Myh4 (myosin heavy chain 4) - Rat Genome Database

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Gene: Myh4 (myosin heavy chain 4) Rattus norvegicus
Analyze
Symbol: Myh4
Name: myosin heavy chain 4
RGD ID: 3139
Description: Predicted to enable actin filament binding activity; double-stranded RNA binding activity; and microfilament motor activity. Involved in several processes, including response to gravity; response to muscle activity; and response to muscle stretch. Predicted to be located in myofibril. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Biomarker of sciatic neuropathy. Orthologous to human MYH4 (myosin heavy chain 4); PARTICIPATES IN myocarditis pathway; INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2B myosin heavy chain; LOC360543; myHC-2b; myosin heavy chain 2b; myosin heavy chain type IIb; Myosin heavy polypeptide 4 skeletal muscle; myosin, heavy chain 4, skeletal muscle; myosin, heavy polypeptide 4; Myosin, heavy polypeptide 4, skeletal muscle; myosin-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81052,422,148 - 52,445,296 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1052,421,951 - 52,445,294 (+)EnsemblGRCr8
mRatBN7.21051,923,149 - 51,946,297 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1051,885,913 - 51,946,295 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1056,580,078 - 56,603,219 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01056,069,077 - 56,092,220 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01051,579,604 - 51,603,148 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01053,778,456 - 53,801,605 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1053,713,938 - 53,848,347 (+)Ensemblrn6Rnor6.0
Rnor_5.01053,530,747 - 53,553,896 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41053,931,880 - 53,955,029 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1051,105,822 - 51,128,615 (+)NCBICelera
RGSC_v3.11053,948,285 - 53,968,548 (+)NCBI
RH 3.4 Map10571.9RGD
Cytogenetic Map10q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Parallel and divergent adaptations of rat soleus and plantaris to chronic exercise and hypergravity. Fuller PM, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Feb;290(2):R442-8. Epub 2005 Sep 22.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4. Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline. Li Q, etal., Gene 2002 Jan 23;283(1-2):255-62.
5. Cloning and in situ hybridization of type 2A and 2B rat skeletal muscle myosin tail region: implications for filament assembly. Lieber RL, etal., Biochem Biophys Res Commun 1993 Dec 30;197(3):1312-8.
6. Heart failure-induced diaphragm myopathy. Lima AR, etal., Cell Physiol Biochem. 2014;34(2):333-45. doi: 10.1159/000363003. Epub 2014 Jul 8.
7. BDNF rescues myosin heavy chain IIB muscle fibers after neonatal nerve injury. Mousavi K, etal., Am J Physiol Cell Physiol. 2004 Jul;287(1):C22-9. Epub 2004 Feb 18.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Differential modification of myosin heavy chain expression by tenotomy in regenerating fast and slow muscles of the rat. Noirez P, etal., Exp Physiol. 2000 Mar;85(2):187-91.
10. Sternohyoid and diaphragm muscle form and function during postnatal development in the rat. O'Connell RA, etal., Exp Physiol. 2013 Sep;98(9):1386-400. doi: 10.1113/expphysiol.2013.073346. Epub 2013 May 24.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1302224   PMID:8145163   PMID:8227143   PMID:12477932   PMID:15489334   PMID:17030512   PMID:18310078   PMID:18384641   PMID:19040707   PMID:19182904   PMID:19260067   PMID:21266579  
PMID:22206666  


Genomics

Comparative Map Data
Myh4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81052,422,148 - 52,445,296 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1052,421,951 - 52,445,294 (+)EnsemblGRCr8
mRatBN7.21051,923,149 - 51,946,297 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1051,885,913 - 51,946,295 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1056,580,078 - 56,603,219 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01056,069,077 - 56,092,220 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01051,579,604 - 51,603,148 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01053,778,456 - 53,801,605 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1053,713,938 - 53,848,347 (+)Ensemblrn6Rnor6.0
Rnor_5.01053,530,747 - 53,553,896 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41053,931,880 - 53,955,029 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1051,105,822 - 51,128,615 (+)NCBICelera
RGSC_v3.11053,948,285 - 53,968,548 (+)NCBI
RH 3.4 Map10571.9RGD
Cytogenetic Map10q24NCBI
MYH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381710,443,263 - 10,469,559 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1710,443,290 - 10,469,559 (-)Ensemblhg38GRCh38
GRCh371710,346,607 - 10,372,876 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361710,287,332 - 10,313,601 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341710,287,331 - 10,313,601NCBI
Celera1710,377,452 - 10,403,722 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef1710,246,185 - 10,272,452 (-)NCBIHuRef
CHM1_11710,356,450 - 10,382,720 (-)NCBICHM1_1
T2T-CHM13v2.01710,350,703 - 10,377,048 (-)NCBIT2T-CHM13v2.0
Myh4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391167,128,638 - 67,151,273 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1167,128,855 - 67,151,272 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381167,237,812 - 67,260,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1167,238,029 - 67,260,446 (+)Ensemblmm10GRCm38
MGSCv371167,051,531 - 67,073,948 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361167,054,224 - 67,076,641 (+)NCBIMGSCv36mm8
Celera1174,181,234 - 74,203,668 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1140.59NCBI
Myh4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554676,719,572 - 6,744,147 (+)Ensembl
ChiLan1.0NW_0049554676,719,572 - 6,744,147 (+)NCBIChiLan1.0ChiLan1.0
LOC103786029
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21963,279,606 - 63,305,571 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11768,090,162 - 68,116,127 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01741,183,808 - 41,209,774 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11745,931,196 - 45,957,156 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1745,931,196 - 45,957,149 (+)EnsemblpanPan2panpan1.1
MYH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1534,743,454 - 34,767,076 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl534,743,314 - 34,767,076 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha534,880,006 - 34,903,497 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0534,848,401 - 34,871,931 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl534,848,261 - 34,871,931 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1534,813,883 - 34,837,393 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0534,771,325 - 34,794,835 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0534,952,259 - 34,975,786 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101973267
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560249,850,157 - 49,875,181 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365953,324,345 - 3,349,606 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1255,190,433 - 55,212,813 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11255,190,545 - 55,216,294 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103242385
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1169,786,143 - 9,811,908 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl169,786,240 - 9,809,098 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605911,533,281 - 11,556,520 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101698292
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478612,858,776 - 12,884,213 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478612,814,777 - 12,886,129 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Myh4
111 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:63
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000045718
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
Myh1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21051,923,037 - 51,923,141 (+)MAPPERmRatBN7.2
Rnor_6.01053,778,345 - 53,778,448NCBIRnor6.0
Rnor_5.01053,530,636 - 53,530,739UniSTSRnor5.0
RGSC_v3.41053,931,769 - 53,931,872UniSTSRGSC3.4
Celera1051,105,711 - 51,105,814UniSTS
Cytogenetic Map10q24UniSTS
UniSTS:265579  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21051,946,137 - 51,946,260 (+)MAPPERmRatBN7.2
Rnor_6.01053,801,446 - 53,801,568NCBIRnor6.0
Rnor_5.01053,553,737 - 53,553,859UniSTSRnor5.0
RGSC_v3.41053,954,870 - 53,954,992UniSTSRGSC3.4
Cytogenetic Map10q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 34 119 58 57 26 26 26 6 159 93 11 95 22 49 31 8 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC113948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ872907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L24897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: NM_019325   ⟹   NP_062198
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81052,422,148 - 52,445,296 (+)NCBI
mRatBN7.21051,923,149 - 51,946,297 (+)NCBI
Rnor_6.01053,778,456 - 53,801,605 (+)NCBI
Rnor_5.01053,530,747 - 53,553,896 (+)NCBI
RGSC_v3.41053,931,880 - 53,955,029 (+)RGD
Celera1051,105,822 - 51,128,615 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062198 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA72046 (Get FASTA)   NCBI Sequence Viewer  
  AAI13949 (Get FASTA)   NCBI Sequence Viewer  
  ABI34118 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046362
GenBank Protein Q29RW1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062198   ⟸   NM_019325
- UniProtKB: Q29RW1 (UniProtKB/Swiss-Prot),   F1LMU0 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
IQ   Myosin motor   Myosin N-terminal SH3-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q29RW1-F1-model_v2 AlphaFold Q29RW1 1-1939 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697293
Promoter ID:EPDNEW_R7816
Type:multiple initiation site
Name:Myh4_2
Description:myosin heavy chain 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7815  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01053,778,653 - 53,778,713EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3139 AgrOrtholog
BioCyc Gene G2FUF-24651 BioCyc
Ensembl Genes ENSRNOG00000049695 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000045718 ENTREZGENE
Gene3D-CATH 1.10.10.820 UniProtKB/Swiss-Prot
  1.20.5.340 UniProtKB/Swiss-Prot
  1.20.5.370 UniProtKB/Swiss-Prot
  1.20.5.4820 UniProtKB/Swiss-Prot
  1.20.58.530 UniProtKB/Swiss-Prot
  2.30.30.360 UniProtKB/Swiss-Prot
  3.40.850.10 UniProtKB/Swiss-Prot
  6.10.250.2420 UniProtKB/Swiss-Prot
  Myosin VI head, motor domain, U50 subdomain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7937870 IMAGE-MGC_LOAD
InterPro Kinesin_motor_dom_sf UniProtKB/Swiss-Prot
  Myosin_head_motor_dom UniProtKB/Swiss-Prot
  Myosin_N UniProtKB/Swiss-Prot
  Myosin_S1_N UniProtKB/Swiss-Prot
  Myosin_tail UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  XRCC4-like_C UniProtKB/Swiss-Prot
KEGG Report rno:360543 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124733 IMAGE-MGC_LOAD
NCBI Gene Myh4 ENTREZGENE
PANTHER MYOSIN HEAVY CHAIN, NON-MUSCLE UniProtKB/Swiss-Prot
  MYOSIN-4 UniProtKB/Swiss-Prot
Pfam Myosin_head UniProtKB/Swiss-Prot
  Myosin_N UniProtKB/Swiss-Prot
  Myosin_tail_1 UniProtKB/Swiss-Prot
PhenoGen Myh4 PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot
PROSITE MYOSIN_MOTOR UniProtKB/Swiss-Prot
  PS50096 UniProtKB/Swiss-Prot
  SH3_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000049695 RatGTEx
SMART MYSc UniProtKB/Swiss-Prot
Superfamily-SCOP Myosin rod fragments UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  Tropomyosin UniProtKB/Swiss-Prot
TIGR TC204122
UniProt F1LMU0 ENTREZGENE, UniProtKB/TrEMBL
  MYH4_RAT UniProtKB/Swiss-Prot
  Q0GC38_RAT UniProtKB/TrEMBL
  Q29RW1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Myh4  myosin heavy chain 4  Myh4  myosin, heavy chain 4, skeletal muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Myh4  myosin, heavy chain 4, skeletal muscle  Myh4  myosin, heavy polypeptide 4, skeletal muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Myh4  myosin, heavy polypeptide 4, skeletal muscle  Myh4  myosin, heavy polypeptide 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-06-13 Myh4  myosin, heavy polypeptide 4  Myh4_predicted  myosin, heavy polypeptide 4, skeletal muscle (predicted)  Data merged from RGD:1311997 737654 APPROVED
2005-09-19 Myh4_predicted  myosin, heavy polypeptide 4, skeletal muscle (predicted)  Ctnnb1  catenin (cadherin-associated protein), beta 1 (88kD)  Data merged from RGD:620703 737654 APPROVED
2005-01-12 Myh4_predicted  myosin, heavy polypeptide 4, skeletal muscle (predicted)      Symbol and Name status set to approved 70820 APPROVED
2003-04-09 Myh4  myosin, heavy polypeptide 4    Myosin, heavy polypeptide 4, skeletal muscle  Name updated 629478 APPROVED
2002-08-07 Ctnnb1  catenin (cadherin-associated protein), beta 1 (88kD)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Myh4  Myosin, heavy polypeptide 4, skeletal muscle      Symbol and Name status set to approved 70586 APPROVED