Mcpt9 (mast cell protease 9) - Rat Genome Database

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Gene: Mcpt9 (mast cell protease 9) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mcpt9 (Ensembl: Mcpt8)
Name: mast cell protease 9 (Ensembl:mast cell protease 8)
RGD ID: 3068
Description: ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN proteolysis (inferred); INTERACTS WITH 3,7-dihydropurine-6-thione; flavonoids; furan
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: granzyme J
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,827,348 - 33,830,396 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1533,827,378 - 33,830,396 (+)EnsemblGRCr8
mRatBN7.21529,857,182 - 29,860,145 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,799,357 - 29,860,148 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1531,703,166 - 31,706,129 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,850,367 - 32,853,330 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01531,108,500 - 31,111,463 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01535,018,087 - 35,020,842 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,644,464 - 34,694,244 (-)Ensemblrn6Rnor6.0
Rnor_5.01538,906,078 - 38,908,833 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41534,541,911 - 34,544,835 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1529,431,920 - 29,434,844 (+)NCBICelera
RGSC_v3.11534,446,671 - 34,560,535 (+)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. cDNA cloning of granzyme J. Ewoldt GR, etal., Immunogenetics. 1997;45(6):452-4.
2. Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations. Lutzelschwab C, etal., J Exp Med 1997 Jan 6;185(1):13-29.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Genomics

Variants

.
Variants in Mcpt9
4 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
RH130893  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01534,667,438 - 34,668,061NCBIRnor6.0
Rnor_5.01538,557,543 - 38,558,166UniSTSRnor5.0
Rnor_5.0X6,578,989 - 6,579,613UniSTSRnor5.0
RH 3.4 Map15260.09UniSTS
Cytogenetic Map15p12UniSTS
Cytogenetic Map15p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 12 20 66 128 88 11 11 33 21 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000027950   ⟹   ENSRNOP00000027950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,799,357 - 29,860,148 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000049315   ⟹   ENSRNOP00000043846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,857,981 - 29,860,148 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072426   ⟹   ENSRNOP00000067099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,857,514 - 29,860,148 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079782   ⟹   ENSRNOP00000075590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,857,130 - 29,860,145 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099690   ⟹   ENSRNOP00000097551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,799,357 - 29,802,380 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101483   ⟹   ENSRNOP00000092595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,799,861 - 29,802,383 (+)Ensembl
RefSeq Acc Id: NM_019323   ⟹   NP_062196
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,827,430 - 33,830,393 (+)NCBI
mRatBN7.21529,857,182 - 29,860,145 (+)NCBI
Rnor_6.01535,018,087 - 35,020,842 (+)NCBI
Rnor_5.01538,906,078 - 38,908,833 (+)NCBI
RGSC_v3.41534,541,911 - 34,544,835 (+)RGD
Celera1529,431,920 - 29,434,844 (+)RGD
Sequence:
RefSeq Acc Id: XM_063274590   ⟹   XP_063130660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,827,348 - 33,830,396 (+)NCBI
RefSeq Acc Id: NP_062196   ⟸   NM_019323
- Peptide Label: precursor
- UniProtKB: A0A0G2KAZ8 (UniProtKB/TrEMBL),   A6KH77 (UniProtKB/TrEMBL),   A0A8L2QF87 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027950   ⟸   ENSRNOT00000027950
Ensembl Acc Id: ENSRNOP00000092595   ⟸   ENSRNOT00000101483
Ensembl Acc Id: ENSRNOP00000075590   ⟸   ENSRNOT00000079782
Ensembl Acc Id: ENSRNOP00000097551   ⟸   ENSRNOT00000099690
Ensembl Acc Id: ENSRNOP00000043846   ⟸   ENSRNOT00000049315
Ensembl Acc Id: ENSRNOP00000067099   ⟸   ENSRNOT00000072426
RefSeq Acc Id: XP_063130660   ⟸   XM_063274590
- Peptide Label: isoform X1
Protein Domains
Peptidase S1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3068 AgrOrtholog
BioCyc Gene G2FUF-13666 BioCyc
Ensembl Genes ENSRNOG00000049991 Ensembl
  ENSRNOG00000063482 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000081927 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027950.7 UniProtKB/TrEMBL
  ENSRNOT00000049315.6 UniProtKB/TrEMBL
  ENSRNOT00000072426.4 UniProtKB/TrEMBL
  ENSRNOT00000079782 ENTREZGENE
  ENSRNOT00000079782.3 UniProtKB/TrEMBL
  ENSRNOT00000101483.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Pept_cys/ser_Trypsin-like UniProtKB/TrEMBL
  Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:54272 UniProtKB/TrEMBL
NCBI Gene 54272 ENTREZGENE
PANTHER KALLIKREIN-RELATED UniProtKB/TrEMBL
  MAST CELL PROTEASE 8 UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Mcpt9 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049991 RatGTEx
  ENSRNOG00000063482 RatGTEx
  ENSRNOG00000081927 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
TIGR TC208062
UniProt A0A0A0MY26_RAT UniProtKB/TrEMBL
  A0A0G2KAZ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AHB8_RAT UniProtKB/TrEMBL
  A0A8L2QF87 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QXY5_RAT UniProtKB/TrEMBL
  A6KH77 ENTREZGENE, UniProtKB/TrEMBL
  P97611_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Mcpt9  mast cell protease 9      Name updated 70584 APPROVED