Myh4 (myosin heavy chain 4) - Rat Genome Database

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Gene: Myh4 (myosin heavy chain 4) Rattus norvegicus
Analyze
Symbol: Myh4 (Ensembl: Myh2)
Name: myosin heavy chain 4 (Ensembl:myosin heavy chain 2)
RGD ID: 3139
Description: Predicted to enable actin filament binding activity; double-stranded RNA binding activity; and microfilament motor activity. Involved in several processes, including response to gravity; response to muscle activity; and response to muscle stretch. Predicted to be located in myofibril. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Biomarker of sciatic neuropathy. Orthologous to human MYH4 (myosin heavy chain 4); PARTICIPATES IN myocarditis pathway; INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2B myosin heavy chain; LOC360543; myHC-2b; myosin heavy chain 2b; myosin heavy chain type IIb; Myosin heavy polypeptide 4 skeletal muscle; myosin, heavy chain 4, skeletal muscle; myosin, heavy polypeptide 4; Myosin, heavy polypeptide 4, skeletal muscle; myosin-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81052,422,148 - 52,445,296 (+)NCBIGRCr8
mRatBN7.21051,923,149 - 51,946,297 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1051,885,913 - 51,946,295 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1056,580,078 - 56,603,219 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01056,069,077 - 56,092,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01051,579,604 - 51,603,148 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01053,778,456 - 53,801,605 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1053,713,938 - 53,848,347 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01053,530,747 - 53,553,896 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41053,931,880 - 53,955,029 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11053,948,285 - 53,968,548 (+)NCBI
Celera1051,105,822 - 51,128,615 (+)NCBICelera
RH 3.4 Map10571.9RGD
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Myh4RatRight Ventricular Hypertrophy  IEP 9686065associated with Heart Failure and protein:decreased expression:diaphragmRGD 
Myh4Ratsciatic neuropathy treatmentIEP 9686059 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Myh4Ratcongenital myopathy 6  ISOMYH4 (Homo sapiens)8554872ClinVar Annotator: match by term: Myopathy more ...ClinVarPMID:28492532

1 to 20 of 52 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Myh4Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MYH4 mRNA]CTDPMID:31150632
Myh4Rat17beta-estradiol decreases expressionISOMyh4 (Mus musculus)6480464Estradiol results in decreased expression of MYH4 mRNACTDPMID:19484750
Myh4Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of MYH4 mRNACTDPMID:24780913
Myh4Ratacrylamide increases expressionEXP 6480464Acrylamide results in increased expression of MYH4 mRNACTDPMID:28959563
Myh4Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of MYH4 mRNACTDPMID:16483693
Myh4Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of MYH4 mRNACTDPMID:25181051 and PMID:34947998
Myh4Ratbisphenol A increases expressionISOMYH4 (Homo sapiens)6480464bisphenol A results in increased expression of MYH4 proteinCTDPMID:37567409
Myh4Ratbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of MYH4 mRNACTDPMID:29552716 more ...
Myh4RatBotulinum toxin type A decreases expressionEXP 6480464Botulinum Toxins and Type A results in decreased expression of MYH4 proteinCTDPMID:19260067
Myh4Ratcadmium atom decreases expressionISOMyh4 (Mus musculus)6480464Cadmium results in decreased expression of MYH4 mRNACTDPMID:25149082
Myh4Ratcarbon nanotube increases expressionISOMyh4 (Mus musculus)6480464Nanotubes and Carbon results in increased expression of MYH4 mRNACTDPMID:25620056
Myh4Ratcarbon nanotube decreases expressionISOMyh4 (Mus musculus)6480464Nanotubes more ...CTDPMID:25554681 and PMID:25620056
Myh4Ratcarbon nanotube affects expressionISOMyh4 (Mus musculus)6480464Nanotubes and Carbon analog affects the expression of MYH4 mRNACTDPMID:25554681
Myh4RatCGP 52608 multiple interactionsISOMYH4 (Homo sapiens)6480464CGP 52608 promotes the reaction [RORA protein binds to MYH4 gene]CTDPMID:28238834
Myh4Ratchrysene increases expressionISOMyh4 (Mus musculus)6480464chrysene results in increased expression of MYH4 mRNACTDPMID:26377693
Myh4Ratciguatoxin CTX1B affects expressionISOMyh4 (Mus musculus)6480464Ciguatoxins affects the expression of MYH4 mRNACTDPMID:18353800
Myh4Ratdecabromodiphenyl ether increases expressionEXP 6480464decabromobiphenyl ether results in increased expression of MYH4 mRNACTDPMID:23640034
Myh4Ratdexamethasone multiple interactionsISOMyh4 (Mus musculus)6480464Dexamethasone promotes the reaction [IGF1 protein results in increased expression of MYH4 mRNA] and IGF1 protein promotes the reaction [Dexamethasone results in increased expression of MYH4 mRNA]CTDPMID:22936724
Myh4Ratdexamethasone increases expressionISOMyh4 (Mus musculus)6480464Dexamethasone results in increased expression of MYH4 mRNACTDPMID:22733784 and PMID:22936724
Myh4Ratdibutyl phthalate decreases expressionEXP 6480464Dibutyl Phthalate results in decreased expression of MYH4 mRNACTDPMID:21266533

1 to 20 of 52 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Myh4Ratmuscle contraction involved_inISOMYH4 (Homo sapiens)1624291 PMID:8145163RGDPMID:8145163
Myh4Ratmuscle contraction involved_inIBAPANTHER:PTN002897332 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myh4Ratmuscle structure development  IEP 9686068 RGD 
Myh4Ratresponse to gravity  IEP 9686070 RGD 
Myh4Ratresponse to muscle activity  IEP 9686070 RGD 
Myh4Ratresponse to muscle activity acts_upstream_of_or_withinIEAUniProtKB:Q5SX39 and ensembl:ENSMUSP000000186321600115GO_REF:0000107EnsemblGO_REF:0000107
Myh4Ratresponse to muscle activity acts_upstream_of_or_withinISOMyh4 (Mus musculus)1624291 PMID:18310078RGDPMID:18310078
Myh4Ratresponse to muscle stretch  IEP 9686066 RGD 

Cellular Component
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Myh4Ratcytoplasm is_active_inIBACGD:CAL0000200546 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myh4Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Myh4Ratintracellular membraneless organelle located_inIEAARBA:ARBA000290791600115GO_REF:0000117UniProtGO_REF:0000117
Myh4Ratmyofibril located_inISOMYH4 (Homo sapiens)1624291 PMID:8145163RGDPMID:8145163
Myh4Ratmyofibril located_inIEAUniProtKB-SubCell:SL-03121600115GO_REF:0000044UniProtGO_REF:0000044
Myh4Ratmyosin complex part_ofIEAInterPro:IPR001609 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Myh4Ratmyosin complex part_ofIEAUniProtKB-KW:KW-05181600115GO_REF:0000043UniProtGO_REF:0000043
Myh4Ratmyosin filament located_inIEAUniProtKB-KW:KW-07871600115GO_REF:0000043UniProtGO_REF:0000043
Myh4Ratmyosin filament is_active_inIBAPANTHER:PTN005210253 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myh4Ratmyosin II complex part_ofIBAFB:FBgn0287873 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
1 to 10 of 10 rows

Molecular Function
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Myh4Ratactin binding enablesIEAUniProtKB-KW:KW-00091600115GO_REF:0000043UniProtGO_REF:0000043
Myh4Ratactin filament binding enablesIEAInterPro:IPR0089891600115GO_REF:0000002InterProGO_REF:0000002
Myh4Ratactin filament binding enablesIBAFB:FBgn0026059 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myh4RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Myh4RatATP binding enablesIEAInterPro:IPR001609 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Myh4RatATP binding enablesIEAUniRule:UR0006864691600115GO_REF:0000104UniProtGO_REF:0000104
Myh4Ratcalmodulin binding enablesIEAUniProtKB-KW:KW-01121600115GO_REF:0000043UniProtGO_REF:0000043
Myh4Ratcytoskeletal motor activity enablesIEAInterPro:IPR001609 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Myh4Ratcytoskeletal motor activity enablesIEAUniRule:UR0006864691600115GO_REF:0000104UniProtGO_REF:0000104
Myh4Ratdouble-stranded RNA binding enablesISOMYH4 (Homo sapiens)1624291 PMID:21266579RGDPMID:21266579
Myh4Ratmicrofilament motor activity enablesIBAFB:FBgn0264695 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myh4Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
1 to 12 of 12 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Myh4Ratmyocarditis pathway  IEA 6907045 KEGGrno:05416

1 to 16 of 16 rows
#
Reference Title
Reference Citation
1. Parallel and divergent adaptations of rat soleus and plantaris to chronic exercise and hypergravity. Fuller PM, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Feb;290(2):R442-8. Epub 2005 Sep 22.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4. Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline. Li Q, etal., Gene 2002 Jan 23;283(1-2):255-62.
5. Cloning and in situ hybridization of type 2A and 2B rat skeletal muscle myosin tail region: implications for filament assembly. Lieber RL, etal., Biochem Biophys Res Commun 1993 Dec 30;197(3):1312-8.
6. Heart failure-induced diaphragm myopathy. Lima AR, etal., Cell Physiol Biochem. 2014;34(2):333-45. doi: 10.1159/000363003. Epub 2014 Jul 8.
7. BDNF rescues myosin heavy chain IIB muscle fibers after neonatal nerve injury. Mousavi K, etal., Am J Physiol Cell Physiol. 2004 Jul;287(1):C22-9. Epub 2004 Feb 18.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Differential modification of myosin heavy chain expression by tenotomy in regenerating fast and slow muscles of the rat. Noirez P, etal., Exp Physiol. 2000 Mar;85(2):187-91.
10. Sternohyoid and diaphragm muscle form and function during postnatal development in the rat. O'Connell RA, etal., Exp Physiol. 2013 Sep;98(9):1386-400. doi: 10.1113/expphysiol.2013.073346. Epub 2013 May 24.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
1 to 16 of 16 rows
PMID:1302224   PMID:8145163   PMID:8227143   PMID:12477932   PMID:15489334   PMID:17030512   PMID:18310078   PMID:18384641   PMID:19040707   PMID:19182904   PMID:19260067   PMID:21266579  
PMID:22206666  



Myh4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81052,422,148 - 52,445,296 (+)NCBIGRCr8
mRatBN7.21051,923,149 - 51,946,297 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1051,885,913 - 51,946,295 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1056,580,078 - 56,603,219 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01056,069,077 - 56,092,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01051,579,604 - 51,603,148 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01053,778,456 - 53,801,605 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1053,713,938 - 53,848,347 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01053,530,747 - 53,553,896 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41053,931,880 - 53,955,029 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11053,948,285 - 53,968,548 (+)NCBI
Celera1051,105,822 - 51,128,615 (+)NCBICelera
RH 3.4 Map10571.9RGD
Cytogenetic Map10q24NCBI
MYH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381710,443,263 - 10,469,559 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1710,443,290 - 10,469,559 (-)EnsemblGRCh38hg38GRCh38
GRCh371710,346,607 - 10,372,876 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361710,287,332 - 10,313,601 (-)NCBINCBI36Build 36hg18NCBI36
Build 341710,287,331 - 10,313,601NCBI
Celera1710,377,452 - 10,403,722 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef1710,246,185 - 10,272,452 (-)NCBIHuRef
CHM1_11710,356,450 - 10,382,720 (-)NCBICHM1_1
T2T-CHM13v2.01710,350,703 - 10,377,048 (-)NCBIT2T-CHM13v2.0
Myh4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391167,128,638 - 67,151,273 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1167,128,855 - 67,151,272 (+)EnsemblGRCm39 Ensembl
GRCm381167,237,812 - 67,260,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1167,238,029 - 67,260,446 (+)EnsemblGRCm38mm10GRCm38
MGSCv371167,051,531 - 67,073,948 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361167,054,224 - 67,076,641 (+)NCBIMGSCv36mm8
Celera1174,181,234 - 74,203,668 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1140.59NCBI
Myh4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554676,719,572 - 6,744,147 (+)NCBIChiLan1.0ChiLan1.0
LOC103786029
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21963,279,606 - 63,305,571 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11768,090,162 - 68,116,127 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01741,183,808 - 41,209,774 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11745,931,196 - 45,957,156 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1745,931,196 - 45,957,149 (+)Ensemblpanpan1.1panPan2
MYH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1534,743,454 - 34,767,076 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl534,743,314 - 34,767,076 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha534,880,006 - 34,903,497 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0534,848,401 - 34,871,931 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl534,848,261 - 34,871,931 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1534,813,883 - 34,837,393 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0534,771,325 - 34,794,835 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0534,952,259 - 34,975,786 (-)NCBIUU_Cfam_GSD_1.0
LOC101973267
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560249,850,157 - 49,875,181 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365953,324,345 - 3,349,606 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1255,190,433 - 55,212,813 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11255,190,545 - 55,216,294 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MYH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1169,786,143 - 9,811,908 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl169,786,240 - 9,809,098 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605911,533,281 - 11,556,520 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101698292
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478612,858,776 - 12,884,213 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478612,814,777 - 12,886,129 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Myh4
168 total Variants

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:63
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000045718
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 72 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat

1 to 10 of 72 rows
Myh1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21051,923,037 - 51,923,141 (+)MAPPERmRatBN7.2
Rnor_6.01053,778,345 - 53,778,448NCBIRnor6.0
Rnor_5.01053,530,636 - 53,530,739UniSTSRnor5.0
RGSC_v3.41053,931,769 - 53,931,872UniSTSRGSC3.4
Celera1051,105,711 - 51,105,814UniSTS
Cytogenetic Map10q24UniSTS
UniSTS:265579  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21051,946,137 - 51,946,260 (+)MAPPERmRatBN7.2
Rnor_6.01053,801,446 - 53,801,568NCBIRnor6.0
Rnor_5.01053,553,737 - 53,553,859UniSTSRnor5.0
RGSC_v3.41053,954,870 - 53,954,992UniSTSRGSC3.4
Cytogenetic Map10q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 11 27 99 58 57 26 25 26 6 137 75 79 20 47 31


1 to 21 of 21 rows
RefSeq Transcripts NM_019325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC113948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ872907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L24897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 21 of 21 rows

RefSeq Acc Id: NM_019325   ⟹   NP_062198
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81052,422,148 - 52,445,296 (+)NCBI
mRatBN7.21051,923,149 - 51,946,297 (+)NCBI
Rnor_6.01053,778,456 - 53,801,605 (+)NCBI
Rnor_5.01053,530,747 - 53,553,896 (+)NCBI
RGSC_v3.41053,931,880 - 53,955,029 (+)RGD
Celera1051,105,822 - 51,128,615 (+)RGD
Sequence:
Protein RefSeqs NP_062198 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA72046 (Get FASTA)   NCBI Sequence Viewer  
  AAI13949 (Get FASTA)   NCBI Sequence Viewer  
  ABI34118 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046362
GenBank Protein Q29RW1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062198   ⟸   NM_019325
- UniProtKB: Q29RW1 (UniProtKB/Swiss-Prot),   F1LMU0 (UniProtKB/TrEMBL)
- Sequence:
Name Modeler Protein Id AA Range Protein Structure
AF-Q29RW1-F1-model_v2 AlphaFold Q29RW1 1-1939 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697293
Promoter ID:EPDNEW_R7816
Type:multiple initiation site
Name:Myh4_2
Description:myosin heavy chain 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7815  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01053,778,653 - 53,778,713EPDNEW


1 to 40 of 45 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-24651 BioCyc
Ensembl Genes ENSRNOG00000049695 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000045718 ENTREZGENE
Gene3D-CATH 1.10.10.820 UniProtKB/Swiss-Prot
  1.20.5.340 UniProtKB/Swiss-Prot
  1.20.5.370 UniProtKB/Swiss-Prot
  1.20.5.4820 UniProtKB/Swiss-Prot
  1.20.58.530 UniProtKB/Swiss-Prot
  2.30.30.360 UniProtKB/Swiss-Prot
  3.40.850.10 UniProtKB/Swiss-Prot
  6.10.250.2420 UniProtKB/Swiss-Prot
  Myosin VI head, motor domain, U50 subdomain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7937870 IMAGE-MGC_LOAD
InterPro Kinesin_motor_dom_sf UniProtKB/Swiss-Prot
  Myosin_head_motor_dom UniProtKB/Swiss-Prot
  Myosin_N UniProtKB/Swiss-Prot
  Myosin_S1_N UniProtKB/Swiss-Prot
  Myosin_tail UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  XRCC4-like_C UniProtKB/Swiss-Prot
KEGG Report rno:360543 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124733 IMAGE-MGC_LOAD
NCBI Gene Myh4 ENTREZGENE
PANTHER MYOSIN HEAVY CHAIN, NON-MUSCLE UniProtKB/Swiss-Prot
  MYOSIN-4 UniProtKB/Swiss-Prot
Pfam Myosin_head UniProtKB/Swiss-Prot
  Myosin_N UniProtKB/Swiss-Prot
  Myosin_tail_1 UniProtKB/Swiss-Prot
PhenoGen Myh4 PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot
PROSITE MYOSIN_MOTOR UniProtKB/Swiss-Prot
  PS50096 UniProtKB/Swiss-Prot
  SH3_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000049695 RatGTEx
SMART MYSc UniProtKB/Swiss-Prot
Superfamily-SCOP Myosin rod fragments UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  Tropomyosin UniProtKB/Swiss-Prot
TIGR TC204122
UniProt A0A0G2K1V4_RAT UniProtKB/TrEMBL
1 to 40 of 45 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Myh4  myosin heavy chain 4  Myh4  myosin, heavy chain 4, skeletal muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Myh4  myosin, heavy chain 4, skeletal muscle  Myh4  myosin, heavy polypeptide 4, skeletal muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Myh4  myosin, heavy polypeptide 4, skeletal muscle  Myh4  myosin, heavy polypeptide 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-06-13 Myh4  myosin, heavy polypeptide 4  Myh4_predicted  myosin, heavy polypeptide 4, skeletal muscle (predicted)  Data merged from RGD:1311997 737654 APPROVED
2005-09-19 Myh4_predicted  myosin, heavy polypeptide 4, skeletal muscle (predicted)  Ctnnb1  catenin (cadherin-associated protein), beta 1 (88kD)  Data merged from RGD:620703 737654 APPROVED
2005-01-12 Myh4_predicted  myosin, heavy polypeptide 4, skeletal muscle (predicted)      Symbol and Name status set to approved 70820 APPROVED
2003-04-09 Myh4  myosin, heavy polypeptide 4    Myosin, heavy polypeptide 4, skeletal muscle  Name updated 629478 APPROVED
2002-08-07 Ctnnb1  catenin (cadherin-associated protein), beta 1 (88kD)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Myh4  Myosin, heavy polypeptide 4, skeletal muscle      Symbol and Name status set to approved 70586 APPROVED