Otc (ornithine transcarbamylase) - Rat Genome Database

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Gene: Otc (ornithine transcarbamylase) Rattus norvegicus
Analyze
Symbol: Otc
Name: ornithine transcarbamylase
RGD ID: 3236
Description: Enables several functions, including identical protein binding activity; ornithine carbamoyltransferase activity; and phosphate ion binding activity. Involved in several processes, including non-proteinogenic amino acid metabolic process; response to biotin; and urea cycle. Located in mitochondrial inner membrane. Used to study ornithine carbamoyltransferase deficiency. Biomarker of cholestasis; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in ornithine carbamoyltransferase deficiency. Orthologous to human OTC (ornithine transcarbamylase); PARTICIPATES IN urea cycle pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC108742; ornithine carbamoyltransferase; ornithine carbamoyltransferase, mitochondrial; ornithine transcarbamylase, mitochondrial; OTCase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X15,126,358 - 15,202,473 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX15,126,358 - 15,239,555 (-)EnsemblGRCr8
mRatBN7.2X12,453,834 - 12,529,954 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX12,453,834 - 12,566,918 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX12,637,792 - 12,714,464 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X16,134,742 - 16,211,402 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X12,391,289 - 12,467,959 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X13,524,804 - 13,601,074 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX13,524,607 - 13,601,069 (-)Ensemblrn6Rnor6.0
Rnor_5.0X14,314,381 - 14,390,615 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X24,609,141 - 24,685,341 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX13,066,848 - 13,142,959 (-)NCBICelera
RGSC_v3.1X24,662,538 - 24,738,739 (-)NCBI
Cytogenetic MapXq12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(5-hydroxyindol-3-yl)acetic acid  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
amiodarone  (EXP)
ammonia  (ISO)
ammonium chloride  (EXP)
arsenic acid  (EXP)
arsenite(3-)  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Calcimycin  (EXP)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chloroform  (EXP)
clofibrate  (EXP)
cyclosporin A  (EXP,ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
endosulfan  (EXP,ISO)
erythromycin estolate  (EXP)
Evodiamine  (ISO)
flutamide  (EXP)
furan  (EXP)
glafenine  (EXP)
glycine  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gossypol  (EXP)
indometacin  (EXP)
L-ethionine  (EXP)
lactacystin  (ISO)
lead diacetate  (EXP,ISO)
masoprocol  (EXP)
methapyrilene  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naloxone  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP,ISO)
Propiverine  (EXP)
quercetin  (EXP)
quinacrine  (EXP)
quinidine  (EXP)
rac-1,2-dichloropropane  (EXP)
serotonin  (ISO)
sodium arsenite  (EXP,ISO)
sodium benzoate  (ISO)
sodium dichromate  (EXP)
tartrazine  (ISO)
tauroursodeoxycholic acid  (EXP)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
theophylline  (EXP)
thioacetamide  (EXP)
triclosan  (ISO)
troglitazone  (EXP,ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Decreased urea synthesis in cafeteria-diet-induced obesity in the rat. Barber T, etal., Biochem J. 1985 Sep 15;230(3):675-81.
2. Hepatic gene expression and cytokine responses to sterile inflammation: comparison with cecal ligation and puncture sepsis in the rat. Bazel S, etal., Shock. 1999 May;11(5):347-55.
3. The activity of ornithine transcarbamoylase and arginase during mechanical jaundice in the rat model. Beck B, etal., J Surg Res. 2005 Jun 1;126(1):19-26.
4. Import of carbamylphosphate synthetase and ornithine transcarbamylase into mitochondria of rat liver: detection of aggregates of enzyme in cytoplasm and mitochondria using immunoelectron microscopy with the protein A-gold method. Brands R and Hoogenraad N, Aust J Exp Biol Med Sci. 1986 Apr;64 ( Pt 2):165-73.
5. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion. Cao Y, etal., J Proteome Res. 2019 May 3;18(5):2032-2044. doi: 10.1021/acs.jproteome.8b00921. Epub 2019 Mar 29.
6. Hypotensive hemorrhage increases calcium uptake capacity and Bcl-XL content of liver mitochondria. Carlson DE, etal., Shock. 2007 Feb;27(2):192-8.
7. Arginine-metabolizing enzymes in the developing rat small intestine. De Jonge WJ, etal., Pediatr Res. 1998 Apr;43(4 Pt 1):442-51.
8. Development of the ornithine cycle in rat liver: zonation of a metabolic pathway. Dingemanse MA, etal., Hepatology. 1996 Aug;24(2):407-11.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. The influences of insulin and food intake on intestinal ornithine transcarbamylase activity in diabetic rats. Hirota R, etal., Exp Clin Endocrinol Diabetes. 1998;106(2):117-22.
12. The spfash mouse: a missense mutation in the ornithine transcarbamylase gene also causes aberrant mRNA splicing. Hodges PE and Rosenberg LE, Proc Natl Acad Sci U S A. 1989 Jun;86(11):4142-6.
13. Molecular cloning of the cDNA coding for rat ornithine transcarbamoylase. Horwich AL, etal., Proc Natl Acad Sci U S A 1983 Jul;80(14):4258-62.
14. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
15. A cDNA clone for the precursor of rat mitochondrial ornithine transcarbamylase: comparison of rat and human leader sequences and conservation of catalytic sites. Kraus JP, etal., Nucleic Acids Res 1985 Feb 11;13(3):943-52.
16. Altered hepatic gene expression of enzymes involved in energy metabolism in the growth-retarded fetal rat. Lane RH, etal., Pediatr Res. 1996 Mar;39(3):390-4.
17. Alterations in renal and hepatic nitrogen metabolism in rats during HCl ingestion. Lardner AL and O'Donovan DJ, Metabolism. 1998 Feb;47(2):163-7.
18. Misoprostol hepatoprotection against ischemia-reperfusion-induced liver injury in the rat. Lim SP, etal., Dig Dis Sci. 1992 Aug;37(8):1275-81.
19. Biotin deficiency decreases ornithine transcarbamylase activity and mRNA in rat liver. Maeda Y, etal., J Nutr. 1996 Jan;126(1):61-6.
20. Effect of hepatocyte volume on energy status in the cirrhotic rat liver. Matsui Y, etal., J Gastroenterol Hepatol. 1994 Nov-Dec;9(6):613-9.
21. Site-directed mutagenesis of Arg60 and Cys271 in ornithine transcarbamylase from rat liver. McDowall S, etal., Protein Eng. 1990 Oct;4(1):73-7.
22. The primary structure of the imported mitochondrial protein, ornithine transcarbamylase from rat liver: mRNA levels during ontogeny. McIntyre P, etal., DNA 1985 Apr;4(2):147-56.
23. Selection of a cDNA clone which contains the complete coding sequence for the mature form of ornithine transcarbamylase from rat liver: expression of the cloned protein in Escherichia coli. Molecular cloning of rat ornithine transcarbamylase. McIntyre P, etal., Eur J Biochem 1984 Aug 15;143(1):183-7.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Ornithine carbamyltransferase is a sensitive marker for alcohol-induced liver injury. Murayama H, etal., Clin Chim Acta. 2009 Mar;401(1-2):100-4. Epub 2008 Dec 10.
26. Marked elevation of serum mitochondrion-derived markers in mild models of non-alcoholic steatohepatitis in rats. Murayama H, etal., J Gastroenterol Hepatol. 2009 Feb;24(2):270-7. Epub 2008 Sep 24.
27. Novel mutation in OTC gene causes neonatal death in twin brothers. Nagy GR, etal., J Perinatol. 2007 Feb;27(2):123-4.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. Ornithine transcarbamylase deficiency: characterization of gene mutations and polymorphisms. Oppliger Leibundgut EO, etal., Hum Mutat. 1996;8(4):333-9.
31. Enzyme-linked immunosorbent assay of carbamoylphosphate synthetase I: plasma enzyme in rat experimental hepatitis and its clearance. Ozaki M, etal., Enzyme Protein. 1994-1995;48(4):213-21.
32. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
33. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
34. The interaction of rat liver carbamoyl phosphate synthetase and ornithine transcarbamoylase with inner mitochondrial membranes. Powers-Lee SG, etal., J Biol Chem. 1987 Nov 15;262(32):15683-8.
35. GOA pipeline RGD automated data pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. [Nitrogen detoxification in artificially-fed zinc-deficient rats] Roth VH J Anim Physiol Anim Nutr (Berl). 2001 Jun;85(5-6):158-63.
39. Importance of ornithine transcarbamylase (OTC) deficiency in small intestine for urinary orotic acid excretion: analysis of OTC-deficient spf-ash mice with OTC transgene. Saheki T, etal., Biochim Biophys Acta. 1995 Jan 25;1270(1):87-93.
40. Molecular cloning and nucleotide sequence of cDNA for rat ornithine carbamoyltransferase precursor. Takiguchi M, etal., Proc Natl Acad Sci U S A 1984 Dec;81(23):7412-6.
41. Structure of the rat ornithine carbamoyltransferase gene, a large, X chromosome-linked gene with an atypical promoter. Takiguchi M, etal., Proc Natl Acad Sci U S A 1987 Sep;84(17):6136-40.
42. Toward the identification of liver toxicity markers: a proteome study in human cell culture and rats. Thome-Kromer B, etal., Proteomics. 2003 Oct;3(10):1835-62.
43. Mutations and polymorphisms in the human ornithine transcarbamylase gene. Tuchman M, etal., Hum Mutat. 2002 Feb;19(2):93-107.
44. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
45. Adaptation in enzyme (metabolic) pathways to obesity, carbohydrate diet and to the occurrence of NIDDM in male and female SHR/N-cp rats. Yamini S, etal., Int J Obes Relat Metab Disord. 1992 Oct;16(10):765-74.
Additional References at PubMed
PMID:2556444   PMID:2575934   PMID:3390141   PMID:3472484   PMID:6372096   PMID:6548714   PMID:8112735   PMID:12477932   PMID:12865426   PMID:14651853   PMID:18614015   PMID:33957483  


Genomics

Comparative Map Data
Otc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X15,126,358 - 15,202,473 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX15,126,358 - 15,239,555 (-)EnsemblGRCr8
mRatBN7.2X12,453,834 - 12,529,954 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX12,453,834 - 12,566,918 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX12,637,792 - 12,714,464 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X16,134,742 - 16,211,402 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X12,391,289 - 12,467,959 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X13,524,804 - 13,601,074 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX13,524,607 - 13,601,069 (-)Ensemblrn6Rnor6.0
Rnor_5.0X14,314,381 - 14,390,615 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X24,609,141 - 24,685,341 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX13,066,848 - 13,142,959 (-)NCBICelera
RGSC_v3.1X24,662,538 - 24,738,739 (-)NCBI
Cytogenetic MapXq12NCBI
OTC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X38,327,684 - 38,422,928 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX38,327,598 - 38,424,632 (+)Ensemblhg38GRCh38
GRCh37X38,186,937 - 38,282,181 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X38,096,680 - 38,165,647 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X37,967,574 - 38,036,826NCBI
CeleraX42,349,386 - 42,418,351 (+)NCBICelera
Cytogenetic MapXp11.4NCBI
HuRefX35,956,917 - 36,026,112 (+)NCBIHuRef
CHM1_1X38,242,780 - 38,311,752 (+)NCBICHM1_1
T2T-CHM13v2.0X37,731,277 - 37,826,523 (+)NCBIT2T-CHM13v2.0
Otc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X10,118,584 - 10,187,275 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX10,118,544 - 10,187,263 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X10,252,230 - 10,321,024 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX10,252,305 - 10,321,024 (+)Ensemblmm10GRCm38
MGSCv37X9,829,485 - 9,898,150 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X9,409,318 - 9,477,983 (+)NCBIMGSCv36mm8
CeleraX7,959,918 - 8,027,592 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX4.66NCBI
Otc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955601481,480 - 543,176 (+)Ensembl
ChiLan1.0NW_004955601481,524 - 543,176 (+)NCBIChiLan1.0ChiLan1.0
OTC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X39,976,018 - 40,067,640 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X39,979,399 - 40,071,021 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X30,796,828 - 30,868,144 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X38,505,232 - 38,575,819 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX38,505,232 - 38,575,819 (+)EnsemblpanPan2panpan1.1
OTC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X33,130,921 - 33,200,441 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX33,131,040 - 33,199,595 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX20,480,372 - 20,549,747 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X33,180,977 - 33,250,571 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX33,180,997 - 33,250,567 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X33,260,092 - 33,329,644 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X33,232,194 - 33,301,531 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X33,274,004 - 33,343,384 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Otc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X25,393,542 - 25,451,192 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365025,234,253 - 5,291,891 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365025,234,253 - 5,291,891 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OTC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX34,322,298 - 34,391,821 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X34,322,398 - 34,391,711 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X38,182,326 - 38,251,612 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXpNCBI
OTC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X35,494,334 - 35,570,923 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX35,494,287 - 35,570,845 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666076680,373 - 750,338 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Otc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476217,038,223 - 17,104,965 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476217,038,223 - 17,104,853 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Otc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X10,932,257 - 11,012,170 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Otc
390 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:218
Count of miRNA genes:148
Interacting mature miRNAs:171
Transcripts:ENSRNOT00000004686
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X400149324470521Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 8 51 131 91 90 59 40 59 6 272 117 7 111 72 86 31 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000004686   ⟹   ENSRNOP00000004686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX15,126,358 - 15,202,473 (-)Ensembl
mRatBN7.2 EnsemblX12,453,834 - 12,529,954 (-)Ensembl
Rnor_6.0 EnsemblX13,524,607 - 13,601,069 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098008   ⟹   ENSRNOP00000091915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX15,126,358 - 15,239,555 (-)Ensembl
mRatBN7.2 EnsemblX12,453,834 - 12,566,918 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105755   ⟹   ENSRNOP00000085012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX15,126,358 - 15,202,111 (-)Ensembl
mRatBN7.2 EnsemblX12,458,924 - 12,529,954 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113098   ⟹   ENSRNOP00000082946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX15,131,220 - 15,202,473 (-)Ensembl
mRatBN7.2 EnsemblX12,458,696 - 12,529,954 (-)Ensembl
RefSeq Acc Id: NM_013078   ⟹   NP_037210
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,126,358 - 15,202,473 (-)NCBI
mRatBN7.2X12,453,834 - 12,529,954 (-)NCBI
Rnor_6.0X13,524,804 - 13,601,074 (-)NCBI
Rnor_5.0X14,314,381 - 14,390,615 (-)NCBI
RGSC_v3.4X24,609,141 - 24,685,341 (-)RGD
CeleraX13,066,848 - 13,142,959 (-)RGD
Sequence:
RefSeq Acc Id: NP_037210   ⟸   NM_013078
- Peptide Label: precursor
- UniProtKB: Q63407 (UniProtKB/Swiss-Prot),   P00481 (UniProtKB/Swiss-Prot),   A6K017 (UniProtKB/TrEMBL),   A0A8I5ZYC6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004686   ⟸   ENSRNOT00000004686
Ensembl Acc Id: ENSRNOP00000085012   ⟸   ENSRNOT00000105755
Ensembl Acc Id: ENSRNOP00000082946   ⟸   ENSRNOT00000113098
Ensembl Acc Id: ENSRNOP00000091915   ⟸   ENSRNOT00000098008
Protein Domains
Aspartate/ornithine carbamoyltransferase Asp/Orn-   Aspartate/ornithine carbamoyltransferase carbamoyl-P

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00481-F1-model_v2 AlphaFold P00481 1-354 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701717
Promoter ID:EPDNEW_R12241
Type:initiation region
Name:Otc_1
Description:ornithine carbamoyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X13,601,037 - 13,601,097EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3236 AgrOrtholog
BioCyc Gene G2FUF-3029 BioCyc
BioCyc Pathway CITRULBIO-PWY [L-citrulline biosynthesis] BioCyc
  CITRULLINE-DEG-PWY [L-citrulline degradation] BioCyc
  PWY-4984 [urea cycle] BioCyc
BioCyc Pathway Image CITRULBIO-PWY BioCyc
  CITRULLINE-DEG-PWY BioCyc
  PWY-4984 BioCyc
Ensembl Genes ENSRNOG00000003370 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004686 ENTREZGENE
  ENSRNOT00000004686.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1370 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7325875 IMAGE-MGC_LOAD
InterPro Asp/Orn_carbamoyltranf_P-bd UniProtKB/Swiss-Prot
  Asp/Orn_carbamoylTrfase UniProtKB/Swiss-Prot
  Asp/Orn_carbamoylTrfase_sf UniProtKB/Swiss-Prot
  Asp_carbamoyltransf_Asp/Orn-bd UniProtKB/Swiss-Prot
  Orn/put_carbamltrans UniProtKB/Swiss-Prot
KEGG Report rno:25611 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108742 IMAGE-MGC_LOAD
NCBI Gene 25611 ENTREZGENE
PANTHER ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
  ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam OTCace UniProtKB/Swiss-Prot
  OTCace_N UniProtKB/Swiss-Prot
PhenoGen Otc PhenoGen
PRINTS AOTCASE UniProtKB/Swiss-Prot
  OTCASE UniProtKB/Swiss-Prot
PROSITE CARBAMOYLTRANSFERASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003370 RatGTEx
Superfamily-SCOP SSF53671 UniProtKB/Swiss-Prot
UniProt A0A8I5ZYC6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGK5_RAT UniProtKB/TrEMBL
  A0A8I6G855_RAT UniProtKB/TrEMBL
  A6K016_RAT UniProtKB/TrEMBL
  A6K017 ENTREZGENE, UniProtKB/TrEMBL
  A6K018_RAT UniProtKB/TrEMBL
  OTC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5M897_RAT UniProtKB/TrEMBL
  Q63407 ENTREZGENE
UniProt Secondary Q63407 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-11-12 Otc  ornithine transcarbamylase  Otc  ornithine carbamoyltransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Otc  ornithine carbamoyltransferase  Otc  ornithine transcarbamylase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Otc  Ornithine carbamoyltransferase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the mitochondrial matrix 633477