Myo1e (myosin IE) - Rat Genome Database

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Gene: Myo1e (myosin IE) Rattus norvegicus
Analyze
Symbol: Myo1e
Name: myosin IE
RGD ID: 3144
Description: Predicted to enable several functions, including ATP hydrolysis activity; actin filament binding activity; and calmodulin binding activity. Predicted to be involved in several processes, including actin filament organization; glomerular filtration; and glomerulus development. Predicted to act upstream of or within several processes, including platelet-derived growth factor receptor signaling pathway; post-embryonic hemopoiesis; and vasculogenesis. Located in cuticular plate. Part of protein-containing complex. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Orthologous to human MYO1E (myosin IE); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: myosin heavy chain myr 3; myosin I e; myosin-Ie; Myr3; MYR5; unconventional myosin 1E; Unconventional myosin from rat 5; unconventional myosin-Ie
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Vetf5
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8879,768,828 - 79,961,048 (+)NCBIGRCr8
mRatBN7.2870,887,934 - 71,080,180 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl870,887,870 - 71,080,169 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx876,421,230 - 76,614,265 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0874,694,252 - 74,887,286 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0872,532,530 - 72,725,108 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0876,644,715 - 76,840,240 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl876,754,492 - 76,839,593 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0876,241,676 - 76,432,611 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4874,680,727 - 74,884,376 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1874,699,780 - 74,903,430 (+)NCBI
Celera870,648,832 - 70,842,630 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Myo1eRatCOVID-19  ISOMYO1E (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
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Original Reference(s)
Myo1eRatbenign familial hematuria  ISOMYO1E (Homo sapiens)8554872ClinVar Annotator: match by term: Microscopic hematuriaClinVarPMID:24033266 more ...
Myo1eRatBloom syndrome  ISOMYO1E (Homo sapiens)8554872ClinVar Annotator: match by term: Bloom syndromeClinVarPMID:28492532
Myo1eRatcolorectal cancer  ISOMYO1E (Homo sapiens)8554872ClinVar Annotator: match by term: Familial colorectal cancerClinVarPMID:28492532
Myo1eRatfocal segmental glomerulosclerosis 6  ISOMYO1E (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17576681 more ...
Myo1eRatgenetic disease  ISOMYO1E (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
Myo1eRatkidney disease  ISOMYO1E (Homo sapiens)8554872ClinVar Annotator: match by term: renal diseaseClinVarPMID:24033266 more ...
Myo1eRatnephrotic syndrome  ISOMYO1E (Homo sapiens)8554872ClinVar Annotator: match by term: Nephrotic syndromeClinVarPMID:25741868 and PMID:29127259
Myo1eRatschizophrenia  ISOMYO1E (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVar 
Object Symbol
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Original Reference(s)
Myo1eRatfocal segmental glomerulosclerosis  ISOMYO1E (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
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Original Reference(s)
Myo1eRatfocal segmental glomerulosclerosis 6  ISOMYO1E (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Myo1eRat(-)-epigallocatechin 3-gallate multiple interactionsISOMYO1E (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MYO1E mRNACTDPMID:22079256
Myo1eRat(1->4)-beta-D-glucan multiple interactionsISOMyo1e (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of MYO1E mRNACTDPMID:36331819
Myo1eRat1,2-dimethylhydrazine increases expressionISOMyo1e (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of MYO1E mRNACTDPMID:22206623
Myo1eRat1-chloro-2,4-dinitrobenzene affects bindingISOMYO1E (Homo sapiens)6480464Dinitrochlorobenzene binds to MYO1E proteinCTDPMID:32991956
Myo1eRat17beta-estradiol decreases expressionISOMyo1e (Mus musculus)6480464Estradiol results in decreased expression of MYO1E mRNACTDPMID:39298647
Myo1eRat17beta-estradiol increases expressionISOMYO1E (Homo sapiens)6480464Estradiol results in increased expression of MYO1E mRNACTDPMID:31614463
Myo1eRat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOMYO1E (Homo sapiens)6480464Dihydrotestosterone results in increased expression of MYO1E mRNACTDPMID:29581250
Myo1eRat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOMYO1E (Homo sapiens)64804642 more ...CTDPMID:23146750
Myo1eRat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOMYO1E (Homo sapiens)64804642 more ...CTDPMID:31675489
Myo1eRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOMYO1E (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of MYO1E mRNACTDPMID:20106945
Myo1eRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of MYO1E mRNACTDPMID:21215274
Myo1eRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of MYO1E mRNA]CTDPMID:21215274
Myo1eRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOMyo1e (Mus musculus)6480464Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MYO1E promoter]CTDPMID:19654925
Myo1eRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOMyo1e (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of MYO1E mRNACTDPMID:19770486
Myo1eRat2,4,6-tribromophenol decreases expressionISOMYO1E (Homo sapiens)64804642 more ...CTDPMID:31675489
Myo1eRat2,6-dimethoxyphenol multiple interactionsISOMYO1E (Homo sapiens)6480464[Furaldehyde co-treated with pyrogallol 1 more ...CTDPMID:38598786
Myo1eRat2-deoxy-D-glucose decreases expressionISOMYO1E (Homo sapiens)6480464Deoxyglucose results in decreased expression of MYO1E mRNACTDPMID:33770205
Myo1eRat2-hydroxypropanoic acid decreases expressionISOMYO1E (Homo sapiens)6480464Lactic Acid results in decreased expression of MYO1E mRNACTDPMID:30851411
Myo1eRat3,3',5,5'-tetrabromobisphenol A decreases expressionISOMYO1E (Homo sapiens)6480464tetrabromobisphenol A results in decreased expression of MYO1E proteinCTDPMID:31675489
Myo1eRat3,4-methylenedioxymethamphetamine increases expressionISOMyo1e (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of MYO1E mRNACTDPMID:20188158

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Biological Process
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Original Reference(s)
Myo1eRatactin filament organization involved_inIBAFB:FBgn0000317 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo1eRatendocytosis involved_inISSUniProtKB:Q129651600115GO_REF:0000024UniProtGO_REF:0000024
Myo1eRatendocytosis involved_inIBACGD:CAL0000199209 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo1eRatendocytosis involved_inISOMYO1E (Homo sapiens)1624291 PMID:17257598RGDPMID:17257598
Myo1eRatglomerular basement membrane development involved_inISSUniProtKB:E9Q6341600115GO_REF:0000024UniProtGO_REF:0000024
Myo1eRatglomerular basement membrane development involved_inISOMyo1e (Mus musculus)1624291 PMID:19005011RGDPMID:19005011
Myo1eRatglomerular filtration involved_inISOMyo1e (Mus musculus)1624291 PMID:19005011RGDPMID:19005011
Myo1eRatglomerular filtration involved_inISSUniProtKB:E9Q6341600115GO_REF:0000024UniProtGO_REF:0000024
Myo1eRatglomerulus development involved_inIBAMGI:106621 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo1eRathemopoiesis acts_upstream_of_or_withinISOMyo1e (Mus musculus)1624291MGI:3526864 PMID:17143286RGDPMID:17143286
Myo1eRatin utero embryonic development acts_upstream_of_or_withinISOMyo1e (Mus musculus)1624291MGI:3526864 PMID:17143286RGDPMID:17143286
Myo1eRatkidney development acts_upstream_of_or_withinISOMyo1e (Mus musculus)1624291MGI:3526864 PMID:17143286RGDPMID:17143286
Myo1eRatplatelet-derived growth factor receptor signaling pathway acts_upstream_of_or_withinISOMyo1e (Mus musculus)1624291MGI:3526864 PMID:17143286RGDPMID:17143286
Myo1eRatpodocyte development involved_inISSUniProtKB:E9Q6341600115GO_REF:0000024UniProtGO_REF:0000024
Myo1eRatpodocyte development involved_inISOMyo1e (Mus musculus)1624291 PMID:19005011RGDPMID:19005011
Myo1eRatpost-embryonic hemopoiesis acts_upstream_of_or_withinISOMyo1e (Mus musculus)1624291MGI:3526864 PMID:17143286RGDPMID:17143286
Myo1eRatvasculogenesis acts_upstream_of_or_withinISOMyo1e (Mus musculus)1624291MGI:3526864 PMID:17143286RGDPMID:17143286
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Cellular Component
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Original Reference(s)
Myo1eRatactin cytoskeleton is_active_inIBACGD:CAL0000199209 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo1eRatadherens junction located_inISSUniProtKB:E9Q6341600115GO_REF:0000024UniProtGO_REF:0000024
Myo1eRatadherens junction located_inISOMyo1e (Mus musculus)1624291 PMID:19005011RGDPMID:19005011
Myo1eRatanchoring junction located_inIEAUniProtKB-KW:KW-09651600115GO_REF:0000043UniProtGO_REF:0000043
Myo1eRatanchoring junction located_inIEAUniProtKB-SubCell:SL-00381600115GO_REF:0000044UniProtGO_REF:0000044
Myo1eRatbrush border located_inISOMyo1e (Mus musculus)1624291 PMID:20089841 and PMID:22114352RGDPMID:20089841 and PMID:22114352
Myo1eRatclathrin-coated endocytic vesicle located_inISSUniProtKB:Q129651600115GO_REF:0000024UniProtGO_REF:0000024
Myo1eRatclathrin-coated endocytic vesicle located_inISOMYO1E (Homo sapiens)1624291 PMID:17257598RGDPMID:17257598
Myo1eRatclathrin-coated vesicle located_inIEAUniProtKB-SubCell:SL-00701600115GO_REF:0000044UniProtGO_REF:0000044
Myo1eRatcuticular plate  IDA 1298992 RGD 
Myo1eRatcytoplasm located_inISOMyo1e (Mus musculus)1624291 PMID:19005011RGDPMID:19005011
Myo1eRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Myo1eRatcytoplasm is_active_inIBACGD:CAL0000199209 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo1eRatcytoplasm located_inISSUniProtKB:E9Q6341600115GO_REF:0000024UniProtGO_REF:0000024
Myo1eRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Myo1eRatcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
Myo1eRatcytoskeleton located_inIEAUniProtKB-SubCell:SL-00901600115GO_REF:0000044UniProtGO_REF:0000044
Myo1eRatcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
Myo1eRatcytoskeleton located_inISOMYO1E (Homo sapiens)1624291 PMID:17257598RGDPMID:17257598
Myo1eRatcytoskeleton located_inISSUniProtKB:Q129651600115GO_REF:0000024UniProtGO_REF:0000024
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Molecular Function
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Original Reference(s)
Myo1eRatactin binding enablesIEAUniProtKB-KW:KW-00091600115GO_REF:0000043UniProtGO_REF:0000043
Myo1eRatactin filament binding enablesISOMYO1E (Homo sapiens)1624291 PMID:11940582RGDPMID:11940582
Myo1eRatactin filament binding enablesIBAFB:FBgn0011225 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo1eRatactin filament binding enablesISSUniProtKB:Q129651600115GO_REF:0000024UniProtGO_REF:0000024
Myo1eRatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Myo1eRatATP binding enablesIEAInterPro:IPR0016091600115GO_REF:0000002InterProGO_REF:0000002
Myo1eRatATP binding enablesIEAUniRule:UR0006864691600115GO_REF:0000104UniProtGO_REF:0000104
Myo1eRatATP hydrolysis activity enablesISOMYO1E (Homo sapiens)1624291 PMID:11940582RGDPMID:11940582
Myo1eRatATP hydrolysis activity enablesISSUniProtKB:Q129651600115GO_REF:0000024UniProtGO_REF:0000024
Myo1eRatcalmodulin binding enablesISSUniProtKB:Q129651600115GO_REF:0000024UniProtGO_REF:0000024
Myo1eRatcalmodulin binding enablesIEAUniProtKB-KW:KW-01121600115GO_REF:0000043UniProtGO_REF:0000043
Myo1eRatcalmodulin binding enablesISOMYO1E (Homo sapiens)1624291 PMID:11940582RGDPMID:11940582
Myo1eRatcytoskeletal motor activity enablesIEAUniRule:UR0006864691600115GO_REF:0000104UniProtGO_REF:0000104
Myo1eRatcytoskeletal motor activity enablesIEAInterPro:IPR001609 and InterPro:IPR0109261600115GO_REF:0000002InterProGO_REF:0000002
Myo1eRatlipid binding enablesIEAUniProtKB-KW:KW-04461600115GO_REF:0000043UniProtGO_REF:0000043
Myo1eRatmicrofilament motor activity enablesIBAFB:FBgn0000317 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo1eRatnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Myo1eRatphosphatidylinositol binding enablesISSUniProtKB:Q129651600115GO_REF:0000024UniProtGO_REF:0000024
Myo1eRatphosphatidylinositol binding enablesISOMYO1E (Homo sapiens)1624291 PMID:20860408RGDPMID:20860408
Myo1eRatprotein binding enablesISOMYO1E (Homo sapiens)1624291UniProtKB:P21575 more ...RGDPMID:17257598 more ...
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1 to 9 of 9 rows
#
Reference Title
Reference Citation
1. Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia. Dumont RA, etal., J Assoc Res Otolaryngol 2002 Dec;3(4):375-89. Epub 2002 Feb 27.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis. Krendel M, etal., FEBS Lett. 2007 Feb 20;581(4):644-50. Epub 2007 Jan 18.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. A novel mammalian myosin I from rat with an SH3 domain localizes to Con A-inducible, F-actin-rich structures at cell-cell contacts. Stoffler HE, etal., J Cell Biol 1995 May;129(3):819-30.
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PMID:11208135   PMID:11940582   PMID:17143286   PMID:19005011   PMID:20089841   PMID:20458337   PMID:20860408   PMID:22114352  



Myo1e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8879,768,828 - 79,961,048 (+)NCBIGRCr8
mRatBN7.2870,887,934 - 71,080,180 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl870,887,870 - 71,080,169 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx876,421,230 - 76,614,265 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0874,694,252 - 74,887,286 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0872,532,530 - 72,725,108 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0876,644,715 - 76,840,240 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl876,754,492 - 76,839,593 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0876,241,676 - 76,432,611 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4874,680,727 - 74,884,376 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1874,699,780 - 74,903,430 (+)NCBI
Celera870,648,832 - 70,842,630 (-)NCBICelera
Cytogenetic Map8q24NCBI
MYO1E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381559,132,434 - 59,372,871 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1559,132,434 - 59,372,871 (-)EnsemblGRCh38hg38GRCh38
GRCh371559,424,633 - 59,665,070 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361557,215,855 - 57,452,363 (-)NCBINCBI36Build 36hg18NCBI36
Build 341557,215,855 - 57,452,363NCBI
Celera1536,316,513 - 36,553,029 (-)NCBICelera
Cytogenetic Map15q22.2NCBI
HuRef1536,250,377 - 36,487,296 (-)NCBIHuRef
CHM1_11559,546,143 - 59,783,017 (-)NCBICHM1_1
T2T-CHM13v2.01556,934,526 - 57,174,966 (-)NCBIT2T-CHM13v2.0
Myo1e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39970,114,632 - 70,307,349 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl970,114,632 - 70,307,048 (+)EnsemblGRCm39 Ensembl
GRCm38970,207,350 - 70,400,067 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl970,207,350 - 70,399,766 (+)EnsemblGRCm38mm10GRCm38
MGSCv37970,055,157 - 70,247,874 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36970,006,514 - 70,199,231 (+)NCBIMGSCv36mm8
Celera967,429,438 - 67,616,081 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.41NCBI
Myo1e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545015,456,580 - 15,551,584 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545015,421,843 - 15,551,680 (+)NCBIChiLan1.0ChiLan1.0
MYO1E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21648,401,647 - 48,638,895 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11552,584,087 - 52,820,740 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01538,106,599 - 38,343,040 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11556,413,570 - 56,649,683 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1556,413,570 - 56,649,722 (-)Ensemblpanpan1.1panPan2
MYO1E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13024,067,622 - 24,265,567 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3024,068,283 - 24,265,311 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3024,041,333 - 24,239,771 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03024,236,065 - 24,434,141 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3024,236,074 - 24,433,904 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13024,161,240 - 24,360,201 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03024,244,241 - 24,442,581 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03024,387,998 - 24,586,599 (-)NCBIUU_Cfam_GSD_1.0
Myo1e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640102,396,361 - 102,587,555 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647120,244,397 - 20,435,648 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647120,244,424 - 20,435,604 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO1E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1112,677,821 - 112,901,993 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11112,677,545 - 112,902,005 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21124,676,396 - 124,901,516 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYO1E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12624,138,462 - 24,378,602 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2624,138,829 - 24,379,143 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048116,944,885 - 117,186,889 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myo1e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478112,682,514 - 12,871,099 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478112,682,614 - 12,866,990 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Myo1e
848 total Variants

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:49
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000016482
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 55 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat

1 to 10 of 55 rows
D8Rat195  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,035,636 - 71,035,802 (+)MAPPERmRatBN7.2
Rnor_6.0876,792,194 - 76,792,361NCBIRnor6.0
Rnor_5.0876,285,024 - 76,285,191UniSTSRnor5.0
RGSC_v3.4874,831,544 - 74,831,712RGDRGSC3.4
RGSC_v3.4874,831,545 - 74,831,712UniSTSRGSC3.4
RGSC_v3.1874,850,457 - 74,850,839RGD
Celera870,694,432 - 70,694,597UniSTS
FHH x ACI Map851.31RGD
FHH x ACI Map851.31UniSTS
Cytogenetic Map8q24UniSTS
D8Got203  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8879,932,582 - 79,932,785 (+)Marker Load Pipeline
mRatBN7.2871,051,708 - 71,051,915 (+)MAPPERmRatBN7.2
Rnor_6.0876,808,267 - 76,808,469NCBIRnor6.0
Rnor_5.0876,268,916 - 76,269,118UniSTSRnor5.0
RGSC_v3.4874,847,618 - 74,847,821RGDRGSC3.4
RGSC_v3.4874,847,619 - 74,847,821UniSTSRGSC3.4
RGSC_v3.1874,866,672 - 74,866,875RGD
Celera870,678,340 - 70,678,554UniSTS
RH 2.0 Map8677.0RGD
Cytogenetic Map8q24UniSTS
D8Got307  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8879,932,585 - 79,932,829 (+)Marker Load Pipeline
mRatBN7.2871,051,711 - 71,051,959 (+)MAPPERmRatBN7.2
Rnor_6.0876,808,270 - 76,808,513NCBIRnor6.0
Rnor_5.0876,268,872 - 76,269,115UniSTSRnor5.0
RGSC_v3.4874,847,622 - 74,847,865UniSTSRGSC3.4
Celera870,678,296 - 70,678,551UniSTS
Cytogenetic Map8q24UniSTS
RH132530  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,079,970 - 71,080,185 (+)MAPPERmRatBN7.2
Rnor_6.0876,840,352 - 76,840,566NCBIRnor6.0
Rnor_5.0876,241,350 - 76,241,564UniSTSRnor5.0
RGSC_v3.4874,884,488 - 74,884,702UniSTSRGSC3.4
Celera870,648,506 - 70,648,720UniSTS
Cytogenetic Map8q24UniSTS
AU049451  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,059,769 - 71,059,909 (+)MAPPERmRatBN7.2
Rnor_6.0876,816,488 - 76,816,627NCBIRnor6.0
Rnor_5.0876,260,971 - 76,261,110UniSTSRnor5.0
RGSC_v3.4874,856,251 - 74,856,390UniSTSRGSC3.4
Cytogenetic Map8q24UniSTS
STS-Z41090  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,068,063 - 71,068,716 (+)MAPPERmRatBN7.2
Rnor_6.0876,828,445 - 76,829,097NCBIRnor6.0
Rnor_5.0876,252,819 - 76,253,471UniSTSRnor5.0
Celera870,659,983 - 70,660,635UniSTS
Cytogenetic Map8q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000085727   ⟹   ENSRNOP00000074970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl870,997,105 - 71,080,169 (+)Ensembl
Rnor_6.0 Ensembl876,754,492 - 76,839,593 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104863   ⟹   ENSRNOP00000083425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl870,887,870 - 71,080,169 (+)Ensembl
RefSeq Acc Id: NM_173101   ⟹   NP_775124
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8879,768,828 - 79,960,727 (+)NCBI
mRatBN7.2870,887,934 - 71,079,859 (+)NCBI
Rnor_6.0876,644,715 - 76,840,240 (+)NCBI
Rnor_5.0876,241,676 - 76,432,611 (-)NCBI
RGSC_v3.4874,680,727 - 74,884,376 (+)RGD
Celera870,648,832 - 70,842,630 (-)RGD
Sequence:
RefSeq Acc Id: XM_039080888   ⟹   XP_038936816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8879,848,450 - 79,961,048 (+)NCBI
mRatBN7.2870,967,578 - 71,080,180 (+)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_775124 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936816 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA52815 (Get FASTA)   NCBI Sequence Viewer  
  EDL84189 (Get FASTA)   NCBI Sequence Viewer  
  EDL84190 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074970
  ENSRNOP00000083425.1
  ENSRNOP00000101453
GenBank Protein Q63356 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_775124   ⟸   NM_173101
- UniProtKB: Q63356 (UniProtKB/Swiss-Prot),   A0A0G2K9E8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074970   ⟸   ENSRNOT00000085727
RefSeq Acc Id: XP_038936816   ⟸   XM_039080888
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K9E8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083425   ⟸   ENSRNOT00000104863
IQ   Myosin motor   SH3   TH1

Name Modeler Protein Id AA Range Protein Structure
AF-Q63356-F1-model_v2 AlphaFold Q63356 1-1107 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 42 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-29937 BioCyc
Ensembl Genes ENSRNOG00000061928 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000085727 ENTREZGENE
  ENSRNOT00000104863.1 UniProtKB/Swiss-Prot
  ENSRNOT00000171134 ENTREZGENE
Gene3D-CATH 1.10.10.820 UniProtKB/Swiss-Prot
  1.20.5.4820 UniProtKB/Swiss-Prot
  1.20.58.530 UniProtKB/Swiss-Prot
  3.40.850.10 UniProtKB/Swiss-Prot
  Myosin VI head, motor domain, U50 subdomain UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro Ie/If_SH3 UniProtKB/Swiss-Prot
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot
  Myosin_head_motor_dom UniProtKB/Swiss-Prot
  Myosin_TH1 UniProtKB/Swiss-Prot
  MYSc_Myo1 UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report rno:25484 UniProtKB/Swiss-Prot
NCBI Gene 25484 ENTREZGENE
PANTHER MYOSIN UniProtKB/Swiss-Prot
  UNCONVENTIONAL MYOSIN-IE UniProtKB/Swiss-Prot
Pfam Myosin_head UniProtKB/Swiss-Prot
  Myosin_TH1 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Myo1e PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot
  SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE MYOSIN_MOTOR UniProtKB/Swiss-Prot
  PS50096 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  TH1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000061928 RatGTEx
SMART MYSc UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2K9E8 ENTREZGENE, UniProtKB/TrEMBL
  A6KET8_RAT UniProtKB/TrEMBL
1 to 40 of 42 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Myo1e  myosin IE  Myr3  Unconventional myosin from rat 5  Symbol and Name updated 625702 APPROVED
2002-06-10 Myr3  Unconventional myosin from rat 5      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression highly expressed in hair cells of the auditory and vestibular epithelia 1298992
gene_expression localized in cytoplasm and in elongated structures to F-actin-rich structures at regions of cell-cell contact 1298993
gene_function function may be mediated by cell-cell contact 1298993