Igfbp2 (insulin-like growth factor binding protein 2) - Rat Genome Database

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Gene: Igfbp2 (insulin-like growth factor binding protein 2) Rattus norvegicus
Analyze
Symbol: Igfbp2
Name: insulin-like growth factor binding protein 2
RGD ID: 2873
Description: Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including response to estradiol; response to estrogen; and response to retinoic acid. Located in apical plasma membrane and extracellular space. Biomarker of hypertension and hypothyroidism. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP2 (insulin like growth factor binding protein 2); PARTICIPATES IN insulin-like growth factor signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BRL-BP; IBP-2; IGF-binding protein 2; IGFBP-2; ILGFBPA; insulin-like growth factor-binding protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8981,864,811 - 81,892,179 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl981,864,783 - 81,892,171 (+)EnsemblGRCr8
mRatBN7.2974,415,574 - 74,442,945 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl974,415,546 - 74,442,937 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx982,870,444 - 82,897,811 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0987,999,330 - 88,026,694 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0986,386,056 - 86,413,442 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0980,118,029 - 80,144,804 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl980,118,029 - 80,144,789 (+)Ensemblrn6Rnor6.0
Rnor_5.0979,888,642 - 79,915,196 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4971,966,877 - 71,994,211 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera972,008,814 - 72,036,115 (+)NCBICelera
RGSC_v3.1972,113,854 - 72,141,188 (+)NCBI
Cytogenetic Map9q33NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
Ampullosporin  (EXP)
anthracen-2-amine  (EXP)
antimycin A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bicalutamide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
bromochloroacetic acid  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chlorohydrocarbon  (ISO)
chloropicrin  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
cocaine  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP)
elemental selenium  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP)
fenpyroximate  (ISO)
fentin chloride  (EXP)
fluoxetine  (EXP)
flutamide  (EXP,ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
griseofulvin  (ISO)
GSK-J4  (ISO)
hexachlorobenzene  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-ethionine  (EXP)
leflunomide  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lycopene  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
omeprazole  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
rotenone  (EXP,ISO)
RU 58668  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium tungstate  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vemurafenib  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc oxide  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Protective role of retinoic acid from antiproliferative action of TNF-alpha on lung epithelial cells. Besnard V, etal., Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L863-71.
2. Insulin-like growth factor binding protein-2 expression is decreased by lithium. Bezchlibnyk YB, etal., Neuroreport. 2006 Jun 26;17(9):897-901.
3. Nucleotide sequence and expression of a cDNA clone encoding a fetal rat binding protein for insulin-like growth factors. Brown AL, etal., J Biol Chem 1989 Mar 25;264(9):5148-54.
4. Estradiol and progesterone regulate the expression of insulin-like growth factor-I receptor and insulin-like growth factor binding protein-2 in the hypothalamus of adult female rats. Cardona-Gomez GP, etal., J Neurobiol. 2000 Jun 5;43(3):269-81.
5. Comparative analysis of aqueous humor cytokine levels between patients with exudative age-related macular degeneration and normal controls. Cha DM, etal., Invest Ophthalmol Vis Sci. 2013 Oct 25;54(10):7038-44. doi: 10.1167/iovs.13-12730.
6. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
7. The regulation of IGFs and IGFBPs by prolactin in primary culture of fetal rat hepatocytes is influenced by maternal malnutrition. El Khattabi I, etal., Am J Physiol Endocrinol Metab. 2006 Oct;291(4):E835-42. Epub 2006 May 23.
8. Neonatal isolation changes the expression of IGF-IR and IGFBP-2 in the hippocampus in response to adulthood restraint stress. Erabi K, etal., Int J Neuropsychopharmacol. 2007 Jun;10(3):369-81. Epub 2006 Jul 19.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. A 14-kDa cathepsin L-derived carboxyl IGFBP-2 fragment is sequestered by cultured rat ileal crypt cells. Gordon PV, etal., Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G79-87. Epub 2005 Feb 10.
12. Insulin-like growth factor binding protein-2 (IGFBP-2) is a marker for the metabolic syndrome. Heald AH, etal., Exp Clin Endocrinol Diabetes. 2006 Jul;114(7):371-6.
13. Depolarization induces insulin-like growth factor binding protein-2 expression in vivo via NMDA receptor stimulation. Holmin S, etal., Growth Horm IGF Res 2001 Dec;11(6):399-406.
14. Microarray analysis of hippocampal gene expression in global cerebral ischemia. Jin K, etal., Ann Neurol. 2001 Jul;50(1):93-103.
15. Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes. Landau D, etal., Endocrinology. 1995 May;136(5):1835-42. doi: 10.1210/endo.136.5.7536658.
16. Perinatal growth disturbance in the spontaneously hypertensive rat. Lewis RM, etal., Pediatr Res. 1997 Dec;42(6):758-64.
17. A low molecular weight insulin-like growth factor binding protein from rat: cDNA cloning and tissue distribution of its messenger RNA. Margot JB, etal., Mol Endocrinol 1989 Jul;3(7):1053-60.
18. Protein-caloric food restriction affects insulin-like growth factor system in fetal Wistar rat. Martin MA, etal., Endocrinology. 2005 Mar;146(3):1364-71. Epub 2004 Dec 2.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Moloney AM, etal., Neurobiol Aging. 2010 Feb;31(2):224-43. doi: 10.1016/j.neurobiolaging.2008.04.002. Epub .
21. Purification and amino-terminal sequence of an insulin-like growth factor-binding protein secreted by rat liver BRL-3A cells. Mottola C, etal., J Biol Chem. 1986 Aug 25;261(24):11180-8.
22. Expression profile of IGF system during lung injury and recovery in rats exposed to hyperoxia: a possible role of IGF-1 in alveolar epithelial cell proliferation and differentiation. Narasaraju TA, etal., J Cell Biochem. 2006 Apr 1;97(5):984-98.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Potentiating role of IGFBP-2 on IGF-II-stimulated alkaline phosphatase activity in differentiating osteoblasts. Palermo C, etal., Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E648-57. Epub 2003 Dec 9.
25. Influence of hypothyroidism on circulating concentrations and liver expression of IGF-binding proteins mRNA from neonatal and adult rats. Ramos S, etal., J Endocrinol. 2002 Feb;172(2):363-73.
26. Effect of weight loss on free insulin-like growth factor-I in obese women with hyposomatotropism. Rasmussen MH, etal., Obesity (Silver Spring). 2007 Apr;15(4):879-86.
27. In vivo mechanical loading modulates insulin-like growth factor binding protein-2 gene expression in rat osteocytes. Reijnders CM, etal., Calcif Tissue Int. 2007 Feb;80(2):137-43. Epub 2007 Feb 3.
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Altered IGF-I and IGFBPs in senescent male and female rats. Severgnini S, etal., J Gerontol A Biol Sci Med Sci. 1999 Mar;54(3):B111-5.
32. Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human. Shimasaki S, etal., J Biol Chem 1991 Jun 5;266(16):10646-53.
33. Identification of a novel binding protein for insulin-like growth factors in adult rat serum. Shimonaka M, etal., Biochem Biophys Res Commun. 1989 Nov 30;165(1):189-95.
34. Insulin-Like Growth Factors and Their Binding Proteins Define Specific Phases of Myometrial Differentiation During Pregnancy. Shynlova O, etal., Biol Reprod. 2006 Nov 22;.
35. Insulin-like growth factors and their binding proteins define specific phases of myometrial differentiation during pregnancy in the rat. Shynlova O, etal., Biol Reprod. 2007 Apr;76(4):571-8. Epub 2006 Nov 22.
36. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
37. Isolation of a biologically active fragment from the carboxy terminus of the fetal rat binding protein for insulin-like growth factors. Wang JF, etal., Biochem Biophys Res Commun. 1988 Dec 15;157(2):718-26.
38. IGF-binding protein-2 protects against the development of obesity and insulin resistance. Wheatcroft SB, etal., Diabetes. 2007 Feb;56(2):285-94.
39. Gene expression profiling of the effects of castration and estrogen treatment in the rat uterus. Wu X, etal., Biol Reprod. 2003 Oct;69(4):1308-17. Epub 2003 Jun 11.
40. Growth factors and proliferation of cultured rat gingival cells in response to cyclosporin A. Yoshida T, etal., J Periodontal Res. 2005 Feb;40(1):11-9.
Additional References at PubMed
PMID:7510770   PMID:7679139   PMID:10601973   PMID:12477932   PMID:12902319   PMID:15248291   PMID:15694994   PMID:16055936   PMID:16131350   PMID:18549709   PMID:18563800   PMID:18946176  
PMID:19081843   PMID:23376485   PMID:23533145   PMID:24006456   PMID:24352370   PMID:39412224  


Genomics

Comparative Map Data
Igfbp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8981,864,811 - 81,892,179 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl981,864,783 - 81,892,171 (+)EnsemblGRCr8
mRatBN7.2974,415,574 - 74,442,945 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl974,415,546 - 74,442,937 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx982,870,444 - 82,897,811 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0987,999,330 - 88,026,694 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0986,386,056 - 86,413,442 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0980,118,029 - 80,144,804 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl980,118,029 - 80,144,789 (+)Ensemblrn6Rnor6.0
Rnor_5.0979,888,642 - 79,915,196 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4971,966,877 - 71,994,211 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera972,008,814 - 72,036,115 (+)NCBICelera
RGSC_v3.1972,113,854 - 72,141,188 (+)NCBI
Cytogenetic Map9q33NCBI
IGFBP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382216,632,828 - 216,664,436 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2216,632,828 - 216,664,441 (+)Ensemblhg38GRCh38
GRCh372217,497,551 - 217,529,159 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,206,372 - 217,237,404 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342217,323,632 - 217,354,665NCBI
Celera2211,266,003 - 211,297,047 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2209,352,529 - 209,383,563 (+)NCBIHuRef
CHM1_12217,504,294 - 217,535,337 (+)NCBICHM1_1
T2T-CHM13v2.02217,115,243 - 217,146,861 (+)NCBIT2T-CHM13v2.0
Igfbp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39172,863,650 - 72,891,633 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl172,863,662 - 72,891,633 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38172,824,480 - 72,852,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl172,824,503 - 72,852,474 (+)Ensemblmm10GRCm38
MGSCv37172,871,078 - 72,899,048 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36172,756,390 - 72,785,681 (+)NCBIMGSCv36mm8
Celera173,392,679 - 73,420,660 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.94NCBI
Igfbp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545316,557,194 - 16,584,634 (-)Ensembl
ChiLan1.0NW_00495545316,556,873 - 16,584,737 (-)NCBIChiLan1.0ChiLan1.0
IGFBP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213119,259,714 - 119,292,783 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B119,276,573 - 119,307,747 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B103,893,724 - 103,925,318 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B222,498,392 - 222,527,302 (+)NCBIPanPan1.1PanPan1.1panPan2
IGFBP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13723,553,227 - 23,569,321 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3723,559,501 - 23,569,312 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3724,374,276 - 24,397,898 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03723,573,472 - 23,597,135 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3723,573,472 - 23,596,810 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13723,456,971 - 23,480,636 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03723,417,432 - 23,433,721 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03723,436,098 - 23,452,395 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Igfbp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303171,929,066 - 171,954,100 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936586672,091 - 696,692 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936586671,760 - 696,783 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15118,822,047 - 118,850,976 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115118,822,092 - 118,850,985 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IGFBP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110102,469,611 - 102,503,229 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10102,469,669 - 102,503,276 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604096,906,056 - 96,936,013 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igfbp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248238,460,553 - 8,486,495 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248238,460,968 - 8,486,495 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Igfbp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14146,340,498 - 146,367,860 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Igfbp2
224 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:108
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000023068
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
RH130162  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2974,442,629 - 74,442,832 (+)MAPPERmRatBN7.2
Rnor_6.0980,144,489 - 80,144,691NCBIRnor6.0
Rnor_5.0979,914,881 - 79,915,083UniSTSRnor5.0
RGSC_v3.4971,993,896 - 71,994,098UniSTSRGSC3.4
Celera972,035,800 - 72,036,002UniSTS
RH 3.4 Map9679.4UniSTS
Cytogenetic Map9q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 64 151 91 90 59 34 59 6 289 125 5 130 81 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000023068   ⟹   ENSRNOP00000023068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl981,864,783 - 81,892,171 (+)Ensembl
mRatBN7.2 Ensembl974,415,546 - 74,442,937 (+)Ensembl
Rnor_6.0 Ensembl980,118,029 - 80,144,789 (+)Ensembl
RefSeq Acc Id: NM_013122   ⟹   NP_037254
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8981,864,811 - 81,892,179 (+)NCBI
mRatBN7.2974,415,574 - 74,442,945 (+)NCBI
Rnor_6.0980,118,029 - 80,144,804 (+)NCBI
Rnor_5.0979,888,642 - 79,915,196 (+)NCBI
RGSC_v3.4971,966,877 - 71,994,211 (+)RGD
Celera972,008,814 - 72,036,115 (+)RGD
Sequence:
RefSeq Acc Id: XM_063266738   ⟹   XP_063122808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8981,865,763 - 81,892,179 (+)NCBI
RefSeq Acc Id: NP_037254   ⟸   NM_013122
- Peptide Label: precursor
- UniProtKB: Q569C7 (UniProtKB/Swiss-Prot),   P12843 (UniProtKB/Swiss-Prot),   A6JVQ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023068   ⟸   ENSRNOT00000023068
RefSeq Acc Id: XP_063122808   ⟸   XM_063266738
- Peptide Label: isoform X1
- UniProtKB: A6JVQ7 (UniProtKB/TrEMBL),   Q6LDF9 (UniProtKB/TrEMBL)
Protein Domains
IGFBP N-terminal   Thyroglobulin type-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12843-F1-model_v2 AlphaFold P12843 1-304 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696739
Promoter ID:EPDNEW_R7264
Type:initiation region
Name:Igfbp2_1
Description:insulin-like growth factor binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0980,118,011 - 80,118,071EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2873 AgrOrtholog
BioCyc Gene G2FUF-27191 BioCyc
Ensembl Genes ENSRNOG00000016957 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023068 ENTREZGENE
  ENSRNOT00000023068.4 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.40.20 UniProtKB/Swiss-Prot
  4.10.800.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7308779 IMAGE-MGC_LOAD
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  IGFBP-2 UniProtKB/Swiss-Prot
  IGFBP-like UniProtKB/Swiss-Prot
  IGFBP_1-6_chordata UniProtKB/Swiss-Prot
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
  Thyroglobulin_1_sf UniProtKB/Swiss-Prot
KEGG Report rno:25662 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108749 IMAGE-MGC_LOAD
NCBI Gene 25662 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN UniProtKB/Swiss-Prot
  INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2 UniProtKB/Swiss-Prot
Pfam IGFBP UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
PhenoGen Igfbp2 PhenoGen
PRINTS IGFBPFAMILY UniProtKB/Swiss-Prot
  IGFBPFAMILY2 UniProtKB/Swiss-Prot
PROSITE IGFBP_N_1 UniProtKB/Swiss-Prot
  IGFBP_N_2 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_1 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016957 RatGTEx
SMART SM00121 UniProtKB/Swiss-Prot
  SM00211 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot
  SSF57610 UniProtKB/Swiss-Prot
TIGR TC216909
UniProt A6JVQ6 ENTREZGENE, UniProtKB/TrEMBL
  A6JVQ7 ENTREZGENE, UniProtKB/TrEMBL
  A6JVQ8_RAT UniProtKB/TrEMBL
  IBP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q569C7 ENTREZGENE
  Q6LDF9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q569C7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Igfbp2  Insulin-like growth factor binding protein 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver, kidney, intestine, and lung 729148
gene_regulation expression is upregulated by NMDA receptor-mediated depolarization in astrocytes 729220