Pcbd1 (pterin-4 alpha-carbinolamine dehydratase 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Pcbd1 (pterin-4 alpha-carbinolamine dehydratase 1) Rattus norvegicus
Analyze
Symbol: Pcbd1
Name: pterin-4 alpha-carbinolamine dehydratase 1
RGD ID: 3263
Description: Enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity and transcription coactivator activity. Involved in L-phenylalanine metabolic process. Acts upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia D. Orthologous to human PCBD1 (pterin-4 alpha-carbinolamine dehydratase 1); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4-alpha-hydroxy-tetrahydropterin dehydratase; 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1); DCOH; dimerization cofactor of hepatocyte nuclear factor 1-alpha; dimerization cofactor of hepatocyte nuclear factor-1-alpha; dimerization cofactor of HNF1; PCBD; PCD; phenylalanine hydroxylase-stimulating protein; PHS; pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1; pterin carbinolamine dehydratase; pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; pterin-4-alpha-carbinolamine dehydratase; TCF1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82029,573,362 - 29,587,181 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2029,573,423 - 29,587,180 (+)EnsemblGRCr8
mRatBN7.22029,037,545 - 29,044,322 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2028,953,864 - 29,044,321 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl2028,953,864 - 29,044,292 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2030,054,834 - 30,060,353 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,441,137 - 29,446,654 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,183,596 - 30,189,109 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02030,689,690 - 30,696,465 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2030,690,810 - 30,696,476 (+)Ensemblrn6Rnor6.0
Rnor_5.02032,484,965 - 32,491,740 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42028,448,703 - 28,454,184 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2030,472,263 - 30,477,776 (+)NCBICelera
RGSC_v3.12028,462,435 - 28,467,964 (+)NCBI
Cytogenetic Map20q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chlordecone  (ISO)
choline  (EXP)
cobalt dichloride  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP)
flutamide  (EXP)
folic acid  (EXP,ISO)
fulvestrant  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
hydralazine  (ISO)
inulin  (ISO)
ketoconazole  (ISO)
L-methionine  (EXP)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methylseleninic acid  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nitrofen  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
potassium dichromate  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of homeodomain proteins. Citron BA, etal., Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11891-4.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Characterization of the wild-type form of 4a-carbinolamine dehydratase and two naturally occurring mutants associated with hyperphenylalaninemia. Johnen G, etal., Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12384-8.
4. Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein. Mendel DB, etal., Science 1991 Dec 20;254(5039):1762-7.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:7744010   PMID:8444860   PMID:8897596   PMID:9865610   PMID:15182178   PMID:16189514   PMID:19056867   PMID:21047120   PMID:21516116   PMID:23376485   PMID:23533145   PMID:25416956  


Genomics

Comparative Map Data
Pcbd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82029,573,362 - 29,587,181 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2029,573,423 - 29,587,180 (+)EnsemblGRCr8
mRatBN7.22029,037,545 - 29,044,322 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2028,953,864 - 29,044,321 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl2028,953,864 - 29,044,292 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2030,054,834 - 30,060,353 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,441,137 - 29,446,654 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,183,596 - 30,189,109 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02030,689,690 - 30,696,465 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2030,690,810 - 30,696,476 (+)Ensemblrn6Rnor6.0
Rnor_5.02032,484,965 - 32,491,740 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42028,448,703 - 28,454,184 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2030,472,263 - 30,477,776 (+)NCBICelera
RGSC_v3.12028,462,435 - 28,467,964 (+)NCBI
Cytogenetic Map20q11NCBI
PCBD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381070,882,280 - 70,888,565 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1070,882,280 - 70,888,605 (-)Ensemblhg38GRCh38
GRCh371072,642,037 - 72,648,322 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361072,313,273 - 72,318,547 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1065,925,552 - 65,930,826 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1066,637,269 - 66,642,544 (-)NCBIHuRef
CHM1_11072,926,052 - 72,931,326 (-)NCBICHM1_1
T2T-CHM13v2.01071,752,084 - 71,758,371 (-)NCBIT2T-CHM13v2.0
Pcbd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391060,925,110 - 60,930,108 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1060,925,110 - 60,930,103 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381061,089,331 - 61,094,329 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,089,331 - 61,094,324 (+)Ensemblmm10GRCm38
MGSCv371060,552,091 - 60,557,077 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361060,484,716 - 60,489,676 (+)NCBIMGSCv36mm8
Celera1062,189,905 - 62,194,954 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.14NCBI
Pcbd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543720,482,589 - 20,488,249 (+)Ensembl
ChiLan1.0NW_00495543720,482,589 - 20,487,337 (+)NCBIChiLan1.0ChiLan1.0
PCBD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2883,033,986 - 83,039,162 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11083,039,307 - 83,044,479 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01067,353,903 - 67,359,073 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11069,877,545 - 69,884,030 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1069,878,773 - 69,881,174 (-)EnsemblpanPan2panpan1.1
PCBD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1421,719,863 - 21,723,493 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl421,719,863 - 21,721,574 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha421,854,056 - 21,858,488 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0421,997,912 - 22,002,345 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl421,997,904 - 22,002,274 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1421,893,535 - 21,897,967 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0422,098,728 - 22,103,182 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0422,451,020 - 22,455,453 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pcbd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721359,351,220 - 59,355,096 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365217,845,870 - 7,848,426 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365217,843,945 - 7,847,827 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCBD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1473,800,765 - 73,807,281 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11473,769,339 - 73,807,278 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21479,648,886 - 79,655,375 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PCBD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1960,417,301 - 60,422,313 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604821,141,594 - 21,146,607 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcbd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247544,893,868 - 4,898,363 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247544,893,868 - 4,898,410 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pcbd1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11826,923,749 - 26,930,589 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pcbd1
86 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:199
Count of miRNA genes:133
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000000687
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202668936256021148Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202668936256021148Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202679235356021148Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202668936256021148Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202668936256021148Rat

Markers in Region
RH128638  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22029,044,003 - 29,044,188 (+)MAPPERmRatBN7.2
Rnor_6.02030,696,147 - 30,696,331NCBIRnor6.0
Rnor_5.02032,491,422 - 32,491,606UniSTSRnor5.0
RGSC_v3.42028,453,876 - 28,454,060UniSTSRGSC3.4
Celera2030,477,459 - 30,477,643UniSTS
Cytogenetic Map20q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 161 91 90 59 77 59 6 340 176 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000687   ⟹   ENSRNOP00000000687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2029,041,484 - 29,044,321 (+)Ensembl
Rnor_6.0 Ensembl2030,690,810 - 30,696,476 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102353   ⟹   ENSRNOP00000094935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2029,038,844 - 29,044,321 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107746   ⟹   ENSRNOP00000086732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2029,573,423 - 29,587,180 (+)Ensembl
mRatBN7.2 Ensembl2029,037,483 - 29,044,321 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115927   ⟹   ENSRNOP00000080781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2028,953,864 - 29,044,292 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120036   ⟹   ENSRNOP00000085944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2028,953,864 - 29,044,292 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120712   ⟹   ENSRNOP00000098343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2029,584,344 - 29,587,180 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000130263   ⟹   ENSRNOP00000100247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2029,581,624 - 29,587,151 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000166070   ⟹   ENSRNOP00000104417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2029,574,792 - 29,587,180 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000172463   ⟹   ENSRNOP00000106770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2029,581,705 - 29,587,180 (+)Ensembl
RefSeq Acc Id: NM_001007601   ⟹   NP_001007602
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82029,581,667 - 29,587,180 (+)NCBI
mRatBN7.22029,038,806 - 29,044,321 (+)NCBI
Rnor_6.02030,690,951 - 30,696,464 (+)NCBI
Rnor_5.02032,484,965 - 32,491,740 (+)NCBI
RGSC_v3.42028,448,703 - 28,454,184 (+)RGD
Celera2030,472,263 - 30,477,776 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256414   ⟹   XP_006256476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82029,579,144 - 29,587,181 (+)NCBI
mRatBN7.22029,037,545 - 29,044,322 (+)NCBI
Rnor_6.02030,689,690 - 30,696,465 (+)NCBI
Rnor_5.02032,484,965 - 32,491,740 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063279085   ⟹   XP_063135155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82029,573,362 - 29,587,181 (+)NCBI
RefSeq Acc Id: NP_001007602   ⟸   NM_001007601
- UniProtKB: P61459 (UniProtKB/Swiss-Prot),   A6K3Y5 (UniProtKB/TrEMBL),   A0A8L2PZL1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256476   ⟸   XM_006256414
- Peptide Label: isoform X1
- UniProtKB: P61459 (UniProtKB/Swiss-Prot),   A6K3Y5 (UniProtKB/TrEMBL),   A0A8L2PZL1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000687   ⟸   ENSRNOT00000000687
Ensembl Acc Id: ENSRNOP00000080781   ⟸   ENSRNOT00000115927
Ensembl Acc Id: ENSRNOP00000086732   ⟸   ENSRNOT00000107746
Ensembl Acc Id: ENSRNOP00000094935   ⟸   ENSRNOT00000102353
Ensembl Acc Id: ENSRNOP00000085944   ⟸   ENSRNOT00000120036
RefSeq Acc Id: XP_063135155   ⟸   XM_063279085
- Peptide Label: isoform X1
- UniProtKB: P61459 (UniProtKB/Swiss-Prot),   A6K3Y5 (UniProtKB/TrEMBL),   A0A8L2PZL1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098343   ⟸   ENSRNOT00000120712
Ensembl Acc Id: ENSRNOP00000104417   ⟸   ENSRNOT00000166070
Ensembl Acc Id: ENSRNOP00000106770   ⟸   ENSRNOT00000172463
Ensembl Acc Id: ENSRNOP00000100247   ⟸   ENSRNOT00000130263

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61459-F1-model_v2 AlphaFold P61459 1-104 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701599
Promoter ID:EPDNEW_R12122
Type:initiation region
Name:Pcbd1_1
Description:pterin-4 alpha-carbinolamine dehydratase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02030,690,963 - 30,691,023EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3263 AgrOrtholog
BioCyc Gene G2FUF-3730 BioCyc
BioCyc Pathway PWY-8099 [tetrahydropteridine recycling] BioCyc
BioCyc Pathway Image PWY-8099 BioCyc
Ensembl Genes ENSRNOG00000000566 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000067614 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000107746 ENTREZGENE
  ENSRNOT00000115927.1 UniProtKB/Swiss-Prot
  ENSRNOT00000120036.1 UniProtKB/Swiss-Prot
  ENSRNOT00000130263 ENTREZGENE
Gene3D-CATH 3.30.1360.20 UniProtKB/Swiss-Prot
InterPro PCD_sf UniProtKB/Swiss-Prot
  Pterin_deHydtase UniProtKB/Swiss-Prot
KEGG Report rno:29700 UniProtKB/Swiss-Prot
NCBI Gene 29700 ENTREZGENE
PANTHER PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE UniProtKB/Swiss-Prot
  PTHR12599 UniProtKB/Swiss-Prot
Pfam Pterin_4a UniProtKB/Swiss-Prot
PhenoGen Pcbd1 PhenoGen
RatGTEx ENSRNOG00000000566 RatGTEx
  ENSRNOG00000067614 RatGTEx
Superfamily-SCOP SSF55248 UniProtKB/Swiss-Prot
UniProt A0A8I6A6U5_RAT UniProtKB/TrEMBL
  A0A8L2PZL1 ENTREZGENE
  A0ABK0L728_RAT UniProtKB/TrEMBL
  A0ABK0L936_RAT UniProtKB/TrEMBL
  A0ABK0LRS6_RAT UniProtKB/TrEMBL
  A6K3Y5 ENTREZGENE, UniProtKB/TrEMBL
  P61459 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P70519 UniProtKB/Swiss-Prot
  P80095 UniProtKB/Swiss-Prot
  Q9D930 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Pcbd1  pterin-4 alpha-carbinolamine dehydratase 1  Pcbd1  pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-26 Pcbd1  pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha  Pcbd1  pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-08-22 Pcbd1  pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1  Pcbd  6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)  Name updated 1299863 APPROVED
2004-09-10 Pcbd  6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)    6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha  Name updated 1299863 APPROVED
2002-06-10 Pcbd  6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha      Name updated 70584 APPROVED