Mmp11 (matrix metallopeptidase 11) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mmp11 (matrix metallopeptidase 11) Rattus norvegicus
Analyze
Symbol: Mmp11
Name: matrix metallopeptidase 11
RGD ID: 3099
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to act upstream of or within basement membrane organization; collagen fibril organization; and negative regulation of fat cell differentiation. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Orthologous to human MMP11 (matrix metallopeptidase 11); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103694874; matrix metalloproteinase 11; Matrix metalloproteinase 11 (stromelysin 3); matrix metalloproteinase-11; MMP-11; SL-3; ST3; stromelysin-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,730,284 - 12,739,067 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2012,730,277 - 12,739,290 (+)EnsemblGRCr8
mRatBN7.22012,730,846 - 12,739,629 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,730,836 - 12,739,628 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2013,437,476 - 13,446,257 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,798,397 - 12,807,178 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,270,190 - 13,278,971 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,670,051 - 13,678,834 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,670,066 - 13,678,089 (+)Ensemblrn6Rnor6.0
Rnor_5.02015,825,614 - 15,834,397 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42013,129,667 - 13,138,449 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2014,222,131 - 14,230,914 (+)NCBICelera
RGSC_v3.12013,129,893 - 13,138,676 (+)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
Cirsimarin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
doxorubicin  (ISO)
drometrizole  (ISO)
endosulfan  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-linolenic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP,ISO)
isoprenaline  (ISO)
lipopolysaccharide  (ISO)
microcystin-LR  (ISO)
Moniliformin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
niclosamide  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Rat stromelysin 3: cDNA cloning from healing skin wound, activation by furin and expression in rat tissues. Okada A, etal., Gene 1997 Feb 7;185(2):187-93.
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:15489334   PMID:16401721   PMID:18622425  


Genomics

Comparative Map Data
Mmp11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,730,284 - 12,739,067 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2012,730,277 - 12,739,290 (+)EnsemblGRCr8
mRatBN7.22012,730,846 - 12,739,629 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,730,836 - 12,739,628 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2013,437,476 - 13,446,257 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,798,397 - 12,807,178 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,270,190 - 13,278,971 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,670,051 - 13,678,834 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,670,066 - 13,678,089 (+)Ensemblrn6Rnor6.0
Rnor_5.02015,825,614 - 15,834,397 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42013,129,667 - 13,138,449 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2014,222,131 - 14,230,914 (+)NCBICelera
RGSC_v3.12013,129,893 - 13,138,676 (+)NCBI
Cytogenetic Map20p12NCBI
MMP11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,772,849 - 23,784,316 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,768,226 - 23,784,322 (+)Ensemblhg38GRCh38
GRCh372224,115,036 - 24,126,503 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,445,036 - 22,456,503 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342222,439,589 - 22,451,056NCBI
Celera227,954,127 - 7,965,595 (+)NCBICelera
Cytogenetic Map22q11.23ENTREZGENE
HuRef227,103,103 - 7,114,555 (+)NCBIHuRef
CHM1_12224,127,275 - 24,138,742 (+)NCBICHM1_1
T2T-CHM13v2.02224,220,041 - 24,231,509 (+)NCBIT2T-CHM13v2.0
Mmp11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,759,056 - 75,768,336 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,759,056 - 75,772,330 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381075,923,221 - 75,932,502 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,923,222 - 75,936,496 (-)Ensemblmm10GRCm38
MGSCv371075,385,969 - 75,395,208 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361075,366,940 - 75,376,179 (-)NCBIMGSCv36mm8
Celera1076,967,909 - 76,977,148 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.62NCBI
Mmp11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,459,428 - 8,469,053 (-)Ensembl
ChiLan1.0NW_0049554558,458,622 - 8,464,037 (-)NCBIChiLan1.0ChiLan1.0
MMP11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22333,504,434 - 33,515,963 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12236,240,937 - 36,252,465 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0224,528,639 - 4,540,118 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12222,610,626 - 22,625,335 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,615,969 - 22,624,567 (+)EnsemblpanPan2panpan1.1
MMP11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,730,173 - 28,741,506 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2628,727,332 - 28,741,415 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2627,804,212 - 27,813,598 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02630,135,355 - 30,147,019 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,135,354 - 30,146,606 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,217,197 - 28,226,583 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,835,130 - 27,844,514 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,823,000 - 28,832,388 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mmp11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118141,433,947 - 141,443,698 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,310,846 - 1,320,062 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366191,309,013 - 1,320,062 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,907,687 - 49,912,617 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11449,907,684 - 49,917,494 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,349,978 - 53,359,794 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1196,889,343 - 6,900,563 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl196,889,385 - 6,899,788 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666100472,421 - 483,648 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474710,398,130 - 10,408,376 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474710,398,167 - 10,408,397 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mmp11
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11811,515,084 - 11,524,020 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mmp11
23 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:235
Count of miRNA genes:152
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000031400
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
AA892528  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22012,739,255 - 12,739,492 (+)MAPPERmRatBN7.2
Rnor_6.02013,678,461 - 13,678,697NCBIRnor6.0
Rnor_5.02015,834,024 - 15,834,260UniSTSRnor5.0
RGSC_v3.42013,138,077 - 13,138,313UniSTSRGSC3.4
Celera2014,230,541 - 14,230,777UniSTS
RH 3.4 Map20180.57UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 11 61 129 55 58 39 83 39 292 164 11 120 71 73 19 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000031400   ⟹   ENSRNOP00000035334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2012,730,277 - 12,739,290 (+)Ensembl
mRatBN7.2 Ensembl2012,730,836 - 12,739,623 (+)Ensembl
Rnor_6.0 Ensembl2013,670,066 - 13,678,089 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087725   ⟹   ENSRNOP00000074176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2012,732,736 - 12,739,290 (+)Ensembl
mRatBN7.2 Ensembl2012,733,298 - 12,739,628 (+)Ensembl
RefSeq Acc Id: NM_012980   ⟹   NP_037112
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,730,284 - 12,739,067 (+)NCBI
mRatBN7.22012,730,846 - 12,739,629 (+)NCBI
Rnor_6.02013,670,051 - 13,678,834 (+)NCBI
Rnor_5.02015,825,614 - 15,834,397 (+)NCBI
RGSC_v3.42013,129,667 - 13,138,449 (+)RGD
Celera2014,222,131 - 14,230,914 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098460   ⟹   XP_038954388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,732,059 - 12,739,067 (+)NCBI
mRatBN7.22012,734,393 - 12,739,629 (+)NCBI
RefSeq Acc Id: XM_063278979   ⟹   XP_063135049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,732,061 - 12,739,067 (+)NCBI
RefSeq Acc Id: NP_037112   ⟸   NM_012980
- Peptide Label: precursor
- UniProtKB: P97568 (UniProtKB/Swiss-Prot),   Q499S5 (UniProtKB/Swiss-Prot),   A6JKF2 (UniProtKB/TrEMBL),   A0A8L2R8J4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035334   ⟸   ENSRNOT00000031400
RefSeq Acc Id: XP_038954388   ⟸   XM_039098460
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000074176   ⟸   ENSRNOT00000087725
RefSeq Acc Id: XP_063135049   ⟸   XM_063278979
- Peptide Label: isoform X1
Protein Domains
Peptidase metallopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q499S5-F1-model_v2 AlphaFold Q499S5 1-491 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701528
Promoter ID:EPDNEW_R12052
Type:single initiation site
Name:Mmp11_1
Description:matrix metallopeptidase 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,670,044 - 13,670,104EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3099 AgrOrtholog
BioCyc Gene G2FUF-4166 BioCyc
Ensembl Genes ENSRNOG00000028344 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000031400 ENTREZGENE
  ENSRNOT00000031400.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.110.10.10 UniProtKB/Swiss-Prot
  3.40.390.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7933545 IMAGE-MGC_LOAD
InterPro Hemopexin-like_dom UniProtKB/Swiss-Prot
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot
  Hemopexin-like_repeat UniProtKB/Swiss-Prot
  Hemopexin_CS UniProtKB/Swiss-Prot
  M10A_MMP UniProtKB/Swiss-Prot
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot
  Pept_M10A UniProtKB/Swiss-Prot
  Peptidase_Metallo UniProtKB/Swiss-Prot
KEGG Report rno:25481 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124636 IMAGE-MGC_LOAD
NCBI Gene 25481 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot
  PTHR10201:SF20 UniProtKB/Swiss-Prot
Pfam Hemopexin UniProtKB/Swiss-Prot
  Peptidase_M10 UniProtKB/Swiss-Prot
PhenoGen Mmp11 PhenoGen
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot
PRINTS MATRIXIN UniProtKB/Swiss-Prot
PROSITE HEMOPEXIN UniProtKB/Swiss-Prot
  HEMOPEXIN_2 UniProtKB/Swiss-Prot
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028344 RatGTEx
SMART SM00120 UniProtKB/Swiss-Prot
  ZnMc UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF50923 UniProtKB/Swiss-Prot
TIGR TC229689
UniProt A0A8L2R8J4 ENTREZGENE, UniProtKB/TrEMBL
  A6JKF1_RAT UniProtKB/TrEMBL
  A6JKF2 ENTREZGENE, UniProtKB/TrEMBL
  MMP11_RAT UniProtKB/Swiss-Prot
  P97568 ENTREZGENE
  Q499S5 ENTREZGENE
UniProt Secondary P97568 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Mmp11  matrix metallopeptidase 11  LOC103694874  stromelysin-3  Data merged from RGD:9106139 737654 PROVISIONAL
2014-08-25 LOC103694874  stromelysin-3      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Mmp11  matrix metallopeptidase 11    matrix metalloproteinase 11  Name updated 1299863 APPROVED
2002-06-10 Mmp11  Matrix metalloproteinase 11 (stromelysin 3)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in adult uterus and ovary 633185
gene_protein 491 amino acids 633185