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Gene: Mep1a (meprin A subunit alpha) Rattus norvegicus

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Symbol:

Mep1a

Name:

meprin A subunit alpha

RGD ID:

3080

Description:

Predicted to enable metallodipeptidase activity and metalloendopeptidase activity. Predicted to be involved in epidermal growth factor receptor ligand maturation. Predicted to act upstream of or within epidermal growth factor receptor signaling pathway. Part of meprin A complex. Orthologous to human MEP1A (meprin A subunit alpha); INTERACTS WITH ammonium chloride; copper atom; copper(0).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

E-24.18; endopeptidase-2; endopeptidase-24.18 subunit alpha; LOC688307; MEP-1; meprin 1 alpha; meprin 1 subunit alpha; meprin A alpha; similar to Meprin A alpha-subunit precursor (Endopeptidase-2) (MEP-1) (Endopeptidase-24.18 alpha-subunit) (E-24.18)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MEP1A (meprin A subunit alpha)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Mep1a (meprin 1 alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mep1a (meprin A subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MEP1A (meprin A subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MEP1A (meprin A subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mep1a (meprin A subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MEP1A (meprin A subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MEP1A (meprin A subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mep1a (meprin A subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Mep1a (meprin A subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Mep1a (meprin 1 alpha)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MEP1A (meprin A subunit alpha)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mep1a.2 (meprin A, alpha (PABA peptide hydrolase), tandem duplicate 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mep1a.1 (meprin A, alpha (PABA peptide hydrolase), tandem duplicate 1)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	mep1a.1 (meprin A, alpha (PABA peptide hydrolase), tandem duplicate 1)	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG15253	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	CG15254	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	CG15255	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	CG15255	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG5715	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG6696	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6763	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6763	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG7631	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Semp1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	nas-13	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6974	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG6974	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	mep1a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mep1a	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	24,971,901 - 25,001,414 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	24,971,886 - 25,001,414 (+)	Ensembl				GRCr8
mRatBN7.2	9	17,474,634 - 17,504,147 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	17,474,619 - 17,504,147 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	26,065,182 - 26,095,281 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	31,139,752 - 31,169,851 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	29,428,977 - 29,459,076 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	20,048,163 - 20,077,678 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	20,048,121 - 20,077,702 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	18,925,181 - 18,953,891 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	13,170,762 - 13,201,094 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	15,197,113 - 15,224,494 (+)	NCBI		Celera
RGSC_v3.1	9	13,168,083 - 13,198,416 (+)	NCBI
Cytogenetic Map	9	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Colonic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-diaminodiphenylmethane (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

bisphenol F (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

choline (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

eugenol (EXP)

folic acid (ISO)

fulvestrant (ISO)

hexadecanoic acid (ISO)

hydrogen peroxide (ISO)

L-ascorbic acid (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

N-nitrosodiethylamine (EXP)

okadaic acid (ISO)

PhIP (EXP)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

Propiverine (EXP)

quercetin (ISO)

resveratrol (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

streptozocin (EXP,ISO)

titanium dioxide (ISO)

Triptolide (EXP)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

epidermal growth factor receptor ligand maturation (ISO)

proteolysis (IEA,NAS)

signaling receptor ligand precursor processing (IBA,ISO)

Cellular Component

extracellular space (IBA)

membrane (IEA,ISO)

meprin A complex (IDA,ISO)

plasma membrane (ISO)

Molecular Function

hydrolase activity (IEA)

metal ion binding (IEA)

metallodipeptidase activity (ISO)

metalloendopeptidase activity (IBA,IEA)

metallopeptidase activity (IEA,ISO)

peptidase activity (IEA)

protein binding (ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Probing the active sites and mechanisms of rat metalloproteases meprin A and B.	Bertenshaw GP, etal., Biol Chem 2002 Jul-Aug;383(7-8):1175-83.
2.	Molecular cloning of the alpha-subunit of rat endopeptidase-24.18 (endopeptidase-2) and co-localization with endopeptidase-24.11 in rat kidney by in situ hybridization.	Corbeil D, etal., FEBS Lett 1992 Sep 7;309(2):203-8.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Cloning a rat meprin cDNA reveals the enzyme is a heterodimer.	Johnson GD and Hersh LB, J Biol Chem 1992 Jul 5;267(19):13505-12.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	GOA pipeline	RGD automated data pipeline
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:7683677	PMID:8407940	PMID:8760356	PMID:9288916	PMID:11487543	PMID:12399461

Genomics

Comparative Map Data

Mep1a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	24,971,901 - 25,001,414 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	24,971,886 - 25,001,414 (+)	Ensembl				GRCr8
mRatBN7.2	9	17,474,634 - 17,504,147 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	17,474,619 - 17,504,147 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	26,065,182 - 26,095,281 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	31,139,752 - 31,169,851 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	29,428,977 - 29,459,076 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	20,048,163 - 20,077,678 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	20,048,121 - 20,077,702 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	18,925,181 - 18,953,891 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	13,170,762 - 13,201,094 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	15,197,113 - 15,224,494 (+)	NCBI		Celera
RGSC_v3.1	9	13,168,083 - 13,198,416 (+)	NCBI
Cytogenetic Map	9	q13	NCBI

MEP1A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	46,793,389 - 46,845,984 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	46,793,368 - 46,839,801 (+)	Ensembl			hg38	GRCh38
GRCh37	6	46,761,126 - 46,807,515 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	46,869,053 - 46,915,478 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	46,869,085 - 46,915,473	NCBI
Celera	6	48,313,551 - 48,359,899 (+)	NCBI		Celera
Cytogenetic Map	6	p12.3	NCBI
HuRef	6	46,484,757 - 46,530,783 (+)	NCBI		HuRef
CHM1_1	6	46,764,471 - 46,810,789 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	46,631,036 - 46,683,461 (+)	NCBI		T2T-CHM13v2.0

Mep1a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	43,785,215 - 43,815,034 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	43,785,215 - 43,813,703 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	43,474,324 - 43,504,143 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	43,474,324 - 43,502,812 (-)	Ensembl			mm10	GRCm38
MGSCv37	17	43,611,278 - 43,639,722 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	42,938,373 - 42,967,156 (-)	NCBI		MGSCv36	mm8
Celera	17	46,896,845 - 46,925,249 (-)	NCBI		Celera
Cytogenetic Map	17	B3	NCBI
cM Map	17	19.73	NCBI

Mep1a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	11,622,717 - 11,635,607 (+)	Ensembl
ChiLan1.0	NW_004955437	11,602,113 - 11,636,144 (+)	NCBI	ChiLan1.0	ChiLan1.0

MEP1A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	61,294,694 - 61,337,889 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	57,160,890 - 57,204,126 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	46,382,105 - 46,425,300 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	47,647,721 - 47,690,331 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	47,647,721 - 47,691,070 (+)	Ensembl			panPan2	panpan1.1

MEP1A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	14,966,215 - 15,004,069 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	14,966,209 - 15,003,867 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	14,997,039 - 15,035,329 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	15,465,854 - 15,500,412 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	15,465,839 - 15,500,421 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	14,981,007 - 15,015,182 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	15,070,190 - 15,108,254 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	15,216,475 - 15,254,182 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mep1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	50,406,962 - 50,445,654 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	13,514,965 - 13,553,209 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	13,514,965 - 13,553,209 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MEP1A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	7	41,587,698 - 41,625,014 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	48,248,938 - 48,286,181 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MEP1A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	25,439,415 - 25,479,092 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	25,439,442 - 25,473,681 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666044	46,813,671 - 46,854,220 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mep1a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624754	13,845,949 - 13,865,792 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mep1a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	86,340,028 - 86,366,552 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mep1a
122 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	502
Count of miRNA genes:	267
Interacting mature miRNAs:	316
Transcripts:	ENSRNOT00000014791
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	6714888	84474983	Rat
631211	Bw4	Body weight QTL4	5.31		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	9	5346479	50346479	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	8750492	53750492	Rat
7207814	Bmd91	Bone mineral density QTL 91	3.5		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	9	1	31250552	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	496645	45496645	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	6214995	51214995	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	8750492	53750492	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	41763315	Rat
61425	Cia15	Collagen induced arthritis QTL 15	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	9	5346479	50416711	Rat
631643	Bp120	Blood pressure QTL 120	3	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	6714888	29567695	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	496645	45496645	Rat
1600365	Mcs20	Mammary carcinoma susceptibility QTL 20	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	9	21031430	49025574	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	496645	45496645	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	6214995	51214995	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	6	44	96	54	54	23	25	23	6	214	88	1	77	81	57	31	9	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_013143	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008766838	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC119458	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081834	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473987	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S43408	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000014791 ⟹ ENSRNOP00000014791

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	24,971,886 - 25,001,414 (+)	Ensembl
mRatBN7.2 Ensembl	9	17,474,619 - 17,504,147 (+)	Ensembl
Rnor_6.0 Ensembl	9	20,048,121 - 20,077,702 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105548 ⟹ ENSRNOP00000077952

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	24,971,886 - 25,001,414 (+)	Ensembl
mRatBN7.2 Ensembl	9	17,474,619 - 17,504,147 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000126070 ⟹ ENSRNOP00000105421

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	24,972,400 - 25,001,414 (+)	Ensembl

RefSeq Acc Id:

NM_013143 ⟹ NP_037275

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	24,971,901 - 25,001,414 (+)	NCBI
mRatBN7.2	9	17,474,634 - 17,504,147 (+)	NCBI
Rnor_6.0	9	20,048,163 - 20,077,675 (+)	NCBI
Rnor_5.0	9	18,925,181 - 18,953,891 (+)	NCBI
RGSC_v3.4	9	13,170,762 - 13,201,094 (+)	RGD
Celera	9	15,197,113 - 15,224,494 (+)	RGD

Sequence:

show sequence

GAGGTTCTGCCAAACGCAGTTCACTTGCAACAATGCTGTGGACACTACCTGTGTGTCTTCTCTC
ACTGAGTTTTTCTGCCCACATTGCAGCTGTGTCCATTCAGCATCTTTCGACTGGACATGACCAC
GATGATGTAGACGTTGGTGAACAACAGAAGGACATTTCAGAAATCAACTCAGCTGCAGGCCTGA
ACCTTTTTCAAGGGGACATCCTTCTGCCCAGAACCAGAAATGCCCTGAGAGATCCGTCAAGCAG
ATGGAAGCCCCCCATTCCATACATTCTGGCTGACAATCTGGATCTGAACGCCAAAGGAGCCATC
CTCAATGCCTTTGAGATGTTCCGCCTCAAGTCTTGTGTGGACTTCAAGCCCTATGAGGGGGAGA
GCTCGTACATCATCTTCCAGCAGTTTTCTGGGTGCTGGTCTATGGTCGGTGATCAACACGTGGG
ACAGAATATTTCCATTGGTGAGGGCTGCGACTATAAGGCCATCATTGAACATGAGATCCTGCAT
GCTCTGGGATTCTTCCATGAGCAGTCAAGGACTGACCGGGATGATTATGTGAACATCTGGTGGA
ATGAAATTATGACAGATTATGAACATAATTTCAACACGTATGATGACAAGACCATCACAGACCT
CAACACACCCTATGATTATGAGTCCTTGATGCACTATGGGCCATTTTCATTTAACAAGAATGAA
ACCATCCCGACCATCACTACCAAGATCCCTGAGTTCAACGCCATCATTGGACAGCGCCTGGATT
TCAGTGCCACTGATTTAACGAGACTGAATCGGATGTACAACTGCACCAGAACACATACCCTGCT
GGACCACTGTGCGTTTGAGAAGACCAACATCTGTGGAATGATCCAGGGGACCAGAGATGATGCT
GACTGGGTTCATGAGGACAGCAGTCAGCCTGGACAAGTGGATCACACCTTGGTGGGACGGTGCA
AAGCTGCTGGCTACTTCATGTACTTCAATACCAGCTCGGGGGTGACCGGAGAGGTAGCCCTTCT
GGAGTCTCGGATCCTTTACCCCAAGAGGAAGCAGCAGTGTTTGCAGTTTTTTTATAAGATGACA
GGAAGCCCTTCAGACAGACTCCTCATCTGGGTGAGAAGGGACGACAACACGGGCAACGTGCGCC
AGCTGGCCAAGATCCAGACTTTTCAAGGAGATTCTGATCACAACTGGAAAATTGCTCACGTGAC
ACTCAACGAAGAGAAGAAATTTCGCTATGTTTTCCAGGGTACCAAAGGTGACCCTGGTAACTCA
GATGGCGGTATTTACCTTGATGACATCACTCTGACAGAAACCCCCTGCCCTACAGGGGTTTGGA
CCATCCGGAATATCTCCCAGGTCCTTGAGAACACAGTGAAAGGGGACAGGCTCGTGAGCCCTAG
GTTCTACAATTCCGAGGGTTATGGTTTTGGGGTGACCTTGTACCCCAATGGTAGAATCACCAGT
AACTCTGGCTACCTGGGACTCGCTTTCCACTTGTACAGTGGGGATAACGATGTGATTCTGGAGT
GGCCAGTGGAGAACGAGCAGGCCATAATGACCATCCTGGACCAGGAACCTGATGCCAGGAACAG
GATGTCCTTGAGTTTGATGTTCACTACCTCCAAGTACCAAACATCTTCAGCTATAAATGGCTCT
GTCATCTGGGACAGGCCAACCAAGGTTGGAGTCTATGATAAGGACTGTGATTGTTTTAGAAGCA
TTGACTGGGGTTGGGGTCAGGCCATTTCCCACCAGATGCTGATGAGAAGAAATTTCCTTAAAGA
TGACACCCTCATCATCTTCGTGGACTTTAAAGACCTTACCCACTTGAGGCAGACTGAAGTCCCC
ATTTCCAGCAGAAGCGTGATACCCCGAGGACTCCTTCTGCAAGGCCAGGAGCCTCTTGCCTTGG
GAGACTCCAGAATAGCCATGATGGAGGAATCCCTGCCAAGAAGGCTGGACCAGAGACAGCCCAG
CAGACCAAAGCGCTCAGTGGAAAATACTGGTCCCATGGAGGACCACAACTGGCCACAGTACTTC
AGAGACCCATGTGACCCAAACCCTTGCCAGAATGAAGGCACCTGTGTGAACGTAAAGGGAATGG
CCAGCTGCAGGTGCGTCTCTGGGCATGCCTTTTTCTACACAGGGGAGCGCTGTCAGGCTATGCA
TGTGCACGGAAGCTTGCTGGGCCTGCTCATTGGCTGCATCACTGCTTTGATCTTCTTGACCTTC
ATCACATTCTCCAACACTTACCAAAAGCTGAGGCAGTGAGCTGATGTCCACTAGACTGCAGAAG
GGCCTCCTTCACCTAGACTTTCCTTCCAGTAGTCAGTATAATTTGGGGATATTCTTCATCAAAC
ATGTTTGAAAGAGCCTCCAAAACCAAAGCCCCAAACCTCATGTGGGGCTCTTGCCACTCCATTT
CTGTACAGTTCTGCTATCCTTCTATGAGTTTCTGGTGAATCCATTATGTCCTAAGATAACAGTC
ATTGCATTTTACTATAAACACTTTGCTTGCTTGACCTTCTCCCCTTAAATCACCAAGTCTAGTT
GGGTAGGAGCATGTTATCCTCTGCTACCACATTGACCCCAGTGCTAGAAGCATACCTTACTGGT
GTATTGTGGGTACTCAGTAAGCATTAAATGAATGAACCAATAAGCAAGTGAATAGCTGTGGTAT
AATAAGTCTTTTTTTCTTCCTCATATTGTAAAACATATGATTAAGTCTATTTGCAGGTGTATCA
GAACCAAATACCCAGTTTACACTAGATGGGAAAACTACTGTCTTATTGCTCATGTAGTTTCTTG
TGAAATGATTTCACAGATTCCTCTGGTCAGCTGAGTTTCCATGGCATGTACTTTTTTCTTGTTC
TGATTTTAAGGAAAAGGCTTAATAAAACCATTAAATATGAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_037275	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB23030	(Get FASTA)	NCBI Sequence Viewer
	AAH81834	(Get FASTA)	NCBI Sequence Viewer
	EDM18694	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000014791
	ENSRNOP00000014791.5
GenBank Protein	Q64230	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_037275 ⟸ NM_013143
- Peptide Label:	precursor
- UniProtKB:	Q642C9 (UniProtKB/Swiss-Prot), Q64230 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MLWTLPVCLLSLSFSAHIAAVSIQHLSTGHDHDDVDVGEQQKDISEINSAAGLNLFQGDILLPR TRNALRDPSSRWKPPIPYILADNLDLNAKGAILNAFEMFRLKSCVDFKPYEGESSYIIFQQFSG CWSMVGDQHVGQNISIGEGCDYKAIIEHEILHALGFFHEQSRTDRDDYVNIWWNEIMTDYEHNF NTYDDKTITDLNTPYDYESLMHYGPFSFNKNETIPTITTKIPEFNAIIGQRLDFSATDLTRLNR MYNCTRTHTLLDHCAFEKTNICGMIQGTRDDADWVHEDSSQPGQVDHTLVGRCKAAGYFMYFNT SSGVTGEVALLESRILYPKRKQQCLQFFYKMTGSPSDRLLIWVRRDDNTGNVRQLAKIQTFQGD SDHNWKIAHVTLNEEKKFRYVFQGTKGDPGNSDGGIYLDDITLTETPCPTGVWTIRNISQVLEN TVKGDRLVSPRFYNSEGYGFGVTLYPNGRITSNSGYLGLAFHLYSGDNDVILEWPVENEQAIMT ILDQEPDARNRMSLSLMFTTSKYQTSSAINGSVIWDRPTKVGVYDKDCDCFRSIDWGWGQAISH QMLMRRNFLKDDTLIIFVDFKDLTHLRQTEVPISSRSVIPRGLLLQGQEPLALGDSRIAMMEES LPRRLDQRQPSRPKRSVENTGPMEDHNWPQYFRDPCDPNPCQNEGTCVNVKGMASCRCVSGHAF FYTGERCQAMHVHGSLLGLLIGCITALIFLTFITFSNTYQKLRQ hide sequence

Ensembl Acc Id:

ENSRNOP00000014791 ⟸ ENSRNOT00000014791

Ensembl Acc Id:

ENSRNOP00000077952 ⟸ ENSRNOT00000105548

Ensembl Acc Id:

ENSRNOP00000105421 ⟸ ENSRNOT00000126070

Protein Domains

EGF-like MAM MATH Peptidase M12A

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q64230-F1-model_v2	AlphaFold	Q64230	1-748	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696557

Promoter ID:

EPDNEW_R7081

Type:

multiple initiation site

Name:

Mep1a_1

Description:

meprin A subunit alpha

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	20,048,180 - 20,048,240	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3080	AgrOrtholog
BioCyc Gene	G2FUF-28105	BioCyc
Ensembl Genes	ENSRNOG00000011022	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000014791	ENTREZGENE
	ENSRNOT00000014791.8	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.120.200	UniProtKB/Swiss-Prot
	3.40.390.10	UniProtKB/Swiss-Prot
	Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A	UniProtKB/Swiss-Prot
	Laminin	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7128404	IMAGE-MGC_LOAD
InterPro	ConA-like_dom_sf	UniProtKB/Swiss-Prot
	EGF-like_dom	UniProtKB/Swiss-Prot
	MAM_dom	UniProtKB/Swiss-Prot
	MATH/TRAF_dom	UniProtKB/Swiss-Prot
	Meprin	UniProtKB/Swiss-Prot
	MetalloPept_cat_dom_sf	UniProtKB/Swiss-Prot
	Peptidase_M12A	UniProtKB/Swiss-Prot
	Peptidase_Metallo	UniProtKB/Swiss-Prot
	TRAF-like	UniProtKB/Swiss-Prot
KEGG Report	rno:25684	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93579	IMAGE-MGC_LOAD
NCBI Gene	25684	ENTREZGENE
PANTHER	DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING	UniProtKB/Swiss-Prot
	PTHR10127:SF824	UniProtKB/Swiss-Prot
Pfam	Astacin	UniProtKB/Swiss-Prot
	EGF	UniProtKB/Swiss-Prot
	MAM	UniProtKB/Swiss-Prot
	MATH_2	UniProtKB/Swiss-Prot
PhenoGen	Mep1a	PhenoGen
PIRSF	Meprin	UniProtKB/Swiss-Prot
PRINTS	ASTACIN	UniProtKB/Swiss-Prot
	MAMDOMAIN	UniProtKB/Swiss-Prot
PROSITE	ASTACIN	UniProtKB/Swiss-Prot
	EGF_3	UniProtKB/Swiss-Prot
	MAM_1	UniProtKB/Swiss-Prot
	MAM_2	UniProtKB/Swiss-Prot
	MATH	UniProtKB/Swiss-Prot
	ZINC_PROTEASE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000011022	RatGTEx
SMART	MAM	UniProtKB/Swiss-Prot
	MATH	UniProtKB/Swiss-Prot
	ZnMc	UniProtKB/Swiss-Prot
Superfamily-SCOP	EGF/Laminin	UniProtKB/Swiss-Prot
	Metalloproteases ('zincins'), catalytic domain	UniProtKB/Swiss-Prot
	SSF49899	UniProtKB/Swiss-Prot
	TRAF domain-like	UniProtKB/Swiss-Prot
UniProt	A0A8I5Y808_RAT	UniProtKB/TrEMBL
	A0ABK0LIQ1_RAT	UniProtKB/TrEMBL
	A6JJ38_RAT	UniProtKB/TrEMBL
	MEP1A_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q642C9	ENTREZGENE
UniProt Secondary	Q642C9	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-03-29	Mep1a	meprin A subunit alpha	Mep1a	meprin 1 subunit alpha	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-03-04	Mep1a	meprin 1 subunit alpha	Mep1a	meprin 1 alpha	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-04-12	Mep1a	meprin 1 alpha	LOC688307	similar to Meprin A alpha-subunit precursor (Endopeptidase-2) (MEP-1) (Endopeptidase-24.18 alpha-subunit) (E-24.18)	Data merged from RGD:1590063	737654	PROVISIONAL
2006-11-20	LOC688307	similar to Meprin A alpha-subunit precursor (Endopeptidase-2) (MEP-1) (Endopeptidase-24.18 alpha-subunit) (E-24.18)			Symbol and Name status set to provisional	70820	PROVISIONAL
2002-06-10	Mep1a	Meprin 1 alpha			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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