Mcpt4 (mast cell protease 4) - Rat Genome Database

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Gene: Mcpt4 (mast cell protease 4) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mcpt4
Name: mast cell protease 4
RGD ID: 3064
Description: Enables heparin binding activity; peptide binding activity; and serine-type endopeptidase activity. Involved in protein catabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space; INTERACTS WITH 17alpha-ethynylestradiol; alendronic acid; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mast cell protease IV; rMCP-4; rMCP-IV
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,471,491 - 33,474,112 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1533,471,491 - 33,474,110 (+)EnsemblGRCr8
mRatBN7.21529,501,595 - 29,504,216 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,501,595 - 29,504,214 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1531,347,217 - 31,349,838 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,494,435 - 32,497,056 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,736,810 - 30,739,431 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,751,550 - 34,754,409 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,751,550 - 34,796,223 (+)Ensemblrn6Rnor6.0
Rnor_5.01538,644,897 - 38,647,756 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41534,167,643 - 34,170,264 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1529,073,058 - 29,075,679 (+)NCBICelera
RGSC_v3.11534,183,342 - 34,185,962 (+)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat mast cell protease 4 is a beta-chymase with unusually stringent substrate recognition profile. Karlson U, etal., J Biol Chem 2002 May 24;277(21):18579-85.
3. Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations. Lutzelschwab C, etal., J Exp Med 1997 Jan 6;185(1):13-29.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Mcpt4
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:70
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000027918
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
13 1 8 14 47 49 31 36 31 4 133 48 2 7 41 40 18

Sequence


RefSeq Acc Id: NM_019321   ⟹   NP_062194
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,471,491 - 33,474,112 (+)NCBI
mRatBN7.21529,501,595 - 29,504,216 (+)NCBI
Rnor_6.01534,751,550 - 34,754,409 (+)NCBI
Rnor_5.01538,644,897 - 38,647,756 (+)NCBI
RGSC_v3.41534,167,643 - 34,170,264 (+)RGD
Celera1529,073,058 - 29,075,679 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062194 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB48260 (Get FASTA)   NCBI Sequence Viewer  
  EDM14299 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069727
  ENSRNOP00000069727.1
GenBank Protein P97592 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062194   ⟸   NM_019321
- Peptide Label: precursor
- UniProtKB: P97592 (UniProtKB/Swiss-Prot),   A6KH70 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97592-F1-model_v2 AlphaFold P97592 1-246 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699700
Promoter ID:EPDNEW_R10224
Type:single initiation site
Name:Mcpt3_1
Description:mast cell peptidase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01534,751,529 - 34,751,589EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3064 AgrOrtholog
BioCyc Gene G2FUF-13671 BioCyc
Ensembl Genes ENSRNOG00000024785 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000089559 ENTREZGENE
  ENSRNOT00000089559.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
KEGG Report rno:54270 UniProtKB/Swiss-Prot
NCBI Gene 54270 ENTREZGENE
PANTHER CHYMASE 2, MAST CELL-RELATED UniProtKB/Swiss-Prot
  KALLIKREIN-RELATED UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Mcpt4 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000024785 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt A6KH70 ENTREZGENE, UniProtKB/TrEMBL
  MCPT4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Mcpt4  mast cell protease 4      Name updated 70584 APPROVED