   PMID:23650361   PMID:31904090  



.

.
Variants in Prss2
58 total Variants

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:68
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000018852, ENSRNOT00000066789
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 57 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat

1 to 10 of 57 rows
D4Mgh32  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8471,245,453 - 71,245,857 (+)Marker Load Pipeline
mRatBN7.2470,278,793 - 70,279,197 (+)MAPPERmRatBN7.2
Rnor_6.0470,690,227 - 70,690,630NCBIRnor6.0
Rnor_5.04135,481,243 - 135,481,646UniSTSRnor5.0
Rnor_5.04135,420,192 - 135,420,595UniSTSRnor5.0
RGSC_v3.4469,088,777 - 69,089,181RGDRGSC3.4
RGSC_v3.4469,088,778 - 69,089,181UniSTSRGSC3.4
RGSC_v3.1469,364,907 - 69,365,311RGD
Celera465,244,057 - 65,244,460UniSTS
RH 3.4 Map4419.12UniSTS
RH 3.4 Map4419.12RGD
RH 2.0 Map4470.7RGD
Cytogenetic Map4q22UniSTS
D4Wox23  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8471,249,116 - 71,249,285 (+)Marker Load Pipeline
mRatBN7.2470,282,456 - 70,282,627 (+)MAPPERmRatBN7.2
Rnor_6.0470,693,890 - 70,694,058NCBIRnor6.0
Rnor_5.04135,416,764 - 135,416,932UniSTSRnor5.0
Rnor_5.04135,484,906 - 135,485,074UniSTSRnor5.0
RGSC_v3.4469,092,440 - 69,092,609RGDRGSC3.4
RGSC_v3.4469,092,441 - 69,092,609UniSTSRGSC3.4
RGSC_v3.1469,368,570 - 69,368,739RGD
Celera465,247,719 - 65,247,887UniSTS
RH 3.4 Map4403.82RGD
RH 3.4 Map4403.82UniSTS
RH 2.0 Map4440.8RGD
Cytogenetic Map4q22UniSTS
D4Arb9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2470,279,628 - 70,279,998 (+)MAPPERmRatBN7.2
Rnor_6.0470,691,062 - 70,691,431NCBIRnor6.0
Rnor_5.04135,482,078 - 135,482,447UniSTSRnor5.0
RGSC_v3.4469,089,613 - 69,089,982UniSTSRGSC3.4
Celera465,244,892 - 65,245,260UniSTS
FHH x ACI Map444.65RGD
FHH x ACI Map444.65UniSTS
Cytogenetic Map4q22UniSTS
D4Arb36  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8471,249,115 - 71,249,285 (+)Marker Load Pipeline
mRatBN7.2470,282,455 - 70,282,627 (+)MAPPERmRatBN7.2
Rnor_6.0470,693,889 - 70,694,058NCBIRnor6.0
Rnor_5.04135,416,764 - 135,416,933UniSTSRnor5.0
Rnor_5.04135,484,905 - 135,485,074UniSTSRnor5.0
RGSC_v3.4469,092,439 - 69,092,609RGDRGSC3.4
RGSC_v3.4469,092,440 - 69,092,609UniSTSRGSC3.4
RGSC_v3.1469,368,569 - 69,368,739RGD
Celera465,247,718 - 65,247,887UniSTS
SHRSP x BN Map434.06RGD
SHRSP x BN Map434.06UniSTS
FHH x ACI Map444.65RGD
Cytogenetic Map4q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 7 6 13 26 30 10 21 10 57 33 8 5 16 20



Ensembl Acc Id: ENSRNOT00000018852   ⟹   ENSRNOP00000018853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl470,689,737 - 70,694,761 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095908   ⟹   ENSRNOP00000082459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl470,278,304 - 70,283,385 (+)Ensembl
RefSeq Acc Id: NM_012729   ⟹   NP_036861
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8471,244,964 - 71,250,043 (+)NCBI
mRatBN7.2470,278,304 - 70,283,385 (+)NCBI
Rnor_6.0470,689,737 - 70,694,816 (+)NCBI
Rnor_5.04135,480,753 - 135,485,777 (+)NCBI
RGSC_v3.4469,088,288 - 69,093,312 (+)RGD
Celera465,243,567 - 65,248,645 (+)NCBI
Sequence:
Protein RefSeqs NP_036861 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA98517 (Get FASTA)   NCBI Sequence Viewer  
  CAA24581 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000082459
  ENSRNOP00000082459.1
GenBank Protein P00763 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036861   ⟸   NM_012729
- Peptide Label: precursor
- UniProtKB: P00763 (UniProtKB/Swiss-Prot),   A6IF27 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018853   ⟸   ENSRNOT00000018852
Ensembl Acc Id: ENSRNOP00000082459   ⟸   ENSRNOT00000095908
Peptidase S1

Name Modeler Protein Id AA Range Protein Structure
AF-P00763-F1-model_v2 AlphaFold P00763 1-246 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692997
Promoter ID:EPDNEW_R3521
Type:single initiation site
Name:Prss2_1
Description:protease, serine, 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0470,689,724 - 70,689,784EPDNEW


1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-45121 BioCyc
Ensembl Genes ENSRNOG00000032916 Ensembl
  ENSRNOG00000064731 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000095908 ENTREZGENE
  ENSRNOT00000095908.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Serine_Proteases_S1 UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:25052 UniProtKB/Swiss-Prot
NCBI Gene 25052 ENTREZGENE
PANTHER PROTEASE, SERINE 1 (TRYPSIN 1)-RELATED UniProtKB/Swiss-Prot
  TRYPSIN-RELATED UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Prss2 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032916 RatGTEx
  ENSRNOG00000064731 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt A6IF27 ENTREZGENE, UniProtKB/TrEMBL
  P00763 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Prss2  protease, serine, 2    pancreatic trypsin 2  Name updated 1299863 APPROVED
2003-04-09 Prss2  pancreatic trypsin 1    Pancreatic trypsin II  Name updated 629478 APPROVED
2002-06-10 Prss2  Pancreatic trypsin II      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_homology nucleotide sequence is 88% homologous with that of trypsinogen I mRNA 633744
gene_homology preproenzyme has 89% amino acid sequence identity with trypsinogen I 633744