Pnoc (prepronociceptin) - Rat Genome Database

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Gene: Pnoc (prepronociceptin) Rattus norvegicus
Analyze
Symbol: Pnoc
Name: prepronociceptin
RGD ID: 3362
Description: Predicted to enable opioid receptor binding activity and receptor ligand activity. Involved in several processes, including cellular response to ethanol; gamma-aminobutyric acid secretion, neurotransmission; and modulation of chemical synaptic transmission. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon terminus; neuronal cell body; and synaptic membrane. Biomarker of fetal alcohol spectrum disorder. Human ortholog(s) of this gene implicated in neonatal abstinence syndrome. Orthologous to human PNOC (prepronociceptin); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: N23K; neuropeptide nociceptin 1; nociceptin; Npnc1; orphanin FQ; Prepronociceptin (neuropeptide nociceptin) (N23K)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81543,800,240 - 43,827,841 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1543,800,246 - 43,827,470 (-)EnsemblGRCr8
mRatBN7.21539,624,635 - 39,652,463 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1539,624,641 - 39,651,867 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1541,488,469 - 41,501,440 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01542,638,659 - 42,651,630 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,085,000 - 41,097,863 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01548,805,841 - 48,833,071 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1548,805,228 - 48,833,285 (-)Ensemblrn6Rnor6.0
Rnor_5.01552,547,677 - 52,574,687 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41544,822,635 - 44,835,637 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1539,298,658 - 39,311,512 (-)NCBICelera
RGSC_v3.11544,838,334 - 44,851,337 (-)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
atropine  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
CP-96345(1+)  (ISO)
Cuprizon  (EXP)
Dibutyl phosphate  (ISO)
diuron  (EXP)
ethanol  (EXP)
flavonoids  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
gabapentin  (ISO)
genistein  (EXP,ISO)
hydrazine  (ISO)
indole-3-methanol  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
maneb  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
morphine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
naloxone  (EXP)
nicotine  (EXP,ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
nociceptin  (EXP)
oxidopamine  (EXP)
paraquat  (EXP)
phenobarbital  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation of nociceptin/orphanin FQ gene expression in astrocytes by ceramide. Buzas B Neuroreport 2002 Oct 7;13(14):1707-10.
2. Inflammatory mediators increase the expression of nociceptin/orphanin FQ in rat astrocytes in culture. Buzas B, etal., Glia 2002 Sep;39(3):237-46.
3. Dysregulation of Nociceptin/Orphanin FQ and Dynorphin Systems in the Extended Amygdala of Alcohol Preferring Marchigian Sardinian (msP) Rats. Caputi FF, etal., Int J Mol Sci. 2021 Feb 28;22(5):2448. doi: 10.3390/ijms22052448.
4. Repeated nicotine exposure modulates prodynorphin and pronociceptin levels in the reward pathway. Carboni L, etal., Drug Alcohol Depend. 2016 Sep 1;166:150-8. doi: 10.1016/j.drugalcdep.2016.07.002. Epub 2016 Jul 12.
5. Possible mechanism of hypothermia induced by intracerebroventricular injection of orphanin FQ/nociceptin. Chen X, etal., Brain Res 2001 Jun 22;904(2):252-8.
6. Effect of nociceptin/orphanin FQ on the rewarding properties of morphine. Ciccocioppo R, etal., Eur J Pharmacol. 2000 Sep 15;404(1-2):153-9. doi: 10.1016/s0014-2999(00)00590-2.
7. Pharmacological characterization of the nociceptin receptor which mediates reduction of alcohol drinking in rats. Ciccocioppo R, etal., Peptides. 2002 Jan;23(1):117-25.
8. The nociceptin/orphanin FQ/NOP receptor system as a target for treatment of alcohol abuse: a review of recent work in alcohol-preferring rats. Ciccocioppo R, etal., Physiol Behav. 2003 Jun;79(1):121-8. doi: 10.1016/s0031-9384(03)00112-4.
9. Nociceptin/orphanin FQ blockade of corticotropin-releasing factor-induced gamma-aminobutyric acid release in central amygdala is enhanced after chronic ethanol exposure. Cruz MT, etal., Biol Psychiatry. 2012 Apr 15;71(8):666-76. doi: 10.1016/j.biopsych.2011.10.032. Epub 2011 Dec 6.
10. Different alcohol exposures induce selective alterations on the expression of dynorphin and nociceptin systems related genes in rat brain. D'Addario C, etal., Addict Biol. 2013 May;18(3):425-33. doi: 10.1111/j.1369-1600.2011.00326.x. Epub 2011 Apr 20.
11. Activation of brain NOP receptors attenuates acute and protracted alcohol withdrawal symptoms in the rat. Economidou D, etal., Alcohol Clin Exp Res. 2011 Apr;35(4):747-55. doi: 10.1111/j.1530-0277.2010.01392.x. Epub 2011 Jan 11.
12. Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat. Economidou D, etal., Biol Psychiatry. 2008 Aug 1;64(3):211-8. doi: 10.1016/j.biopsych.2008.02.004. Epub 2008 Mar 25.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats. Kallupi M, etal., Neuropsychopharmacology. 2014 Apr;39(5):1081-92. doi: 10.1038/npp.2013.308. Epub 2013 Oct 30.
16. Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. Kallupi M, etal., Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2140-2148. doi: 10.1073/pnas.1915143117. Epub 2020 Jan 13.
17. Nociceptin inhibits uterine contractions in term-pregnant rats by signaling through multiple pathways. Klukovits A, etal., Biol Reprod. 2010 Jul;83(1):36-41. doi: 10.1095/biolreprod.109.082222. Epub 2010 Mar 17.
18. Influence of nociceptin(1-17) fragments and its tyrosine-substituted derivative on morphine-withdrawal signs in rats. Kotlinska J, etal., Neuropeptides. 2004 Oct;38(5):277-82. doi: 10.1016/j.npep.2004.05.001.
19. Orphanin FQ/nociceptin inhibits morphine withdrawal. Kotlińska J, etal., Life Sci. 2000 Jan 14;66(8):PL119-23. doi: 10.1016/s0024-3205(99)00648-7.
20. Antioscillatory effects of nociceptin/orphanin FQ in synaptic networks of the rat thalamus. Meis S, etal., J Neurosci 2002 Feb 1;22(3):718-27.
21. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Meunier JC, etal., Nature 1995 Oct 12;377(6549):532-5.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene. Mollereau C, etal., Proc Natl Acad Sci U S A 1996 Aug 6;93(16):8666-70.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Primary structure and tissue distribution of the orphanin FQ precursor. Nothacker HP, etal., Proc Natl Acad Sci U S A 1996 Aug 6;93(16):8677-82.
26. Expression of orphanin FQ/nociceptin and its receptor in rat peripheral ganglia and spinal cord. Pettersson LM, etal., Brain Res 2002 Aug 2;945(2):266-75.
27. Effects of maternal separation on brain nociceptin/orphanin FQ peptide levels in male Wistar rats. Ploj K, etal., Pharmacol Biochem Behav 2002 Aug;73(1):123-9.
28. GOA pipeline RGD automated data pipeline
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Nociceptin/orphanin FQ presynaptically decreases GABAergic transmission and blocks the ethanol-induced increase of GABA release in central amygdala. Roberto M and Siggins GR, Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9715-20. doi: 10.1073/pnas.0601899103.
31. Retrodialysis of N/OFQ into the nucleus accumbens shell blocks cocaine-induced increases in extracellular dopamine and locomotor activity. Vazquez-DeRose J, etal., Eur J Pharmacol. 2013 Jan 15;699(1-3):200-6. doi: 10.1016/j.ejphar.2012.11.050. Epub 2012 Dec 5.
32. Variations in opioid receptor genes in neonatal abstinence syndrome. Wachman EM, etal., Drug Alcohol Depend. 2015 Oct 1;155:253-9. doi: 10.1016/j.drugalcdep.2015.07.001. Epub 2015 Jul 8.
33. Conditioned opioid withdrawal decreases nociceptin/orphanin FQ levels in the frontal cortex and olfactory tubercle. Walker JR, etal., Neuropsychopharmacology. 2002 Aug;27(2):203-11. doi: 10.1016/S0893-133X(02)00292-0.
34. Prenatal ethanol induces an anxiety phenotype and alters expression of dynorphin & nociceptin/orphanin FQ genes. Wille-Bille A, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jul 13;85:77-88. doi: 10.1016/j.pnpbp.2018.04.005. Epub 2018 Apr 18.
35. Accelerated release and production of orphanin FQ in brain of chronic morphine tolerant rats. Yuan L, etal., Brain Res. 1999 May 1;826(2):330-4. doi: 10.1016/s0006-8993(99)01337-2.
36. [Increased release of orphanin FQ (OFQ) in brain of chronic morphine tolerant rats]. Yuan L, etal., Sheng Li Xue Bao. 1999 Aug;51(4):454-8.
37. Immunomodulatory activity of orphanin FQ/nociceptin on traumatic rats. Zhao H, etal., Acta Pharmacol Sin. 2002 Apr;23(4):343-8.
Additional References at PubMed
PMID:11214319   PMID:12677331   PMID:12932825   PMID:14561874   PMID:14624331   PMID:15282268   PMID:15584926   PMID:15649868   PMID:15890775   PMID:15919744   PMID:16584812   PMID:16887913  
PMID:16935273   PMID:16935438   PMID:17202427   PMID:17274997   PMID:17382298   PMID:17478889   PMID:17493706   PMID:17499930   PMID:17640482   PMID:17681177   PMID:17766480   PMID:18027846  
PMID:18191820   PMID:18280651   PMID:18987291   PMID:19070636   PMID:19418633   PMID:19429134   PMID:19544046   PMID:19561314   PMID:19720395   PMID:19747494   PMID:20025627   PMID:20331962  
PMID:20427724   PMID:21095077   PMID:21162294   PMID:21191090   PMID:21215744   PMID:22075222   PMID:22120202   PMID:23082795   PMID:23264212   PMID:23735696   PMID:25161013   PMID:25171201  
PMID:30112574   PMID:30302539   PMID:38316167   PMID:38338936  


Genomics

Comparative Map Data
Pnoc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81543,800,240 - 43,827,841 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1543,800,246 - 43,827,470 (-)EnsemblGRCr8
mRatBN7.21539,624,635 - 39,652,463 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1539,624,641 - 39,651,867 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1541,488,469 - 41,501,440 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01542,638,659 - 42,651,630 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,085,000 - 41,097,863 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01548,805,841 - 48,833,071 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1548,805,228 - 48,833,285 (-)Ensemblrn6Rnor6.0
Rnor_5.01552,547,677 - 52,574,687 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41544,822,635 - 44,835,637 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1539,298,658 - 39,311,512 (-)NCBICelera
RGSC_v3.11544,838,334 - 44,851,337 (-)NCBI
Cytogenetic Map15p12NCBI
PNOC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38828,316,988 - 28,343,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl828,316,986 - 28,343,355 (+)Ensemblhg38GRCh38
GRCh37828,174,785 - 28,200,868 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36828,230,568 - 28,256,787 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34828,230,567 - 28,256,786NCBI
Celera827,134,504 - 27,160,720 (+)NCBICelera
Cytogenetic Map8p21.1NCBI
HuRef826,719,942 - 26,746,164 (+)NCBIHuRef
CHM1_1828,376,658 - 28,402,833 (+)NCBICHM1_1
T2T-CHM13v2.0828,595,062 - 28,621,518 (+)NCBIT2T-CHM13v2.0
Pnoc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391465,638,931 - 65,662,908 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1465,638,122 - 65,662,921 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381465,400,673 - 65,425,564 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1465,400,673 - 65,425,472 (-)Ensemblmm10GRCm38
MGSCv371466,019,510 - 66,044,046 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361464,354,783 - 64,379,319 (-)NCBIMGSCv36mm8
Celera1463,152,191 - 63,176,787 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.33NCBI
Pnoc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540350,735,390 - 50,755,902 (+)Ensembl
ChiLan1.0NW_00495540350,735,567 - 50,755,892 (+)NCBIChiLan1.0ChiLan1.0
PNOC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2746,856,738 - 46,883,138 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1822,571,113 - 22,597,566 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0827,596,413 - 27,622,844 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1824,796,490 - 24,822,764 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl824,796,638 - 24,822,758 (+)EnsemblpanPan2panpan1.1
PNOC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12529,223,758 - 29,246,487 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2529,224,092 - 29,245,851 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2529,873,540 - 29,896,041 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02529,382,377 - 29,404,891 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2529,382,715 - 29,404,498 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12529,342,437 - 29,364,950 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02529,226,990 - 29,249,199 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02529,393,029 - 29,415,545 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pnoc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049437,451,235 - 7,473,199 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366751,113,435 - 1,134,910 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366751,113,435 - 1,134,916 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNOC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1412,101,698 - 12,133,778 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11412,101,223 - 12,134,174 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21413,256,659 - 13,288,651 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PNOC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1826,418,473 - 26,444,689 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl826,418,815 - 26,444,677 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605215,687,564 - 15,713,855 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pnoc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475823,007,573 - 23,028,704 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475823,007,530 - 23,026,962 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pnoc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11259,006,224 - 59,033,496 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pnoc
90 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:260
Count of miRNA genes:175
Interacting mature miRNAs:195
Transcripts:ENSRNOT00000019117
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)154367724488677244Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)154367724488677244Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)154367724488677244Rat

Markers in Region
RH130731  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21539,624,790 - 39,624,975 (+)MAPPERmRatBN7.2
Rnor_6.01548,806,029 - 48,806,213NCBIRnor6.0
Rnor_5.01552,547,836 - 52,548,020UniSTSRnor5.0
RGSC_v3.41544,822,791 - 44,822,975UniSTSRGSC3.4
Celera1539,298,814 - 39,298,998UniSTS
Cytogenetic Map15p12UniSTS
RH94661  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21539,624,778 - 39,624,970 (+)MAPPERmRatBN7.2
Rnor_6.01548,806,017 - 48,806,208NCBIRnor6.0
Rnor_5.01552,547,824 - 52,548,015UniSTSRnor5.0
RGSC_v3.41544,822,779 - 44,822,970UniSTSRGSC3.4
Celera1539,298,802 - 39,298,993UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 67 125 83 82 51 38 51 6 255 128 106 59 92 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000019117   ⟹   ENSRNOP00000019117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1543,800,246 - 43,827,470 (-)Ensembl
mRatBN7.2 Ensembl1539,624,641 - 39,651,867 (-)Ensembl
Rnor_6.0 Ensembl1548,805,228 - 48,833,285 (-)Ensembl
RefSeq Acc Id: NM_013007   ⟹   NP_037139
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81543,800,240 - 43,813,103 (-)NCBI
mRatBN7.21539,624,635 - 39,637,500 (-)NCBI
Rnor_6.01548,805,873 - 48,818,594 (-)NCBI
Rnor_5.01552,547,677 - 52,574,687 (-)NCBI
RGSC_v3.41544,822,635 - 44,835,637 (-)RGD
Celera1539,298,658 - 39,311,512 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252196   ⟹   XP_006252258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81543,800,240 - 43,827,592 (-)NCBI
mRatBN7.21539,624,639 - 39,651,943 (-)NCBI
Rnor_6.01548,805,841 - 48,833,071 (-)NCBI
Rnor_5.01552,547,677 - 52,574,687 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093010   ⟹   XP_038948938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81543,800,240 - 43,827,841 (-)NCBI
mRatBN7.21539,624,639 - 39,652,463 (-)NCBI
RefSeq Acc Id: XM_063273998   ⟹   XP_063130068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81543,803,623 - 43,827,546 (-)NCBI
RefSeq Acc Id: NP_037139   ⟸   NM_013007
- Peptide Label: precursor
- UniProtKB: Q64162 (UniProtKB/Swiss-Prot),   Q62923 (UniProtKB/Swiss-Prot),   A6K6J8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252258   ⟸   XM_006252196
- Peptide Label: isoform X1
- UniProtKB: A6K6J7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019117   ⟸   ENSRNOT00000019117
RefSeq Acc Id: XP_038948938   ⟸   XM_039093010
- Peptide Label: isoform X1
- UniProtKB: A6K6J7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130068   ⟸   XM_063273998
- Peptide Label: isoform X2
- UniProtKB: Q64162 (UniProtKB/Swiss-Prot),   Q62923 (UniProtKB/Swiss-Prot),   A6K6J8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62923-F1-model_v2 AlphaFold Q62923 1-181 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3362 AgrOrtholog
BioCyc Gene G2FUF-13356 BioCyc
Ensembl Genes ENSRNOG00000014231 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019117 ENTREZGENE
  ENSRNOT00000019117.8 UniProtKB/Swiss-Prot
InterPro Nociceptin UniProtKB/Swiss-Prot
  Opioid_neupept UniProtKB/Swiss-Prot
KEGG Report rno:25516 UniProtKB/Swiss-Prot
NCBI Gene 25516 ENTREZGENE
PANTHER PREPRONOCICEPTIN UniProtKB/Swiss-Prot
  PTHR11438 UniProtKB/Swiss-Prot
Pfam Opiods_neuropep UniProtKB/Swiss-Prot
PhenoGen Pnoc PhenoGen
PRINTS OPIOIDPRCRSR UniProtKB/Swiss-Prot
  ORPHNNPRCRSR UniProtKB/Swiss-Prot
PROSITE OPIOIDS_PRECURSOR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014231 RatGTEx
UniProt A6K6J7 ENTREZGENE, UniProtKB/TrEMBL
  A6K6J8 ENTREZGENE, UniProtKB/TrEMBL
  PNOC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64162 ENTREZGENE
  Q99NQ1_RAT UniProtKB/TrEMBL
UniProt Secondary Q64162 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pnoc  Prepronociceptin (neuropeptide nociceptin) (N23K)      Symbol and Name status set to approved 70586 APPROVED