Mcpt8 (mast cell protease 8) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mcpt8 (mast cell protease 8) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mcpt8 (Ensembl: Mcpt10)
Name: mast cell protease 8 (Ensembl:mast cell protease 10)
RGD ID: 3067
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be located in extracellular region. Predicted to be active in extracellular space; INTERACTS WITH 3,7-dihydropurine-6-thione; acrylamide; alachlor.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498519; mast cell protease 10; mast cell protease VIII; RGD1565970; RMCP-10; rMCP-8; rMCP-VIII; RMCP8; similar to mast cell protease 8
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,769,575 - 33,772,633 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21529,799,328 - 29,802,387 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,799,357 - 29,860,148 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1531,645,385 - 31,648,367 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,792,586 - 32,795,568 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01531,050,712 - 31,053,694 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,691,255 - 34,694,209 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,644,464 - 34,694,244 (-)Ensemblrn6Rnor6.0
Rnor_5.01538,534,578 - 38,537,536 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41534,408,591 - 34,411,549 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1529,296,173 - 29,299,131 (+)NCBICelera
RGSC_v3.11534,424,290 - 34,427,246 (+)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations. Lutzelschwab C, etal., J Exp Med 1997 Jan 6;185(1):13-29.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15060002  


Genomics

Variants

.
Variants in Mcpt8
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:79
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000072426
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 3 39 44 81 89 59 91 59 5 268 149 11 29 42 66 30 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000027950   ⟹   ENSRNOP00000027950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,799,357 - 29,860,148 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000049315   ⟹   ENSRNOP00000043846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,828,229 - 33,830,396 (+)Ensembl
mRatBN7.2 Ensembl1529,857,981 - 29,860,148 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072426   ⟹   ENSRNOP00000067099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,827,762 - 33,830,396 (+)Ensembl
mRatBN7.2 Ensembl1529,857,514 - 29,860,148 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079782   ⟹   ENSRNOP00000075590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,827,378 - 33,830,393 (+)Ensembl
mRatBN7.2 Ensembl1529,857,130 - 29,860,145 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099690   ⟹   ENSRNOP00000097551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,799,357 - 29,802,380 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101483   ⟹   ENSRNOP00000092595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,828,304 - 33,830,396 (+)Ensembl
mRatBN7.2 Ensembl1529,799,861 - 29,802,383 (+)Ensembl
RefSeq Acc Id: NM_021598   ⟹   NP_067609
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,769,649 - 33,772,631 (+)NCBI
mRatBN7.21529,799,401 - 29,802,383 (+)NCBI
RefSeq Acc Id: XM_039093840   ⟹   XP_038949768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,769,575 - 33,772,633 (+)NCBI
mRatBN7.21529,799,328 - 29,802,387 (+)NCBI
Protein Sequences
Protein RefSeqs NP_067609 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949768 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB48266 (Get FASTA)   NCBI Sequence Viewer  
  EDM14303 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000083076
  ENSRNOP00000097551.1
GenBank Protein P97594 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_038949768   ⟸   XM_039093840
- Peptide Label: isoform X1
- UniProtKB: Q6IE58 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092595   ⟸   ENSRNOT00000101483
Ensembl Acc Id: ENSRNOP00000067099   ⟸   ENSRNOT00000072426
Ensembl Acc Id: ENSRNOP00000043846   ⟸   ENSRNOT00000049315
Ensembl Acc Id: ENSRNOP00000027950   ⟸   ENSRNOT00000027950
Ensembl Acc Id: ENSRNOP00000075590   ⟸   ENSRNOT00000079782
Ensembl Acc Id: ENSRNOP00000097551   ⟸   ENSRNOT00000099690
RefSeq Acc Id: NP_067609   ⟸   NM_021598
- Peptide Label: precursor
- UniProtKB: P97594 (UniProtKB/Swiss-Prot),   A6KH76 (UniProtKB/TrEMBL),   Q6IE58 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97594-F1-model_v2 AlphaFold P97594 1-248 view protein structure
AF-Q06606-F1-model_v2 AlphaFold Q06606 1-248 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699708
Promoter ID:EPDNEW_R10223
Type:single initiation site
Name:Mcpt8_1
Description:mast cell protease 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01534,694,228 - 34,694,288EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3067 AgrOrtholog
BioCyc Gene G2FUF-13669 BioCyc
Ensembl Genes ENSRNOG00000049991 Ensembl
  ENSRNOG00000063482 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000084528 ENTREZGENE
Ensembl Transcript ENSRNOT00000097106 ENTREZGENE
  ENSRNOT00000099690.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:29269 UniProtKB/Swiss-Prot
  rno:54269 UniProtKB/Swiss-Prot
NCBI Gene 29269 ENTREZGENE
PANTHER KALLIKREIN-RELATED UniProtKB/Swiss-Prot
  MAST CELL PROTEASE 8 UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Mcpt8 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000049991 RatGTEx
  ENSRNOG00000063482 RatGTEx
  ENSRNOG00000084528 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt A0A0A0MY26_RAT UniProtKB/TrEMBL
  A0A8I5ZW69_RAT UniProtKB/TrEMBL
  A0A8I6AHB8_RAT UniProtKB/TrEMBL
  A0A8L2QXY5_RAT UniProtKB/TrEMBL
  A6KH74_RAT UniProtKB/TrEMBL
  A6KH76 ENTREZGENE, UniProtKB/TrEMBL
  MCPT8_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6IE58 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Mcpt8  mast cell protease 8  RGD1565970  similar to mast cell protease 8  Data merged from RGD:1565970 737654 PROVISIONAL
2008-04-30 RGD1565970  similar to mast cell protease 8   RGD1565970_predicted  similar to mast cell protease 8 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565970_predicted  similar to mast cell protease 8 (predicted)  LOC498519  similar to mast cell protease 8  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498519  similar to mast cell protease 8      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Mcpt8  mast cell protease 8      Name updated 70584 APPROVED