Guca2a (guanylate cyclase activator 2A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Guca2a (guanylate cyclase activator 2A) Rattus norvegicus
Analyze
Symbol: Guca2a
Name: guanylate cyclase activator 2A
RGD ID: 2766
Description: Enables guanylate cyclase activator activity. Predicted to be located in extracellular region. Orthologous to human GUCA2A (guanylate cyclase activator 2A); INTERACTS WITH 3,7-dihydropurine-6-thione; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: guanyl; Guanylate cyclase activator 2 (guanylin); guanylate cyclase activator 2a (guanylin); guanylin; Guca2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85138,522,446 - 138,524,288 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5138,522,446 - 138,524,287 (+)EnsemblGRCr8
mRatBN7.25133,237,177 - 133,239,019 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5133,237,177 - 133,239,018 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5135,965,843 - 135,967,692 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05137,722,285 - 137,724,134 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05137,742,889 - 137,744,738 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05138,685,634 - 138,687,476 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5138,685,624 - 138,687,816 (+)Ensemblrn6Rnor6.0
Rnor_5.05142,487,928 - 142,489,770 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45140,227,304 - 140,229,146 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5131,760,599 - 131,762,441 (+)NCBICelera
RGSC_v3.15140,232,529 - 140,234,371 (+)NCBI
RH 3.4 Map5875.9RGD
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Guanylin: an endogenous activator of intestinal guanylate cyclase. Currie MG, etal., Proc Natl Acad Sci U S A 1992 Feb 1;89(3):947-51.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Cloning and expression of guanylin. Its existence in various mammalian tissues. Schulz S, etal., J Biol Chem 1992 Aug 15;267(23):16019-21.
10. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
11. Rat guanylin cDNA: characterization of the precursor of an endogenous activator of intestinal guanylate cyclase. Wiegand RC, etal., Biochem Biophys Res Commun 1992 Jun 30;185(3):812-7.
Additional References at PubMed
PMID:14986129   PMID:15901896   PMID:16814407   PMID:22310983   PMID:23081987   PMID:23376485   PMID:26249840   PMID:27044258   PMID:29097254  


Genomics

Comparative Map Data
Guca2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85138,522,446 - 138,524,288 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5138,522,446 - 138,524,287 (+)EnsemblGRCr8
mRatBN7.25133,237,177 - 133,239,019 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5133,237,177 - 133,239,018 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5135,965,843 - 135,967,692 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05137,722,285 - 137,724,134 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05137,742,889 - 137,744,738 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05138,685,634 - 138,687,476 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5138,685,624 - 138,687,816 (+)Ensemblrn6Rnor6.0
Rnor_5.05142,487,928 - 142,489,770 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45140,227,304 - 140,229,146 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5131,760,599 - 131,762,441 (+)NCBICelera
RGSC_v3.15140,232,529 - 140,234,371 (+)NCBI
RH 3.4 Map5875.9RGD
Cytogenetic Map5q36NCBI
GUCA2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38142,162,690 - 42,164,745 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl142,162,690 - 42,164,745 (-)Ensemblhg38GRCh38
GRCh37142,628,361 - 42,630,416 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36142,400,949 - 42,402,982 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34142,297,454 - 42,299,488NCBI
Celera140,910,655 - 40,912,688 (-)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef140,747,927 - 40,749,960 (-)NCBIHuRef
CHM1_1142,745,486 - 42,747,519 (-)NCBICHM1_1
T2T-CHM13v2.0142,033,343 - 42,035,398 (-)NCBIT2T-CHM13v2.0
Guca2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394119,494,929 - 119,496,662 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4119,494,901 - 119,496,668 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384119,637,732 - 119,639,465 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4119,637,704 - 119,639,471 (+)Ensemblmm10GRCm38
MGSCv374119,310,337 - 119,312,070 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364119,135,664 - 119,137,397 (+)NCBIMGSCv36mm8
Celera4118,370,520 - 118,372,251 (+)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map455.47NCBI
Guca2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555371,805,671 - 1,807,662 (-)Ensembl
ChiLan1.0NW_0049555371,805,671 - 1,808,797 (-)NCBIChiLan1.0ChiLan1.0
GUCA2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21184,647,667 - 184,649,748 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11183,789,725 - 183,791,806 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,462,047 - 41,464,122 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1142,841,930 - 42,844,005 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl142,841,930 - 42,844,005 (-)EnsemblpanPan2panpan1.1
GUCA2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1151,090,109 - 1,091,277 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl151,090,109 - 1,091,375 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha151,347,225 - 1,348,394 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0151,177,643 - 1,178,815 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl151,177,643 - 1,178,913 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1151,082,785 - 1,083,953 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0151,144,533 - 1,145,694 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0151,159,429 - 1,160,598 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Guca2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505857,815,809 - 57,818,040 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647423,640,586 - 23,642,599 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647423,640,589 - 23,642,573 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUCA2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6169,146,334 - 169,148,286 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16169,146,336 - 169,148,284 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26156,476,368 - 156,478,316 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GUCA2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12090,757,887 - 90,760,598 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2090,758,455 - 90,760,641 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603326,144,687 - 26,146,880 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Guca2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248921,512,585 - 1,514,339 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248921,498,123 - 1,514,419 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Guca2a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1137,336,523 - 37,338,292 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Guca2a
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:37
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000011867
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133308734140009902Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
RH142427  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85138,523,339 - 138,524,060 (+)Marker Load Pipeline
mRatBN7.25133,238,070 - 133,238,791 (+)MAPPERmRatBN7.2
Rnor_6.05138,686,528 - 138,687,248NCBIRnor6.0
Rnor_5.05142,488,822 - 142,489,542UniSTSRnor5.0
RGSC_v3.45140,228,198 - 140,228,918UniSTSRGSC3.4
Celera5131,761,493 - 131,762,213UniSTS
Cytogenetic Map5q36UniSTS
RH94420  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25133,238,841 - 133,239,001 (+)MAPPERmRatBN7.2
Rnor_6.05138,687,299 - 138,687,458NCBIRnor6.0
Rnor_5.05142,489,593 - 142,489,752UniSTSRnor5.0
RGSC_v3.45140,228,969 - 140,229,128UniSTSRGSC3.4
Celera5131,762,264 - 131,762,423UniSTS
RH 3.4 Map5875.9UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 61 139 84 83 52 80 52 6 316 165 2 124 77 91 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000011867   ⟹   ENSRNOP00000011867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5138,522,446 - 138,524,287 (+)Ensembl
mRatBN7.2 Ensembl5133,237,177 - 133,239,018 (+)Ensembl
Rnor_6.0 Ensembl5138,685,624 - 138,687,816 (+)Ensembl
RefSeq Acc Id: NM_013118   ⟹   NP_037250
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85138,522,446 - 138,524,288 (+)NCBI
mRatBN7.25133,237,177 - 133,239,019 (+)NCBI
Rnor_6.05138,685,634 - 138,687,476 (+)NCBI
Rnor_5.05142,487,928 - 142,489,770 (+)NCBI
RGSC_v3.45140,227,304 - 140,229,146 (+)RGD
Celera5131,760,599 - 131,762,441 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037250 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41300 (Get FASTA)   NCBI Sequence Viewer  
  AAA41302 (Get FASTA)   NCBI Sequence Viewer  
  CAA47901 (Get FASTA)   NCBI Sequence Viewer  
  EDL90107 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011867
  ENSRNOP00000011867.2
GenBank Protein P28902 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037250   ⟸   NM_013118
- Peptide Label: precursor
- UniProtKB: P28902 (UniProtKB/Swiss-Prot),   A6JZP6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011867   ⟸   ENSRNOT00000011867

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28902-F1-model_v2 AlphaFold P28902 1-115 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693985
Promoter ID:EPDNEW_R4510
Type:single initiation site
Name:Guca2a_1
Description:guanylate cyclase activator 2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05138,685,610 - 138,685,670EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2766 AgrOrtholog
BioCyc Gene G2FUF-40081 BioCyc
Ensembl Genes ENSRNOG00000008849 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011867 ENTREZGENE
  ENSRNOT00000011867.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.1450.10 UniProtKB/Swiss-Prot
InterPro Guanylin UniProtKB/Swiss-Prot
  Guanylin_sf UniProtKB/Swiss-Prot
KEGG Report rno:25656 UniProtKB/Swiss-Prot
NCBI Gene 25656 ENTREZGENE
PANTHER GUANYLIN UniProtKB/Swiss-Prot
  PTHR11318 UniProtKB/Swiss-Prot
Pfam Guanylin UniProtKB/Swiss-Prot
PhenoGen Guca2a PhenoGen
PIRSF Guanylin UniProtKB/Swiss-Prot
PRINTS GUANYLIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008849 RatGTEx
Superfamily-SCOP SSF89890 UniProtKB/Swiss-Prot
TIGR TC220815
UniProt A6JZP6 ENTREZGENE, UniProtKB/TrEMBL
  GUC2A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Guca2a  guanylate cyclase activator 2A  Guca2a  guanylate cyclase activator 2a (guanylin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Guca2a  guanylate cyclase activator 2a (guanylin)    guanylate cyclase activator 2A   Name updated 1299863 APPROVED
2002-11-06 Guca2a  guanylate cyclase activator 2A     Guanylate cyclase activator 2 (guanylin)  Name updated 625702 APPROVED
2002-06-10 Guca2a  Guanylate cyclase activator 2 (guanylin)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein synthesized as a pro-guanylin polypeptide that may undergo processing to release the mature peptide 728502