Mstn (myostatin) - Rat Genome Database

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Gene: Mstn (myostatin) Rattus norvegicus
Analyze
Symbol: Mstn
Name: myostatin
RGD ID: 3115
Description: Predicted to enable cytokine activity; heparin binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of skeletal muscle tissue growth; response to testosterone; and skeletal muscle atrophy. Located in extracellular space. Used to study amyotrophic lateral sclerosis. Biomarker of congestive heart failure; hypothyroidism; muscular atrophy; peripheral vascular disease; and uremia. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy. Orthologous to human MSTN (myostatin); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GDF-8; Gdf8; growth differentiation factor 8; growth/differentiation factor 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Mstnem2Mcwi   Mstnem3Mcwi   Mstnem1Mcwi   Mstnem1Cqin  
Genetic Models: SD-Mstnem1Cqin SS-Mstnem2Mcwi SS-Mstnem1Mcwi-/- SS-Mstnem3Mcwi-/- SS-Mstnem1Mcwi SS-Mstnem3Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8955,944,513 - 55,950,913 (-)NCBIGRCr8
mRatBN7.2948,452,533 - 48,458,933 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,452,533 - 48,458,933 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx956,995,653 - 57,000,498 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0962,118,483 - 62,123,328 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0960,414,473 - 60,419,318 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0953,310,977 - 53,315,804 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl953,309,598 - 53,315,915 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0952,977,371 - 52,982,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4945,426,831 - 45,431,658 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1945,428,244 - 45,433,072 (-)NCBI
Celera946,124,738 - 46,129,565 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IDA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Myostatin expression in age and denervation-induced skeletal muscle atrophy. Baumann AP, etal., J Musculoskelet Neuronal Interact. 2003 Mar;3(1):8-16.
2. Hypothyroidism is associated with increased myostatin expression in rats. Carneiro I, etal., J Endocrinol Invest. 2008 Sep;31(9):773-8.
3. Presence, actions, and regulation of myostatin in rat uterus and myometrial cells. Ciarmela P, etal., Endocrinology. 2009 Feb;150(2):906-14. Epub 2008 Oct 9.
4. Muscle myostatin signalling is enhanced in experimental cancer cachexia. Costelli P, etal., Eur J Clin Invest. 2008 Jul;38(7):531-8.
5. Skeletal muscle atrophy is associated with an increased expression of myostatin and impaired satellite cell function in the portacaval anastamosis rat. Dasarathy S, etal., Am J Physiol Gastrointest Liver Physiol 2004 Jul 15;.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Establishment and phenotypic analysis of an Mstn knockout rat. Gu H, etal., Biochem Biophys Res Commun. 2016 Aug 12;477(1):115-22. doi: 10.1016/j.bbrc.2016.06.030. Epub 2016 Jun 8.
9. Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis. Holzbaur EL, etal., Neurobiol Dis. 2006 Sep;23(3):697-707. Epub 2006 Jul 11.
10. Role of serum myostatin during the lactation period. Hosoyama T, etal., J Reprod Dev. 2006 Aug;52(4):469-78. Epub 2006 Mar 31.
11. Long term adrenal insufficiency induces skeletal muscle atrophy and increases the serum levels of active form myostatin in rat serum. Hosoyama T, etal., Zoolog Sci. 2005 Feb;22(2):229-36.
12. Peripheral venous occlusion causing cardiac hypertrophy and changes in biological parameters in rats. Kawada S and Ishii N, Eur J Appl Physiol. 2009 Jan 6.
13. Myostatin and insulin-like growth factor-I and -II expression in the muscle of rats exposed to the microgravity environment of the NeuroLab space shuttle flight. Lalani R, etal., J Endocrinol. 2000 Dec;167(3):417-28.
14. IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats. Lang CH, etal., Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E916-26. Epub 2004 Jan 28.
15. Regulation of myostatin by glucocorticoids after thermal injury. Lang CH, etal., FASEB J. 2001 Aug;15(10):1807-9.
16. Muscle and nerve responses after different intervals of electrical stimulation sessions on denervated rat muscle. Lima SC, etal., Am J Phys Med Rehabil. 2009 Feb;88(2):126-35.
17. Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression. Ma K, etal., Am J Physiol Endocrinol Metab 2003 Aug;285(2):E363-71. Epub 2003 Apr 29.
18. Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass. Magee TR, etal., J Gene Med. 2006 Sep;8(9):1171-81.
19. Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury. Magga J, etal., Mol Ther. 2019 Mar 6;27(3):600-610. doi: 10.1016/j.ymthe.2019.01.013. Epub 2019 Jan 24.
20. Short-term endurance training results in a muscle-specific decrease of myostatin mRNA content in the rat. Matsakas A, etal., Acta Physiol Scand. 2005 Mar;183(3):299-307.
21. Double muscling in cattle due to mutations in the myostatin gene. McPherron AC and Lee SJ, Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12457-61.
22. Changes in skeletal muscle and tendon structure and function following genetic inactivation of myostatin in rats. Mendias CL, etal., J Physiol. 2015 Apr 15;593(8):2037-52. doi: 10.1113/jphysiol.2014.287144. Epub 2015 Feb 25.
23. Myostatin levels in regenerating rat muscles and in myogenic cell cultures. Mendler L, etal., J Muscle Res Cell Motil. 2000;21(6):551-63.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Spatiotemporal expression of decorin and myostatin during rat skeletal muscle development. Nishimura T, etal., Biochem Biophys Res Commun. 2007 Oct 5;361(4):896-902. Epub 2007 Jul 30.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Comprehensive gene review and curation RGD comprehensive gene curation
33. Muscle expressions of MGF, IGF-IEa, and myostatin in intact and hypophysectomized rats: effects of rhGH and testosterone alone or combined. Rigamonti AE, etal., Horm Metab Res. 2009 Jan;41(1):23-9. Epub 2008 Oct 7.
34. The effect of glutamine on prevention of glucocorticoid-induced skeletal muscle atrophy is associated with myostatin suppression. Salehian B, etal., Metabolism. 2006 Sep;55(9):1239-47.
35. Myostatin expression in ventricular myocardium in a rat model of volume-overload heart failure. Shyu KG, etal., Eur J Clin Invest. 2006 Oct;36(10):713-9.
36. Work-induced changes in skeletal muscle IGF-1 and myostatin gene expression in uremia. Sun DF, etal., Kidney Int. 2006 Jun 28.
37. Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function. Szabó Z, etal., FASEB J. 2020 Aug;34(8):9911-9924. doi: 10.1096/fj.201903074RR. Epub 2020 May 19.
Additional References at PubMed
PMID:9139826   PMID:11459935   PMID:11877467   PMID:12595574   PMID:14517293   PMID:15215484   PMID:16182246   PMID:16450055   PMID:16873457   PMID:16941139   PMID:17395701   PMID:17959844  
PMID:18089396   PMID:18286185   PMID:18422491   PMID:18801898   PMID:19218333   PMID:19357233   PMID:19406121   PMID:19591015   PMID:19644449   PMID:19736304   PMID:19903098   PMID:19959771  
PMID:20002838   PMID:20007454   PMID:20103742   PMID:20191313   PMID:20396675   PMID:20677217   PMID:20801187   PMID:20884321   PMID:21390326   PMID:21539891   PMID:22033906   PMID:22244812  
PMID:22332899   PMID:22464481   PMID:22684687   PMID:22696074   PMID:22854904   PMID:23255067   PMID:23752591   PMID:23829672   PMID:23844238   PMID:24076600   PMID:25575785   PMID:25960249  
PMID:26151859   PMID:26205544   PMID:26342801   PMID:26927339   PMID:27128567   PMID:27625211   PMID:28257634   PMID:28533206   PMID:28539643   PMID:29330193   PMID:30366029   PMID:31054482  
PMID:32173683   PMID:34453705   PMID:34576046   PMID:35758824   PMID:39093510  


Genomics

Comparative Map Data
Mstn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8955,944,513 - 55,950,913 (-)NCBIGRCr8
mRatBN7.2948,452,533 - 48,458,933 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,452,533 - 48,458,933 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx956,995,653 - 57,000,498 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0962,118,483 - 62,123,328 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0960,414,473 - 60,419,318 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0953,310,977 - 53,315,804 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl953,309,598 - 53,315,915 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0952,977,371 - 52,982,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4945,426,831 - 45,431,658 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1945,428,244 - 45,433,072 (-)NCBI
Celera946,124,738 - 46,129,565 (-)NCBICelera
Cytogenetic Map9q22NCBI
MSTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382190,055,700 - 190,062,729 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2190,055,700 - 190,062,729 (-)EnsemblGRCh38hg38GRCh38
GRCh372190,920,426 - 190,927,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362190,628,671 - 190,635,700 (-)NCBINCBI36Build 36hg18NCBI36
Build 342190,745,932 - 190,752,961NCBI
Celera2184,515,357 - 184,522,386 (-)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2182,780,433 - 182,787,462 (-)NCBIHuRef
CHM1_12190,926,378 - 190,933,407 (-)NCBICHM1_1
T2T-CHM13v2.02190,545,060 - 190,552,089 (-)NCBIT2T-CHM13v2.0
Mstn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39153,100,799 - 53,107,238 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl153,100,799 - 53,107,238 (+)EnsemblGRCm39 Ensembl
GRCm38153,061,640 - 53,068,079 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl153,061,640 - 53,068,079 (+)EnsemblGRCm38mm10GRCm38
MGSCv37153,118,507 - 53,124,923 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36153,006,208 - 53,012,624 (+)NCBIMGSCv36mm8
Celera153,601,512 - 53,607,928 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.99NCBI
Mstn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,914,482 - 8,923,465 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554038,914,505 - 8,921,190 (+)NCBIChiLan1.0ChiLan1.0
MSTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21392,751,094 - 92,761,026 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B92,765,891 - 92,773,149 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B77,364,927 - 77,452,426 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B195,283,903 - 195,290,922 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B195,283,903 - 195,290,922 (-)Ensemblpanpan1.1panPan2
MSTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.137729,172 - 734,255 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl37729,172 - 734,362 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha371,685,007 - 1,690,090 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.037623,197 - 628,235 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl37621,860 - 628,368 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.137633,617 - 638,697 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.037601,655 - 606,733 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.037629,871 - 634,951 (-)NCBIUU_Cfam_GSD_1.0
Mstn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303148,842,726 - 148,849,304 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,988,718 - 7,996,971 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365067,988,879 - 7,996,260 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1594,620,270 - 94,628,545 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11594,623,526 - 94,628,440 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215105,734,309 - 105,739,223 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MSTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11075,564,816 - 75,570,956 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1075,565,152 - 75,570,528 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040123,900,932 - 123,908,109 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mstn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248545,892,938 - 5,899,473 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248545,893,051 - 5,899,380 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mstn
27 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:229
Count of miRNA genes:149
Interacting mature miRNAs:183
Transcripts:ENSRNOT00000038093
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
6903937Bp356Blood pressure QTL 3560.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94790220852283252Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat

Markers in Region
GDF8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2948,454,110 - 48,454,300 (+)MAPPERmRatBN7.2
Rnor_6.0953,311,106 - 53,311,295NCBIRnor6.0
Rnor_5.0952,977,500 - 52,977,689UniSTSRnor5.0
RGSC_v3.4945,426,960 - 45,427,149UniSTSRGSC3.4
Celera946,124,867 - 46,125,056UniSTS
Cytogenetic Map9q22UniSTS


Genetic Models
This gene Mstn is modified in the following models/strains:
SD-Mstnem1Cqin     SS-Mstnem2Mcwi     SS-Mstnem1Mcwi-/-     SS-Mstnem3Mcwi-/-     SS-Mstnem1Mcwi     SS-Mstnem3Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 94 31 40 12 25 12 6 151 84 87 38 28 28

Sequence


Ensembl Acc Id: ENSRNOT00000038093   ⟹   ENSRNOP00000038159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl948,452,533 - 48,458,933 (-)Ensembl
Rnor_6.0 Ensembl953,309,598 - 53,315,915 (-)Ensembl
RefSeq Acc Id: NM_019151   ⟹   NP_062024
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8955,944,513 - 55,950,913 (-)NCBI
mRatBN7.2948,452,533 - 48,458,933 (-)NCBI
Rnor_6.0953,310,977 - 53,315,804 (-)NCBI
Rnor_5.0952,977,371 - 52,982,198 (-)NCBI
RGSC_v3.4945,426,831 - 45,431,658 (-)RGD
Celera946,124,738 - 46,129,565 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062024 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB86691 (Get FASTA)   NCBI Sequence Viewer  
  EDL99109 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038159.1
  ENSRNOP00055005820
  ENSRNOP00060023342
  ENSRNOP00065042617
GenBank Protein O35312 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062024   ⟸   NM_019151
- Peptide Label: precursor
- UniProtKB: O35312 (UniProtKB/Swiss-Prot),   A6INV1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038159   ⟸   ENSRNOT00000038093
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35312-F1-model_v2 AlphaFold O35312 1-376 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3115 AgrOrtholog
BioCyc Gene G2FUF-27623 BioCyc
Ensembl Genes ENSRNOG00000021294 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055004850 UniProtKB/Swiss-Prot
  ENSRNOG00060016957 UniProtKB/Swiss-Prot
  ENSRNOG00065029971 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000038093.4 UniProtKB/Swiss-Prot
  ENSRNOT00055007724 UniProtKB/Swiss-Prot
  ENSRNOT00060028990 UniProtKB/Swiss-Prot
  ENSRNOT00065051777 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
  2.60.120.970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystine-knot cytokines UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29152 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29152 ENTREZGENE
PANTHER GROWTH/DIFFERENTIATION FACTOR 8 UniProtKB/TrEMBL
  PTHR11848 UniProtKB/Swiss-Prot
  PTHR11848:SF150 UniProtKB/Swiss-Prot
  TGF-BETA FAMILY UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mstn PhenoGen
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021294 RatGTEx
  ENSRNOG00055004850 RatGTEx
  ENSRNOG00060016957 RatGTEx
  ENSRNOG00065029971 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Cystine-knot cytokines UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6INV1 ENTREZGENE, UniProtKB/TrEMBL
  GDF8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Mstn  myostatin  Gdf8  growth differentiation factor 8   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gdf8  growth differentiation factor 8       Name updated 70584 APPROVED
2002-02-27 Gdf8  growth differentiation factor 8      Symbol and Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may contribute to cirrhosis-associated skeletal muscle atrophy by causing impairment of satellite cell proliferation 1302208
gene_function positive regulator of satellite cell function 1302208
gene_mutations_overexpression overexpression leads to skeletal muscle atrophy 1302208
gene_physical_interaction binds to receptor activinR2b 1302208