Rhoxf5 (Rhox homeobox family member 5) - Rat Genome Database

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Gene: Rhoxf5 (Rhox homeobox family member 5) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Rhoxf5 (Ensembl: Rhox5)
Name: Rhox homeobox family member 5
RGD ID: 3295
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Homeobox gene Pem; homeobox protein Pem; homeobox protein Rhox5; Pem; placenta and embryonic expression protein; placentae and embryos oncofetal; placentae and embryos oncofetal gene; reproductive homeobox 5; reproductive homeobox on chromosome X 5; Rhox5
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X121,401,888 - 121,407,643 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2X116,536,207 - 116,541,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,537,994 - 116,541,965 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX118,639,563 - 118,645,177 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X122,208,714 - 122,214,328 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X119,754,569 - 119,760,211 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X123,900,357 - 123,916,988 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX123,912,361 - 123,916,988 (+)Ensemblrn6Rnor6.0
Rnor_5.0X123,988,093 - 124,006,411 (+)NCBIRnor_5.0Rnor_5.0rn5
CeleraX115,768,121 - 115,771,966 (+)NCBICelera
Cytogenetic MapXq35NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The Pem homeobox gene: rapid evolution of the homeodomain, X chromosomal localization, and expression in reproductive tissue. Maiti S, etal., Genomics 1996 Jun 15;34(3):304-16.
2. The Pem homeobox gene. Androgen-dependent and -independent promoters and tissue-specific alternative RNA splicing. Maiti S, etal., J Biol Chem 1996 Jul 19;271(29):17536-46.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. A highly active homeobox gene promoter regulated by Ets and Sp1 family members in normal granulosa cells and diverse tumor cell types. Rao MK, etal., J Biol Chem 2002 Jul 19;277(29):26036-45.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16093360   PMID:22322598   PMID:22423045  


Genomics

Variants

.
Variants in Rhoxf5
17 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:82
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000071376
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X120028026141353710Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X120028026141353710Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X105468858125434318Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118973754157758123Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
DXWox35  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X116,539,292 - 116,539,536 (+)MAPPERmRatBN7.2
Rnor_6.0X123,914,309 - 123,914,552NCBIRnor6.0
Rnor_5.0X124,003,732 - 124,003,975UniSTSRnor5.0
CeleraX115,769,358 - 115,769,601UniSTS
RH142214  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X116,541,446 - 116,541,601 (+)MAPPERmRatBN7.2
Rnor_6.0X123,916,463 - 123,916,617NCBIRnor6.0
Rnor_5.0X124,005,886 - 124,006,040UniSTSRnor5.0
CeleraX115,771,512 - 115,771,666UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 12 63 138 78 86 59 68 59 5 294 155 11 123 60 90 27 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000071376   ⟹   ENSRNOP00000064947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX123,913,072 - 123,916,917 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092622   ⟹   ENSRNOP00000075927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX116,537,994 - 116,541,965 (+)Ensembl
Rnor_6.0 EnsemblX123,912,361 - 123,916,988 (+)Ensembl
RefSeq Acc Id: NM_022175   ⟹   NP_071511
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X121,402,049 - 121,407,643 (+)NCBI
mRatBN7.2X116,536,378 - 116,541,972 (+)NCBI
Rnor_6.0X123,913,072 - 123,916,917 (+)NCBI
Rnor_5.0X123,988,093 - 124,006,411 (+)NCBI
CeleraX115,768,121 - 115,771,966 (+)RGD
Sequence:
RefSeq Acc Id: XM_039099476   ⟹   XP_038955404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X121,401,889 - 121,407,643 (+)NCBI
mRatBN7.2X116,536,208 - 116,541,972 (+)NCBI
RefSeq Acc Id: XM_039099477   ⟹   XP_038955405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X121,401,889 - 121,407,643 (+)NCBI
mRatBN7.2X116,536,208 - 116,541,972 (+)NCBI
RefSeq Acc Id: XM_039099479   ⟹   XP_038955407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X121,401,893 - 121,407,643 (+)NCBI
mRatBN7.2X116,536,210 - 116,541,972 (+)NCBI
RefSeq Acc Id: XM_039099480   ⟹   XP_038955408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X121,401,888 - 121,407,643 (+)NCBI
mRatBN7.2X116,536,207 - 116,541,972 (+)NCBI
RefSeq Acc Id: XM_063279791   ⟹   XP_063135861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X121,401,888 - 121,407,643 (+)NCBI
RefSeq Acc Id: NP_071511   ⟸   NM_022175
- UniProtKB: A0A0U1RS42 (UniProtKB/TrEMBL),   A6JMI5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075927   ⟸   ENSRNOT00000092622
Ensembl Acc Id: ENSRNOP00000064947   ⟸   ENSRNOT00000071376
RefSeq Acc Id: XP_038955408   ⟸   XM_039099480
- Peptide Label: isoform X2
- UniProtKB: A0A0U1RS42 (UniProtKB/TrEMBL),   A6JMI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955405   ⟸   XM_039099477
- Peptide Label: isoform X1
- UniProtKB: A6JMI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955404   ⟸   XM_039099476
- Peptide Label: isoform X1
- UniProtKB: A6JMI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955407   ⟸   XM_039099479
- Peptide Label: isoform X2
- UniProtKB: A0A0U1RS42 (UniProtKB/TrEMBL),   A6JMI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135861   ⟸   XM_063279791
- Peptide Label: isoform X2
- UniProtKB: A0A0U1RS42 (UniProtKB/TrEMBL),   A6JMI5 (UniProtKB/TrEMBL)
Protein Domains
C3H1-type   Homeobox   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63630-F1-model_v2 AlphaFold Q63630 1-211 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3295 AgrOrtholog
BioCyc Gene G2FUF-1287 BioCyc
Ensembl Genes ENSRNOG00000046548 Ensembl
KEGG Report rno:24631 UniProtKB/Swiss-Prot
NCBI Gene 24631 ENTREZGENE
PANTHER HOMEOBOX PROTEIN RHOX5 UniProtKB/Swiss-Prot
  MCG113260-RELATED-RELATED UniProtKB/Swiss-Prot
PhenoGen Rhoxf5 PhenoGen
RatGTEx ENSRNOG00000046548 RatGTEx
UniProt A0A0U1RS42 ENTREZGENE
  A6JMI5 ENTREZGENE, UniProtKB/TrEMBL
  Q5PPN1_RAT UniProtKB/TrEMBL
  Q63630 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P97736 UniProtKB/Swiss-Prot
  Q4TU77 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-07-21 Rhoxf5  Rhox homeobox family member 5  Rhox5  Rhox homeobox family member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-07-14 Rhox5  Rhox homeobox family member 5  Rhox5  reproductive homeobox 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-14 Rhox5  reproductive homeobox 5  Pem  placentae and embryos oncofetal gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Pem  placentae and embryos oncofetal gene    Homeobox gene Pem  Name updated 625702 APPROVED
2002-06-10 Pem  Homeobox gene Pem      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease aberrantly expressed in a wide range of tumor cell types regardless of their origin 625577
gene_expression expressed in ovary, testis, and epididymis in parietal and visceral endodermal cells 625577
gene_expression expression is restricted to granulosa cells of preovulatory follicles in the ovary and to Sertoli cells at stages VI-VIII of the seminiferous epithelial cycle in the testis 625577
gene_expression enriched in male and female reproductive tissues; present in skeletal muscle 729615
gene_process may play a role in the development of the placenta 625577
gene_regulation the region between nucleotides - 80 and - 104 was essential for the expression from the distal promoter and contains two consensus Ets sites and a single Sp1 site; transcription from the distal promoter is ras pathway dependent 625577