Nr2c1 (nuclear receptor subfamily 2, group C, member 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Nr2c1 (nuclear receptor subfamily 2, group C, member 1) Rattus norvegicus
Analyze
Symbol: Nr2c1
Name: nuclear receptor subfamily 2, group C, member 1
RGD ID: 3200
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Predicted to be involved in cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of retinoic acid receptor signaling pathway. Predicted to be located in PML body. Orthologous to human NR2C1 (nuclear receptor subfamily 2 group C member 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: nuclear receptor subfamily 2 group C member 1; nuclear receptor subfamily 2, group H, member 1; orphan nuclear receptor TR2; orphan receptor; orphan receptor, TR2-11; pregnancy specific beta-1-glycoprotein 4; Psg4; testicular receptor 2; Tr2; TR2-11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8730,602,338 - 30,655,610 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl730,603,018 - 30,658,349 (+)EnsemblGRCr8
mRatBN7.2728,715,347 - 28,768,624 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl728,715,562 - 28,767,160 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx730,713,646 - 30,765,220 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0732,875,895 - 32,927,468 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0732,646,428 - 32,698,239 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0735,069,807 - 35,122,810 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl735,069,814 - 35,122,796 (+)Ensemblrn6Rnor6.0
Rnor_5.0735,137,598 - 35,189,641 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4731,293,180 - 31,345,189 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera725,816,321 - 25,858,083 (+)NCBICelera
RGSC_v3.1731,313,973 - 31,365,460 (+)NCBI
Cytogenetic Map7q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium sulfate  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clofibrate  (ISO)
coumestrol  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
inulin  (ISO)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
PML body  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Mouse Genome Database (MGD) Mouse Genome Database (MGD)
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7794280   PMID:8858600   PMID:9071982   PMID:9369481   PMID:9774688   PMID:9795341   PMID:11463856   PMID:12477932   PMID:16130175   PMID:17974920   PMID:18682553  


Genomics

Comparative Map Data
Nr2c1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8730,602,338 - 30,655,610 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl730,603,018 - 30,658,349 (+)EnsemblGRCr8
mRatBN7.2728,715,347 - 28,768,624 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl728,715,562 - 28,767,160 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx730,713,646 - 30,765,220 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0732,875,895 - 32,927,468 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0732,646,428 - 32,698,239 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0735,069,807 - 35,122,810 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl735,069,814 - 35,122,796 (+)Ensemblrn6Rnor6.0
Rnor_5.0735,137,598 - 35,189,641 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4731,293,180 - 31,345,189 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera725,816,321 - 25,858,083 (+)NCBICelera
RGSC_v3.1731,313,973 - 31,365,460 (+)NCBI
Cytogenetic Map7q13NCBI
NR2C1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381295,020,229 - 95,073,618 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1295,020,229 - 95,073,628 (-)Ensemblhg38GRCh38
GRCh371295,414,005 - 95,467,394 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361293,939,802 - 93,991,487 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341293,918,138 - 93,969,676NCBI
Celera1295,085,340 - 95,138,686 (-)NCBICelera
Cytogenetic Map12q22NCBI
HuRef1292,481,137 - 92,534,428 (-)NCBIHuRef
CHM1_11295,378,558 - 95,432,374 (-)NCBICHM1_1
T2T-CHM13v2.01295,000,934 - 95,054,323 (-)NCBIT2T-CHM13v2.0
Nr2c1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391093,983,491 - 94,033,078 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1093,983,885 - 94,033,073 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381094,147,542 - 94,197,216 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1094,148,023 - 94,197,211 (+)Ensemblmm10GRCm38
MGSCv371093,610,676 - 93,659,959 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361093,586,085 - 93,625,150 (+)NCBIMGSCv36mm8
Celera1096,123,279 - 96,172,755 (+)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1048.81NCBI
Nr2c1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540531,635,113 - 31,691,465 (-)Ensembl
ChiLan1.0NW_00495540531,637,832 - 31,693,621 (-)NCBIChiLan1.0ChiLan1.0
NR2C1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210103,094,441 - 103,146,827 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112103,090,832 - 103,144,945 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01292,611,459 - 92,664,405 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11296,007,293 - 96,060,878 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1296,007,293 - 96,060,878 (-)EnsemblpanPan2panpan1.1
NR2C1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11535,003,658 - 35,049,812 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1535,005,066 - 35,038,968 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1535,390,524 - 35,436,592 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01535,668,122 - 35,714,259 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1535,668,136 - 35,714,227 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11534,941,455 - 34,987,561 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01535,036,660 - 35,082,732 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01535,299,269 - 35,345,360 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nr2c1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494524,915,800 - 24,968,872 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650711,264,737 - 11,319,642 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650711,266,408 - 11,319,642 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR2C1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl588,231,274 - 88,277,997 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1588,231,180 - 88,278,803 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2592,480,138 - 92,527,231 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NR2C1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11190,430,307 - 90,481,269 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1190,430,194 - 90,481,493 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037154,685,782 - 154,738,815 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr2c1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475011,981,783 - 12,023,282 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475011,972,826 - 12,022,603 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nr2c1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11173,300,421 - 173,354,698 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nr2c1
424 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:21
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000009578
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)72154197751639954Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)72154197751639954Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)72154197735707405Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72092049437412865Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009578   ⟹   ENSRNOP00000009578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl730,603,018 - 30,654,147 (+)Ensembl
mRatBN7.2 Ensembl728,716,093 - 28,767,160 (+)Ensembl
Rnor_6.0 Ensembl735,070,284 - 35,121,346 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089228   ⟹   ENSRNOP00000071901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl730,603,018 - 30,658,349 (+)Ensembl
mRatBN7.2 Ensembl728,715,562 - 28,767,071 (+)Ensembl
Rnor_6.0 Ensembl735,069,814 - 35,122,796 (+)Ensembl
RefSeq Acc Id: NM_145780   ⟹   NP_665723
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8730,602,607 - 30,654,148 (+)NCBI
mRatBN7.2728,715,616 - 28,767,162 (+)NCBI
Rnor_6.0735,069,807 - 35,121,348 (+)NCBI
Rnor_5.0735,137,598 - 35,189,641 (+)NCBI
RGSC_v3.4731,293,180 - 31,345,189 (+)RGD
Celera725,816,321 - 25,858,083 (+)RGD
Sequence:
RefSeq Acc Id: XM_017594671   ⟹   XP_017450160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8730,602,794 - 30,655,610 (+)NCBI
mRatBN7.2728,715,802 - 28,768,624 (+)NCBI
Rnor_6.0735,069,973 - 35,122,810 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078458   ⟹   XP_038934386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8730,602,338 - 30,655,610 (+)NCBI
mRatBN7.2728,715,347 - 28,768,624 (+)NCBI
RefSeq Acc Id: XM_039078459   ⟹   XP_038934387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8730,602,953 - 30,655,610 (+)NCBI
mRatBN7.2728,715,990 - 28,768,624 (+)NCBI
RefSeq Acc Id: XR_005486547
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8730,602,338 - 30,648,237 (+)NCBI
mRatBN7.2728,715,347 - 28,761,249 (+)NCBI
RefSeq Acc Id: NP_665723   ⟸   NM_145780
- UniProtKB: Q8VIJ4 (UniProtKB/Swiss-Prot),   A0A8L2R4T2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450160   ⟸   XM_017594671
- Peptide Label: isoform X1
- UniProtKB: Q8VIJ4 (UniProtKB/Swiss-Prot),   A0A8L2R4T2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071901   ⟸   ENSRNOT00000089228
Ensembl Acc Id: ENSRNOP00000009578   ⟸   ENSRNOT00000009578
RefSeq Acc Id: XP_038934386   ⟸   XM_039078458
- Peptide Label: isoform X1
- UniProtKB: Q8VIJ4 (UniProtKB/Swiss-Prot),   A0A8L2R4T2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934387   ⟸   XM_039078459
- Peptide Label: isoform X1
- UniProtKB: Q8VIJ4 (UniProtKB/Swiss-Prot),   A0A8L2R4T2 (UniProtKB/TrEMBL)
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VIJ4-F1-model_v2 AlphaFold Q8VIJ4 1-590 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695154
Promoter ID:EPDNEW_R5678
Type:initiation region
Name:Nr2c1_1
Description:nuclear receptor subfamily 2, group C, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0735,069,816 - 35,069,876EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3200 AgrOrtholog
BioCyc Gene G2FUF-34372 BioCyc
Ensembl Genes ENSRNOG00000006983 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009578 ENTREZGENE
  ENSRNOT00000009578.5 UniProtKB/Swiss-Prot
  ENSRNOT00000089228 ENTREZGENE
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599041 IMAGE-MGC_LOAD
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot
  NR2C1/2-like_DBD UniProtKB/Swiss-Prot
  NR2C1/2-like_LBD UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hormone_rcpt_NR2 UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:252924 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72289 IMAGE-MGC_LOAD
NCBI Gene Nr2c1 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PhenoGen Nr2c1 PhenoGen
PRINTS STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006983 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
UniProt A0A8L2R4T2 ENTREZGENE, UniProtKB/TrEMBL
  A6IG09_RAT UniProtKB/TrEMBL
  NR2C1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-06 Nr2c1  nuclear receptor subfamily 2, group C, member 1  Psg4  pregnancy specific beta-1-glycoprotein 4  Data merged from RGD:628790 737654 APPROVED
2003-02-27 Psg4  pregnancy specific beta-1-glycoprotein 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2001-06-20 Tr2  Orphan receptor, TR2-11      Symbol withdrawn, duplicate of Nr2c1 (RGD:3200) 67952 WITHDRAWN
2001-06-20 Nr2c1  Nuclear receptor subfamily 2, group C, member 1      Name updated 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology mouse Nr2c1 exhibits transcription factor, subtilase, ligand-dependent nuclear receptor and steroid hormone activities 704405